Online citations, reference lists, and bibliographies.
← Back to Search

Somite Subdomains, Muscle Cell Origins, And The Four Muscle Regulatory Factor Proteins

T. Smith, A. M. Kachinsky, J. Miller
Published 1994 · Medicine, Biology

Cite This
Download PDF
Analyze on Scholarcy
We show by immunohistology that distinct expression patterns of the four muscle regulatory factor (MRF) proteins identify subdomains of mouse somites. Myf-5 and MyoD are, at specific stages, each expressed in both myotome and dermatome cells. Myf-5 expression is initially restricted to dorsal cells in all somites, as is MyoD expression in neck somites. In trunk somites, however, MyoD is initially expressed in ventral cells. Myogenin and MRF4 are restricted to myotome cells, though the MRF4-expressing cells are initially less widely distributed than the myogenin-expressing cells, which are at all stages found throughout the myotome. All somitic myocytes express one or more MRFs. The transiently distinct expression patterns of the four MRF proteins identify dorsal and ventral subdomains of somites, and suggest that skeletal muscle cells in somites originate at multiple sites and via multiple molecular pathways.
This paper references
Early expression of the myogenic regulatory gene, myf-5, in precursor cells of skeletal muscle in the mouse embryo.
M. Ott (1991)
The myoD gene family: nodal point during specification of the muscle cell lineage.
H. Weintraub (1991)
Developmental regulation of the multiple myogenic cell lineages of the avian embryo
J. B. Miller (1986)
Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene
P. Hasty (1993)
Developmental origins of skeletal muscle fibers: clonal analysis of myogenic cell lineages based on expression of fast and slow myosin heavy chains.
J. B. Miller (1986)
Evolutionarily conserved sequences specific for striated muscle myosin heavy chain isoforms: epitope mapping by cDNA expression
J. B. Miller (1989)
Aberrant regulation
T. J. Brennan (1990)
Developmental origins of skeletal muscle fibers: clonal analysis of myogenic cell lineages based on fast and slow myosin heavy chain Miller, expression
J. B. Miller (1986)
Targeted inactivation of the muscle regulatory gene Myf-5 results in abnormal rib development and perinatal death
T. Braun (1992)
Distinct myogenic programs of embryonic and fetal mouse muscle cells: expression of the perinatal myosin heavy chain isoform in vitro.
T. Smith (1992)
Slow and fast myosin heavy chain expression defines three types of myombes in early muscle cell cultures
J. B. Miller (1985)
J. Milaire (1976)
Myogenic regulatory factors: dissecting their role and regulation during vertebrate embryogenesis.
D. Sassoon (1993)
Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development
M. Rudnicki (1992)
Chapter 9 Cell Heterogeneity in The Myogenic Lineage
G. Cossu (1987)
Two myogenic lineages within the developing somite.
C. Ordahl (1992)
The MyoD family and myogenesis: Redundancy, networks, and thresholds
H. Weintraub (1993)
Evolutionarily conserved sequences of striated muscle myosin heavy chain isoforms. Epitope mapping by cDNA expression.
J. B. Miller (1989)
Cell heterogeneity in the myogenic lineage.
G. Cossu (1987)
Cellular and molecular diversity in skeletal muscle development: News from in vitro and in vivo
J. Miller (1993)
Slow and fast myosin heavy chain content defines three types of myotubes in early muscle cell cultures
J. B. Miller (1985)
A unique pattern of expression of the four muscle regulatory factor proteins distinguishes somitic from embryonic, fetal and newborn mouse myogenic cells.
T. Smith (1993)
Myoblast diversity in skeletal myogenesis: How much and to what end?
J. Miller (1992)
The regulation of myogenin gene expression during the embryonic development of the mouse.
S. Yee (1993)
Regulation of Pax-3 expression in the dermomyotome and its role in muscle development.
M. Goulding (1994)
Making muscle in mammals.
M. Buckingham (1992)
Desmin sequence elements regulating skeletal muscle-specific expression in transgenic mice.
Z. Li (1993)
Isolated sequences from the linked Myf-5 and MRF4 genes drive distinct patterns of muscle-specific expression in transgenic mice.
A. Patapoutian (1993)
Expression of MRF 4 , a myogenic helix - loop - helix protein , produces multiple changes in the myogenic program of BC 3 H - 1 cells
E. Bober (1992)
Aberrant regulation of MyoD1 contributes to the partially defective myogenic phenotype of BC3H-1 cells
T J Brennan (1990)
Myoblasts, myosins, MyoDs, and the diversification of muscle fibers
J. Miller (1991)
Differential trans activation associated with the muscle regulatory factors MyoD1, myogenin, and MRF4.
K. Yutzey (1990)
Expression of the muscle regulatory factor MRF4 during somite and skeletal myofiber development.
T. Hinterberger (1991)
Limb-somite relationship: origin of the limb musculature.
A. Chevallier (1977)
Cyclic amplification and selection of targets (CASTing) for the myogenin consensus binding site.
W. Wright (1991)
Aberrant regulation of MyoD1 contributes to the partially defective myogenic phenotype of BC3H1 cells [published erratum appears in J Cell Biol 1990 Jun;110(6):2231]
T. Brennan (1990)
The MRF4 activation domain is required to induce muscle-specific gene expression.
K. L. Mak (1992)
The neural tube/notochord complex is necessary for vertebral but not limb and body wall striated muscle differentiation.
P. M. Rong (1992)
Cyclic amplification and target selection (CASTING) for the myogenin consensus binding site
W. E. Wright (1991)
The House Mouse: Atlas of Embryonic Development
K. Theiler (1972)
MyoD, myoganin independent differentiation of primordial myohlasts in mouse somites
M. Cusella-De Angelis (1992)
Aberrant Regulation of MyoD 1 Contributes to the Partially Defective Myogenic Phenotype of BC 3 H 1 Cells
N. Olson (1990)
Separable regulatory elements governing myogenin transcription in mouse embryogenesis.
T. Cheng (1993)
MyoD or Myf-5 is required for the formation of skeletal muscle
M. Rudnicki (1993)
Myogenic programs of mouse muscle cell lines: expression of myosin heavy chain isoforms, MyoD1, and myogenin
J. Miller (1990)
Expression of MRF4, a myogenic helix-loop-helix protein, produces multiple changes in the myogenic program of BC3H-1 cells.
N. Block (1992)
Interplay between proliferation and differentiation within the myogenic lineage.
E. Olson (1992)
Myogenic cell lineages.
F. Stockdale (1992)
Myogenic differentiation in early chick wing mesenchyme in the absence of the brachial somites.
T. Kenny-Mobbs (1985)
Myogenin gene disruption results in perinatal lethality because of severe muscle defect
Y. Nabeshima (1993)
Interactions between somite cells: the formation and maintenance of segment boundaries in the chick embryo.
C. Stern (1987)
Sequential activation of three myogenic regulatory genes during somite morphogenesis in quail embryos.
M. Pownall (1992)
Pax-3 is required for the development of limb muscles: a possible role for the migration of dermomyotomal muscle progenitor cells.
E. Bober (1994)

