Online citations, reference lists, and bibliographies.

Green Nanotechnology-based Drug Delivery Systems For Osteogenic Disorders

David Medina-Cruz, Ebrahim Mostafavi, Ada Vernet-Crua, Junjiang Cheng, Veer Shah, Jorge Luis Cholula-Diaz, Grégory Guisbiers, Juan Tao, José Miguel García-Martín, Thomas J Webster
Published 2020 · Medicine, Materials Science
Cite This
Download PDF
Analyze on Scholarcy
Share
ABSTRACT Introduction Current treatments for osteogenic disorders are often successful, however they are not free of drawbacks, such as toxicity or side effects. Nanotechnology offers a platform for drug delivery in the treatment of bone disorders, which can overcome such limitations. Nevertheless, traditional synthesis of nanomaterials presents environmental and health concerns due to its production of toxic by-products, the need for extreme and harsh raw materials, and their lack of biocompatibility over time. Areas covered This review article contains an overview of the current status of treating osteogenic disorders employing green nanotechnological approaches, showing some of the latest advances in the application of green nanomaterials, as drug delivery carriers, for the effective treatment of osteogenic disorders. Expert opinion Green nanotechnology, as a potential solution, is understood as the use of living organisms, biomolecules and environmentally friendly processes for the production of nanomaterials. Nanomaterials derived from bacterial cultures or biomolecules isolated from living organisms, such as carbohydrates, proteins, and nucleic acids, have been proven to be effective composites. These nanomaterials introduce enhancements in the treatment and prevention of osteogenic disorders, compared to physiochemically-synthesized nanostructures, specifically in terms of their improved cell attachment and proliferation, as well as their ability to prevent bacterial adhesion.
This paper references
10.1007/s13346-018-0561-1
Bone-targeted delivery of simvastatin-loaded PEG-PLGA micelles conjugated with tetracycline for osteoporosis treatment
Yonghui Xie (2018)
10.1002/adhm.201400397
Combinatorial gene therapy accelerates bone regeneration: non-viral dual delivery of VEGF and BMP2 in a collagen-nanohydroxyapatite scaffold.
Caroline M Curtin (2015)
Overview of the use of nanotechnology in an environmentally-friendly approach
The pros and cons of the use of laser ablation synthesis for the production of silver nano-antimicrobials. Antibiot (Basel, Switzerland) [Internet] 2018;7
MC Sportelli (2019)
10.3390/antibiotics7030067
The Pros and Cons of the Use of Laser Ablation Synthesis for the Production of Silver Nano-Antimicrobials
M. C. Sportelli (2018)
10.1016/j.jconrel.2018.01.006
Gelatin‐ hydroxyapatite‐ calcium sulphate based biomaterial for long term sustained delivery of bone morphogenic protein‐2 and zoledronic acid for increased bone formation: In‐vitro and in‐vivo carrier properties
Deepak Bushan Raina (2018)
Updated overview of the use of green nanomaterials in biological applications
10.1016/S0142-9612(03)00524-6
Bioactive glass as a drug delivery system of tetracycline and tetracycline associated with beta-cyclodextrin.
Z R Domingues (2004)
10.22203/ECM.V031A23
Delivery of pharmaceutics to bone: nanotechnologies, high-throughput processing and in silico mathematical models
Inês S Alencastre (2016)
10.1002/jbm.a.32247
PEGylation strategies for active targeting of PLA/PLGA nanoparticles.
Tania Betancourt (2009)
10.1098/rsfs.2011.0121
Mesoporous bioactive glasses: structure characteristics, drug/growth factor delivery and bone regeneration application
Chengtie Wu (2012)
10.1016/j.ijpharm.2011.05.033
The characterization of protein release from sericin film in the presence of an enzyme: towards fibroblast growth factor-2 delivery.
Ayumu Nishida (2011)
10.1016/j.jconrel.2018.04.011
Mesoporous silicate nanoparticles/3D nanofibrous scaffold‐mediated dual‐drug delivery for bone tissue engineering
Qingqing Yao (2018)
10.2174/1381612821666150115152841
Systemic drug delivery systems for bone tissue regeneration- a mini review.
