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Hydrogen Peroxide Induces Arl1 Degradation And Impairs Golgi-mediated Trafficking

Stephen C. Ireland, Haoran Huang, Jianchao Zhang, Jie Li, Yanzhuang Wang

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H2O2 treatment induces the degradation of Golgi structural proteins in the trans-Golgi, including Arl1, Golgin-97, and Golgin-245, and thereby impairs membrane trafficking. This study revealed the trans-Golgi and trafficking at the trans-Golgi as novel targets of ROS in cells.