← Back to Search
Acetylcholinesterase Inhibitors From Corydalis Yanhusuo
Hai-tao Xiao, Jiao Peng, Yan Liang, Jie Yang, Xue Bai, X. Hao, Fu-mei Yang, Qian-yun Sun
Published 2011 · Chemistry, Medicine
Save to my Library
Download via 🐼 PaperPanda Download via oaDOI Download via OAB Download via LibKey Download via Google Google ScholarAnalyze on Scholarcy Visualize in Litmaps
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
In a bioassay-guided search for acetylcholinesterase (AChE) inhibitors from Chinese natural resources, eight isoquinoline alkaloids, tetrahydropalmatine (1), corydaline (2), protopine (3), berberine (4), palmatine (5), jatrorrhizine (6), coptisine (7) and dehydrocorydaline (8), were isolated from the methanolic extract of the tubers of Corydalis yanhusuo. Structures of these compounds were identified by spectroscopic techniques. Compounds 4–8 inhibited AChE activity in a dose-dependent manner, and the IC50 values were 0.47 ± 0.01, 0.74 ± 0.06, 2.08 ± 0.09, 1.01 ± 0.03 and 0.62 ± 0.05 µM, respectively. Structure–activity relationship analysis suggested that aromatisation at ring C, as well as substitutions at C-2, C-3, C-9, C-10 and C-13 affect the AChE activity of protoberberine alkaloids.
This paper references
A new and rapid colorimetric determination of acetylcholinesterase activity.
G. Ellman (1961)
Structure-activity relationships of quaternary protoberberine alkaloids having an antimalarial activity
K. Iwasa (1999)
Structure—Activity Relationships of Quaternary Protoberberine Alkaloids Having an Antimalarial Activity.
K. Iwasa (2000)
On Neurodegenerative Diseases, Models, and Treatment Strategies: Lessons Learned and Lessons Forgotten a Generation Following the Cholinergic Hypothesis
R. Bartus (2000)
New cholinesterase inhibiting steroidal alkaloids from the leaves of Sarcococca coriacea of Nepalese origin.
S. Kalauni (2002)
Protopine alkaloids in horse urine.
P. Wynne (2004)
The combination of rat mast cell and rabbit aortic smooth muscle is the simple bioassay for the screening of anti-allergic ingredient from methanolic extract of Corydalis tuber.
Shin-ya Saito (2004)
Preparative Isolation and Purification of Alkaloids from Corydalis yanhusuo W. T. Wang by High Speed Counter‐Current Chromatography
S. Tong (2005)
Preparative isolation and purification of alkaoids from Corydalis yanhusuo W. T. Wang by high speed counter-current chromatography
S. Q. Tong (2005)
Qualitative and quantitative determination of ten alkaloids in traditional Chinese medicine Corydalis yanhusuo W.T. Wang by LC-MS/MS and LC-DAD.
B. Ding (2007)
Chemical constituents from Mahonia duclouxiana Gagnep.(I)
Liu Bu-ming (2008)
Separation and purification of dl-tetrahydropalmatine from Corydalis yanhusuo by high-speed counter-current chromatography
Zhilan Liu (2008)
This paper is referenced by
Urinary Metabolomic Profiling after Administration of Corydalis Tuber and Pharbitis Seed Extract in Healthy Korean Volunteers
H. Jeong (2021)
Establishment of a High-Resolution Liquid Chromatography-Mass Spectrometry Spectral Library for Screening Toxic Natural Products.
Y. R. Luo (2021)
Rapid Quality Identification of Decoction Pieces of Crude and Processed Corydalis Rhizoma by Near-Infrared Spectroscopy Coupled with Chemometrics
Weihao Zhu (2021)
Motilitone toxicity in a dog
Yoon-Hwan Kim (2021)
A Computational Approach for Exploring Herbal Inhibitors of Acetylcholinesterase in Alzheimer's Disease
Bishajit Sarkar (2020)
Corydalis edulis total alkaloids (CETA) ameliorates cognitive dysfunction in rat model of Alzheimer disease through regulation of the antioxidant stress and MAP2/NF-κB.
