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GPR91 Senses Extracellular Succinate Released From Inflammatory Macrophages And Exacerbates Rheumatoid Arthritis

A. Littlewood-Evans, Sophie Sarret, Verena Apfel, Perrine Loesle, J. Dawson, Juan Zhang, Alban Muller, B. Tigani, R. Kneuer, S. Patel, Stephanie Valeaux, N. Gommermann, T. Rubic-Schneider, T. Junt, J. Carballido
Published 2016 · Chemistry, Medicine

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Littlewood-Evans et al. demonstrate that extracellular succinate leads to the propagation of inflammatory macrophage activation, providing translational evidence to support the development of GPR91 antagonists for the treatment of rheumatoid arthritis.
This paper references
10.1002/ART.1780250806
Gas-liquid chromatographic analysis of synovial fluid. Succinic acid and lactic acid as markers for septic arthritis.
D. Borenstein (1982)
10.1093/RHEUMATOLOGY/38.9.818
Liposomal clodronate eliminates synovial macrophages, reduces inflammation and ameliorates joint destruction in antigen-induced arthritis.
P. J. Richards (1999)
10.1006/JAUT.2001.0534
Systemic macrophage activation in locally-induced experimental arthritis.
J. Simon (2001)
10.1002/1439-7633(20020802)3:8<784::AID-CBIC784>3.0.CO;2-X
A Receptor‐Targeted Near‐Infrared Fluorescence Probe for In Vivo Tumor Imaging
C. Tung (2002)
10.1038/nature02488
Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors
W. He (2004)
10.1136/ARD.2004.029751
Synovial tissue macrophages: a sensitive biomarker for response to treatment in patients with rheumatoid arthritis.
J. Haringman (2005)
10.1016/J.JHEP.2007.03.016
Succinate is a paracrine signal for liver damage.
P. R. Correa (2007)
10.1038/nri2094
Cytokines in the pathogenesis of rheumatoid arthritis
I. McInnes (2007)
10.1182/BLOOD-2006-07-036269
Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins.
I. Macaulay (2007)
10.1016/J.AMJHYPER.2007.05.010
Circulating succinate is elevated in rodent models of hypertension and metabolic disease.
N. Sadagopan (2007)
Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory
I. C. Macaulay (2007)
10.1172/JCI33293
Succinate receptor GPR91 provides a direct link between high glucose levels and renin release in murine and rabbit kidney.
I. Toma (2008)
10.1093/ndt/gfn377
Activation of the renal renin-angiotensin system in diabetes--new concepts.
J. Peti-Peterdi (2008)
10.1038/ni.1657
Triggering the succinate receptor GPR91 on dendritic cells enhances immunity
T. Rubic (2008)
Activation of the renal reninangiotensin system in diabetes—new concepts. Nephrol
J. 20151570 Peti-Peterdi (2008)
10.3899/jrheum.090348
Synovial Tissue Sublining CD68 Expression Is a Biomarker of Therapeutic Response in Rheumatoid Arthritis Clinical Trials: Consistency Across Centers
B. Bresnihan (2009)
10.4049/jimmunol.0901698
Substrate Fate in Activated Macrophages: A Comparison between Innate, Classic, and Alternative Activation
Juan-Carlos Rodríguez-Prados (2010)
10.1016/j.bmcl.2011.04.091
Discovery of a potent and selective small molecule hGPR91 antagonist.
Debnath Bhuniya (2011)
10.3389/fimmu.2011.00052
Macrophages in Synovial Inflammation
A. Kennedy (2011)
Macrophages in synovial inflammation. Front. Immunol. 2:52
A Kennedy (2011)
Discovery of a potent and selective small molecule hGPR 91 antagonist
D. G. Borenstein (2011)
10.1167/iovs.12-9662
The Rd8 mutation of the Crb1 gene is present in vendor lines of C57BL/6N mice and embryonic stem cells, and confounds ocular induced mutant phenotypes.
M. Mattapallil (2012)
10.3389/fendo.2012.00022
The Succinate Receptor as a Novel Therapeutic Target for Oxidative and Metabolic Stress-Related Conditions
A. Ariza (2012)
10.1038/nature11986
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
G. Tannahill (2013)
10.1016/j.smim.2013.10.008
Treating inflammation by blocking interleukin-1 in humans.
C. Dinarello (2013)
10.1038/nature13909
Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS
Edward T Chouchani (2014)
10.3389/fimmu.2014.00420
Metabolic Reprograming in Macrophage Polarization
Silvia Galván-Peña (2014)
10.1371/journal.pone.0097501
Global Metabolite Profiling of Synovial Fluid for the Specific Diagnosis of Rheumatoid Arthritis from Other Inflammatory Arthritis
S. Kim (2014)
10.1080/19420862.2015.1081323
The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1β
J. Rondeau (2015)
10.1021/acs.molpharmaceut.5b00134
Prediction of Response to Therapy for Autoimmune/Inflammatory Diseases Using an Activated Macrophage-Targeted Radioimaging Agent.
Lindsay E. Kelderhouse (2015)
10.1016/j.immuni.2015.02.005
Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization.
Abhishek K. Jha (2015)
10.1083/jcb.2121OIA306
Immunometabolism governs dendritic cell and macrophage function
L. O’Neill (2016)
10.1084/jem.20151570
Immunometabolism governs dendritic cell and macrophage function
L. O'Neill (2016)
J. Hepatol



