Gastrointestinal Microflora Studies In Late-onset Autism.
S. Finegold, D. Molitoris, Y. Song, C. Liu, M. Vaisanen, E. Bolte, M. McTeague, R. Sandler, H. Wexler, E. Marlowe, M. Collins, P. Lawson, P. Summanen, M. Baysallar, T. J. Tomzynski, Erik K. Read, E. Johnson, R. Rolfe, Palwasha Nasir, H. Shah, D. Haake, P. Manning, Ajay Kaul
Published 2002 · Medicine
Download PDFAnalyze on Scholarcy
Some cases of late-onset (regressive) autism may involve abnormal flora because oral vancomycin, which is poorly absorbed, may lead to significant improvement in these children. Fecal flora of children with regressive autism was compared with that of control children, and clostridial counts were higher. The number of clostridial species found in the stools of children with autism was greater than in the stools of control children. Children with autism had 9 species of Clostridium not found in controls, whereas controls yielded only 3 species not found in children with autism. In all, there were 25 different clostridial species found. In gastric and duodenal specimens, the most striking finding was total absence of non-spore-forming anaerobes and microaerophilic bacteria from control children and significant numbers of such bacteria from children with autism. These studies demonstrate significant alterations in the upper and lower intestinal flora of children with late-onset autism and may provide insights into the nature of this disorder.
This paper references
Assays for bacterial mucindesulfating sulfatases
AM Roberton (1997)
Innate and adaptive immune responses in children with regression autism: evaluation of the effects of environmental factors including vaccination [abstract]
H Jyonouchi (2001)
The biology of the autistic syndromes
Hiroshi Naruse (1993)
Formation of Phenolic and Indolic Compounds by Anaerobic Bacteria in the Human Large Intestine
E. Smith (1997)
Characterization of a Bacteroides species from human intestine that degrades glycosaminoglycans.
Mi-young Ahn (1998)
Autistic children: infancy to adulthood.
M. Rutter (1970)
Studies on the intestinal flora. I. The bacterial flora of the gastrointestinal tract in healthy and achlorhydric persons.
B. Drasar (1969)
Short-term benefit from S16 @BULLET CID 2002:35 (Suppl 1) @BULLET Finegold et al. oral vancomycin treatment of regressive-onset autism
Rh Sandler (2000)
Circulating autoantibodies to neuronal and glial filament proteins in autism.
V. Singh (1997)
Biochemical parameters in autistic children
Rh Waring (1997)
BACTERIAL CHANGES IN THE SMALL INTESTINE IN MALABSORPTIVE STATES AND IN PERNICIOUS ANAEMIA.
A. W. Dellipiani (1964)
Er Bolte (1998)
Short-term benefit from Downloaded from https://academic.oup.com/cid/article-abstract/35/Supplement_1/S6/445849 by guest on 21 January 2018
RH Sandler (2000)
The association of MHC genes with autism.
A. Torres (2001)
Mercury methylation by bacteria.
J. T. Trevors (1986)
Bacterial flora of the small bowel before and after bypass procedure for morbid obesity.
P. Corrodi (1978)
Short-term benefit from S16
RH Sandler (2000)
Antibodies to Myelin Basic Protein in Children with Autistic Behavior
V. Singh (1993)
Gas-chromatographic and mass-spectrometric analysis of the odor of human feces.
J. G. Moore (1987)
Wadsworth and KTL anaerobic bacteriology manual
H Jousimies-Somer (2002)
oral vancomycin treatment of regressiveonset autism
P Summanen (2000)
Studies on natural gastric flora. I. Bacterial flora of fasting human subjects.
Mary Ann Franklin (1966)
Methylation of inorganic mercury in experimental jejunal blind-loop.
Mohamed Abdulla (1973)
COLONIC ABSORPTION OF TRYPTOPHAN METABOLITES IN MAN.
John S. Fordtran (1964)
Neurofunctional mechanisms in autism.
L. Waterhouse (1996)
Assessment and significance of bacterial overgrowth in the small bowel.
J. Hamilton (1970)
Acute tryptophan depletion in autistic disorder: A controlled case study
C. McDougle (1993)
Exposure to Reduced Sulfur Gases Impairs Neurobehavioral Function
Kaye H. Kilburn (1997)
The biology of the autistic syndromes, 2nd ed.
C. Gillberg (1992)
Mucin degradation in the human colon: production of sialidase, sialate O-acetylesterase, N-acetylneuraminate lyase, arylesterase, and glycosulfatase activities by strains of fecal bacteria.
A. Corfield (1992)
Enterocolitis in children with developmental disorders
A. Wakefield (2000)
Brief report: Epidemiology of autism
S. Bryson (1996)
Autism and Clostridium tetani.
E. Bolte (1998)
Tissue content of mercury in rats given methylmercuric chloride orally: influence of intestinal flora.
I. Rowland (1980)
Effect of gastrointestinal surgery and bacterial overgrowth on the urinary excretion of sulfur amino acids and their main degradation products.
J. Mårtensson (1984)
Clostridia isolated from human mouths.
J F van Reenen (1970)
The end products of the metabolism of aromatic amino acids by clostridia
S. Elsden (2004)
Glycoprotein Methods and Protocols. The Mucins
J. E. Burchell (2000)
Cross-reactivity between the rheumatoid arthritis-associated motif EQKRAA and structurally related sequences found in Proteus mirabilis.
