Online citations, reference lists, and bibliographies.
← Back to Search

Glutathione S-transferase M1 And T1 Null Genotypes As Risk Factors For Oral Leukoplakia In Ethnic Indian Betel Quid/tobacco Chewers.

U. Nair, J. Nair, B. Mathew, H. Bartsch
Published 1999 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy Visualize in Litmaps
Share
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Get Citationsy
Oral cancer is the most common cancer in males and third most common in females in India, the main causative agent being the use of chewing tobacco with or without betel quid (BQ). However, nothing is known about the role of the host metabolic genes in oral cancer in ethnic Indian population. In this study, the prevalence of GSTM1 and GSTT1 null genotypes (GSTM1*2 and GSTT1*2) in oral premalignant leukoplakia cases and controls was ascertained in genomic DNA by a multiplex PCR technique. Biopsies taken from 98 oral leukoplakia patients and exfoliated cells from 82 healthy controls both of Indian ethnicity were analysed. GSTM1*1 (active) was present in 83% and GSTT1*1 (active) was present in 78% of all control subjects, while prevalence of GSTM1*2 and GSTT1*2 null genotypes was significantly higher among oral leukoplakia cases. The prevalence of GSTM1*2 in leukoplakia cases was 81.6% compared with 17% in controls [odds ratio (OR), 22; 95% confidence interval (CI), 1047] and GSTT1*2 was 75.5% in the cases versus 22% in controls (OR, 11; 95% CI, 5-22). Combined null genotypes of GSTM1 and GSTT1 prevailed in 60.2% of the cases with none detected in controls. Glutathione S-transferase M1 and T1 enzymes are both known to catalyse detoxification of reactive oxygen species, lipid peroxidation products and tobacco-derived carcinogens that have been found in the saliva of BQ/tobacco chewers. Our results, still requiring confirmation by a larger study, demonstrate that the null genotypes of both GSTM1 and GSTT1 increase with high penetrance, separately or in combination, the risk for developing leukoplakia in an Indian ethnic population.
This paper references
10.1007/978-3-642-85851-2
Cancer Incidence in Five Continents
Freddie Ian Bray (1970)
Control of oral cancer in developing countries. A WHO meeting.
(1984)
Nicotine-derived N-nitrosamines and tobacco-related cancer: current status and future directions.
D. Hoffmann (1985)
Tobacco habits other than smoking; betel-quid and areca-nut chewing; and some related nitrosamines. IARC Working Group. Lyon, 23-30 October 1984.
(1985)
10.1002/1097-0142(19860215)57:4<843::AID-CNCR2820570426>3.0.CO;2-W
Leukoplakia‐associated multiple carcinomas in patients with tongue carcinoma
H. Shibuya (1986)
Formation of reactive oxygen species and of 8-hydroxy-2'-deoxyguanosine in DNA in vitro with betel-quid ingredients.
M. Friesen (1988)
10.1016/0030-4220(88)90166-1
Leukoplakia and carcinoma in situ synchronously associated with invasive oral/oropharyngeal carcinoma in Rochester, Minn., 1935-1984.
J. Bouquot (1988)
10.1016/0163-7258(90)90054-6
Genetic heterogeneity of the human glutathione transferases: a complex of gene families.
P. Board (1990)
10.1016/0165-1218(91)90063-R
Evaluation of frequency of micronucleated oral mucosa cells as a marker for genotoxic damage in chewers of betel quid with or without tobacco.
U. Nair (1991)
10.1289/EHP.929875
Elucidation of catalytic specificities of human cytochrome P450 and glutathione S-transferase enzymes and relevance to molecular epidemiology.
F. Guengerich (1992)
10.1289/EHP.9298203
Role of lime in the generation of reactive oxygen species from betel-quid ingredients.
U. Nair (1992)
10.1111/j.1349-7006.1992.tb01992.x
High Susceptibility to Lung Cancer Analyzed in Terms of Combined Genotypes of P450IA1 and Mu‐class Glutathione S‐Transferase Genes
S. Hayashi (1992)
10.1016/0304-3835(93)90218-X
Human glutathione S-transferase mu (GST mu) deficiency as a marker for the susceptibility to bladder and larynx cancer among smokers.
A. Lafuente (1993)
10.3109/9780415874984-2
Trends in cancer incidence and mortality.
M. Coleman (1993)
10.1093/CARCIN/14.7.1279
Principal xenobiotic-metabolizing enzyme systems in human head and neck squamous cell carcinoma.
