Online citations, reference lists, and bibliographies.
← Back to Search

Determination Of The Magnetic Particle Distribution In Tumour Tissue By Means Of X-ray Tomography

O. Brunke, S. Odenbach, R. Jurgons, C. Alexiou, I. Hilger, F. Beckmann
Published 2006 · Physics

Cite This
Download PDF
Analyze on Scholarcy
Share
In biomedical applications of ferrofluids, the resulting distribution of the magnetic nanoparticles is a crucial parameter for the effect of the therapeutic approach. In order to increase the efficacy of local cancer treatments incorporating ferrofluids like magnetic drug targeting and hyperthermia, the bio-distribution of theses fluids in the respective tissue has to be optimized. Usually, the distribution of particles is determined by histological cuts of the investigated specimen, a technique which provides only local information about the overall distribution of the magnetic material, e.g.?in a tumour. Radioscopic techniques based on gamma or x-rays are well established, suitable for in?vivo examination and non-destructive, but only provide two-dimensional integral information in the direction of the beam. Here we have used micro-tomography?incorporating a conventional x-ray tube as well as monochromatic synchrotron radiation?as a tool for a three-dimensional analysis of the distribution of magnetic nanoparticles in biological applications. Compared to biological matter, the iron-based magnetic nanoparticles provide sufficiently high absorption for x-rays and thus serve as an intrinsic contrast agent for the examinations. The results show the principle feasibility of the method for a quantitative determination of the agglomeration behaviour of the nanoparticles within carcinogenic tissue after intravascular or intratumoural injection.
This paper references
10.1016/J.NIMB.2005.12.048
Blood vessel staining in the myocardium for 3D visualization down to the smallest capillaries
B. Müller (2006)
10.1016/S1054-3589(08)60246-X
Magnetically responsive microspheres and other carriers for the biophysical targeting of antitumor agents.
K. Widder (1979)
10.1088/0953-8984/16/33/011
Tomography studies of biological cells on polymer scaffolds
P. Thurner (2004)
10.1007/s00249-006-0042-1
Targeting cancer cells: magnetic nanoparticles as drug carriers
C. Alexiou (2006)
10.1118/1.1455742
Principles of computerized tomographic imaging
A. Kak (2001)
10.3109/02656739709046543
Ferromagnetic hyperthermia: functional and histopathologic effects on normal rabbit ocular tissue.
T. Murray (1997)
10.1118/1.594401
Single-step calculation of the MTF from the ERF.
N. Schneiders (1978)
10.1364/JOSAA.1.000612
Practical cone-beam algorithm
L. A. Feldkamp (1984)
10.1016/0304-8853(93)91113-L
Synthesis and evaluation of colloidal magnetic iron oxides for the site-specific radiofrequency-induced hyperthermia of cancer
D. Chan (1993)
10.1148/RADIOLOGY.218.2.R01FE19570
Electromagnetic heating of breast tumors in interventional radiology: in vitro and in vivo studies in human cadavers and mice.
I. Hilger (2001)
10.1097/00000658-195710000-00007
Selective Inductive Heating of Lymph Nodes
R. Gilchrist (1957)
Magnetically controlled targeted chemotherapy Microspheres and Regional Cancer Therapy ed
P KGupta (1994)
10.1117/12.559025
Characterization of polyurethane scaffolds using synchrotron radiation based computed microtomography
T. Donath (2004)
Developments in X-Ray Tomography V
U. Bonse (1999)
10.1016/S0021-9290(03)00254-9
Time-lapsed microstructural imaging of bone failure behavior.
A. Nazarian (2004)
X-ray tomography in material science
J. Baruchel (2000)
10.1080/1061186031000150791
Magnetic drug targeting--biodistribution of the magnetic carrier and the chemotherapeutic agent mitoxantrone after locoregional cancer treatment.
C. Alexiou (2003)
Locoregional cancer treatment with magnetic drug targeting.
C. Alexiou (2000)
X-Ray Tomography in Material Science
P. Merle (2000)



This paper is referenced by
XX Application of Magnetic Particles in Medicine and Biology
W. Andrä (2007)
10.1088/0953-8984/20/20/204152
Microcomputed tomography analysis of ferrofluids used for cancer treatment.
H. Rahn (2008)
10.3390/APP10196805
Investigation on the Formation Mechanism of Crack Indications and the Influences of Related Parameters in Magnetic Particle Inspection
L. Li (2020)
10.1016/J.JMMM.2014.02.021
3-Dimensional quantitative detection of nanoparticle content in biological tissue samples after local cancer treatment
H. Rahn (2014)
10.1109/TMAG.2015.2437849
Study of Magnetoviscosity of Ferromagnetic MnZn-Ferrite Ferrofluid
G. Thirupathi (2015)
10.1002/PAMM.200810959
Microcomputed tomography analysis of ferrofluids used as drug carriers for cancer treatment
H. Rahn (2008)
10.1021/MA102708B
Cobalt Ferrite Nanoparticles as Multifunctional Cross-Linkers in PAAm Ferrohydrogels
R. Messing (2011)
10.2147/IJN.S63433
Development and characterization of magnetic iron oxide nanoparticles with a cisplatin-bearing polymer coating for targeted drug delivery
H. Unterweger (2014)
10.1016/J.JMMM.2010.02.046
Application of computed tomography images in the evaluation of magnetic nanoparticles biodistribution
Argleydson Leão Dias (2010)
10.3390/ijms18091837
Synthesis and Characterization of Tissue Plasminogen Activator—Functionalized Superparamagnetic Iron Oxide Nanoparticles for Targeted Fibrin Clot Dissolution
Susanne Heid (2017)
10.1007/978-3-642-24133-8_18
3D Semi-quantification of Nanoparticle Content in Tissue on Experimental and Commercial μCT-Scanner
H. Rahn (2012)
10.2147/IJN.S92336
Hypericin-bearing magnetic iron oxide nanoparticles for selective drug delivery in photodynamic therapy
H. Unterweger (2015)
10.1016/J.JMMM.2019.01.077
Magnetoviscous effect investigation of water based Mn-Zn Fe2O4 magnetic nanofluid under the influence of magnetic field: An experimental study
E. Shojaeizadeh (2019)
10.1109/MCS.2012.2189052
Towards Control of Magnetic Fluids in Patients: Directing Therapeutic Nanoparticles to Disease Locations
A. Nacev (2012)
10.2217/nnm.09.82
X-ray microcomputed tomography as a tool for the investigation of the biodistribution of magnetic nanoparticles.
H. Rahn (2009)
10.1002/PAMM.200910231
Cross‐calibration of X‐ray µCT and MRX for tissue analysis
H. Rahn (2009)
10.1007/s00418-011-0780-8
Visualization of superparamagnetic nanoparticles in vascular tissue using XμCT and histology
R. Tietze (2011)
10.1016/j.jconrel.2018.07.007
Targeting of drug‐loaded nanoparticles to tumor sites increases cell death and release of danger signals
Magdalena Alev (2018)
Biodistribution magnetischer Nanopartikel in der Krebstherapie
S. Odenbach (2008)
10.1016/J.JMMM.2009.02.078
Tomographic examination of magnetic nanoparticles used as drug carriers
H. Rahn (2009)
10.1016/j.jchromb.2019.05.033
Non-magnetic chromatographic separation of colloidally metastable superparamagnetic iron oxide nanoparticles and suspension cells.
Marina Mühlberger (2019)
10.1109/TMAG.2009.2019128
Three-Dimensional Model for Determining Inhomogeneous Thermal Dosage in a Liver Tumor During Arterial Embolization Hyperthermia Incorporating Magnetic Nanoparticles
Ruizhi Xu (2009)
10.2147/IJN.S42367
Cytotoxicity of nickel zinc ferrite nanoparticles on cancer cells of epithelial origin
M. Al-Qubaisi (2013)
10.1016/J.JMMM.2018.10.022
Functionalization of T lymphocytes for magnetically controlled immune therapy: Selection of suitable superparamagnetic iron oxide nanoparticles
Marina Mühlberger (2019)
10.1016/j.ejpb.2016.01.017
Pharmaceutical formulation of HSA hybrid coated iron oxide nanoparticles for magnetic drug targeting.
J. Zaloga (2016)
10.1016/J.NIMB.2009.03.008
X-ray tomography as a complementary technique to nuclear microscopy for biomedical applications
I. Gómez-Morilla (2009)
Semantic Scholar Logo Some data provided by SemanticScholar