Wang Xinluan (2015)
10.1002/jbm.a.34002
Bisphosphonate-decorated lipid nanoparticles designed as drug carriers for bone diseases.
Guilin Wang (2012)
10.1002/jbm.a.36347
Synthesis and characterization of biogenic selenium nanoparticles with antimicrobial properties made by Staphylococcus aureus, methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli, and Pseudomonas aeruginosa.
David Medina Cruz (2018)
10.1016/j.biomaterials.2012.06.075
Cholesteryl group- and acryloyl group-bearing pullulan nanogel to deliver BMP2 and FGF18 for bone tissue engineering.
Masako Fujioka-Kobayashi (2012)
10.1016/j.ijpharm.2011.01.006
Sustained-release of protein from biodegradable sericin film, gel and sponge.
Ayumu Nishida (2011)
10.1038/boneres.2016.50
Recent advances in nano scaffolds for bone repair
Huan Yi (2016)
10.1016/j.drudis.2017.04.021
Development of nanomaterials for bone-targeted drug delivery.
Hao Cheng (2017)
10.1016/j.nano.2018.12.009
Synergic antibacterial coatings combining titanium nanocolumns and tellurium nanorods.
David Medina-Cruz (2019)
10.1016/j.copbio.2016.02.029
Local and targeted drug delivery for bone regeneration.
Maureen R. Newman (2016)
10.1021/CM402592T
Multifunctional Mesoporous Silica Nanoparticles as a Universal Platform for Drug Delivery
Christian Argyo (2014)
10.1172/JCI23825
The Staphylococcus aureus "superbug".
Timothy Foster (2004)
10.31768/2312-8852.2018.40(3):178-183
Role of dendrimers in advanced drug delivery and biomedical applications: a review.
A Akbarzadeh (2018)
Cholesteryl groupand acryloyl group-bearing pullulan nanogel to deliver BMP2 and FGF18 for bone tissue engineering. Biomaterials [Internet
M Fujioka-Kobayashi (2012)
10.1038/s41598-017-15956-8
Three Dimensional Honeycomb Patterned Fibrinogen Based Nanofibers Induce Substantial Osteogenic Response of Mesenchymal Stem Cells
Salima Nedjari (2017)
10.1016/j.nano.2015.02.013
Nanotechnology in bone tissue engineering.
Graham G Walmsley (2015)
10.1039/c5nr07806g
Stem cell secretome-rich nanoclay hydrogel: a dual action therapy for cardiovascular regeneration.
Renae Waters (2016)
Interesting example of the application of green nanomaterials for the enhancements of biomedical applications of implantable materials
Bone health and osteoporosis: a report of the surgeon general
(2004)
10.1016/j.biomaterials.2018.07.046
A bone-targeting delivery system carrying osteogenic phytomolecule icaritin prevents osteoporosis in mice.
Le Huang (2018)
10.3390/ijms20061311
Use of Materials Based on Polymeric Silica as Bone-Targeted Drug Delivery Systems for Metronidazole
K. Czarnobaj (2019)
10.2174/1381612023393585
Bisphosphonates as a foundation of drug delivery to bone.
Hasan Uludağ (2002)
10.1016/j.ijpharm.2012.04.046
Calcium phosphate embedded PLGA nanoparticles: a promising gene delivery vector with high gene loading and transfection efficiency.
Jie Tang (2012)
10.1002/9781119418900.CH12
Green Synthesis of Silver Nanoparticles for Biomedical and Environmental Applications
Varadavenkatesan Thivaharan (2018)
10.1007/s11914-016-0306-3
Advances in Nanotechnology for the Treatment of Osteoporosis
Mikayla E. Barry (2016)
10.1016/j.addr.2008.03.012
Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers.
