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Improving Effects Of Long-term Growth Hormone Treatment On Monoaminergic Neurotransmission And Related Behavioral Tests In Aged Rats.

S. Esteban, C. Garau, S. Aparicio, D. Moranta, P. Barceló, M. Ramis, J. Tresguerres, R. Rial
Published 2010 · Biology, Medicine

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An age-related decline in cognitive functions and physical performance has been associated with reductions in growth hormone (GH) secretion and brain neurotransmitter function. In vivo experiments were performed to study the long-term effects of exogenously administered GH on the central monoaminergic neurotransmitters serotonin, dopamine, and noradrenaline and behavioral tests in old Wistar rats. The accumulation of 5-hydroxytryptophan (5-HTP) and L-3,4-dihydroxyphenylalanine (DOPA) after decarboxylase inhibition was used as a measure of the rate of tryptophan and tyrosine hydroxylation in vivo. Also, the content of the neurotransmitters serotonin, dopamine, and noradrenaline and some metabolites was measured by high-pressure liquid chromatography (HPLC) in the hippocampus and striatum, brain regions involved in adult memory processing and motor coordination. The age-related decline observed in all the neurochemical parameters in control rats was significantly reversed after repeated subcutaneous administration of GH (2 mg/kg per day, 4 weeks). Thus, GH treatment exerted a long-term effect on serotonin, dopamine, and noradrenaline neurotransmission by enhancing neurotransmitter synthesis and metabolism in aged rats. The results obtained after examining working memory tasks in the eight-radial maze and motor ability in the Rotarod treadmill in aged rats were consistent with these neurochemical data; both tests were significantly improved after chronic GH treatment. Overall, these in vivo findings suggest that the positive effects induced by GH on serotonin, dopamine, and noradrenaline neurotransmitters might explain, at least in part, the effects of chronic GH treatment in improving cognitive and motor ability in aged rats, and could aid in preventing or delaying deficits in monoamines associated with learning or motor disabilities.
This paper references
10.1016/j.neulet.2003.09.070
Protective effect of growth hormone on neuronal apoptosis after hypoxia–ischemia in the neonatal rat brain
D. H. Shin (2004)
10.1016/S0304-3940(01)01599-3
The imidazoline receptor ligand 2-(2-benzofuranyl)-2-imidazoline is a dopamine-releasing agent in the rat striatum in vivo
A. Sastre-Coll (2001)
10.1111/j.1532-5415.1987.tb04641.x
Dopamine and Serotonin Systems in Human and Rodent Brain: Effects of Age and Neurodegenerative Disease
D. G. Morgan (1987)
10.1210/EDRV-16-1-63
Clinical aspects of growth hormone deficiency in adults.
H. D. de Boer (1995)
10.1126/science.178.4059.414
Brain Serotonin Content: Physiological Regulation by Plasma Neutral Amino Acids
J. Fernstrom (1972)
10.1126/SCIENCE.112679
Cognitive deficit caused by regional depletion of dopamine in prefrontal cortex of rhesus monkey.
T. J. Brozoski (1979)
10.1023/A:1016283003747
Effect of Aging on the Kinetics of Blood–Brain Barrier Uptake of Tryptophan in Rats
J. Tang (2004)
10.1016/j.yhbeh.2004.11.015
Long-term growth hormone treatment preserves GH-induced memory and mood improvements: a 10-year follow-up study in GH-deficient adult men
L. Arwert (2005)
10.1016/S0896-6273(02)00830-9
The Human Hippocampus and Spatial and Episodic Memory
N. Burgess (2002)
10.1126/SCIENCE.1078197
Synthesis of Serotonin by a Second Tryptophan Hydroxylase Isoform
D. Walther (2003)
10.1016/S0079-6123(08)00928-X
Serotonin/dopamine interaction in memory formation.
I. González-Burgos (2008)
10.1016/j.exger.2005.03.003
Estradiol and soy extract increase the production of new cells in the dentate gyrus of old rats
M. Pérez-Martín (2005)
10.1006/frne.2000.0200
Growth Hormone in the Brain: Characteristics of Specific Brain Targets for the Hormone and Their Functional Significance
F. Nyberg (2000)
10.1007/s00210-008-0337-0
Chronic treatment and withdrawal of the cannabinoid agonist WIN 55,212-2 modulate the sensitivity of presynaptic receptors involved in the regulation of monoamine syntheses in rat brain
D. Moranta (2008)
10.1016/j.exger.2005.09.010
Age-related changes in circadian rhythm of serotonin synthesis in ring doves: Effects of increased tryptophan ingestion
C. Garau (2006)
10.1073/PNAS.93.10.4765
Age-related losses of cognitive function and motor skills in mice are associated with oxidative protein damage in the brain.
