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The Insular Lobe Of Reil–its Anatamico-Functional, Behavioural And Neuropsychiatric Attributes In Humans–a Review

B. Shelley, M. Trimble
Published 2004 · Psychology, Medicine

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Summary There is considerable clinical and experimental research to explore the anatamico-functional correlations of the limbic lobe to establish its relevance in modern neuroscience. The insula being a pivotal structure in the concept of the greater limbic lobe, we have attempted to highlight in this review the topographical anatomy and development, the remarkable heterogeneity of the insular cortical architecture, the widespread multifaceted spectrum of functional connectivity patterns and how this is translated to its behavioural specialisation in humans. The insula serves as an intergration cortex for multimodal convergence of distributed neural networks such as the somesthetic-limbic, insulolimbic, insulo-orbito-temporal and the prefrontalstriato- pallidal-basal forebrain. This provides the conceptual framework to facilitate functional and clinical considerations relevant to the various behavioural and neuropsychiatric disorders outlined in this review. The functional role of the insula in these disorders with particular reference to the current functional neuroimaging data has been also reviewed in this article.
This paper references
Stereotaxic approach to epilepsy: methodology of anatomofunctional stereotaxic investigations
J Talairach (1973)
10.1002/ANA.410350406
Vestibular cortex lesions affect the perception of verticality
T. Brandt (1994)
10.1155/1998/423645
The opercular-subopercular syndrome: four cases with review of the literature.
M. Bakar (1998)
10.1080/01616412.1985.11739692
The insular lobe in primates including humans.
J. Augustine (1985)
Behavioural effects of damage to the right insula and surrounding regions
M Berthier (1987)
10.3171/JNS.1971.35.5.0554
Circling and rotational automatisms in patients with frontotemporal cortical and subcortical lesions.
R. Schneider (1971)
10.1016/S0024-3205(03)00512-5
Quantitative assessment of DNA fragmentation and beta-amyloid deposition in insular cortex and midfrontal gyrus from patients with Alzheimer's disease.
G. J. Colurso (2003)
10.1016/S0022-510X(02)00006-0
Progression and staging of Lewy pathology in brains from patients with dementia with Lewy bodies
W. Marui (2002)
Wernicke works on aphasia: A source book and review
K Wernicke
Herpes simplex virus antigen detection in human acute encephalitis: an immunohistochemical study using avidin-biotin-peroxidase complex method
C Charpin (1985)
10.1523/JNEUROSCI.11-08-02383.1991
Selective and divided attention during visual discriminations of shape, color, and speed: functional anatomy by positron emission tomography
M. Corbetta (1991)
10.1016/S0010-0277(00)00104-9
Recognizing one's own face
T. Kircher (2001)
10.1016/S0304-3959(02)00276-2
Temporo-spatial analysis of cortical activation by phasic innocuous and noxious cold stimuli – a magnetoencephalographic study
C. Maihöfner (2002)
10.1159/000008105
Prolongation of the Frequency-Corrected QT Dispersion following Cerebral Strokes with Involvement of the Insula of Reil
M. Eckardt (1999)
Effects of stroke localisation on cardiac autonomic balance and sudden death
S L Tokgozoglu (1999)
High order gustatory projections in the human brain studied with positron emission tomography. The Salt Science Annual Research Report, Section of Physiology and Food Science
H Fukuda (1991)
Fiber connections of the corpus striatum of the monkeys and baboon Monro A (1783) Observations on the structure and function of the nervous system
Fa Mettler (1945)
The cytoarchitectonics of the human cerebral cortex. Translated Parker S
Von Economo (1929)
10.1136/jnnp.74.10.1398
A study of stereotypic behaviours in Alzheimer’s disease and frontal and temporal variant frontotemporal dementia
S. Nyatsanza (2003)
10.3171/JNS.1999.90.4.0720
Topographic anatomy of the insular region.
U. Türe (1999)
10.1002/CNE.901170109
Somatovisceral motor patterns in the insula
M. J. Showers (1961)
Perte de la parole, ramouissement chronique et destruction partielle du lobe antérieur gauche du cerveau
P. Broca (1861)
10.1038/sj.ijir.3900649
A new potential of blood oxygenation level dependent (BOLD) functional MRI for evaluating cerebral centers of penile erection
K. Park (2001)
10.1002/ANA.410240109
Asymbolia for pain: A sensory‐limbic disconnection syndrome
M. Berthier (1988)
Visual-vestibular and visuovisual cortical interaction: new insights from fMRI and pet.
