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Synthesis Of Biocompatible Multicolor Luminescent Carbon Dots For Bioimaging Applications

Nagaprasad Puvvada, B. P. Kumar, Suraj Konar, Himani Kalita, M. Mandal, A. Pathak
Published 2012 · Materials Science, Medicine

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Abstract Water-soluble carbon dots (C-dots) were prepared through microwave-assisted pyrolysis of an aqueous solution of dextrin in the presence of sulfuric acid. The C-dots produced showed multicolor luminescence in the entire visible range, without adding any surface-passivating agent. X-ray diffraction and Fourier transform infrared spectroscopy studies revealed the graphitic nature of the carbon and the presence of hydrophilic groups on the surface, respectively. The formation of uniformly distributed C-dots and their luminescent properties were, respectively, revealed from transmission electron microscopy and confocal laser scanning microscopy. The biocompatible nature of C-dots was confirmed by a cytotoxicity assay on MDA-MB-468 cells and their cellular uptake was assessed through a localization study.
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