I. Slowing (2008)
10.3390/ijms160920492
Influence of Parathyroid Hormone-Loaded PLGA Nanoparticles in Porous Scaffolds for Bone Regeneration
Piergiorgio Gentile (2015)
10.1128/MMBR.65.2.232-260.2001
Tetracycline Antibiotics: Mode of Action, Applications, Molecular Biology, and Epidemiology of Bacterial Resistance
Ian Chopra (2001)
10.1021/nn103130q
Facile synthesis of monodispersed mesoporous silica nanoparticles with ultralarge pores and their application in gene delivery.
Mi-Hee Kim (2011)
10.1016/j.bioactmat.2018.05.006
Bioactive hydrogels for bone regeneration
Xin Peng Bai (2018)
Interesting and complete example of the application of sustained released of biomolecules from film, gel and sponges
10.1038/nrd.2016.199
Aptamers as targeted therapeutics: current potential and challenges
Jiehua Zhou (2017)
10.1016/j.colsurfb.2018.05.045
A comprehensive review on green nanomaterials using biological systems: Recent perception and their future applications.
Rijuta Ganesh Saratale (2018)
10.1159/000332228
Osteogenesis Imperfecta: A Review with Clinical Examples
Fleur S. van Dijk (2011)
10.2147/IJN.S94270
Controlled-release of tetracycline and lovastatin by poly(d,l-lactide-co-glycolide acid)-chitosan nanoparticles enhances periodontal regeneration in dogs
Bor-Shiunn Lee (2016)
10.1039/C8RA07255H
The potential use of thermosensitive chitosan/silk sericin hydrogels loaded with longan seed extract for bone tissue engineering
Porntipa Pankongadisak (2018)
10.1002/adma.200602770
Coating of Human Mesenchymal Cells in 3D Culture with Bioinorganic Nanoparticles Promotes Osteoblastic Differentiation and Gene Transfection
Rosanna Gonzalez-McQuire (2007)
10.5681/bi.2014.009
The challenges of green nanotechnology
Miguel de la Guardia (2014)
10.1016/j.colsurfb.2009.09.001
Biodegradable polymeric nanoparticles based drug delivery systems.
Avnesh Kumari (2010)
10.1146/annurev-pathol-011110-130203
Disorders of bone remodeling.
Xu Feng (2011)
10.1007/12_2011_137
Chitosan and chitosan derivatives in drug delivery and tissue engineering
Raphaël Riva (2011)
10.2147/IJN.S88798
Tetracycline-grafted PLGA nanoparticles as bone-targeting drug delivery system
Hua Wang (2015)
Treasure Island (FL): StatPearls Publishing
Statpearls
10.1021/acsnano.5b07828
Osteoblast-Targeting-Peptide Modified Nanoparticle for siRNA/microRNA Delivery.
Yao Sun (2016)
10.2147/IJN.S188003
In vivo SELEX of bone targeting aptamer in prostate cancer bone metastasis model
Lingxiao Chen (2019)
10.1016/J.PROGSOLIDSTCHEM.2007.10.002
Bone-regenerative bioceramic implants with drug and protein controlled delivery capability
María Vallet-Regí (2008)
Osteomyelitis [Internet]. StatPearls
II Momodu (2019)
Nanotechnology and picotechnology: a new arena for translational medicine
E Mostafavi (2019)
10.2147/IJN.S100156
Sustained dual release of placental growth factor-2 and bone morphogenic protein-2 from heparin-based nanocomplexes for direct osteogenesis
Yun Liu (2016)
Effects of tetracyclines on skeletal growth and dentition. A report by the Nutrition Committee of the Canadian Paediatric Society.
Pascale Demers (1968)
10.1155/2016/4648287
Desarrollo y caracterización de recubrimientos activos a base de nanofibras electrohiladas de policaprolactona, quitosano y extractos oleosos de propóleos colombianos para la conservación de filetes de lomo de cerdo.