H. Tiwana (1999)
Abnormal intestinal permeability in children with autism.
P. D’Eufemia (1996)
RELAPSE OF PSEUDOMEMBRANOUS COLITIS AFTER VANCOMYCIN THERAPY
RogerG. Finch (1979)
Evaluation of urinary profiles obtained from people with autism and associated disorders
P Shattock (1964)
The impact of different antimicrobial agents on the normal gastrointestinal microflora of humans.
C. Nord (1984)
Human Monoclonal Immunoglobulin M Antibodies to Ganglioside GM1 Show Diverse Cross-Reactivities with Lipopolysaccharides of Campylobacter jejuni Strains Associated with Guillain-Barré Syndrome
M. Prendergast (1999)
N Engl J Med
I Rapin (1997)
p-Cresol sulfate is the dominant component of urinary myelin basic protein like material.
L Cao (2000)
Autism: review of neurochemical investigation.
E. Cook (1990)
Studies of intestinal microflora. II. Microorganisms of the small intestine and their relations to oral and fecal flora.
S. Gorbach (1967)
Brief report: Stability and change in cognitive and behavioral characteristics of autism through childhood
L. Eaves (1996)
Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children
A. Sabrá (1998)
Wadsworth Anaerobic Bacteriology Manual
Vera L. Sutter (1980)
Sulphur metabolism in autism
R. Waring (2000)
This paper is referenced by
Possible Impact of Innate Immunity on Autism
Harumi Jyonouchi (2009)
Clinical reviews in allergy and immunology
Donald Y.M. Leung (2012)
A Microbial Association with Autism
Jorge L Benach (2012)
Metabolic perturbance in autism spectrum disorders: a metabolomics study.
Xue Ming (2012)
Dose Escalation, Safety and Impact of a Strain-Specific Probiotic (Renadyl™) on Stages III and IV Chronic Kidney Disease Patients
Natarajan Ranganathan (2013)
The Role of Inflammation in Autism Spectrum Disorder
Casara Jean Ferretti (2015)
Gut bacteria in children with autism spectrum disorders: challenges and promise of studying how a complex community influences a complex disease
Rosa Krajmalnik-Brown (2015)
A Longitudinal Study of the Feline Faecal Microbiome Identifies Changes into Early Adulthood Irrespective of Sexual Development
Oliver Deusch (2015)
The urinary 1 H-NMR metabolomics profile of an italian autistic children population and their unaffected siblings.
M. Lussu (2017)
Zinc in Gut-Brain Interaction in Autism and Neurological Disorders
Guillermo Vela (2015)
The contribution of the gut microbiome to neurodevelopment and neuropsychiatric disorders
Barbara B Warner (2018)
Composition of Gut Microbiota in Children with Autism Spectrum Disorder: A Systematic Review and Meta-Analysis
Lucía Iglesias-Vázquez (2020)
The danger of excessive vaccination during brain development: the case for a link to Autism Spectrum Disorders (ASD)
R. L. Blaylock (2008)
Microbiota transplant therapy and autism: lessons for the clinic
J. B. Adams (2019)
Contributions of the environment and environmentally vulnerable physiology to autism spectrum disorders
Martha Reed Herbert (2010)
Normal gut microbiota modulates brain development and behavior
Rochellys Díaz Heijtz (2011)
Systematic review: faecal microbiota transplantation therapy for digestive and nondigestive disorders in adults and children.
Sumei Sha (2014)
Probiotics and prebiotics
Marie-José Butel (2016)
A Birthday to Remember: ASA Founding President Sydney M. Finegold's 95th
David M. Aronoff (2017)
Gut Microbiota, Inflammation, and Probiotics on Neural Development in Autism Spectrum Disorder
Ceymi Doenyas (2018)
Post-Operative Endophthalmitis Caused by the Nutritionally Variant Streptococcus Granulicatella adiacens
Daisuke Todokoro (2016)
The Effects of Early Adolescent Lipopolysaccharide or Cat Odour Exposure Followed by Propionic Acid Administration on Anxiety, Startle Response, and Sensorimotor Gating in Adolescence and Adulthood
Deanne Tak On Wah (2018)
Autism : Metabolism , Mitochondria , and the Microbiome 自闭症:新陈代谢、线粒体和微生物组 Autismo : metabolismo , mitocondria y microbioma
Derrick F. MacFabe (2013)
Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication
Heather Hulme (2020)
Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms
Megan R. Sanctuary (2019)
The Role of the Gut Microbiome in Mediating Neurotoxic Outcomes to PCB Exposure.
Kavi M. Rude (2019)
GUT MICROBIOTA GUT MICROBIOTA: SUCCINCT OVERVIEW OF IMPACTS ON HUMAN PHYSIQUE AND CURRENT RESEARCH STATUS WITH FUTURE ASPECTS
Md. Imran Hossain (2020)
A review of candidate urinary biomarkers for autism spectrum disorder
Lv Wang (2011)
Improvements in Behavioral Symptoms following Antibiotic Therapy in a 14-Year-Old Male with Autism
Penélope Ramírez (2013)
Urinary p-Cresol in ASD
Antonio M. Persico (2014)
Salecan diet increases short chain fatty acids and enriches beneficial microbiota in the mouse cecum.
Mengyi Zhou (2014)
Gastrointestinal Issues in Autism Spectrum Disorder
Elaine Y. Hsiao (2014)See more