T. Brandt (2002)
Cardiac manifestation of acute neurological lesions Neurology and General Medicine: The neurological aspects of medical disorder
S Oppenheimer (1995)
Cardiac manifestation of acute neurological lesions
JW Norris
Principles of Behavioural Neurology
MM Mesulam (1985)
10.1001/ARCHPSYC.1995.03950130020003
A positron emission tomographic study of simple phobic symptom provocation.
S. Rauch (1995)
Behavioural effects of damage to the right insula and surrounding regions. Cortex
M Berthier (1987)
The cytoarchitectonics of the human cerebral cortex
C Von Economo (1929)
Remarques sur le siege de la faculte du langage articule suivies d'une observation d'aphemie
P. Broca (1861)
10.1016/s0140-6736(55)90021-0
[Visceral epilepsy].
J. Garcia (1953)
10.1016/0168-5597(94)00297-R
Topographic mapping of cortical potentials evoked by distension of the human proximal and distal oesophagus.
Q. Aziz (1995)
10.1136/jnnp.69.2.178
Which neuropsychiatric and behavioural features distinguish frontal and temporal variants of frontotemporal dementia from Alzheimer's disease?
S. Bozeat (2000)
10.1006/nimg.2002.1087
Functional Neuroanatomy of Emotion: A Meta-Analysis of Emotion Activation Studies in PET and fMRI
K. L. Phan (2002)
10.1016/S0893-133X(01)00428-6
The Functional Neuroanatomy of Tourette's Syndrome: An FDG PET Study III: Functional Coupling of Regional Cerebral Metabolic Rates
K. J. Jeffries (2002)
10.1016/S0165-1838(99)00097-1
The human nucleus of the solitary tract: visceral pathways revealed with an "in vitro" postmortem tracing method.
D. Ruggiero (2000)
10.1212/WNL.52.6.1166
Acute blood flow changes and efficacy of vagus nerve stimulation in partial epilepsy
T. Henry (1999)
10.1016/S0079-6123(08)63050-2
"Perestroika" in the basal forebrain: opening the border between neurology and psychiatry.
L. Heimer (1991)
10.1002/CNE.901150304
The claustrum, the external capsule and the extreme capsule of Macaca mulatto A dissertation submitted in partial fulfillment of the requirements for the degree of doctor of philosophy in the University of Michigan.
J. J. Berke (1960)
10.1001/ARCHNEUR.1992.00530340048017
Parietal pseudothalamic pain syndrome. Clinical features and anatomic correlates.
J. Schmahmann (1992)
10.1161/01.STR.30.5.946
Neglect after right insular cortex infarction.
F. Manes (1999)
10.1093/BRAIN/114.5.2203
The neurology of obsessional slowness.
N. Hymas (1991)
Somatic and limbic cortex activation in esophageal distention: a functional magnetic resonance imaging study.
F. Binkofski (1998)
10.1007/BF01249090
Prenatal developmental disturbances in the limbic allocortex in schizophrenics
Dr. H. Jakob (2005)
10.1016/S0887-8994(98)00159-3
Tourette syndrome associated with unilateral cystic changes in the gyrus rectus.
G. Mcabee (1999)
10.1007/978-1-4757-9619-3_5
The Insula of Reil in Man and Monkey
M. Mesulam (1985)
10.1002/CNE.900820205
Fiber connections of the corpus striatum of the monkey and baboon
F. Mettler (1945)
Neuroimaging and obesity: mapping the brain responses to hunger and satiation in humans using positron emission tomography.
A. Del Parigi (2002)
10.1055/S-2000-13179
Neglect and related disorders.
K. Heilman (2000)
10.1093/BRAIN/AWG240
Progressive non-fluent aphasia is associated with hypometabolism centred on the left anterior insula.
P. Nestor (2003)
10.1152/JN.1993.69.4.1009
PET study of voluntary saccadic eye movements in humans: basal ganglia-thalamocortical system and cingulate cortex involvement.
L. Petit (1993)
10.1212/WNL.40.9.1408
Unilateral cerebral inactivation produces differential left/right heart rate responses
E. Zamrini (1990)
10.1046/j.1528-1157.2001.042007912.x
Heart Rate and Heart Rate Variability Changes in the Intracarotid Sodium Amobarbital Test
G. Ahern (2001)
10.1212/WNL.19.8.809
The Human Brain and Spinal Cord
R. Dejong (1969)
1809a) Die sylvische Grube
JC Reil (1952)
Parent ratings of behavioural effects of drugs, nutrients and diets
(2000)
10.1016/S0303-8467(99)00007-4
Neurogenic ST depression in stroke
H. C. Chua (1999)
10.1093/BRAIN/78.4.445
The insula; further observations on its function.