Vargas Romero (2020)
10.2165/00003495-200059060-00003
Carrier Systems for the Local Delivery of Antibiotics in Bone Infections
Kyriaki Kanellakopoulou (2012)
10.1016/j.nano.2016.08.015
Osteotropic nanoscale drug delivery systems based on small molecule bone-targeting moieties.
Erica J. Carbone (2017)
10.1002/jbm.b.33488
A novel liposomal drug delivery system for PMMA bone cements
Wayne Nishio Ayre (2016)
10.2147/IJN.S192757
Starch-mediated synthesis of mono- and bimetallic silver/gold nanoparticles as antimicrobial and anticancer agents
Diana Lomelí-Marroquín (2019)
The epidemiology and pathogenesis of osteoporosis [Internet
CJ Rosen (2000)
10.1016/j.biomaterials.2008.05.012
Advancing dental implant surface technology--from micron- to nanotopography.
Gustavo Borges de Mendonça (2008)
10.1016/j.jconrel.2012.04.038
Macromolecular therapeutics in cancer treatment: the EPR effect and beyond.
Hiroshi Maeda (2012)
10.1002/chem.200600226
Ordered mesoporous materials in the context of drug delivery systems and bone tissue engineering.
María Vallet-Regí (2006)
Physiology, bone remodeling [Internet]. StatPearls. Treasure Island (FL): StatPearls Publishing; 2019
P Rowe (2019)
10.1177/2041731412443530
A short review: Recent advances in electrospinning for bone tissue regeneration
Song-Hee Shin (2012)
10.1007/s40744-016-0046-y
Review of Osteosarcoma and Current Management
Ryan A. Durfee (2016)
10.2147/IJN.S37953
A nanoparticulate injectable hydrogel as a tissue engineering scaffold for multiple growth factor delivery for bone regeneration
D. Dyondi (2013)
10.1039/c2nr31775c
Capacity of mesoporous bioactive glass nanoparticles to deliver therapeutic molecules.
Ahmed El-Fiqi (2012)
Cholesteryl groupand acryloyl group-bearing pullulan nanogel to deliver BMP2 and FGF18 for bone tissue engineering
M Fujioka-Kobayashi (2012)
10.1016/j.talanta.2016.08.064
Dendrimer-assisted hydrophilic magnetic nanoparticles as sensitive substrates for rapid recognition and enhanced isolation of target tumor cells.
Peiming Zhang (2016)
10.1186/1743-8977-3-11
The potential risks of nanomaterials: a review carried out for ECETOC
Paul J A Borm (2006)
10.1007/s10856-008-3528-9
Human bone marrow-derived mesenchymal stem cells and osteoblast differentiation on titanium with surface-grafted chitosan and immobilized bone morphogenetic protein-2
Tee Yong Lim (2009)
10.2147/NSA.S99986
Synthesis, characterization, applications, and challenges of iron oxide nanoparticles
Attarad Ali (2016)
10.1039/b918763b
Green chemistry: principles and practice.
Paul T. Anastas (2010)
Nanotechnology in bone tissue engineering. Nanomedicine [Internet]. 2015;11:1253–1263
GG Walmsley (2019)
10.1051/sicotj/2017028
Osteosarcoma: a comprehensive review
Amirhossein Misaghi (2018)
10.1186/s12891-018-1990-1
Nanotechnology in orthopedics: a clinically oriented review
Walter Ryan Smith (2018)
10.1016/j.jconrel.2011.10.001
Bone targeting for the treatment of osteoporosis.
Tessa Luhmann (2012)
10.1021/bm900203w
Surface functionalization of titanium with carboxymethyl chitosan and immobilized bone morphogenetic protein-2 for enhanced osseointegration.
Zhilong Shi (2009)
10.3390/ijms18071345
Development of Bone Targeting Drugs
Molly Stapleton (2017)
10.1136/bmj.1.5222.355-a
Osteoarthritis: Diagnosis and Treatment
Keith Sinusas (2012)
10.1016/J.APSUSC.2014.12.072
Hydroxyapatite nanocrystals functionalized with alendronate as bioactive components for bone implant coatings to decrease osteoclastic activity
Ruggero Bosco (2015)
10.1089/ten.a.2007.0102
Non-viral bone morphogenetic protein 2 transfection of rat dental pulp stem cells using calcium phosphate nanoparticles as carriers.