This paper is referenced by
MyoD and Myf-5 differentially regulate the development of limb versus trunk skeletal muscle.
B. Kablar (1997)
Roles of Growth Hormone, Insulin-Like Growth Factor I, and Sh3 and Cysteine Rich Domain 3 in Skeletal Muscle Growth
Xiaomei Ge (2012)
Single-cell analysis of regulatory gene expression in quiescent and activated mouse skeletal muscle satellite cells.
D. Cornelison (1997)
Rib truncations and fusions in the Sp2H mouse reveal a role for Pax3 in specification of the ventro-lateral and posterior parts of the somite.
D. Henderson (1999)
The Effects of Poor Maternal Nutrition on Muscle Development in Lambs
J. S. Raja (2013)
Expression of lbx1 involved in the hypaxial musculature formation of the mouse embryo.
K. Uchiyama (2000)
Genome-wide expression dynamics during mouse embryonic development reveal similarities to Drosophila development.
Roger A. Wagner (2005)
The MyoD family of transcription factors and skeletal myogenesis
M. Rudnicki (1995)
Distal regulatory elements control MRF4 gene expression in early and late myogenic cell populations
C. L. Pin (1997)
Location and growth of epaxial myotome precursor cells.
W. Denetclaw (1997)
7 – Somitogenesis: Segmentation of the Paraxial Mesoderm and the Delineation of Tissue Compartments
A. Gossler (2002)
5 Molecular Embryology of Skeletal Myogenesis
J. M. Venuti (1996)
Expression Profiles Analysis and Functional Characterization of MicroRNA‐660 in Skeletal Muscle Differentiation
Binglin Yue (2017)
2 – Myogenic Regulatory Factors
S. Watabe (2001)
The Skeletal Muscle Satellite Cell: The Stem Cell That Came in From the Cold
P. Zammit (2006)
The concerted action of Meox homeobox genes is required upstream of genetic pathways essential for the formation, patterning and differentiation of somites
B. Mankoo (2003)
Novel cis-element in intron 1 represses somite expression of zebrafish myf-5.
cheng-yung Lin (2004)
Molecular cloning of the duck MEF2C gene cDNA coding domain sequence and its expression during fetal muscle tissue development
L. Sun (2013)
Regulation of hypaxial muscle development
Susanne Dietrich (1999)
Drosophila myogenesis and insights into the role of nautilus.
S. Abmayr (1998)
MRF4 can substitute for myogenin during early stages of myogenesis
Zhimin Zhu (1997)
p27Kip1 is expressed transiently in developing myotomes and enhances myogenesis.
S. Zabludoff (1998)
L. Browder (2000)
Sequential expression and redundancy of Pitx2 and Pitx3 genes during muscle development.
A. L'honoré (2007)
The birth of muscle progenitor cells in the mouse: spatiotemporal considerations.
S. Tajbakhsh (2000)
Thoracic skeletal defects in myogenin- and MRF4-deficient mice correlate with early defects in myotome and intercostal musculature.
J. Vivian (2000)
Epigenetic and genetic mechanisms through which Myostatin regulates muscle wasting
Gavian Bing Jia Lua (2016)
Apoptosis of epaxial myotome in Danforth's short-tail (Sd) mice in somites that form following notochord degeneration.
A. Asakura (1998)
Lymphocyte Migration: A new spin on lymphocyte homing
C. Mackay (1995)
I-mf, a Novel Myogenic Repressor, Interacts with Members of the MyoD Family
C.-M.Amy Chen (1996)
Molecular cloning and developmental expression patterns of the MyoD and MEF2 families of muscle transcription factors in the carp.
A. Kobiyama (1998)
Molecular genetics of skeletal muscle development
Michael J. McGrew (1999)
See more
Semantic Scholar Logo Some data provided by SemanticScholar