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Perinatal Complications Are Associated With Seropositivity For Chlamydia Trachomatis During Pregnancy.

K. Numazaki, T. Kusaka, S. Chiba
Published 1996 · Medicine

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SIR-Chlamydial infections during pregnancy may cause a variety of perinatal complications. Recently Gencay et al. [1] reported that the rates of seropositivity for IgM antibodies to Chlamydia trachomatis during pregnancy were significantly higher among mothers who had given birth to infants with complications than among matched controls. Inclusion conjunctivitis, pneumonia, and other complications may develop in neonates born to mothers in­ fected with C. trachomatis. Chlamydial infections in infants are usually caused by transvaginal transmission of C. trachomatisfrom mother to infant. Delivery of low-birth-weight infants and prema­ ture rupture of membranes occurred more frequently among women infected with C. trachomatis. It has been suggested that C. trachomatisinfection in pregnant women may result in prema­ ture labor and perinatal death. From January 1993 to December 1994, serum samples were collected from 178 pregnant women at 10 and 22 weeks of gesta­ tion. A commercially available EIA kit (SERa IPELISA CHLA­ MYDIA, Meiji Milk Products, Tokyo) was also used to detect serum IgG, IgA, and IgM antibodies to C. trachomatis. Testing and interpretation of the results were performed according to the manufacturer's instructions. Of the 178 pregnant women, 10 (5.6%) had IgG and IgM anti­ bodies to C. trachomatisdetected with use of ELISA. Twenty-one (11.8%) of the 178 women had IgG and IgA antibodies to C. trachomatis. None ofthe 10 women with IgG and IgM antibod
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