M. Forster (1996)
10.1016/0006-8993(90)90368-L
Spatial memory deficits in aged rats: contributions of monoaminergic systems
V. Luine (1990)
10.1023/A:1018573105987
Structural alterations of the hippocampal formation of adrenalectomized rats: an unbiased stereological study
N. Sousa (1997)
10.1100/tsw.2006.22
Aspects of Growth Hormone and Insulin-Like Growth Factor-I Related to Neuroprotection, Regeneration, and Functional Plasticity in the Adult Brain
N. Åberg (2006)
10.1016/S0303-7207(02)00014-X
Growth hormone can act as a cytokine controlling survival and proliferation of immune cells: new insights into signaling pathways
S. Jeay (2002)
10.1016/S0079-6123(02)36039-4
Selective vulnerability of corticocortical and hippocampal circuits in aging and Alzheimer's disease.
J. Morrison (2002)
10.1159/000054288
Growth Hormone Prevents Fas-Induced Apoptosis in Lymphocytes through Modulation of Bcl-2 and Caspase-3
Hiroki Mitsunaka (2001)
10.1677/JOE-07-0556
Enhancement of maternal lactation performance during prolonged lactation in the mouse by mouse GH and long-R3-IGF-I is linked to changes in mammary signaling and gene expression.
D. Hadsell (2008)
10.1016/j.neuropharm.2008.06.035
Serotonin depletion in the dorsal and ventral hippocampus: Effects on locomotor hyperactivity, prepulse inhibition and learning and memory
W. Adams (2008)
10.1111/j.1600-079X.2009.00741.x
Chronic melatonin treatment and its precursor L‐tryptophan improve the monoaminergic neurotransmission and related behavior in the aged rat brain
S. Esteban (2010)
10.1210/ENDO.131.2.1353444
Growth hormone receptor messenger ribonucleic acid distribution in the adult male rat brain and its colocalization in hypothalamic somatostatin neurons.
K. Burton (1992)
10.1016/0197-4580(87)90055-8
Degeneration of hippocampal fibers and spatial memory deficit in the aged rat
E. Greene (1987)
10.1523/JNEUROSCI.21-05-01628.2001
Circulating Insulin-Like Growth Factor I Mediates Exercise-Induced Increases in the Number of New Neurons in the Adult Hippocampus
J. Trejo (2001)
10.1023/B:MCBI.0000049363.97713.74
Effect of orally administered l-tryptophan on serotonin, melatonin, and the innate immune response in the rat
S. Esteban (2004)
10.1016/0165-3806(93)90008-X
Localization and ontogeny of growth hormone receptor gene expression in the central nervous system.
P. Lobie (1993)
10.3181/0708-RM-217
Effects of Every-Other-Day Feeding on Prolactin Regulatory Mechanism in Transgenic Human Growth Hormone Mice
V. Jiménez-Ortega (2008)
10.1016/0168-0102(95)00937-O
Vascular permeability to growth hormone in the rat central nervous system after focal spinal cord injury. Influence of a new anti-oxidant H 290/51 and age
A. Mustafa (1995)
10.1016/j.neurobiolaging.2004.06.007
Growth hormone prevents neuronal loss in the aged rat hippocampus
Í. Azcoitia (2005)
10.1016/S0306-4522(01)00109-9
Growth hormone as a neuronal rescue factor during recovery from CNS injury
A. Scheepens (2001)
10.1016/j.neubiorev.2009.03.006
Effects of acute tryptophan depletion on memory, attention and executive functions: A systematic review
Daniel L. Mendelsohn (2009)
10.1016/S0301-0082(02)00126-0
Impact of aging on hippocampal function: plasticity, network dynamics, and cognition
E. Rosenzweig (2003)
10.1056/NEJM199007053230101
Effects of human growth hormone in men over 60 years old.
