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Increased Familial Risk For Non-lung Cancer Among Relatives Of Lung Cancer Patients.

T. A. Sellers, W. Ooi, R. Elston, V. Chen, J. Bailey-Wilson, H. Rothschild
Published 1987 · Medicine

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Reports of two or more anatomically distinct cancer types clustering in families suggest the possible existence of a susceptibility-to-cancer gene. To determine whether a genetic predisposition accounts for such familial aggregation, a retrospective case-control study was conducted in 1976-1979 of 337 southern Louisiana families in each of which a deceased lung cancer patient was used as the proband. A comparison of first-degree relatives of proband families with spouse (control) families revealed a significantly greater overall risk of cancer (odds ratio (OR) = 2.0, p less than 0.0001) in the proband group. Using logistic regression techniques to control for the confounding effects of age, sex, cigarette smoking, and occupational/industrial exposures, relatives of lung cancer probands maintained an increased risk of non-lung cancer (p less than 0.05). The crude odds ratio of a proband family having one family member with cancer was 1.67 compared with control families. Proband families were 2.16 times more likely to have two other family members with cancer. For three cancers and four or more cancers, the risk increased to 3.66 and 5.04, respectively. Each risk estimate was significant at the 0.01 level. The most striking differences in cancer prevalence between proband and control families were noted for cancer of the nasal cavity/sinus, mid-ear, and larynx (OR = 4.6); trachea, bronchus and lung (OR = 3.0); skin (OR = 2.8); and uterus, placenta, ovary, and other female organs (OR = 2.1). These data support the hypothesis of a genetic susceptibility to cancer in families with lung cancer.



This paper is referenced by
10.1093/OXFORDJOURNALS.AJE.A008783
Family history of cancer and risk of lung cancer among lifetime nonsmoking women in the United States.
A. Wu (1996)
10.1002/AJMG.1320520311
Segregation analysis of smoking-associated malignancies: evidence for Mendelian inheritance.
T. Sellers (1994)
10.1007/978-1-4614-3197-8_3
Genetic Susceptibility to Lung Cancer
T. Allen (2012)
10.1002/ijc.22615
Aggregation of cancer among relatives of never‐smoking lung cancer patients
O. Gorlova (2007)
10.1186/1746-5354-5-1-1
Big Tobacco and the human genome: driving the scientific bandwagon?
H. Wallace (2009)
10.1016/0895-4356(91)90202-K
Clustering of cancer in families of patients with primary lung cancer.
H. Mcduffie (1991)
10.1016/0169-5002(91)90386-K
A cancer-prone kindred with four siblings afflicted by aggressive poorly differentiated bronchogenic carcinoma
H. Biran (1991)
10.1007/BF01192314
Formation of benzo[a]pyrene-DNA adducts in blood monocytes from lung cancer patients with a familial history of lung cancer
D. Nowak (2005)
10.1186/1471-2407-5-146
Increased risk of cancer among relatives of patients with lung cancer in China
Y. Jin (2005)
10.1007/BF00993795
Genes and family environment in familial clustering of cancer
K. Borch-Johnsen (1994)
10.1007/978-3-319-62941-4
Precision Molecular Pathology of Lung Cancer
P. Cagle (2018)
10.1016/J.EJCA.2005.01.016
Birth cohort effect on lung cancer incidence in Taiwanese women 1981-1998.
Pei-Fen Wu (2005)
10.1002/(SICI)1098-2272(1999)17:1<1::AID-GEPI1>3.0.CO;2-C
Increased cancer risk among relatives of nonsmoking lung cancer cases
A. Schwartz (1999)
10.1016/1047-2797(94)90054-X
The epidemiology of lung cancer in women.
V. Ernster (1994)
10.1378/CHEST.130.4.968
Association between lung cancer incidence and family history of lung cancer: data from a large-scale population-based cohort study, the JPHC study.
J. Nitadori (2006)
10.1378/CHEST.106.2.610
Hemodynamic compromise secondary to a mediastinal bronchogenic cyst.
P. Fratellone (1994)
10.1136/jmg.29.8.531
Genetic transmission of colorectal cancer: exploratory data analysis from a population based registry.
M. Ponz de Leon (1992)
10.1016/0895-4356(91)90082-K
Lung cancer risk associated with cancer in relatives.
G. L. Shaw (1991)
10.1097/JTO.0b013e3182641b82
A Clinical Model to Estimate the Pretest Probability of Lung Cancer, Based on 1198 Pedigrees in China
H. Lin (2012)
10.1002/1097-0142(19920101)69:1<86::AID-CNCR2820690116>3.0.CO;2-S
Lung cancer histologic type and family history of cancer
T. A. Sellers (1992)
10.1016/B978-0-323-52357-8.00006-8
Genetic Susceptibility to Lung Cancer
M. Spitz (2003)
10.1016/S0169-5002(97)00064-0
Carcinoma of the lung in three brothers and two sisters.
P. Ghadirian (1997)
Agrupación familiar para el cáncer en individuos afectados por cáncer de pulmón Familial aggregation of cancer in individuals with lung cancer
Karel Reyes Bacardí (2010)
10.1016/0169-5002(93)90501-n
Lung cancer detection and prevention: evidence for an interaction between smoking and genetic predisposition.
T. Sellers (1992)
Human Genome Epidemiology ( HuGE ) Review Glutathione S-Transferase M 1 ( GSTM 1 ) Polymorphisms and Lung Cancer : A Literature-based Systematic HuGE Review and Meta-Analysis
C. Carlsten (2008)
10.1136/bmj.313.7059.721
Adequacy of cervical cytology sampling with the Cervex brush and the Aylesbury spatula: a population based randomised controlled trial
P. Dey (1996)
10.2174/1573402052952771
Discovering the Genetics of Complex Disorders Through Integration of Genomic Mapping and Transcriptional Profiling
R. Danziger (2005)
10.1007/978-1-4615-1589-0_1
Biological considerations in lung cancer.
B. Almand (2001)
10.1002/(SICI)1098-2272(199911)17:4<274::AID-GEPI3>3.0.CO;2-A
Familial aggregation of breast cancer with early onset lung cancer
A. Schwartz (1999)
10.1002/IJC.2910630603
Family history of cancer is a risk factor for squamous cell carcinoma of the head and neck in Brazil: A case‐control study
W. Foulkes (1995)
10.1378/CHEST.06-2687
Racial differences in cancer risk among relatives of patients with early onset lung cancer.
Jessica L Naff (2007)
10.1016/S0272-5231(05)70009-5
Smoking and the molecular epidemiology of lung cancer.
D. Christiani (2000)
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