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Induction Of Fc Epsilon R2/CD23 On Human Epidermal Langerhans Cells By Human Recombinant Interleukin 4 And Gamma Interferon.

T Bieber, A Rieger, C Neuchrist, J C Prinz, E P Rieber, G Boltz-Nitulescu, O Scheiner, D Kraft, J Ring, G Stingl

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Human rIL-4 and human rIFN-gamma are able to induce the expression of the low affinity receptor for IgE (Fc epsilon R2/CD23) on normal human epidermal Langerhans cells, whereas IL-2 and PMA have no effect. A synergistic effect is observed when both cytokines are combined. These receptors are synthesized de novo by the LC since cycloheximide completely inhibits the appearance of Fc epsilon R2/CD23. Fc epsilon R2/CD23+ LC may have a major role in the pathogenesis of atopic eczema, as well as in the regulation of IgE synthesis.