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Chemoenzymatic Syntheses Of Homo‐ And Heterodimers Of AZT And D4T, And Evaluation Of Their Anti‐HIV Activity

M. Taourirte, L. Ait Mohamed, A. Rochdi, J.‐J. Vasseur, S. Fernández, M. Ferrero, V. Gotor, C. Pannecouque, E. De Clercq, H. Lazrek
Published 2004 · Chemistry, Medicine

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Homo‐ and heterodimers of AZT and d4T, possessing carbonate and carbamate linkers, have been synthesized with the aim to enhance the antiviral activity of their components. Homo‐ and heterodimer carbamates showed weak anti‐HIV activity. On the other hand, dinucleoside carbonates showed marked antiviral activity.
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