Please confirm you are human (Sign Up for free to never see this)
← Back to Search
Sensorimotor Slowing With Ageing Is Mediated By A Functional Dysregulation Of Motor-generation Processes: Evidence From High-resolution Event-related Potentials.
J. Yordanova, V. Kolev, J. Hohnsbein, M. Falkenstein
Published 2004 · Psychology, Medicine
Save to my Library
Download PDFAnalyze on Scholarcy
The objective of the present study was to identify the origin(s) of ageing-related behavioural slowing in sensorimotor tasks. For this aim, event-related potentials (ERPs) were analysed at 64 electrodes to evaluate the strength and timing of different stages of information processing in the brain. Electrophysiological indices of stimulus processing, sensorimotor integration/response selection and motor-related processing were used to compare the processing speed of young (n = 13, mean age = 22.5 years) and older adults (n = 14, mean age = 58.3 years) in simple- and choice-reaction tasks presented in two modalities, auditory and visual. The behavioural results showed significant ageing-related slowing, but only in the choice-reaction task. The quantification of separate central processing stages, in combination with advanced ERP methodology, helped to reveal that this slowing did not originate from the early processes of stimulus processing and response selection. Instead, it was produced by slower activation patterns over the contralateral motor cortex underlying response generation. It is concluded that ageing is accompanied by a functional dysregulation of motor cortex excitability during sensorimotor processing, with this deficit becoming progressively evident with greater task complexity.
This paper references
Age‐related differences in effective neural connectivity during encoding and recall
R. Cabeza (1997)
Aging and the Simon task.
R. V. D. Van der Lubbe (2002)
A new method for off-line removal of ocular artifact.
G. Gratton (1983)
Aging Gracefully: Compensatory Brain Activity in High-Performing Older Adults
R. Cabeza (2002)
Age-related changes in processing auditory stimuli during visual attention: evidence for deficits in inhibitory control and sensory memory.
C. Alain (1999)
Age-related deficits in generation and manipulation of mental images: I. The role of sensorimotor speed and working memory.
S. D. Briggs (1999)
Individual differences in memory enhancement by encoding enactment: relationships to adult age and biological factors
L. Nyberg (2002)
Role of human prefrontal cortex in attention control.
R. Knight (1995)
Age effects on visual EEG responses reveal distinct frontal alpha networks
V. Kolev (2002)
Neurophysiological correlates of age-related changes in human motor function
V. Mattay (2002)
The in ̄uence of normal aging on the cortical processing of a simple motor
A Sailer (2000)
Event-related brain potentials in the study of visual selective attention.
S. Hillyard (1998)
Altered representation of peripersonal space in the elderly human subject: a sensorimotor approach
M. Ghafouri (2000)
Relations between aging sensory/sensorimotor and cognitive functions
K. Li (2002)
Age-related deficits in generation and manipulation of mental images: II. The role of dorsolateral prefrontal cortex.
N. Raz (1999)
The influence of normal aging on the cortical processing of a simple motor task
A. Sailer (2000)
A new method for the estimation of the onset of the lateralized readiness potential (LRP)
P. Schwarzenau (1998)
Age-related changes of motor evoked potentials in healthy humans: Non-invasive evaluation of central and peripheral motor tracts excitability and conductivity
P. Rossini (1992)
Electric Fields of the Brain: The Neurophysics of Eeg
P. Nunez (2005)
Effects of age on working memory: an event-related potential study.
L. Pelosi (1999)
Age-related changes in fronto-parietal networks during spatial memory: an ERP study.
N. Müller (2002)
Development and aging changes in humans evoked potentials
T. Allison (1987)
Regulating action: alternating activation of midline frontal and motor cortical networks
P. Luu (2001)
EEG theta and frontal alpha oscillations during auditory processing change with aging.
J. Yordanova (1998)
Theoretical Overview of P3a and P3b
J. Polich (2003)
Spherical splines for scalp potential and current density mapping.
F. Perrin (1989)
Use of partial stimulus information in response processing.
R. de Jong (1988)
Brain imaging and age-related changes in cognition
C. Grady (1998)
Age-related changes in involuntary and voluntary attention as reflected in components of the event-related potential (ERP)
A. Kok (2000)
Some physiological characteristics of motor cortex neurons of aged rabbits
Y. S. Mednikova (1994)
Human brain electrophysiology
D. Regan (1989)
Changes of error-related ERPs with age
M. Falkenstein (2001)
Evoked potentials III
C. Barber (1987)
Slow cortical potentials and behavior
B. Rockstroh (1989)
Improved realistic Laplacian estimate of highly-sampled EEG potentials by regularization techniques.
F. Babiloni (1998)
Neuromagnetic fields accompanying unilateral and bilateral voluntary movements: topography and analysis of cortical sources.
R. Kristeva (1991)
From sensation to cognition.
M. Mesulam (1998)
Modern mind-brain reading: psychophysiology, physiology, and cognition.
M. Coles (1989)
Age-related changes in primary somatosensory cortex of rats: evidence for parallel degenerative and plastic-adaptive processes
B. Godde (2002)
Age effects on response monitoring in a mental-rotation task
G. Band (2000)
Association between decline in brain dopamine activity with age and cognitive and motor impairment in healthy individuals.
N. Volkow (1998)
Aging-related changes in processing of non-target and target stimuli during an auditory oddball task
E. Amenedo (1998)
Human brain electrophysiology: Evoked potentials and evoked magnetic fields in science and medicine
D. Regan (1989)
Age-Related Differences in Movement Representation
S. Hutchinson (2002)
New visions of the aging mind and brain
P. Reuter-Lorenz (2002)
Aging and measures of processing
TA Salthouse (2000)
Cortical activation during fast repetitive finger movements in humans: dipole sources of steady-state movement-related cortical potentials.