This paper is referenced by
10.1016/b978-0-12-822564-6.00018-5
Immunometabolism and autoimmunity
Valentina Pucino (2022)
10.1016/j.jbc.2021.100904
Mitochondrial metabolism regulates macrophage biology
Yafang Wang (2021)
10.37489/0235-2990-2021-66-3-4-40-48
Possibilities of Hyperinflammation Correction in COVID-19
I. S. Simutis (2021)
10.1016/j.intimp.2021.108364
Paeoniflorin alleviates CFA-induced inflammatory pain by inhibiting TRPV1 and succinate/SUCNR1-HIF-1α/NLPR3 pathway
(2021)
10.1038/s41598-021-94607-5
Adenosine deaminase modulates metabolic remodeling and orchestrates joint destruction in rheumatoid arthritis
Saikrishna Srimadh Bhagavatham (2021)
10.3390/pathogens10080957
Pseudomonas aeruginosa Consumption of Airway Metabolites Promotes Lung Infection
S. Riquelme (2021)
10.3390/nu13030823
How Changes in the Nutritional Landscape Shape Gut Immunometabolism
Jian Tan (2021)
10.3390/cancers13050996
Stem Cell Impairment at the Host-Microbiota Interface in Colorectal Cancer
Marinella Marzano (2021)
10.1021/acsinfecdis.1c00428
Identification of Small Molecules of the Infective Stage of Human Hookworm Using LCMS-Based Metabolomics and Lipidomics Protocols.
Phurpa Wangchuk (2021)
10.3389/fimmu.2021.673916
Mitochondria as Key Players in the Pathogenesis and Treatment of Rheumatoid Arthritis
Sally A. Clayton (2021)
10.1051/medsci/2021031
Les métabokines, des médiateurs essentiels de l’immunité anti-infectieuse
Adeline Cezard (2021)
10.1002/JLB.6A1120-744R
Use of integrated metabolomics, transcriptomics, and signal protein profile to characterize the effector function and associated metabotype of polarized macrophage phenotypes.
Catherine B Anders (2021)
10.3389/fimmu.2021.661241
Immunometabolism: Towards a Better Understanding the Mechanism of Parasitic Infection and Immunity
Jing-yue Chen (2021)
10.1002/cac2.12182
Metabolic regulation in the immune response to cancer
Qi Wu (2021)
10.1007/978-3-030-56319-6
The Role of Toll-Like Receptor 4 in Infectious and Non Infectious Inflammation
M. Parnham (2021)
10.1016/j.copbio.2021.01.020
Complexity of macrophage metabolism in infection.
Wei He (2021)
10.3389/fimmu.2021.652771
Metabolic Control of Autoimmunity and Tissue Inflammation in Rheumatoid Arthritis
Jingtao Qiu (2021)
10.3389/fimmu.2021.665782
Immunometabolism of Tissue-Resident Macrophages – An Appraisal of the Current Knowledge and Cutting-Edge Methods and Technologies
Giulia Zago (2021)
10.3390/metabo11060406
What We Know So Far about the Metabolite-Mediated Microbiota-Intestinal Immunity Dialogue and How to Hear the Sound of This Crosstalk
Clément Caffaratti (2021)
10.3390/IMMUNO1010001
Reprogramming of Central Carbon Metabolism in Myeloid Cells upon Innate Immune Receptor Stimulation
L. Perrin-Cocon (2021)
10.1016/j.celrep.2021.109246
Extracellular succinate hyperpolarizes M2 macrophages through SUCNR1/GPR91-mediated Gq signaling.
Mette Trauelsen (2021)
10.3390/life11010069
Tricarboxylic Acid (TCA) Cycle Intermediates: Regulators of Immune Responses
Inseo Choi (2021)
10.1038/s41590-021-01048-3
Mitochondrial complex II in intestinal epithelial cells regulates T cell-mediated immunopathology.
Hideaki Fujiwara (2021)
10.1186/s12933-021-01333-3
Elevated plasma succinate levels are linked to higher cardiovascular disease risk factors in young adults
Francisco J. Osuna-Prieto (2021)
10.1371/journal.ppat.1009597
STING regulates metabolic reprogramming in macrophages via HIF-1α during Brucella infection
M. T. Gomes (2021)
10.1007/978-3-030-86684-6_4
Metabolic Pathways in Immune Cells Commitment and Fate
Renan Willian Alves (2021)
10.3390/cells10092463
Mitochondrial Biogenesis, Mitochondrial Dynamics, and Mitophagy in the Maturation of Cardiomyocytes
Qianqian Ding (2021)
10.1016/j.cmet.2021.06.009
Protective succinate-SUCNR1 metabolic stress signaling gone bad.
Sally Winther (2021)
10.1002/cti2.1237
Rheumatoid arthritis CD14+ monocytes display metabolic and inflammatory dysfunction, a phenotype that precedes clinical manifestation of disease
T. Mcgarry (2021)
10.1210/endrev/bnab004
Macrophage Responses to Environmental Stimuli During Homeostasis and Disease.
A. Rasheed (2021)
10.1016/j.celrep.2021.109521
A transepithelial pathway delivers succinate to macrophages, thus perpetuating their pro-inflammatory metabolic state.
Moran Fremder (2021)
10.1038/s42255-021-00389-5
UCP1 governs liver extracellular succinate and inflammatory pathogenesis.
E. Mills (2021)
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