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Motor Cortical Inhibition And The Dopaminergic System. Pharmacological Changes In The Silent Period After Transcranial Brain Stimulation In Normal Subjects, Patients With Parkinson's Disease And Drug-induced Parkinsonism.

A. Priori, A. Berardelli, M. Inghilleri, N. Accornero, M. Manfredi
Published 1994 · Psychology, Medicine

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The silent period after contralateral and ipsilateral transcranial magnetic brain stimulation was studied in patients with Parkinson's disease before and after dopaminergic and anticholinergic therapy; in normal subjects before and after L-dopa administration and in patients with drug-induced parkinsonism. In patients and normal subjects the silent period was also studied after peripheral nerve stimulation. The silent period after transcranial cortical stimulation was shorter in Parkinson's disease patients than in normal subjects. In patients with Parkinson's disease L-dopa prolonged the silent period after transcranial brain stimulation and after ipsilateral cortical stimulation. Biperiden prolonged the silent period after transcranial brain stimulation. In normal subjects, L-dopa produced similar but smaller changes. In the patients with drug-induced parkinsonism the silent period after transcranial magnetic stimulation was shorter than normal subjects. The peripheral silent period was similar in normal subjects and in patients and did not change after drug administration. In conclusion cortical silent period is abnormal in patients with Parkinson's disease and drug-induced parkinsonism. Dopaminergic drugs modulate the duration of the cortical silent periods in patients and in normal subjects, through mechanisms acting mainly at basal ganglia and possibly also directly at cortical level.

This paper is referenced by
Effect of fatiguing maximal voluntary contraction on excitatory and inhibitory responses elicited by transcranial magnetic motor cortex stimulation
W. McKay (1996)
Projections from basal ganglia to tegmentum: a subcortical route for explaining the pathophysiology of Parkinson’s disease signs?
P. J. Delwaide (2000)
Motor cortex dysfunction revealed by cortical excitability studies in Parkinson's disease: influence of antiparkinsonian treatment and cortical stimulation
Jean-Pascal Lefaucheur (2005)
Excitatory and inhibitory effects of caffeíne in the neocortex : a transcranial magnetic stimulation study
Érica Rodrigues Marcelino (2010)
Normalizing motor-related brain activity
S. T. Grafton (2006)
Abnormal Cortical Mechanisms in Voluntary Muscle Relaxation in De Novo Parkinsonian Patients
E. Labyt (2005)
New graphical method to measure silent periods evoked by transcranial magnetic stimulation
M. Garvey (2001)
The restless legs syndrome
G. Barrière (2005)
Mean-field modeling of the basal ganglia-thalamocortical system. II Dynamics of parkinsonian oscillations.
S. V. van Albada (2009)
Changes in motor cortex excitability associated with muscle fatigue in patients with Parkinson's disease Promene ekscitabilnosti motorne kore udruene sa zamorom mišia kod obolelih od Parkinsonove bolesti
S. Milanovi (2013)
Acute neural adaptations to resistance training performed with low and high rates of muscle activation
C. Peterson (2009)
Cortical Excitability in Patients After Loading Doses of Lamotrigine: A Study with Magnetic Brain Stimulation
P. Manganotti (1999)
Transcranial magnetic stimulation during PET: Reaching and verifying the target site
T. Paus (1998)
Changes in corticomotor excitation and inhibition during prolonged submaximal muscle contractions
P. Sacco (1997)
Magnetic stimulation of the motor cortex: Clinical applications
L. Kiers (1997)
Serum levels of carbamazepine and cortical excitability by magnetic brain stimulation
M. Turazzini (2004)
Neurophysiological evaluation of motor corticospinal pathways by TMS in idiopathic early-onset Parkinson’s disease
A. Perretti (2011)
Aus dem Medizinischen Zentrum für Nervenheilkunde der Philipps-Universität Marburg Geschäftsführender Direktor : Prof. Dr. med C. Krieg Klinik für Neurologie mit Poliklinik, Direktor : Prof. Dr. med. W.H. Oertel
Fachbereich Humanmedizin (2002)
Segulörvun heila : yfirlitsgrein
A. Moeller (2004)
Brain stimulation in Huntington's disease.
C. Hartmann (2016)
Plastische Veränderungen des motorischen Kortex nach BIG-Physiotherapie bei Patienten mit idiopathischem Parkinson-Syndrom
Florian Restle (2015)
Pharmacological mechanisms of interhemispheric signal propagation: a TMS-EEG study
J. Hui (2019)
[Transcranial magnetic stimulation in child and adolescent psychiatry: excitability of the motor system in tic disorders and/or attention deficit hyperactivity disorders].
G. Moll (2001)
Excitability of the lower-limb area of the motor cortex in Parkinson's disease
F. Vacherot (2010)
Uticaj transkranijalne magnetne stimulacije na kliničke znake i elektrofiziološke parametre kod obolelih od Parkinsonove bolesti
A. Kačar (2013)
Plasticity of the motor cortex in Parkinson's disease patients on and off therapy
S. Bagnato (2006)
Increased cortical inhibition induced by apomorphine in patients with Parkinson's disease
L. Manfredi (1998)
Slow (1Hz) repetitive transcranial magnetic stimulation (rTMS) induces a sustained change in cortical excitability in patients with Parkinson’s disease
S. Filipovic (2010)
The Interaction of Mental and Neuromuscular Fatigue and the Impact of Mental Fatigue on Function Across Different Age Groups
Amanda Morris (2019)
Transcranial magnetic stimulation: studying motor neurophysiology of psychiatric disorders
F. Maeda (2003)
Changes in basal ganglia processing of cortical input following magnetic stimulation in Parkinsonism
H. Tischler (2012)
Modulation of symptomatic palatal tremor by magnetic stimulation of the motor cortex
Jen-Tse Chen (2000)
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