W. Penfield (1955)
10.1002/CNE.902120104
Insula of the old world monkey. III: Efferent cortical output and comments on function
M. Mesulam (1982)
[Operculo-insular responses to nociceptive skin stimulation in humans. A review of the literature].
M. Frot (1999)
10.1001/ARCHPSYC.1992.01820030027004
Widespread cerebral gray matter volume deficits in schizophrenia.
R. Zipursky (1992)
A facial neural substrate for perceiving facial expressions of disgust
ML Phillips (1997)
10.1007/BF03170635
Development of the Gyri and Sulci on the Surface of the Island of Reil of the Human Brain.
Cunningham Dj (1891)
Stereotaxic approach to epilepsy : methodology of anatomofunctional stereotaxic investigations
JD Teasdale (1973)
English translation by Eggert GH (1977) Wernicke works on aphasia: A source book and review
K Wernicke (1977)
10.1136/jnnp.47.3.326-b
Electroclinical Features of the Psychomotor Seizure
S. Shorvon (1984)
10.1017/S003329170002537X
Reduction of cortical volume in schizophrenia on magnetic resonance imaging.
I. Harvey (1993)
10.1002/CNE.902570206
A role of insular cortex in cardiovascular function
D. Ruggiero (1987)
10.1002/1531-8249(200010)48:4<614::AID-ANA8>3.0.CO;2-S
The role of the insular cortex in temporal lobe epilepsy
J. Isnard (2000)
10.1212/WNL.48.4.927
The metabolic anatomy of Tourette's syndrome
D. Eidelberg (1997)
10.1093/BRAIN/117.6.1271
A graded task approach to the functional mapping of brain areas implicated in auditory-verbal memory.
P. Grasby (1994)
10.1002/ANA.410330208
Individual patterns of functional reorganization in the human cerebral cortex after capsular infraction
C. Weiller (1993)
Thalamic neglect ( 1979 )
RT Watson
10.1002/CNE.901150304
The claustrum, the external capsule and the extreme capsule of Macaca mulatta
J. J. Berke (1960)
Expanding borders of the limbic system concept
WJH Nauta (1979)
World J Biol Psychiatry Downloaded from informahealthcare.com by University of California Los Angeles on
10.3143/GERIATRICS.37.772
[Dementia with Lewy bodies].
E. Mori (2000)
Vicq d' Azyr F (1786) Traite d'anatomie et de physiologie
10.1111/jon199663189
“Semantic” Conduction Aphasia from a Posterior Insular Cortex Infarction
R. Marshall (1996)
10.1192/BJP.167.3.343
Regional brain activity in chronic schizophrenic patients during the performance of a verbal fluency task.
C. Frith (1995)
Expanding borders of the limbic system concept
Nauta WJH (1979)
10.1007/BF00239019
Nucleus ventroposterior inferior (VPI) as the vestibular thalamic relay in the rhesus monkey I. Field potential investigation
L. Deecke (2004)
Exploring Brain Functional Anatomy with Positron Emission Tomography
D. I. Lewis-Jones (1992)
10.1093/BRAIN/88.3.585
Disconnexion syndromes in animals and man. II.
N. Geschwind (1965)
Vergleichende Lokalisationslehre der Großhirnrinde : in ihren Prinzipien dargestellt auf Grund des Zellenbaues
K. Brodmann (1985)
The anatomical drawings of Andreas Vesalius: De Humani Corpus Fabrica, Epitome, Tabulae Sex
CM Saunders JB de (1982)
Parent ratings of behavioural effects of drugs, nutrients and diets
B Rimland (2000)
Die sylvische Grube . Arch Physiol
JC Reil
10.1006/nimg.2002.1315
Role of Operculoinsular Cortices in Human Pain Processing: Converging Evidence from PET, fMRI, Dipole Modeling, and Intracerebral Recordings of Evoked Potentials
R. Peyron (2002)
10.1073/PNAS.90.11.4952
Echo-planar magnetic resonance imaging studies of frontal cortex activation during word generation in humans.
G. Mccarthy (1993)
10.1176/APPI.AJP.158.6.899
Changes in regional brain glucose metabolism measured with positron emission tomography after paroxetine treatment of major depression.
