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Synthesis And Anti-Hiv Activity Of 4′-Modified Cyclopentenyl Pyrimidine C-Nucleosides

L. Liu, J. Hong
Published 2009 · Chemistry, Medicine

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Novel syntheses of 4′-modified cyclopentenyl pyrimidine C-nucleosides were performed via C-C bond formation using SN2 alkylation via the key intermediate mesylates 6 and 16, which were prepared from acyclic ketone derivatives. When antiviral evaluation of synthesized compound was performed against various viruses such as HIV-1, HSV-1 and HSV-2, isocytidine analogue 20 showed moderate anti-HIV activity in CEM cell line (EC50 = 13.1 μmol).7
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