Xuechao Yang (2008)
10.2174/157016308783769405
Targeted drug delivery to bone: pharmacokinetic and pharmacological properties of acidic oligopeptide-tagged drugs.
Tatsuo Takahashi-Nishioka (2008)
10.3810/psm.2008.12.11
Osteomyelitis: Approach to Diagnosis and Treatment
Joseph M Fritz (2008)
10.3390/ijerph8020470
Environmental Implications of Nanotechnology—An Update
Leo Stander (2011)
10.1074/jbc.R109.041087
Cellular and Molecular Mechanisms of Bone Remodeling*
Liza Jane Raggatt (2010)
10.2147/IJN.S44393
Nanotechnology in the targeted drug delivery for bone diseases and bone regeneration
Wenyi Gu (2013)
10.1039/C8RA01539B
Traversing the profile of biomimetically nanoengineered iron substituted hydroxyapatite: synthesis, characterization, property evaluation, and drug release modeling
Lubna Sheikh (2018)
Starchmediated synthesis of mono- and bimetallic silver/gold nanoparticles as antimicrobial and anticancer agents
D Lomelí-Marroquín (2019)
10.1016/j.addr.2015.10.005
Targeted delivery to bone and mineral deposits using bisphosphonate ligands.
Lisa Cole (2016)
10.5152/eurjrheum.2016.048
An overview and management of osteoporosis.
Tümay Sözen (2017)
10.1007/s10856-010-4012-x
Development of bisphosphonates controlled delivery systems for bone implantation: influence of the formulation and process used on in vitro release
A. Billon-Chabaud (2010)
10.1002/adma.201101541
E-selectin-targeted porous silicon particle for nanoparticle delivery to the bone marrow.
Aman P. Mann (2011)
10.1023/B:JMSM.0000021093.84680.bb
Staphylococcus aureus adhesion to different treated titanium surfaces
Llinos G. Harris (2004)
10.1007/s10544-019-0396-7
Organotropic drug delivery: Synthetic nanoparticles and extracellular vesicles
Sara Busatto (2019)
The Epidemiology and Pathogenesis of Osteoporosis
Clifford J. Rosen (2014)
10.1038/boneres.2016.44
Osteoarthritis: toward a comprehensive understanding of pathological mechanism
Di Chen (2017)
10.1034/j.1600-0501.2001.012004287.x
Treatment of peri-implantitis by local delivery of tetracycline. Clinical, microbiological and radiological results.
Andrea Mombelli (2001)
10.1021/nn101373r
Gold nanoparticles promote osteogenic differentiation of mesenchymal stem cells through p38 MAPK pathway.
Changqing Yi (2010)
10.1016/J.PROGPOLYMSCI.2011.06.003
Alginate: properties and biomedical applications.
Kuen Yong Lee (2012)
Gold nanoparticles in delivery applications ?
byBrooke LaBranche (2018)
10.1016/j.actbio.2010.10.004
Increased osteoblast functions in the presence of hydroxyapatite-coated iron oxide nanoparticles.
Nhiem Thai Tran (2011)
10.1016/j.actbio.2011.11.017
Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: a review.
Susmita Bose (2012)
10.2174/138161210793563572
Bisphosphonates and bone diseases: past, present and future.
Dominique Heymann (2010)
10.5772/34775
Osteogenesis Imperfecta.
Roy Morello (1928)
10.1007/s11373-008-9277-4
Enhancement of ectopic bone formation by bone morphogenetic protein-2 delivery using heparin-conjugated PLGA nanoparticles with transplantation of bone marrow-derived mesenchymal stem cells.
Sung Eun Kim (2008)
10.1089/ten.TEA.2015.0576
Gene Delivery of TGF-β3 and BMP2 in an MSC-Laden Alginate Hydrogel for Articular Cartilage and Endochondral Bone Tissue Engineering.