C. Gerloff (1998)
On the relationship between EEG and P300: individual differences, aging, and ultradian rhythms.
J. Polich (1997)
Prefrontal deficits in attention and inhibitory control with aging.
L. Chao (1997)
On the discrimination between global and local trend hypotheses of life-span changes in processing speed.
P. Molenaar (1994)
Detection of change : event-related potential and fMRI findings
J. Polich (2003)
Neural aspects of anticipatory behavior.
C. Brunia (1999)
Age-related dopamine D2/D3 receptor loss in extrastriatal regions of the human brain
V. Kaasinen (2000)
Effects of aging on visuospatial attention: an ERP study
T. Curran (2001)
Spline Laplacian estimate of EEG potentials over a realistic magnetic resonance-constructed scalp surface model.
F. Babiloni (1996)
P300 clinical utility and control of variability.
J. Polich (1998)
Deficit in motor cortical activity for simultaneous bimanual responses
Y. Taniguchi (2001)
Wait and see.
C. Brunia (2001)
Architecture of the Prefrontal Cortex and the Central Executive
P. Goldman-Rakic (1995)
Age‐related decline of presumptive inhibitory synapses in the sensorimotor cortex as revealed by the physical disector
B. H. Poe (2001)
Detecting the onset of the lateralized readiness potential: a comparison of available methods and procedures.
J. T. Mordkoff (2000)
Aging and measures of processing speed
T. Salthouse (2000)
Ageing and the brain
R. Peters (2006)
Aging of the brain, sensorimotor, and cognitive processes
S. Li (2002)
Effects of aging on sensory-motor processing in humans
J Yordanova (2004)
Age-related decrease in paired-pulse intracortical inhibition in the human primary motor cortex
A. Peinemann (2001)
Selective processing of two-dimensional visual stimuli in young and old subjects: electrophysiological analysis.
J. Kenemans (1995)
Electric Fields of the Brain: The Neurophysics of EEG
J. Fermaglich (1982)
Theoretical overview of P 3 a and P 3 b
Ageing and the brain. In: Encyclopedia of life sciences
N. Raz (2001)
This paper is referenced by
Age-related changes in the use of regular patterns for auditory scene analysis
Johanna Rimmele (2012)
Effects of aging on slowing of motor-response generation.
M. Falkenstein (2006)
Préparation à réagir et vieillissement : synthèse et nouvelles perspectives de recherche dans l’étude des effets préparatoires
Guillaume Vallet (2012)
Activities in Retirement: Individual Experience of Silver Work
L. Maxin (2011)
On the time course of attentional focusing in older adults
Lisa N. Jefferies (2015)
Clinical determinants of failure in balance tests in elderly subjects.
P. Manckoundia (2008)
The Aging Motor System as a Model for Plastic Changes of GABA-Mediated Intracortical Inhibition and Their Behavioral Relevance
Kirstin-F Heise (2013)
Age-related differences in corticospinal excitability during a choice reaction time task
K. Cuypers (2012)
Age-related changes in cognitive conflict processing: An event-related potential study
R. Mager (2007)
Compensatory movement-related recruitment in amyotrophic lateral sclerosis patients with dominant upper motor neuron signs: An EEG source analysis study
A. Inuggi (2011)
Cortical control of unilateral simple movement in healthy aging
A. Inuggi (2011)
Factors influencing the latency of simple reaction time
D. Woods (2015)
Neurophysiological adaptations to resistance training and repetitive grasping
M. Falvo (2010)
Beschäftigung statt Ruhestand: individuelles Erleben von Silver Work
L. Maxin (2010)
Slower Visuomotor Corrections with Unchanged Latency are Consistent with Optimal Adaptation to Increased Endogenous Noise in the Elderly
M. Sherback (2010)
Sources of cortical rhythms in adults during physiological aging: A multicentric EEG study
C. Babiloni (2006)
Startle evoked movement is delayed in older adults: implications for brainstem processing in the elderly
Ursina A. Tresch (2014)
Aging and motor inhibition: A converging perspective provided by brain stimulation and imaging approaches
O. Levin (2014)
No Effect of Anodal Transcranial Direct Current Stimulation Over the Motor Cortex on Response-Related ERPs during a Conflict Task
A. Conley (2016)
Psychomotor speed in a random sample of 7979 subjects aged 30 years and over
P. Era (2011)
Focused and divided attention in a simulated cocktail-party situation: ERP evidence from younger and older adults
S. Getzmann (2016)
Age-dependent impairment of auditory processing under spatially focused and divided attention: An electrophysiological study
N. Wild-Wall (2010)
Secondary verbal responses during driving may not be a safer alternative to manual responses irrespective of age
N. Wild-Wall (2014)
Electrophysiological Ageing of the Brain: Ageing-Related Impairments in Neural and Cognitive Functions
R. Singh (2017)
Executive Dysfunctions and Event-Related Brain Potentials in Patients with Amyotrophic Lateral Sclerosis
C. Seer (2015)
Age-related multisensory enhancement in a simple audiovisual detection task
A. Peiffer (2007)
The impact of visual acuity on age-related differences in neural markers of early visual processing
K. Daffner (2013)
Increased Performance Variability as a Marker of Implicit/Explicit Interactions in Knowledge Awareness
J. Yordanova (2015)
Age-related performance differences in compensatory tracking under a dual task condition
Melanie Hahn (2010)
Adult age-dependent differences in resting-state connectivity within and between visual-attention and sensorimotor networks
C. Roski (2013)
Age dependence of primary motor cortex plasticity induced by paired associative stimulation
F. Tecchio (2008)
Running Head : Preparation for non-target stimuli in aging Excessive subthreshold motor preparation for non-target stimuli in normal aging
A. Vallesi (2011)See more