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The Hyaluronate Receptor Is A Member Of The CD44 (H-CAM) Family Of Cell Surface Glycoproteins [published Erratum Appears In J Cell Biol 1991 Feb;112(3):following 513]

M. Culty, K. Miyake, P. Kincade, E. Sikorski, E. Butcher, C. Underhill
Published 1990 · Biology, Medicine

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The present study was undertaken to determine the relationship between the hyaluronate receptor and CD44 (H-CAM), cell-surface glycoproteins of similar molecular weights that have been implicated in cell adhesion. In initial experiments, a panel of monoclonal antibodies directed against CD44 were tested for their ability to cross react with the hyaluronate receptor. These antibodies immunoprecipitated [3H]hyaluronate binding activity from detergent extracts of both mouse and human cells, indicating that the hyaluronate receptor is identical to CD44. In addition, one of these antibodies (KM-201 to mouse CD44) directly blocked the binding of labeled hyaluronate to the receptor and inhibited hyaluronate dependent aggregation of SV-3T3 cells. CD44 has also been implicated in lymphocyte binding to high endothelial venules during lymphocyte homing. Interestingly, the monoclonal antibody Hermes- 3, which blocks lymphocyte binding to the high endothelial venules of mucosal lymphoid tissue, had no effect on the binding of labeled hyaluronate. Furthermore, the binding of lymphocytes to high endothelial cells of lymph nodes and mucosal lymphoid tissue was not significantly affected by treatment with agents that block the binding of hyaluronate (hyaluronidase, excess hyaluronate and specific antibodies). Thus, CD44 appears to have at least two distinct functional domains, one for binding hyaluronate and another involved in interactions with mucosal high endothelial venules.
This paper references
10.1016/0006-291X(87)91632-9
The cell surface hyaluronate binding sites of invasive human bladder carcinoma cells.
R. E. Nemec (1987)
Mouse strain variations in Ly-24 (Pgp-1) expression by peripheral T-cells and thymocytes: Implications for T-cell differentiation
F. Lynch (1989)
The hyaluronate receptor is identical to a glycoprotein of Mr 85,000 (gp85) as shown by a monoclonal antibody that interferes with binding activity.
C. Underhill (1987)
Chemical composition and tissue distribution of the human CDw44 glycoprotein, lmmuno/ogy
B. F. Flanagan (1989)
10.1084/JEM.171.2.477
Monoclonal antibodies to Pgp-1/CD44 block lympho-hemopoiesis in long- term bone marrow cultures
K. Miyake (1990)
Biochemical properties of glycoproteins involved in lymphocyte recognition of high endothelial venules in man.
S. Jalkanen (1988)
10.1016/0167-5699(89)90040-6
CD44--a molecule involved in leukocyte adherence and T-cell activation.
B. Haynes (1989)
10.1016/0014-4827(88)90393-X
Aggregation of macrophages and fibroblasts is inhibited by a monoclonal antibody to the hyaluronate receptor.
S. J. Green (1988)
Interaction of hyaluronate with the surface of simian virus 40-transformed 3T3 cells: aggregation and binding studies.
C. Underhill (1982)
10.1016/0076-6879(83)99037-7
Measurement of hormone-stimulated protein phosphorylation in intact cells.
J. C. Garrison (1983)
Murine cell surface glycoproteins. Characterization of a major component of 80,000 daltons as a polymorphic differentiation antigen of mesenchymal cells.
E. N. Hughes (1981)
10.1038/331041A0
A tissue-specific endothelial cell molecule involved in lymphocyte homing
P. Streeter (1988)
Chemical composition and tissue distribution of the human CDw44 glycoprotein.
B. Flanagan (1989)
A lymphocyte molecule implicated in lymph node homing is a member of the carti- Published December 1, 1990 lage link protein family
I Stamenkovic (1989)
Chemical composition and tissue distribution of the human CDw 44 glycoprotein , lmmuno
E. A. Wayner (1989)
10.1083/JCB.105.2.983
Lymphocyte recognition of high endothelium: antibodies to distinct epitopes of an 85-95-kD glycoprotein antigen differentially inhibit lymphocyte binding to lymph node, mucosal, or synovial endothelial cells
S. Jalkanen (1987)
10.1002/9780470513774.CH6
The interaction of hyaluronate with the cell surface: the hyaluronate receptor and the core protein.
C. Underhill (1989)
10.1016/0092-8674(90)90694-A
CD44 is the principal cell surface receptor for hyaluronate
A. Aruffo (1990)
Characterization and identification of the hyainronate-binding site from membranes of SV-3T3 ceils
C. B. Underhill (1985)
10.1111/j.1600-065X.1989.tb00010.x
Homing Receptors and Vascular Addressins: Cell Adhesion Molecules that Direct Lymphocyte Traffic
Ellen Lakey Berg (1989)
and (3. L. Nicolson. 1986. lmmunoafiinity isolation of membrane antigen with biotinylated monoclonal antibody and streptavidin-agasose
T V Updyke
Characterization of a 95,000 molecule on sheep leucocytes homologous to murine Pgp-1 and human CD44.
