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Vitamin D Deficiency, Muscle Function, And Falls In Elderly People.
H. Janssen, M. Samson, H. Verhaar
Published 2002 · Medicine
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An inadequate serum vitamin D status is commonly seen in elderly people as the result of various risk factors interacting in this population. Apart from the well-known effects on bone metabolism, this condition is also associated with muscle weakness, predominantly of the proximal muscle groups. Muscle weakness below a certain threshold affects functional ability and mobility, which puts an elderly person at increased risk of falling and fractures. Therefore, we wanted to determine the rationale behind vitamin D supplementation in elderly people to preserve and possibly improve muscle strength and subsequently functional ability. From experimental studies it was found that vitamin D metabolites directly influence muscle cell maturation and functioning through a vitamin D receptor. Vitamin D supplementation in vitamin D-deficient, elderly people improved muscle strength, walking distance, and functional ability and resulted in a reduction in falls and non-vertebral fractures. In healthy elderly people, muscle strength declined with age and was not prevented by vitamin D supplementation. In contrast,severe comorbidity might affect muscle strength in such a way that restoration of a good vitamin D status has a limited effect on functional ability. Additional research is needed to further clarify to what extent vitamin D supplementation can preserve muscle strength and prevent falls and fractures in elderly people.
This paper references
Muscular weakness in osteomalacia and hyperparathyroidism.
R. Smith (1969)
25-hydroxycholecalciferol stimulation of muscle metabolism.
S. Birge (1975)
MUSCLE WEAKNESS IN OSTEOMALACIA
G. Schott (1976)
Vitamin D: two dihydroxylated metabolites are required for normal chicken egg hatchability.
H. Henry (1978)
Vitamin D, muscle and phosphate homeostasis
S. Birge (1978)
Skeletal muscle calcium metabolism and contractile force in vitamin D-deficient chicks.
D. Pleasure (1979)
Myopathy in bone loss of ageing: improvement by treatment with 1 alpha-hydroxycholecalciferol and calcium.
O. Sórensen (1979)
Prophylactic vitamin D in the elderly.
K. R. Johnson (1980)
Mechanical factors and the skeleton
I. A. Stokes (1981)
Nutritional status in a healthy elderly population: vitamin D.
J. Omdahl (1982)
Presence of a 1,25-dihydroxy-vitamin D3 receptor in chick skeletal muscle myoblasts.
R. Boland (1985)
Do vitamin D supplements improve the physical capabilities of elderly hospital patients?
D. Corless (1985)
Identification of 1,25-dihydroxyvitamin D3 receptors and activities in muscle.
R. Simpson (1985)
Muscle morphology, enzymatic activity, and muscle strength in elderly men: A follow‐up study
A. Aniansson (1986)
Role of vitamin D in skeletal muscle function.
R. Boland (1986)
1,25-dihydroxyvitamin D3 receptors and hormonal responses in cloned human skeletal muscle cells.
E. Costa (1986)
Normal and abnormal regulation of 1,25-(OH)2D synthesis.
N. Breslau (1988)
Falls by elderly people at home: prevalence and associated factors.
A. J. Blake (1988)
Risk factors for falls among elderly persons living in the community.
M. Tinetti (1988)
Association of muscle strength with functional status of elderly people.
R. Hyatt (1990)
Effects of 1,25-dihydroxy-vitamin D3 on phosphate accumulation by myoblasts.
B. Teresita (1991)
1,25-Dihydroxyvitamin D3 and muscle strength in the elderly: a randomized controlled trial.
D. Grady (1991)
Differences in vitamin D status between countries in young adults and the elderly.
M. Mckenna (1992)
Regulation of Ca2+ uptake in skeletal muscle by 1,25-dihydroxyvitamin D3: Role of phosphorylation and calmodulin
V. Massheimer (1992)
Leg extensor power and functional performance in very old men and women.
E. J. Bassey (1992)
Vitamin D3 and Calcium to Prevent Hip Fractures in Elderly Women
M. Chapuy (1992)
Non-genomic signal transduction pathway of vitamin D in muscle.
A. R. de Boland (1994)
Skeletal muscle weakness in old age: underlying mechanisms.