S. Kennedy (2001)
10.1016/0006-8993(93)90305-7
A modality-specific somatosensory area within the insula of the rhesus monkey
R. Schneider (1993)
10.1111/j.1749-6632.1999.tb09193.x
The Vestibular Cortex: Its Locations, Functions, and Disorders
T. Brandt (1999)
10.1212/WNL.29.5.690
Thalamic neglect
R. T. Watson (1979)
10.1212/WNL.42.9.1727
Cardiovascular effects of human insular cortex stimulation
S. Oppenheimer (1992)
10.1038/npp.1993.64
The Functional Neuroanatomy of Tourette's Syndrome: An FDG-PET Study. I. Regional Changes in Cerebral Glucose Metabolism Differentiating Patients and Controls
A. Braun (1993)
10.1212/01.WNL.0000038905.75660.BD
Strokes restricted to the insular cortex
C. Cereda (2002)
10.1093/BRAIN/123.11.2203
The functional neuroanatomy of social behaviour: changes in cerebral blood flow when people with autistic disorder process facial expressions.
H. Critchley (2000)
Untersuchungen über den Bau des grossen Gehirns im Menschen… Vierte Fortsetzung VIII
J C Reil
10.1002/CNE.900890308
Certain developmental relations and fiber connections of the triangular gyrus in primates
I. Lockard (1948)
10.1176/AJP.154.7.918
Neuroanatomical correlates of externally and internally generated human emotion.
E. Reiman (1997)
10.3171/JNS.1993.79.2.0266
Surgical treatment of partial epilepsy arising from the insular cortex. Report of two cases.
S. Roper (1993)
10.1016/S0987-7053(00)00227-6
Functional imaging of brain responses to pain. A review and meta-analysis (2000)
R. Peyron (2000)
10.1002/9780470514184.CH12
Memory mechanisms in the processing of words and word-like symbols.
M. Raichle (1991)
10.1016/S0006-3223(97)00145-5
The functional neuroanatomy of anxiety: a study of three disorders using positron emission tomography and symptom provocation
S. Rauch (1997)
10.1093/CERCOR/12.4.376
Representation of pain and somatic sensation in the human insula: a study of responses to direct electrical cortical stimulation.
K. Ostrowsky (2002)
10.1016/0278-2626(90)90046-Q
Lesion localization in acquired deficits of emotional expression and comprehension
Andy E. B. Cancelliere (1990)
10.1016/0006-8993(87)90743-8
Cerebral glucose consumption following verbal auditory stimulation
M. Kushner (1987)
10.1016/S0168-5597(98)00054-9
Intracortical recordings of early pain-related CO2-laser evoked potentials in the human second somatosensory (SII) area
Maud Frot (1999)
Apathy and neglect: Aspects of the same phenomenon? (Abstract
A Roaslo (1997)
10.1162/jocn.1997.9.2.254
Functional Neuroanatomy of Recall and Recognition: A PET Study of Episodic Memory
R. Cabeza (1997)
Neural correlates of emotions in psychiatric patients in the light of functional neuroimaging findings.
K. Kucharska-Pietura (2001)
10.1192/BJP.172.2.110
Brain abnormality in schizophrenia. A systematic and quantitative review of volumetric magnetic resonance imaging studies.
S. Lawrie (1998)
10.1038/72131
Thermosensory activation of insular cortex
A. Craig (2000)
10.1046/j.1460-9568.1999.00522.x
Activation of reward circuitry in human opiate addicts
L. Sell (1999)
10.1016/0306-4522(88)90217-5
New perspectives in basal forebrain organization of special relevance for neuropsychiatric disorders: The striatopallidal, amygdaloid, and corticopetal components of substantia innominata
G. Alheid (1988)
10.1212/WNL.4.6.483
Epilepsy and the Functional Anatomy of the Human Brain
R.N.Dej. (1954)
10.1016/S0924-8196(97)80009-7
Chapter VII Chemical neuroanatomy of the primate insula cortex: Relationship to cytoarchitectonics, connectivity, function and neurodegeneration
E. Mufson (1997)
10.1097/00006123-199901000-00123
Intracerebral Whipple's disease diagnosed by stereotactic biopsy: a case report and review of the literature.
E. Mendel (1999)
Apathy and neglect : Aspects of the same phenomenon ? ( Abstract )
TW Robbins (1997)
Monro A (1783) Observations on the structure and function of the nervous system
10.1038/362342A0
The neural correlates of the verbal component of working memory
E. Paulesu (1993)
10.1002/ANA.410290112
The functional anatomy of motor recovery after stroke in humans: A study with positron emission tomography
F. Chollet (1991)
10.1093/BRAIN/116.3.655
Cortical function in amyotrophic lateral sclerosis. A positron emission tomography study.