D. Rudman (1990)
10.1111/j.1460-9568.2007.05840.x
Differential increase of extracellular dopamine and serotonin in the ‘prefrontal cortex’ and striatum of pigeons during working memory
Dilek Karakuyu (2007)
10.1385/JMN:18:1-2:89
Growth hormone (GH) action in the brain
S. Harvey (2007)
10.1159/000026636
Age-Sensitive Cognitive Function, Growth Hormone and Insulin-Like Growth Factor 1 Plasma Levels in Healthy Older Men
A. Aleman (2000)
10.1203/00006450-199903000-00005
Possible Protective Role of Growth Hormone in Hypoxia-Ischemia in Neonatal Rats
K. Gustafson (1999)
10.1159/000184753
Growth hormone and its receptors in the central nervous system--location and functional significance.
F. Nyberg (1996)
10.1016/0196-9781(84)90285-7
The nigrostriatal system and aging
T. Mcneill (1984)
10.1016/S0306-4522(03)00199-4
Arrested neuronal proliferation and impaired hippocampal function following fractionated brain irradiation in the adult rat
T. Madsen (2003)
10.1016/S0197-4580(03)00042-3
Reduced cortical noradrenergic neurotransmission is associated with increased neophobia and impaired spatial memory in aged rats
T. J. Collier (2004)
10.1007/978-3-7091-6846-2_2
Aging and the nigro-striatal pathway.
F. cruz-Sánchez (1997)
10.1159/000090123
Growth Hormone Deficiency and Memory Functioning in Adults Visualized by Functional Magnetic Resonance Imaging
L. Arwert (2005)
10.1210/MEND.15.2.0594
Gene expression profile of the aging process in rat liver: normalizing effects of growth hormone replacement.
P. Tollet-Egnell (2001)
10.1016/S1096-6374(00)80010-6
Growth hormone, insulin-like growthfactor I and the CNS: Localization, function and mechanism of action
P. E. Lobiezz (2000)
10.1126/SCIENCE.278.5337.419
The Endocrinology of Aging
S. J. Lamberts (1997)
10.1016/0306-4530(92)90038-9
Growth hormone therapy in the elderly: Implications for the aging brain
A. Hoffman (1992)
10.1523/JNEUROSCI.3890-09.2009
Ghrelin Promotes and Protects Nigrostriatal Dopamine Function via a UCP2-Dependent Mitochondrial Mechanism
Z. Andrews (2009)
10.1055/S-2001-17605
Physiology and pathophysiology of the serotonergic system and its implications on mental and physical performance. Part I.
H. Strüder (2001)
10.1210/EN.2002-220261
Growth hormone (GH) and GH-releasing peptide-6 increase brain insulin-like growth factor-I expression and activate intracellular signaling pathways involved in neuroprotection.
L. Frago (2002)
10.1016/S0306-4530(02)00045-8
Quality of life of growth hormone (GH) deficient young adults during discontinuation and restart of GH therapy
P. J. Stouthart (2003)
10.1016/j.neubiorev.2004.03.004
Regional dissociations within the hippocampus—memory and anxiety
D. Bannerman (2004)
10.1126/SCIENCE.1097540
Tryptophan Hydroxylase-2 Controls Brain Serotonin Synthesis
X. Zhang (2004)
10.1007/s00210-001-0508-8
Supersensitivity of 5-HT1A-autoreceptors and α2-adrenoceptors regulating monoamine synthesis in the brain of morphine-dependent rats
A. Sastre-Coll (2002)
10.1159/000126813
Treatment of growth hormone-deficient adults with recombinant human growth hormone increases the concentration of growth hormone in the cerebrospinal fluid and affects neurotransmitters.
J. Johansson (1995)
10.1210/endo.140.12.7181
Bovine Growth Hormone Transgenic Mice Display Alterations in Locomotor Activity and Brain Monoamine Neurochemistry1.
Bo So Derpalm (1999)
10.1126/science.1094987
Cognitive Inflexibility After Prefrontal Serotonin Depletion
H. Clarke (2004)
10.1007/BF00432225
Association between learning and cortical catecholamines in non-drug-treated rats
B. Sahakian (2004)
10.1159/000093337
Effects of Growth Hormone Substitution Therapy on Cognitive Functioning in Growth Hormone Deficient Patients: A Functional MRI Study
L. Arwert (2006)
10.1515/jpem-2000-s624
Hypothalamic Growth Hormone-Insulin-like Growth Factor-I Axis across the Human Life Span
E. Ghigo (2000)
10.1210/ER.2003-0023
Coregulator function: a key to understanding tissue specificity of selective receptor modulators.