Shuai Liang (2020)
Advances in phytochemical and modern pharmacological research of Rhizoma Corydalis
Bing-kun Tian (2020)
NeuroDefend, a novel Chinese medicine, attenuates amyloid-β and tau pathology in experimental Alzheimer's disease models.
A. Iyaswamy (2020)
Dehydrocorydaline Accounts the Majority of Anti-Inflammatory Property of Corydalis Rhizoma in Cultured Macrophage
Xiang-Peng Kong (2020)
Potent Acetylcholinesterase Inhibitors: Potential Drugs for Alzheimer's Disease.
Hulya Akincioglu (2020)
Cholinesterase inhibitory isoquinoline alkaloids from Corydalis mucronifera.
J. Zhang (2019)
Palmatine: A review of its pharmacology, toxicity and pharmacokinetics.
Jiaying Long (2019)
Huanrong Hu (2019)
Antibacterial activity of flavonoids and their structure–activity relationship: An update review
F. Farhadi (2019)
Dehydrocorydaline inhibits cell proliferation, migration and invasion via suppressing MEK1/2-ERK1/2 cascade in melanoma
Huanrong Hu (2019)
Considérations sur l’histoire naturelle des Ranunculales
L. Carrive (2019)
Small molecules as inhibitors of PCSK9: Current status and future challenges.
Shengtao Xu (2019)
Dihydroberberine, a hydrogenated derivative of berberine firstly identified in Phellodendri Chinese Cortex, exerts anti-inflammatory effect via dual modulation of NF-κB and MAPK signaling pathways.
Lihua Tan (2019)
Selective inhibition of monoamine oxidase A by chelerythrine, an isoquinoline alkaloid.
S. C. Baek (2018)
Anti‐Metastatic Effect of Dehydrocorydaline on H1299 Non‐Small Cell Lung Carcinoma Cells via Inhibition of Matrix Metalloproteinases and B Cell Lymphoma 2
J. Lee (2017)
Corydaline inhibits enterovirus 71 replication by regulating COX-2 expression
Hui-qiang Wang (2017)
Decreased risk of dementia in migraine patients with traditional Chinese medicine use: a population-based cohort study.
Chun-Ting Liu (2017)
Network Pharmacology-Based Approach to Investigate the Analgesic Efficacy and Molecular Targets of Xuangui Dropping Pill for Treating Primary Dysmenorrhea
Jihan Huang (2017)
Recent progress on the traditional Chinese medicines that regulate the blood.
H. Hung (2016)
Screening of Natural Product Libraries for the Extension of Cell Life-span through Immune System
Bo-Kyung Yoo (2016)
Analyses of Total Alkaloid Extract of Corydalis yanhusuo by Comprehensive RP × RP Liquid Chromatography with pH Difference
Xiaodong Wei (2016)
Synthesis of C3/C1-Substituted Tetrahydroisoquinolines
M. Mihoubi (2015)
Annickia affinis and A. chlorantha (Enantia chlorantha)--A review of two closely related medicinal plants from tropical Africa.
D. Olivier (2015)
A divergent route to 9, 10-oxygenated tetrahydroprotoberberine and 8-oxoprotoberberine alkaloids: synthesis of (±)-isocorypalmine and oxypalmatine.
Satish Gadhiya (2015)
Synergistic Inhibition on Acetylcholinesterase by the Combination of Berberine and Palmatine Originally Isolated from Chinese Medicinal Herbs
S. Mak (2014)
Biologically active isoquinoline alkaloids with drug-like properties from the genus Corydalis
Milad Iranshahy (2014)
Inhibitors of Acetylcholinesterase and Butyrylcholinesterase Meet Immunity
M. Pohanka (2014)See more