S. Brooks (1994)
Calcium, vitamin D, and hip fractures Incidence of falls may have decreased
T. Mets (1994)
Maximal isometric muscle strength and functional ability in daily activities among 75‐year‐old men and women
K. Avlund (1994)
Identification of a specific binding protein for 1 alpha,25-dihydroxyvitamin D3 in basal-lateral membranes of chick intestinal epithelium and relationship to transcaltachia.
I. Nemere (1994)
Age, gender, and muscular strength.
B. Hurley (1995)
Bronchodilator subsensitivity to salbutamol after twice daily salmeterol in asthmatic patients
A. Grove (1995)
Prevention of bone loss by vitamin D supplementation in elderly women: a randomized double-blind trial.
M. Ooms (1995)
Serum vitamin D concentrations among elderly people in Europe
R. V. D. Wielen (1995)
Functional Improvement with Vitamin D Replenishment in a Cohort of Frail, Vitamin D‐Deficient Older People
F. M. Gloth (1995)
Muscle performance and structure in the elderly as studied cross-sectionally and longitudinally.
G. Grimby (1995)
Environmental factors that influence the cutaneous production of vitamin D.
M. Holick (1995)
Human aging, muscle mass, and fiber type composition.
J. Lexell (1995)
Avian muscle cells as targets for the secosteroid hormone 1,25-dihydroxy-vitamin D3
R. Boland (1995)
Strength is a major factor in balance, gait, and the occurrence of falls.
L. Wolfson (1995)
Paracrine role for calcitriol in the immune system and skin creates new therapeutic possibilities for vitamin D analogs.
R. Bouillon (1995)
Invited commentary: evolution of epidemiologic evidence on magnetic fields and childhood cancers.
C. Poole (1996)
Genomic mechanisms involved in the pleiotropic actions of 1,25-dihydroxyvitamin D3.
S. Christakos (1996)
Vitamin D Deficiency in Homebound Elderly Persons
S. E. Whitmore (1996)
Vitamin D deficiency and osteoporosis: the role of vitamin D deficiency and treatment with vitamin D and analogues in the prevention of osteoporosis‐related fractures
P. Lips (1996)
Falls in the elderly: a prospective study of risk factors and risk profiles.
W. Graafmans (1996)
Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older.
B. Dawson-Hughes (1997)
Stimulation of Ca2+ release-activated Ca2+ channels as a potential mechanism involved in non-genomic 1,25(OH)2-vitamin D3-induced Ca2+ entry in skeletal muscle cells.
G. Vazquez (1997)
Quadriceps and Grip Strength Are Related to Vitamin D Receptor Genotype in Elderly Nonobese Women
P. Geusens (1997)
Three‐Fold Induction of Renal 25‐Hydroxyvitamin D3‐24‐Hydroxylase Activity and Increased Serum 24,25‐Dihydroxyvitamin D3 Levels Are Correlated with the Healing Process After Chick Tibial Fracture
Eun‐Gyoung Seo (1997)
Reversible muscle weakness in patients with vitamin D deficiency.
K. Ziambaras (1997)
Dietary calcium and vitamin D intake in elderly women: effect on serum parathyroid hormone and vitamin D metabolites.
H. K. Kinyamu (1998)
Secondary Hyperparathyroidism in the Elderly: Means to Defining Hypovitaminosis D
M. McKenna (1998)
Hypovitaminosis D in medical inpatients.
M. Thomas (1998)
Receptors for 1α,25(OH)2D3: Past, Present, and Future
A. Norman (1998)
Relationship between age-associated endocrine deficiencies and muscle function in elderly women: a cross-sectional study.
S. Boonen (1998)
Mechanisms and functions of vitamin D.
H. DeLuca (1998)
Mechanism of vitamin D action and its regulation.
A. Dusso (1998)
Redefining vitamin D insufficiency
A. Malabanan (1998)
Identification of a Membrane Receptor for 1,25‐Dihydroxyvitamin D3 Which Mediates Rapid Activation of Protein Kinase C
I. Nemere (1998)
Low Serum Calcidiol Concentration in Older Adults with Reduced Muscular Function
M. Mowé (1999)
Falls Relate to Vitamin D and Parathyroid Hormone in an Australian Nursing Home and Hostel
Mark S. Stein (1999)
An International Comparison of Serum 25-Hydroxyvitamin D Measurements
P. Lips (1999)
Muscle strength in the elderly: its relation to vitamin D metabolites.
