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SLX4 Gains Weight With SUMO In Genome Maintenance

J. Guervilly, Pierre-Henri L. Gaillard
Published 2016 · Medicine, Biology

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Replication stress has emerged as a key driver of oncogenesis but also represents an Achilles' heel of cancer cells. Newly reported SUMO binding and SUMO ligase functions of the DNA repair protein SLX4 that influence the outcome of replication stress open new avenues for investigating the roles played by SLX4 in tumorigenesis.
This paper references
FBH1 promotes DNA double-strand breakage and apoptosis in response to DNA replication stress
Yeon-Tae Jeong (2013)
The SLX4 complex is a SUMO E3 ligase that impacts on replication stress outcome and genome stability.
J. Guervilly (2015)
RNF4 and PLK1 are required for replication fork collapse in ATR-deficient cells.
Ryan L. Ragland (2013)
Nuclease Delivery: Versatile Functions of SLX4/FANCP in Genome Maintenance
Y. Kim (2014)
FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress.
Kasper Fugger (2013)
ATR phosphorylates SMARCAL1 to prevent replication fork collapse.
Frank B Couch (2013)
Ac ce pte d M an us cri pt 6 and PLK1 are required for replication fork collapse in ATR-deficient cells
RL Ragland (2013)
Premature Activation of the SLX4 Complex by Vpr Promotes G2/M Arrest and Escape from Innate Immune Sensing
Nadine Laguette (2014)
Mouse SLX4 Is a Tumor Suppressor that Stimulates the Activity of the Nuclease XPF-ERCC1 in DNA Crosslink Repair
Michael R G Hodskinson (2014)
Noncovalent interactions with SUMO and ubiquitin orchestrate distinct functions of the SLX4 complex in genome maintenance.
J. Ouyang (2015)
DNA Repair Scaffolds Dampen Checkpoint Signaling by Counteracting the Rad9 Adaptor
Patrice Y. Ohouo (2013)

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