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Magnetic And Fluorescent Multifunctional Chitosan Nanoparticles As A Smart Drug Delivery System

L. Li, D. Chen, Y. Zhang, Zhengtao Deng, Xiangling Ren, Xianwei Meng, F. Tang, J. Ren, Longhai Zhang
Published 2007 · Materials Science

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An innovative drug delivery system based on magnetic and fluorescent multifunctional chitosan nanoparticles was developed, which combined magnetic targeting, fluorescent imaging and stimulus-responsive drug release properties into one drug delivery system. Water-soluble superparamagnetic Fe3O4 nanoparticles, CdTe quantum dots (QDs) and pharmaceutical drugs were simultaneously incorporated into chitosan nanoparticles; cross-linking the composite particles with glutaraldehyde tailored their size, morphology, surface properties and drug release behaviors. The system showed superparamagnetic and strong fluorescent properties, and was used as a controlled drug release vehicle, which showed pH-sensitive drug release over a long time. The composite magnetic and fluorescent chitosan nanoparticles are potential candidates as a smart drug delivery system.
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