J. Kew (1993)
10.1016/0920-1211(88)90030-7
Ictus emeticus and the insular cortex
M. Fiol (1988)
10.1002/cne.901000103
The form and structure of the human claustrum
A. Rae (1954)
Remarques sur le siège de la faculté du langage articulé, suivies d'une observation d'aphémie (perte de la parole)
P. Broca (1861)
10.1007/bf03170635
Development of the Gyri and Sulci on the Surface of the Island of Reil of the Human Brain.
D. J. Cunningham (1891)
10.1016/0006-8993(91)90412-O
Insular cortex stimulation produces lethal cardiac arrhythmias: a mechanism of sudden death?
S. Oppenheimer (1991)
Brain abnormality in schizophrenia
SM Lawrie (1998)
10.1212/WNL.50.5.1202-a
Frontal lobe neglect in man
K. Heilman (1998)
Functional imaging of brain responses to pain. A meta-analysis
R Peyron (2000)
10.1002/CNE.901910402
Organization of the amygdalopetal projections from modality‐specific cortical association areas in the monkey
B. H. Turner (1980)
10.1007/PL00009529
The Role of the Insular Cortex in Dysphagia
S. Daniels (1997)
10.1121/1.405981
Neural network supporting auditory‐vocal integration in singing
D. Perry (1993)
Disconnection syndromes in animals and man
N Geschwind (1965)
10.1176/JNP.9.3.471
Limbic-cortical dysregulation: a proposed model of depression.
H. Mayberg (1997)
10.1002/ana.10087
Insular cortex involvement in mesiotemporal lobe epilepsy: A positron emission tomography study
V. Bouilleret (2002)
10.1016/S0920-9964(00)00028-1
Insular cortex abnormalities in schizophrenia: a structural magnetic resonance imaging study of first-episode patients
B. Crespo-Facorro (2000)
10.1016/0022-510X(82)90183-6
Herpes simplex encephalitis: An immunohistological study of the distribution of viral antigen within the brain
M. Esiri (1982)
10.1054/MEHY.2001.1440
Anterior insular cortex: linking intestinal pathology and brain function in autism-spectrum subgroups.
T. Binstock (2001)
10.1016/S0090-4295(01)00992-X
Blood-oxygenation-level-dependent functional magnetic resonance imaging for evaluating cerebral regions of female sexual arousal response.
K. Park (2001)
High order gustatory projections in the human brain studied with positron emission tomography
H Fukuda (1991)
10.1002/ANA.410310502
Functional reorganization of the brain in recovery from striatocapsular infarction in man
C. Weiller (1992)
10.1111/j.1749-6632.1999.tb09258.x
The Concepts of the Ventral Striatopallidal System and Extended Amygdala
JOSE S. Olmos (1999)
10.1002/CNE.902120102
Insula of the old world monkey. Architectonics in the insulo‐orbito‐temporal component of the paralimbic brain
M. Mesulam (1982)
Remarques sur le siége de la faculté au langage articulé , suivies d ’ une observation d ’ aphémie ( perte de la parole )
P Broca
10.1097/00006123-199901000-00081
The Insular Cortex: Morphological and Vascular Anatomic Characteristics
A. Rhoton (1999)
10.3757/JSER.61.71
The Vestibular Cortex
S. Nishiike (2002)
10.1176/APPI.AJP.158.2.234
Structural abnormalities in frontal, temporal, and limbic regions and interconnecting white matter tracts in schizophrenic patients with prominent negative symptoms.
T. Sigmundsson (2001)
10.1056/NEJM198102053040602
Herpes simplex encephalitis: vidarabine therapy and diagnostic problems.
R. Whitley (1981)
10.1093/BRAIN/AWF137
Painful stimuli evoke different stimulus-response functions in the amygdala, prefrontal, insula and somatosensory cortex: a single-trial fMRI study.
K. Bornhoevd (2002)
10.1016/0006-8993(74)90275-3
Projections of auditory responsive cortex in the squirrel monkey.
B. F. Forbes (1974)
10.1148/RADIOLOGY.176.3.2389039
Loss of the insular ribbon: another early CT sign of acute middle cerebral artery infarction.
C. Truwit (1990)
10.1023/A:1018733420467
Neuroanatomical Correlates of Visually Evoked Sexual Arousal in Human Males
S. Stoléru (1999)
10.1152/JN.1999.81.4.1917
Identification of the cerebral loci processing human swallowing with H2(15)O PET activation.