F. Janot (1993)
10.1093/CARCIN/14.9.1821
Relationship between the GSTM1 genetic polymorphism and susceptibility to bladder, breast and colon cancer.
S. Zhong (1993)
10.1002/IJC.2910540413
Estimates of the worldwide incidence of eighteen major cancers in 1985
D. M. Parkin (1993)
10.3109/10409239309086794
Glutathione S-transferases: gene structure and regulation of expression.
V. Daniel (1993)
Glutathione S-transferase M1 and its variants A and B as host factors of bladder cancer susceptibility: a case-control study.
J. Brockmöller (1994)
10.1093/CARCIN/15.5.1077
Ethnic distribution of the glutathione transferase Mu 1-1 (GSTM1) null genotype in 1473 individuals and application to bladder cancer susceptibility.
H. Lin (1994)
10.1016/S1054-3589(08)61029-7
Enzymology of cytosolic glutathione S-transferases.
B. Ketterer (1994)
10.1073/PNAS.91.4.1480
Detoxication of base propenals and other alpha, beta-unsaturated aldehyde products of radical reactions and lipid peroxidation by human glutathione transferases.
K. Berhane (1994)
Glutathione S - transferase M 1 and its variants A and B as host factors of bladder cancer susceptibility : a case - control study
G. Chenevix Trench (1994)
10.1093/CARCIN/16.5.1195
Ortho- and meta-tyrosine formation from phenylalanine in human saliva as a marker of hydroxyl radical generation during betel quid chewing.
U. Nair (1995)
10.1093/CARCIN/16.7.1655
Glutathione S-transferase M1 and T1 polymorphisms: susceptibility to colon cancer and age of onset.
G. Chenevix-Trench (1995)
10.1177/10454411950060010401
Bionutrition and oral cancer in humans.
C. Enwonwu (1995)
10.3109/10715769509147539
Potential contribution of the glutathione S-transferase supergene family to resistance to oxidative stress.
J. Hayes (1995)
10.1093/CARCIN/16.5.1243
Ethnic differences in the prevalence of the homozygous deleted genotype of glutathione S-transferase theta.
H. Nelson (1995)
10.1097/00008571-199510000-00010
GLUTATHIONE S-TRANSFERASE THETA (GSTT1) GENETIC POLYMORPHISM AMONG CHINESE, MALAYS AND INDIANS IN INGAPORE
E. Lee (1995)
10.1097/00008571-199510000-00002
Frequency of mutant CYP1A1, NAT2 and GSTM1 alleles in normal Indians and Malays.
B. Zhao (1995)
Glutathione S transferase-theta (GSTT1) genetic polymorphism among Chinese, Malays and Indians in Singapore.
E. Lee (1995)
Gene deletion of glutathione S-transferase theta: correlation with induced genetic damage and potential role in endogenous mutagenesis.
J. Wiencke (1995)
10.3109/10409239509083491
The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance.
J. Hayes (1995)
10.1093/CARCIN/16.3.619
Glutathione S-transferases and glutathione in human head and neck cancer.
T. Mulder (1995)
Susceptibility to astrocytoma and meningioma: influence of allelism at glutathione S-transferase (GSTT1 and GSTM1) and cytochrome P-450 (CYP2D6) loci.
J. Elexpuru-Camiruaga (1995)
10.1016/S0002-9610(99)80339-0
Glutathione s-transferase genotypes as risk factors for head and neck cancer.
Z. Trizna (1995)
Glutathione S - transferase M 1 and T 1 polymorphisms : susceptibility to colon cancer and age of onset
S. Hayashi (1995)
10.1006/ABIO.1996.0153
A multiplex polymerase chain reaction protocol for the simultaneous analysis of the glutathione S-transferase GSTM1 and GSTT1 polymorphisms.
M. Arand (1996)
10.1016/S0194-5998(96)80631-0
Poster 7: A Genetic Progression Model for Head and Neck Cancer: Implications for Field Cancerization
J. Califano (1996)
Gender differences in smoking and risk for oral cancer.
J. Muscat (1996)
10.1093/CARCIN/17.4.881
Glutathione S-transferase GSTT1 genotypes and susceptibility to cancer: studies of interactions with GSTM1 in lung, oral, gastric and colorectal cancers.
M. Deakin (1996)
10.1016/S0194-5998(96)80594-8
11:40 AM: A Genetic Progression Model for Head and Neck Cancer: Implications for Field Cancerization
J. Califano (1996)
10.1093/CARCIN/17.9.1855
Glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) genetic polymorphism and susceptibility to gastric and colorectal adenocarcinoma.