C. L. Smith (2004)
10.1016/0014-2999(83)90645-3
Rat growth hormone and hypothalamic catecholamine nerve terminal systems. Evidence for rapid and discrete reductions in dopamine and noradrenaline levels and turnover in the median eminence of the hypophysectomized male rat.
K. Andersson (1983)
10.1006/exnr.1999.7107
Vulnerability of the Dentate Gyrus to Aging and Intracerebroventricular Administration of Kainic Acid
A. Shetty (1999)
10.1007/s10522-008-9183-1
Adrenergic, dopaminergic and serotonergic gene expression in low dose, long time insulin and somatotropin treatment to ageing rats: rejuvenation of brain function
C. S. Paulose (2008)
10.1016/j.jsbmb.2007.09.010
Molecular mechanisms involved in the hormonal prevention of aging in the rat
J. A. Tresguerres (2008)
10.1016/0306-4530(95)00050-X
Cognitive impairments and mood disturbances in growth hormone deficient men
J. B. Deijen (1996)



This paper is referenced by
10.1038/s41598-020-76219-7
Caloric restriction modulates the monoaminergic system and metabolic hormones in aged rats
Marta Portero-Tresserra (2020)
10.1007/s10522-013-9443-6
Growth hormone and melatonin prevent age-related alteration in apoptosis processes in the dentate gyrus of male rats
R. Kireev (2013)
Dietary polyphenols as promising molecules to prevent dementia
(2017)
10.2174/1570159X15666170703113212
Effects of Resveratrol and other Polyphenols on Sirt1: Relevance to Brain Function During Aging
F. Sarubbo (2018)
Effects of caloric restriction on brain aging and cognitive decline : behavioral and biochemical analysis
Rojic Becker (2018)
10.1007/s11481-017-9759-0
Chronic Silymarin, Quercetin and Naringenin Treatments Increase Monoamines Synthesis and Hippocampal Sirt1 Levels Improving Cognition in Aged Rats
F. Sarubbo (2017)
10.1016/j.exger.2016.03.003
Deficits in coordinated motor behavior and in nigrostriatal dopaminergic system ameliorated and VMAT2 expression up-regulated in aged male rats by administration of testosterone propionate
L. Wang (2016)
10.1016/j.pnpbp.2013.04.005
Cognitive improvement by acute growth hormone is mediated by NMDA and AMPA receptors and MEK pathway
M. Ramis (2013)
10.1134/S0006297916120051
Uncouplers of oxidation and phosphorylation as antiaging compounds
D. Knorre (2016)
Estrategias antienvejecimiento y neurogénesis adulta
Antònia Crespí Roig (2015)
Estudi de la modulació de les vies inflamatòries NF-ĸB y MAPK durant l’envelliment cerebral i efecte del tractament amb resveratrol
C. Comas (2016)
10.1016/j.neuro.2012.03.002
Methamphetamine mimics the neurochemical profile of aging in rats and impairs recognition memory.
P. Melo (2012)
Polyphenols-What ' s Behind their Antiaging Brain Reputation ?
(2018)
10.1007/s11357-015-9777-x
Improving effect of chronic resveratrol treatment on central monoamine synthesis and cognition in aged rats
F. Sarubbo (2015)
10.1016/j.neubiorev.2018.05.011
Dietary polyphenols and neurogenesis: Molecular interactions and implication for brain ageing and cognition
F. Sarubbo (2018)
10.1089/REJ.2015.1685
Chronic α-Tocopherol Increases Central Monoamines Synthesis and Improves Cognitive and Motor Abilities in Old Rats
R. RamisMargarita (2016)
La Hormona de Crecimiento en el Sistema Nervioso Central
Citlalli Regalado Santiago (2012)
10.3390/nu12020326
Chronic Polyphenon-60 or Catechin Treatments Increase Brain Monoamines Syntheses and Hippocampal SIRT1 LEVELS Improving Cognition in Aged Rats
M. Ramis (2020)
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