H. Bischoff (1999)
A woman who left her wheelchair
G. Mingrone (1999)
Severe myopathy associated with vitamin D deficiency in western New York.
A. Prabhala (2000)
Hypovitaminosis D Myopathy Without Biochemical Signs of Osteomalacic Bone Involvement
H. Glerup (2000)
Vitamin D status: effects on parathyroid hormone and 1, 25-dihydroxyvitamin D in postmenopausal women.
A. Need (2000)
Relationships between physical performance measures, age, height and body weight in healthy adults.
M. Samson (2000)
Influence of physical mobility and season on 25-hydroxyvitamin D-parathyroid hormone interaction and bone remodelling in the elderly.
R. Theiler (2000)
Effects of a Short‐Term Vitamin D and Calcium Supplementation on Body Sway and Secondary Hyperparathyroidism in Elderly Women
Michael Pfeifer (2000)
Muscle strength, functional mobility and vitamin D in older women
H. Verhaar (2000)
Extrarenal Expression of 25-Hydroxyvitamin D3-1α-Hydroxylase1
D. Zehnder (2001)
In Situ Detection of 1,25-dihydroxyvitamin D Receptor In human Skeletal Muscle Tissue
H. A. Bischoff (2004)
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Sarcopenia versus cancer cachexia: the muscle wasting continuum in healthy and diseased aging.
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Evaluation of the osteoporosis patient
E. Lewiecki (2021)
How to Overcome Anabolic Resistance in Dialysis-Treated Patients?
G. Garibotto (2021)
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T. Griffin (2020)
A Brief Intervention for Malnutrition among Older Adults: Stepping Up Your Nutrition
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Vitamin D for prevention of sternotomy healing complications: REINFORCE-D trial
Michal Čečrle (2020)
The effects of climate on the incidence of benign paroxysmal positional vertigo
Seung Ri Oh (2020)
Reviews on New Drug Targets in Age-Related Disorders
P. Guest (2020)
Effect of Vitamin D Supplementation on Muscle Strength, Muscle Function, and Body Composition in Vitamin D-Deficient Middle-Aged Women.
Behnaz Abiri (2020)
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C. Balci (2020)
An Empirical Study on the Effect of Short-Term Regular Vitamin D3 Supplement Therapy on Blood Pressure and Exercise Tolerance in Heart Failure Patients
Fahimeh Hosseinzadeh (2020)
The Role of Nutrition in Attenuating Age-Related Skeletal Muscle Atrophy.
Behnaz Abiri (2020)
Prevalence of Vitamin D Deficiency Amongst Indian Orthopaedic Surgeons.
S. Purohit (2020)
Nutritional Supplements to Support Resistance Exercise in Countering the Sarcopenia of Aging
J. McKendry (2020)
Der Einfluss des selektiven Androgenrezeptor- Modulators Enobosarm auf die Skelettmuskulatur im Modellorganismus der osteoporotischen Ratte
Danny Henkies (2020)
Stroke-Induced Peripheral Immune Dysfunction in Vitamin D-Deficient Conditions: Modulation by Progesterone and Vitamin D.
S. Yousuf (2020)
Association Between Plasma 25-hydroxyvitamin D Concentrations and Incident Activities of Daily Living Disability: A Longitudinal Community-Based Cohort Study.
F. Li (2020)
Deficiência de 25(OH)D como fator de risco para incidência de incapacidade funcional em indivíduos maiores de 50 anos – conclusões do estudo ELSA
M. M. Luiz (2020)
Clinical and Preclinical Models for Maximizing Healthspan: Methods and Protocols
P. Guest (2020)
The D-side of COVID-19: musculoskeletal benefits of vitamin D and beyond
Flavia Tramontana (2020)
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H. Ko (2019)
Status of Vitamin D by measuring 25 - Hydroxyvitamin D level in Dhaka City
Syeda Fahmida Afrin (2019)
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