T. Katoh (1996)
10.1016/0964-1955(95)00065-8
Molecular changes in oral cancer may reflect aetiology and ethnic origin.
I. Paterson (1996)
10.3109/10408449609017928
Endogenous formation of nitrosamines and oxidative DNA-damaging agents in tobacco users.
J. Nair (1996)
10.1016/S1357-4310(97)01111-8
Leukoplakia: molecular understanding of pre-malignant lesions and implications for clinical management.
L. Mao (1997)
Genetic polymorphisms of CYP2E1, GSTM1, and GSTT1; environmental factors and risk of oral cancer.
H. C. Hung (1997)
10.1016/S0964-1955(97)00010-9
Chemoprevention of oral leukoplakia with vitamin A and beta carotene: an assessment.
R. Sankaranarayanan (1997)
10.1097/00001622-199709030-00006
Biomarkers in head and neck carcinoma.
Y. Oh (1997)
10.1093/JNCI/89.3.257
Low-dose isotretinoin versus beta-carotene to prevent oral carcinogenesis: long-term follow-up.
V. Papadimitrakopoulou (1997)
CYP1A1 and GSTM1 polymorphisms and oral cancer risk.
J. Park (1997)
10.1016/S1368-8375(97)00002-X
Oral leukoplakia: a clinicopathological review.
I. van der Waal (1997)
10.1093/CARCIN/18.6.1271
Serum, plasma and paraffin-embedded tissues as sources of DNA for studying cancer susceptibility genes.
B. Bloemeke (1997)
10.1016/S1368-8375(97)00029-8
Epidemiology and prevention of oral cancer.
C. la Vecchia (1997)
Molecular epidemiology of the human glutathione S-transferase genotypes GSTM1 and GSTT1 in cancer susceptibility.
T. Rebbeck (1997)
10.3892/IJO.13.4.705
Allelic loss on chromosome 22 in oral cancer: possibility of the existence of a tumor suppressor gene on 22q13.
A. Miyakawa (1998)
10.1097/00008571-199802000-00001
The glutathione S-transferase GSTP1 polymorphism: effects on susceptibility to oral/pharyngeal and laryngeal carcinomas.
C. Matthias (1998)
Cytogenetic and fluorescence in situ hybridization characterization of chromosome 1 rearrangements in head and neck carcinomas delineate a target region for deletions within 1p11-1p13.
Y. Jin (1998)
Association between GSTM polymorphisms and risk for oral cancer in African Americans as compared with Caucasians
Y. Oh (1998)
A nomenclature system for metabolic gene polymorphisms.
S. Garte (1999)



This paper is referenced by
10.1186/s12879-021-06301-6
Prevalence of oral human papillomavirus infection among Indian HIV-positive men who have sex with men: a cross-sectional study
Alexandra L. Hernandez (2021)
10.4103/JASI.JASI_99_19
An assessment of Genotoxic Damage in Exfoliated Buccal Cells using Saliva as a tool
Sonia Jaiswal (2019)
10.1007/s13530-019-0389-1
Acetylcholinesterase, Butyrylcholinesterase and Glutathione S-Transferase Enzyme Activities and Their Correlation with Genotypic Variations Based on GST M1 and GST T1 Loci in Long Term-Pesticide-Exposed Tea Garden Workers of Sub-Himalayan West Bengal
Tanmoy Dutta (2019)
10.18231/2348-0335.2017.0003
Nitrite Contents in Various Masticatories Prevailing in the State of Assam – a Pilot Study
Rituraj Bharadwaj (2017)
10.4103/ijabmr.IJABMR_58_16
Evaluation of Genetic Polymorphisms in Glutathione S-Transferase Theta1, Glutathione S-Transferase Mu1, and Glutathione S-Transferase Mu3 in Oral Leukoplakia and Oral Squamous Cell Carcinoma with Deleterious Habits using Polymerase Chain Reaction
A. K. Rao (2017)
EPIDEMIOLOGY OF ORAL AND PHARYNGEAL CANCER
Nasser M. Baom (2017)
10.1016/J.AJOMS.2017.11.008
GSTM1 and GSTT1 null polymorphism and antioxidant levels in oral submucous fibrosis, leukoplakia and oral cancer patients among a South Indian Population ☆
G. Madhulatha (2017)
10.7314/APJCP.2016.17.2.739
Preliminary Study of the GSTM1 Null Polymorphism and History of Tobacco Smoking among Oral Cancer Patients in Northeastern Thailand.