C. Mackay (1988)
10.1083/JCB.99.5.1624
Lateral diffusion of an 80,000-dalton glycoprotein in the plasma membrane of murine fibroblasts: relationships to cell structure and function
K. Jacobson (1984)
10.1016/0092-8674(89)90638-7
A lymphocyte molecule implicated in lymph node homing is a member of the cartilage link protein family
I. Stamenković (1989)
10.1084/JEM.144.3.828
Lymphocyte homing into lymph nodes: in vitro demonstration of the selective affinity of recirculating lymphocytes for high-endothelial venules
H. B. Stamper (1976)
Effects of detergent solubilization on the hyaluronate-binding protein from membranes of simian virus 40-transformed 3T3 cells.
C. Underhill (1983)
Monoclunal antibodies against the CD44 [In(Lu)-related pS0], and Pgp-I antigens in man recognize the Hermes class of lympbocyte homing receptors
L. J. Picker (1989)
10.1007/BF00375869
Human leucocyte surface glycoprotein CDw44 and lymphocyte homing receptor are identical molecules
I. Štefanová (2004)
10.1073/PNAS.86.12.4654
Structural homology between lymphocyte receptors for high endothelium and class III extracellular matrix receptor.
W. Gallatin (1989)
10.1083/JCB.107.5.1845
Evolutionary conservation of tissue-specific lymphocyte-endothelial cell recognition mechanisms involved in lymphocyte homing
N. Wu (1988)
A lymphocyte molecule implicated in lymph node homing is a member of the cartiCulty et al. Hyaluronate Receptor Is Identical to CD44
I. Stamenkovic (1989)
10.1016/0092-8674(89)90639-9
A human lymphocyte homing receptor, the Hermes antigen, is related to cartilage proteoglycan core and link proteins
L. Goldstein (1989)
10.1002/EJI.1830161003
A lymphoid cell surface glycoprotein involved in endothelial cell recognition and lymphocyte homing in man
S. Jalkanen (1986)
10.1083/JCB.105.3.1395
The hyaluronate receptor is associated with actin filaments
B. Lacy (1987)
10.1083/JCB.106.2.319
Mouse T lymphoma cells contain a transmembrane glycoprotein (GP85) that binds ankyrin
E. Kalomiris (1988)
Characterization of the class III collagen receptor, a phosphorylated, transmembrane glycoprotein expressed in nucleated human cells.
W. Carter (1988)
Identification and characterization of the human Pgp-I glycoprotein, lnmmnogeneties
C. M. Isacke (1986)
10.1172/JCI114285
Adhesion molecules of cultured hematopoietic malignancies. A calcium-dependent lectin is the principle mediator of binding to the high endothelial venule of lymph nodes.
L. Stoolman (1989)
10.1007/BF00364434
Structural heterogeneity of human Pgp-1 and its relationship with p85
M. Omary (2004)
10.1083/JCB.108.4.1557
The hyaluronate receptor is preferentially expressed on proliferating epithelial cells
A. Alho (1989)
Interaction of link protein with collagen.
S. Chandrasekhar (1983)
10.1016/0014-4827(90)90085-O
Binding of hyaluronic acid to lymphoid cell lines is inhibited by monoclonal antibodies against Pgp-1.
J. Lesley (1990)
10.1084/JEM.172.1.69
Hyaluronate can function as a cell adhesion molecule and CD44 participates in hyaluronate recognition
K. Miyake (1990)
10.1083/JCB.109.2.927
Monoclonal antibodies to human lymphocyte homing receptors define a novel class of adhesion molecules on diverse cell types
L. Picker (1989)
L. Nicolson. 1986. lmmunoafiinity isolation of membrane antigen with biotinylated monoclonal antibody and streptavidin-agasose
T V Updyke
Structural heterogeneity of human Pgp-I and its relationship with p85. lmmunogenetics
M B Omary (1988)
10.1002/EJI.1830190202
Mouse strain variation in Ly‐24 (Pgp‐1) expression by peripheral T cells and thymocytes: implications for T cell differentiation
F. Lynch (1989)
Distribution of hyaluronate and hyaluronate receptors in the adult lung.
S. J. Green (1988)
Monoclonal antibodies to human lymphocyte homing receptors define a novel class of adhesion molecules on diverse cell
L. Picker (1989)
lmmunoafiinity isolation of membrane antigen with biotinylated monoclonal antibody and streptavidin-agasose
T. V. Updyke (1986)
10.1016/0014-4827(81)90248-2
Receptors for hyaluronate on the surface of parent and virus-transformed cell lines: binding and aggregation studies.
C. Underhill (1981)



This paper is referenced by
10.11551/JSJD1982.14.63
Effect of High Molecular Hyaluronate on Collagen mRNA Expression in Cultured Articular Chondrocytes
G. Tajima (1995)
10.1016/S0065-2776(08)60022-X
Lymphocyte trafficking and regional immunity.