T. Gonzalez-Fernandez (2016)
10.1016/J.POLYMER.2012.10.032
Microencapsulated chitosan–dextran sulfate nanoparticles for controled delivery of bioactive molecules and cells in bone regeneration
J.F.A. Valente (2013)
10.1517/17425240903044935
Nanotechnology controlled drug delivery for treating bone diseases
Lei Yang (2009)
10.1080/21691401.2019.1576710
The use of stromal vascular fraction (SVF), platelet-rich plasma (PRP) and stem cells in the treatment of osteoarthritis: an overview of clinical trials
Sahar Mehranfar (2019)
10.3390/ijms150813967
Mechanistic Understanding of Toxicity from Nanocatalysts
Cuijuan Jiang (2014)
Skeletal system. Part one--bone structure.
Brendan Docherty (2007)
10.1016/j.phrs.2010.10.006
Using tetracyclines to treat osteoporotic/osteopenic bone loss: from the basic science laboratory to the clinic.
Jeffrey B Payne (2011)
10.1039/C5TB01043H
Hydrogels That Allow and Facilitate Bone Repair, Remodeling, and Regeneration.
Aaron R. Short (2015)
10.1016/j.biomaterials.2008.12.017
Dexamethasone-containing PLGA superparamagnetic microparticles as carriers for the local treatment of arthritis.
Nicoleta Butoescu (2009)
10.1007/s10439-009-9722-1
The Role of Nanomedicine in Growing Tissues
Young Wook Chun (2009)
10.1016/j.carbpol.2018.12.011
Biomedical applications of chitosan electrospun nanofibers as a green polymer - Review.
Katayoon Kalantari (2019)
10.1016/S0001-2998(97)80004-9
Skeletal system: biomechanical concepts and relationships to normal and abnormal conditions.
Frank J. Frassica (1997)
10.1016/j.injury.2015.10.006
Silver ion doped ceramic nano-powder coated nails prevent infection in open fractures: In vivo study.
Nusret Kose (2016)
10.2147/IJN.S23074
Preparation, characterization, and efficient transfection of cationic liposomes and nanomagnetic cationic liposomes
Hamid Reza Samadikhah (2011)
10.18632/oncotarget.4971
Chitosan nanoparticle-mediated delivery of miRNA-34a decreases prostate tumor growth in the bone and its expression induces non-canonical autophagy
Sanchaika Gaur (2015)
10.1007/s00774-008-0004-z
Selective drug delivery to bone using acidic oligopeptides
Junko Ishizaki (2008)
10.4065/83.9.1032
Bisphosphonates: mechanism of action and role in clinical practice.
Matthew T Drake (2008)
10.3109/10611860108997922
Novel Drug Delivery System to Bone Using Acidic Oligopeptide: Pharmacokinetic Characteristics and Pharmacological Potential
Tohru Sekido (2001)
10.1016/B978-0-08-102579-6.00011-3
Green synthesis of metal/metal oxide nanoparticles toward biomedical applications: Boon or bane
Mousumi Das (2019)
10.1016/B978-0-12-802792-9.00001-X
Introduction to Biomaterials and Devices for Bone Disorders
Susmita Bose (2017)
10.1002/adma.201000854
Layer-by-layer assembly of β-estradiol loaded mesoporous silica nanoparticles on titanium substrates and its implication for bone homeostasis.
Yan Hu (2010)
10.1016/j.biomaterials.2017.09.005
Nanomedicine for safe healing of bone trauma: Opportunities and challenges.
Shahed Behzadi (2017)
10.1039/C5TB01956G
Alendronate-loaded hydroxyapatite-TiO2 nanotubes for improved bone formation in osteoporotic rabbits.
X. Shen (2016)
10.1038/srep27336
Inhibition of Osteoclast Differentiation and Bone Resorption by Bisphosphonate-conjugated Gold Nanoparticles
D. Lee (2016)



This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar