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Magnetic And Fluorescent Multifunctional Chitosan Nanoparticles As A Smart Drug Delivery System
L. Li, D. Chen, Y. Zhang, Zhengtao Deng, Xiangling Ren, Xianwei Meng, F. Tang, J. Ren, Longhai Zhang
Published 2007 · Materials Science
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An innovative drug delivery system based on magnetic and fluorescent multifunctional chitosan nanoparticles was developed, which combined magnetic targeting, fluorescent imaging and stimulus-responsive drug release properties into one drug delivery system. Water-soluble superparamagnetic Fe3O4 nanoparticles, CdTe quantum dots (QDs) and pharmaceutical drugs were simultaneously incorporated into chitosan nanoparticles; cross-linking the composite particles with glutaraldehyde tailored their size, morphology, surface properties and drug release behaviors. The system showed superparamagnetic and strong fluorescent properties, and was used as a controlled drug release vehicle, which showed pH-sensitive drug release over a long time. The composite magnetic and fluorescent chitosan nanoparticles are potential candidates as a smart drug delivery system.
This paper references
Nanotechnology: Intelligent Design to Treat Complex Disease
P. Couvreur (2006)
Control of in vivo fate of albumin derivatives utilizing combined chemical modification.
T. Fujita (1994)
Some studies of crosslinking chitosan-glutaraldehyde interaction in a homogeneous system.
O. A. Monteiro (1999)
Folate-conjugated iron oxide nanoparticles for solid tumor targeting as potential specific magnetic hyperthermia mediators: synthesis, physicochemical characterization, and in vitro experiments.
Fabio Sonvico (2005)
Redox-controlled molecular permeability of composite-wall microcapsules
Y. Ma (2006)
Temporal targeting of tumour cells and neovasculature with a nanoscale delivery system
Shiladitya Sengupta (2005)
Immunotargeted nanoshells for integrated cancer imaging and therapy.
C. Loo (2005)
Swelling kinetics and release characteristic of crosslinked chitosan : polyether polymer network (semi-IPN) hydrogels
K. D. Yao (1994)
Light-emitting diodes made from cadmium selenide nanocrystals and a semiconducting polymer
V. Colvin (1994)
Polyarginine enters cells more efficiently than other polycationic homopolymers.
D. Mitchell (2000)
In vivo real-time tracking of single quantum dots conjugated with monoclonal anti-HER2 antibody in tumors of mice.
H. Tada (2007)
Factors governing the quality of aqueous CdTe nanocrystals: calculations and experiment.
A. Shavel (2006)
Incorporating CdTe nanocrystals into polystyrene microspheres: towards robust fluorescent beads.
Yanqiang Yang (2006)
Structure of polypeptide-based diblock copolymers in solution: stimuli-responsive vesicles and micelles.
F. Chécot (2005)
Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo.
O. Farokhzad (2006)
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review.
H. Maeda (2000)
Fabrication of Magnetic Luminescent Nanocomposites by a Layer-by-Layer Self-assembly Approach
X. Hong (2004)
Self-assembled nanoparticles based on glycol chitosan bearing hydrophobic moieties as carriers for doxorubicin: in vivo biodistribution and anti-tumor activity.
Jae Hyung Park (2006)
Polyketal nanoparticles: a new pH-sensitive biodegradable drug delivery vehicle.
Michael J. Heffernan (2005)
Quantum dot bioconjugates for ultrasensitive nonisotopic detection.
W. C. Chan (1998)
Chitosan chemistry and pharmaceutical perspectives.
M. Kumar (2004)
Multifunctional Quantum‐Dot‐Based Magnetic Chitosan Nanobeads
W. B. Tan (2005)
Strongly Photoluminescent CdTe Nanocrystals by Proper Surface Modification
M. Gao (1998)
Spectroscopy of Fluorescein (FITC) Dyed Colloidal Silica Spheres
A. Imhof (1999)
Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects.
W. Cai (2006)
Enhancement of Nasal Absorption of Insulin Using Chitosan Nanoparticles
R. Fernández-Urrusuno (2004)
The dawning era of polymer therapeutics
R. Duncan (2003)
Labeling of Biocompatible Polymer Microcapsules with Near-Infrared Emitting Nanocrystals
N. Gaponik (2003)
Evidence for the role of proteoglycans in cation-mediated gene transfer.
K. A. Mislick (1996)
Nanocrystal targeting in vivo
M. Akerman (2002)
Preparation of aqueous magnetic liquids in alkaline and acidic media
R. Massart (1981)
Superparamagnetic agents in magnetic resonance imaging: physicochemical characteristics and clinical applications. A review.
B. Bonnemain (1998)
Controlled drug delivery system based on magnetic hollow spheres/polyelectrolyte multilayer core-shell structure.
Y. Zhang (2006)
Intracellular hyperthermia for cancer using magnetite cationic liposomes: an in vivo study.
M. Yanase (1998)
Surface chemistry of biodegradable polymers for drug delivery systems.
C. Ha (2005)
Luminescent polymer microcapsules addressable by a magnetic field.
N. Gaponik (2004)
This paper is referenced by
Biomedical Significance of Chitin- and Chitosan-Based Nanocomposites
Aasim Majeed (2017)
Preparation of a polymer surface coated with a gradient of quantum dots.
B. Kim (2008)
Carbon nanotube-based magnetic-fluorescent nanohybrids as highly efficient contrast agents for multimodal cellular imaging
B. Chen (2010)
Chitosan (or alginate)-coated iron oxide nanoparticles: A comparative study
J. Castello (2015)
Colloidal stability of polyethylene glycol functionalized Co0.5Zn0.5Fe2O4 nanoparticles: effect of pH, sample and salt concentration for hyperthermia application
Dipali S. Nikam (2014)
Polyacrylamide Nanoparticles with Visible and Near‐Infrared Autofluorescence
Hongmei Xie (2017)
Magnetic nanoparticles for local drug delivery using magnetic implants.
R. Fernandez-Pacheco (2009)
Water dispersible cross-linked magnetic chitosan beads for increasing the antimicrobial efficiency of aminoglycoside antibiotics.
A. Grumezescu (2013)
Smart Drug Delivery Strategies Based on Porous Nanostructure Materials
Q. Wang (2016)
Poly(allylamine hydrochloride)–dextran microgels functionalized with magnetic and luminescent nanoparticles
L. Wang (2008)
Multifunctional nanoparticles: Analytical prospects
Alejandro Simón de Dios (2010)
Non-Covalent Interactions in the Design and Performance of Macromolecules for Biological Technologies
Allison M. Pekkanen (2017)
Marine Biopolymer-Based Nanomaterials as a Novel Platform for Theranostic Applications
P. Manivasagan (2017)
Preparation of magnetic and fluorescent bifunctional chitosan nanoparticles for optical determination of copper ion
L. Liu (2012)
Design of Functional Magnetic Nanocomposites for Bioseparation.
Qi Yang (2020)
Magnetic targeting for site-specific drug delivery: applications and clinical potential
B. Polyak (2009)
Functionalization of magnetite–chitosan nanocomposite with molybdenum complexes: new efficient catalysts for epoxidation of olefins
M. Mohammadikish (2019)
Synthesis of zeolite nanocrystals and their application for mixed matrix membranes
Li Dan (2017)
Novel nanofiber yarns synchronously endued with tri-functional performance of superparamagnetism, electrical conductivity and enhanced fluorescence prepared by conjugate electrospinning
Libing Fan (2017)
Synthesis and Cell Imaging of a Near-Infrared Fluorescent Magnetic "CdHgTe-Dextran-Magnetic Layered Double Hydroxide-Fluorouracil" Composite.
Xueqin Jin (2016)
AOT reverse micelles as versatile reaction media for chitosan nanoparticles synthesis.
M. S. Orellano (2017)
Preparation of magnetic chitosan microspheres and its applications in wastewater treatment
H. Yang (2009)
Synthesis and characterization of 5-Fu loaded magnetic nanocomposite spheres for advanced drug delivery
H. Wamocha (2010)
Magnetic Nanoparticles: Synthesis, Surface Modifications and Application in Drug Delivery
S. Bucak (2012)
Chitosan-Coated Iron Oxide Nanoparticles for Molecular Imaging and Drug Delivery
H. Arami (2011)
Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and Toxicity
L. S. Arias (2018)
pH-responsive drug-delivery systems.
Y. Zhu (2015)
Magnetorelaxometry using Improved Giant MagnetoResistance Magnetometer
Matthieu Denoual (2010)
Controllable preparation and fluorescence properties of Y3+ and Eu3+ co-doped mesoporous silica
C. Zhang (2010)
Luminescent magnetic particles: structures, syntheses, multimodal imaging, and analytical applications
G. Mistlberger (2010)
Engineering of Polysaccharides via Nanotechnology
Joydeep Dutta (2013)
Chitosan-Coated Magnetic Nanoparticles Prepared in One Step by Reverse Microemulsion Precipitation
R. G. López (2013)See more