S. Hamdy (1999)
10.1016/S0006-3223(99)00308-X
Vagus nerve stimulation: a new tool for brain research and therapy∗
M. George (2000)
10.1007/BF00237252
Vestibular responses in the Rhesus monkey ventroposterior thalamus. II. Vestibulo-proprioceptive convergence at thalamic neurons
L. Deecke (2004)
10.1159/000394343
Stereotaxic Approach to Epilepsy
J. Talairach (1973)
The anatomical drawings of Andreas Vesalius: De Humani Corpus Fabrica, Epitome
O Saunders Jb De Cm (1982)
10.1038/39051
A specific neural substrate for perceiving facial expressions of disgust
M. L. Phillips (1997)
10.1016/S0165-0173(96)00011-2
Circuitry and functional aspects of the insular lobe in primates including humans
J. Augustine (1996)
10.1136/jnnp.67.4.532
Verbal memory impairment after left insular cortex infarction
F. Manes (1999)
10.1093/BRAIN/103.2.337
The anatomical basis of conduction aphasia.
H. Damasio (1980)
10.3109/08990229309028839
Tactile-vibration-activated foci in insular and parietal-opercular cortex studied with positron emission tomography: mapping the second somatosensory area in humans.
H. Burton (1993)
10.1017/S0317167100042281
The insular cortex and the pathophysiology of stroke-induced cardiac changes.
S. Oppenheimer (1992)
10.1056/JN199910010000001
The Insula of Sudden Death
V. Hachinski (1999)
10.1097/00006123-199901000-00079
The insular cortex: morphological and vascular anatomic characteristics.
G. Varnavas (1999)
10.1121/1.405978
Segregation of voiced and whispered concurrent vowels in English and Japanese
A. Lea (1993)
10.1523/JNEUROSCI.16-13-04275.1996
Cerebral Representation of One’s Own Past: Neural Networks Involved in Autobiographical Memory
G. Fink (1996)
10.1006/nimg.2002.1197
Patterns of Cerebral Atrophy in Dementia with Lewy Bodies Using Voxel-Based Morphometry
Emma J. Burton (2002)
10.1176/AJP.156.2.209
Functional MRI study of the cognitive generation of affect.
J. Teasdale (1999)
Connections of the cerebral cortex of the monkey
Krieg WJS (1965)
10.1111/j.1528-1157.2000.tb00228.x
Functional Mapping of the Insular Cortex: Clinical Implication in Temporal Lobe Epilepsy
K. Ostrowsky (2000)
10.1038/384159A0
A new brain region for coordinating speech articulation
N. Dronkers (1996)
10.1097/00001756-200203040-00023
Event-related fMRI of the somatosensory system using electrical finger stimulation
M. Deuchert (2002)
10.1152/JN.1990.63.4.689
Gustatory responses of single neurons in the insula of the macaque monkey.
S. Yaxley (1990)
10.1099/0022-1317-75-9-2379
Oral-oesophageal inoculation of mice with herpes simplex virus type 1 causes latent infection of the vagal sensory ganglia (nodose ganglia).
R. Gesser (1994)
Zur anatomischen Gliederung des Cortex cerebri
O Vogt (1903)
10.1177/070674379504000215
Insula and Obsessive-Compulsive Disorder
E. S. Jeffrey (1995)
The anatomy and physiology of cortical mechanisms of cardiac control.
S. Oppenheimer (1993)
10.1161/01.STR.30.7.1307
Effects of stroke localization on cardiac autonomic balance and sudden death.
S. Tokgözoğlu (1999)
10.1111/j.1528-1157.1964.tb03338.x
Evaluation of Insular Ablation in Surgical Treatment of Temporal Lobe Epilepsy
H. Silfvenius (1964)
Die sylvische Grube
Jc Reil (1809)
The cytoarchitectonics of the human cerebral cortex . Translated Parker S
C VonEconomo (1929)
10.1002/CNE.901120111
Some cortical association systems related to auditory functions
E. Hurst (1959)
10.1007/s00701-002-0941-6
Medically Intractable Epilepsy from Insular Low-Grade Gliomas: Improvement after an Extended Lesionectomy
H. Duffau (2002)
10.1016/S0028-3932(01)00006-9
Phonological agraphia following a focal anterior insulo-opercular infarction
P. Marien (2001)
Insular stroke causing unilateral auditory processing disorder: case report.
R. Fifer (1993)
10.1002/ana.10502
An attention modulated response to disgust in human ventral anterior insula
P. Krolak-Salmon (2003)
10.1212/WNL.58.2.198
Patterns of brain atrophy in frontotemporal dementia and semantic dementia
H. Rosen (2002)
10.1016/S0022-3476(99)70052-1
Gastrointestinal abnormalities in children with autistic disorder.
K. Horváth (1999)
10.1007/BF02408294
Differential autonomic responses of autistic and normal children
R. Palkovitz (1980)
10.1176/APPI.AJP.159.5.728
The functional neuroanatomy of the placebo effect.