E. Butcher (1999)
10.1007/s00251-001-0417-5
Lack of a consistent relationship between demethylation of the CD44 promoter and CD44 expression
R. Hyman (2002)
Análisis de la energía de adhesión intercambiada en la unión CD44- hialuronato.
Grupo de Óptica Aplicada (2009)
10.7916/D8902B0Q
Stressed Astrocytes: Insights on the Pathology of Alexander Disease
Eileen Guilfoyle (2013)
10.1111/J.1048-891X.2005.15015.X
Aggressive angiomyxoma of the female genital tract: a clinicopathologic and immunohistochemical study of 12 cases
C. Amezcua (2005)
10.3109/10428190009059265
CD44v10 in Hematopoiesis and Stem Cell Mobilization
M. Zöller (2000)
10.1016/0012-1606(91)90459-G
Monoclonal antibody to chick embryo hyaluronan-binding protein: changes in distribution of binding protein during early brain development.
S. Banerjee (1991)
Internalization of hyaluronan by chondrocytes occurs via receptor-mediated endocytosis.
Q. Hua (1993)
10.1016/0049-0172(92)90047-H
Does hyaluronan have a role in endothelial cell proliferation of the synovium?
A. Sattar (1992)
Migration of highly aggressive melanoma cells on hyaluronic acid is associated with functional changes, increased turnover and shedding of CD44 receptors.
M. Goebeler (1996)
10.1128/IAI.64.8.3280-3287.1996
Increased susceptibility to primary infection with Listeria monocytogenes in germfree mice may be due to lack of accumulation of L-selectin+ CD44+ T cells in sites of inflammation.
H. Inagaki (1996)
10.1111/j.1600-065X.2006.00483.x
Skin γδ T‐cell functions in homeostasis and wound healing
Julie M Jameson (2007)
10.1016/S0046-8177(97)90250-1
Coordinated expression of integrin α6β1 and laminin in hepatocellular carcinoma
T. Torimura (1997)
10.1074/jbc.273.1.338
Identification of CD44 Residues Important for Hyaluronan Binding and Delineation of the Binding Site*
J. Bajorath (1998)
10.1016/J.YEXCR.2007.07.013
PKC-induced stiffening of hyaluronan/CD44 linkage; local force measurements on glioma cells.
C. Lamontagne (2008)
10.1097/01.EHX.0000396642.87633.92
Endometrial changes induced by prostaglandin E2 and EP4 receptor agonist in albino rats
Nagwa E. El-Nefiawy (2011)
10.1083/JCB.116.2.545
A novel secretory tumor necrosis factor-inducible protein (TSG-6) is a member of the family of hyaluronate binding proteins, closely related to the adhesion receptor CD44
T. H. Lee (1992)
10.1016/B978-0-12-285960-1.50009-5
Stress, Viral Pathogenesis, and Immunity
J. Sheridan (1994)
10.1111/j.1365-3083.1995.tb03667.x
Administration of Antibodies to Hyaluronanreceptor (CD44) Delays the Start and Ameliorates the Severity of Collagen II Arthritis
M. Verdrengh (1995)
10.1016/0960-0760(92)90364-O
Regulation of tumor-host interactions in breast cancer
R. Dickson (1992)
10.1016/0167-5699(92)90151-V
Lymphocyte interactions with endothelial cells.
Y. Shimizu (1992)
10.1007/s004180050100
Differential expression of CD44s and CD4v10 proteins and syndecan in normal and irradiated mouse epidermis
K. Liu (1997)
10.1002/(SICI)1097-4652(199705)171:2<152::AID-JCP5>3.0.CO;2-N
Coexpression of CD44 variant (v10/ex14) and CD44S in human mammary epithelial cells promotes tumorigenesis
N. Iida (1997)
10.1111/j.1365-2249.2004.02638.x
Divalent cation‐dependent and ‐independent augmentation of macrophage phagocytosis of apoptotic neutrophils by CD44 antibody
S. Vivers (2004)
Hyaluronan is a prerequisite for ductal branching morphogenesis.
P. Gakunga (1997)
10.1016/S0301-472X(99)00023-5
CD44 isoforms in normal and leukemic hematopoiesis.
S Ghaffari (1999)
10.1046/J.0022-202X.2004.22205.X
Fibroblast invasive migration into fibronectin/fibrin gels requires a previously uncharacterized dermatan sulfate-CD44 proteoglycan.
R. Clark (2004)
10.1007/978-3-319-44336-2
Trapeziometacarpal Joint Osteoarthritis
Simona Odella (2018)
10.1002/jlb.56.5.605
Hyaluronan receptor (CD44) expression and function in human peripheral blood monocytes and alveolar macrophages
M. Culty (1994)
10.1038/nm0695-558
Anti-CD44 treatment abrogates tissue aedema and leukocyte infiltration in murine arthrtis
K. Mikecz (1995)
10.1007/978-3-642-61107-0_14
Joint features of metastasis formation and lymphocyte maturation and activation.
M. Zöller (1996)
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