S. Natphopsuk (2016)
10.1089/gtmb.2015.0308
Associations Among Glutathione S-Transferase T1, M1, and P1 Polymorphisms and the Risk of Oral Leukoplakia.
P. He (2016)
10.4172/2168-9784.1000200
Pattern of Keratin Expression and its Impact on Nuclear-Cytoplasmic Ratio in Plump Keratinized Squamous Cells during Oral Carcinogenesis
A. Mohanta (2016)
Angadi PV, Krishnapillai R. Cyclin Dl expression in oral squamous cell carcinoma and verrucous carcinoma: correlation with histological differentiation: Oral Surg Oral Med Oral Pathol Oral Radiol
Kathy Eyring (2015)
10.7314/APJCP.2015.16.3.1145
Genetic susceptibility to oral cancer due to combined effects of GSTT1, GSTM1 and CYP1A1 gene variants in tobacco addicted patients of Pashtun ethnicity of Khyber Pakhtunkhwa province of Pakistan.
Zakiullah (2015)
10.21767/2393-8862.100031
Association of Cytochrome P450 with Cancer Induced by Betel Quid (BQ): A Review
A. Adhikari (2015)
10.7314/APJCP.2015.16.1.355
Distributions of the GSTM1 and GSTT1 null genotypes worldwide are characterized by latitudinal clines.
M. Saitou (2015)
10.1097/MOO.0000000000000027
Gingivobuccal mucosal cancers: resection to reconstruction
Y. More (2014)
10.1007/s13277-014-2062-2
Novel p53 codon 240 Ser > Thr coding region mutation in the patients of oral squamous cell carcinoma (OSCC)
S. Saleem (2014)
10.1007/s10238-014-0284-7
Association between single nucleotide polymorphisms (SNPs) of XRCC2 and XRCC3 homologous recombination repair genes and triple-negative breast cancer in Polish women
B. Smolarz (2014)
GSTM1 Polymorphism as Risk Factor in Oral Carcinoma in Central Indian Population: A pilot study
Purnendu Rout (2014)
Tobacco, teeth stains, periodontitis, oral submucous fibrosis oral-pre cancer, oral cancer
K. Mubeen (2013)
10.1371/journal.pone.0057771
Mitochondrial DNA Copy Number and Risk of Oral Cancer: A Report from Northeast India
R. Mondal (2013)
10.1080/09723757.2013.11886190
Toxic Effects of Betel Quid
A. Adhikari (2013)
10.3233/DMA-130967
Interactions between Cigarette Smoking and Polymorphisms of Xenobiotic-Metabolizing Genes: The Risk of Oral Leukoplakia
Y. Li (2013)
10.1016/j.oraloncology.2012.11.003
Association of mitochondrial D-loop mutations with GSTM1 and GSTT1 polymorphisms in oral carcinoma: a case control study from northeast India.
R. Mondal (2013)
10.5958/J.2319-5886.2.4.123
STUDY AMONG BETEL QUID CHEWERS FROM INDIAN POPULATION
Adhikari Aniket (2013)
Clinico-pathological Parameters Of 50 Oral Squamous Cell Carcinoma Cases in Karachi
M. Alamgir (2013)
10.14260/JEMDS/723
EFFECT OF TOBACCO ON ORAL -HEALTH AN OVERVIEW
K. Mubeen (2013)
10.31901/24566330.2013/13.01.02
Toxic Effects of Betel Quid
A. Adhikari (2013)
10.1016/J.EJMHG.2013.07.004
Assessment of DNA damage by panmasala, gutkha chewing and smoking in buccal epithelial cells using alkaline single cell gel electrophoresis (SCGE)
S. Jyoti (2013)
Development of a statistical method for the identification of gene-environment interactions
P. Golding (2012)
10.4103/2277-9175.100128
Micronucleus investigation in human buccal epithelial cells of gutkha users
S. Jyoti (2012)
10.1371/journal.pone.0042759
Association of Betel Nut with Carcinogenesis: Revisit with a Clinical Perspective
R. N. Sharan (2012)
10.7314/APJCP.2012.13.11.5647
Genetic polymorphisms of GSTM1 and GSTT1 genes in Delhi and comparison with other Indian and global populations.
A. Sharma (2012)
See more
Semantic Scholar Logo Some data provided by SemanticScholar