H. Mayberg (2002)
10.1016/S0920-9964(98)00094-2
Mapping of grey matter changes in schizophrenia
I. C. Wright (1999)
10.1111/j.1749-6632.2002.tb04294.x
Neuroimaging and Obesity
A. D. Parigi (2002)
Parent ratings of behavioural effects of drugs , nutrients and diets
A Roaslo (2000)
10.1093/BRAIN/121.6.1013
From sensation to cognition.
M. Mesulam (1998)
10.1016/S0006-3223(01)01269-0
Decreased gray matter concentration in the insular, orbitofrontal, cingulate, and temporal cortices of cocaine patients
T. Franklin (2002)
10.1111/J.1469-7610.1997.TB01508.X
Pathogenesis of Tourette's syndrome.
J. Leckman (1997)
10.1016/0006-8993(94)90890-7
Functional anatomy of taste perception in the human brain studied with positron emission tomography
S. Kinomura (1994)
10.1001/JAMA.286.4.427
Neural mechanisms of anhedonia in schizophrenia: a PET study of response to unpleasant and pleasant odors.
B. Crespo-Facorro (2001)
10.1037/0735-7044.113.4.663
Taste perception in patients with insular cortex lesions.
T. Pritchard (1999)
10.1097/00005053-199912000-00001
Neuropsychiatric effects of insular stroke.
F. Manes (1999)
Zur Anatomie und Morphologie Der Insula Reil
O Eberstaller (1887)
10.1523/JNEUROSCI.17-24-09686.1997
Insular Cortical Projections to Functional Regions of the Striatum Correlate with Cortical Cytoarchitectonic Organization in the Primate
M. Chikama (1997)
10.1016/S0987-7053(00)87264-0
Les réponses operculo-insulaires aux stimulations cutanées nociceptives chez l'homme. Revue de la littérature et données récentes
M. Frot (1999)
10.1111/j.1749-6632.2002.tb02822.x
Visual‐Vestibular and Visuovisual Cortical Interaction
T. Brandt (2002)
10.1111/J.1749-6632.1999.TB09257.X
Advancing from the ventral striatum to the extended amygdala. Implications for neuropsychiatry and drug abuse. Introduction.
J. McGinty (1999)
The case for frontostriatal dysfunction
TW Robbins (1990)
10.3171/JNS.2000.92.4.0676
Arteries of the insula.
U. Türe (2000)
10.1136/jnnp.74.5.649
Reappraisal of early CT signs to predict the arterial occlusion site in acute embolic stroke
M. Koga (2003)
10.1186/1471-2202-4-13
Top-down and bottom-up modulation of language related areas – An fMRI Study
T. Noesselt (2003)
10.1177/088307380001500701
Short-Term Benefit From Oral Vancomycin Treatment of Regressive-Onset Autism
R. Sandler (2000)
10.1016/S0006-3223(00)01065-9
Opposite effects of high and low frequency rTMS on regional brain activity in depressed patients
A. Speer (2000)
Untersuchungen über den Bau des grossen Gehirns im Menschen ... Vierte Fortsetzung VIII . Arch Physiol
JC Reil
The anatomical drawings of Andreas Vesalius: De Humani Corpus Fabrica, Epitome, Tabulae Sex
Jb Saunders (1982)
10.1007/BF00818707
Insula and aphasia
J. Shuren (2004)
10.1093/SCHBUL/16.3.391
The case of frontostriatal dysfunction in schizophrenia.
T. Robbins (1990)
Cardiac manifestation of acute neurological lesions. In: Aminoff MJ (ed) Neurology and General Medicine: The neurological aspects of medical disorder
S Oppenheimer (1995)
10.1093/BRAIN/88.2.237
Disconnexion syndromes in animals and man. I.
N. Geschwind (1965)
10.1016/S0010-9452(87)80057-6
Behavioral Effects of Damage to the Right Insula and Surrounding Regions
M. Berthier (1987)
Connections of the cerebral cortex of the monkey
WJS Krieg (1965)
10.1002/ANA.410440516
Somatic and limbic cortex activation in esophageal distention: A functional imaging study
F. Binkofski (1998)
Eberstaller O (1887) Zur Anatomie und Morphologie Der Insula Reil
Reil JC (1809a) Die sylvische Grube



This paper is referenced by
10.1016/j.clineuro.2013.12.006
Brain perfusion SPECT in limbic encephalitis associated with autoantibody against the glutamate receptor epsilon 2
N. Kimura (2014)
10.1002/erv.890
The fault is not in her parents but in her insula--a neurobiological hypothesis of anorexia nervosa.
K. Nunn (2008)
10.1016/j.neuroimage.2012.03.021
A convergent functional architecture of the insula emerges across imaging modalities
C. Kelly (2012)
10.1016/j.yebeh.2009.07.036
Peri-ictal atrioventricular conduction block in a patient with a lesion in the left insula: Case report and review of the literature
R. Surges (2009)
10.1212/WNL.0b013e318248e544
Neural correlates of disturbed perception of verticality
B. Baier (2012)
10.1016/j.neuroimage.2011.08.050
Neural correlates of blink suppression and the buildup of a natural bodily urge
Brian D. Berman (2012)
10.1016/j.neuroimage.2009.04.020
Control of bladder sensations: An fMRI study of brain activity and effective connectivity
J. Kuhtz-Buschbeck (2009)
10.1016/j.jneumeth.2009.02.022
Anatomical specificity of functional amygdala imaging of responses to stimuli with positive and negative emotional valence
T. Ball (2009)
10.1002/9781119998402.CH8
Towards a Comprehensive, Causal and Explanatory Neuroscience Model of Anorexia Nervosa
K. Nunn (2011)
10.1111/j.1468-1331.2011.03473.x
Lesions to the posterior insular cortex cause dysarthria
B. Baier (2011)
10.3389/fpsyt.2017.00030
Reduced Resting-State Functional Connectivity in Current and Recovered Restrictive Anorexia Nervosa
J. Scaife (2017)
10.1007/978-0-387-92271-3_203
“My Body Is My Template”: Why Do People Suffering from Anorexia Nervosa See Their Bodies Differently?
Naresh Mondraty (2011)
10.1016/j.neuroimage.2010.09.012
Functional connectivity of the human insular cortex during noxious and innocuous thermal stimulation
E. Peltz (2011)
10.1007/s11060-015-1989-5
Subgroup characteristics of insular low-grade glioma based on clinical and molecular analysis of 42 cases
C. Tang (2015)
10.1080/21662630.2013.742970
Research in eating disorders: should we focus on the brain?
Philip Graham (2013)
10.1016/j.pscychresns.2013.02.003
Widespread decreased grey and white matter in paediatric obsessive-compulsive disorder (OCD): A voxel-based morphometric MRI study
J. Chen (2013)
10.1016/j.neuroimage.2006.05.015
Centrifugal regulation of human cortical responses to a task-relevant somatosensory signal triggering voluntary movement
T. Kida (2006)
10.1016/j.brainres.2010.06.024
Cerebral and functional adaptation with chronic hypoxia exposure: A multi-modal MRI study
Xiaodan Yan (2010)
10.3389/fnins.2019.00815
Decreased Gray-Matter Volume in Insular Cortex as a Correlate of Singers’ Enhanced Sensorimotor Control of Vocal Production
W. Wang (2019)
10.3389/fnhum.2012.00323
Major Depressive Disorder and Alterations in Insular Cortical Activity: A Review of Current Functional Magnetic Imaging Research
D. Sliz (2012)
10.1159/000258079
MRI-Based Definition of a Stereotactic Two-Dimensional Template of the Human Insula
Afif Afif (2009)
10.1016/j.brainres.2010.07.059
Neural activation for conceptual identification of correct versus incorrect tool–object pairs
J. C. Mizelle (2010)
10.1016/j.pain.2007.06.022
Abnormal processing of the nociceptive input in Parkinson’s disease: A study with CO2 laser evoked potentials
M. Tinazzi (2008)
10.1093/scan/nss077
A selective role for right insula--basal ganglia circuits in appetitive stimulus processing.
L. Vijayaraghavan (2013)
10.1016/j.jpsychires.2009.10.014
Gray matter density in limbic and paralimbic cortices is associated with trauma load and EMDR outcome in PTSD patients.
D. Nardo (2010)
10.1016/J.PARKRELDIS.2006.04.007
Are the insular cortex and cortisol implicated in Parkinsonian features?
M. Tops (2006)
Insular tumor surgery
(2020)
10.1111/epi.13816
Perisylvian, including insular, childhood epilepsy: Presurgical workup and surgical outcome
E. Freri (2017)
10.3171/2009.1.JNS08807
Microsurgery of epileptic foci in the insular region.
Ramez Malak (2009)
10.1007/978-3-319-75468-0_7
Structural Connectivity of the Insula
J. Ghaziri (2018)
10.1080/21662630.2013.820376
Disgust and Anorexia Nervosa: confusion between self and non-self
Jessica Moncrieff-Boyd (2014)
10.1111/epi.13682
Insular epilepsy surgery
P. Laoprasert (2017)
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