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Novel Regulation Of Lipoprotein Lipase Activity In Rat Brown Adipose Tissue: Effects Of Fasting And Caloric Restriction During Refeeding.

S. Fried, J. Hill, M. Nickel, M. Digirolamo
Published 1983 · Biology, Medicine

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We studied the effects of a 3-day fast and 20 days of refeeding on lipoprotein lipase activity (LPL) in the interscapular brown adipose tissue (BAT) of sexually mature male rats. Rats were refed either ad libitum or restricted quantities (75 or 50% of normal ad libitum food intake). BAT-LPL, expressed on a per depot basis, decreased with fasting and returned to control values by day 3 of refeeding ad libitum. In contrast, refeeding restricted quantities for 5 to 20 days limited regain of body weight and increased BAT-LPL significantly above the values observed in rats refed ad libitum. These adaptations in BAT-LPL activity differ markedly from those observed in rat white adipose tissue or heart muscle and may serve to increase the supply of fatty acids from circulating lipoproteins for BAT metabolic needs and maintenance of thermogenesis during undernutrition.
This paper references
Purification and characterization of lipoprotein lipase from rat brown fat
D. Guerrier (1979)
Onset and development of hypertriglyceridemia in the Zucker rat (fa/fa).
A. Boulangé (1981)
Adipose, muscle and lung tissue lipoprotein lipase activities in young streptozotocin treated rats.
R. Rauramaa (1980)
Developmental changes in the activity of lipoprotein lipase (clearing-factor lipase) in rat lung, cardiac muscle, skeletal muscle and brown adipose tissue.
A. Cryer (1978)
The lipoprotein lipase activity of brown adipose tissue during early post-natal development of the normal and hypothyroid rat.
P. Hémon (1975)
Response of lipoprotein lipase in various tissues to cold exposure.
M. Radomski (1971)
A role for brown adipose tissue in diet-induced thermogenesis
N. Rothwell (1979)
Nonshivering thermogenesis in the rat. II. Measurements of blood flow with microspheres point to brown adipose tissue as the dominant site of the calorigenesis induced by noradrenaline.
D. Foster (1978)
Development and testing of an automated food dispenser for small rodents.
M. Digirolamo (1981)
A simple method for the isolation and purification of total lipides from animal tissues.
J. Folch (1957)
Oxidative phosphorylation and compartmentation of fatty acid metabolism in brown fat mitochondria.
K. Hittelman (1969)
Prolonged effects of fasting-refeeding on rat adipose tissue lipoprotein lipase activity: influence of caloric restriction during refeeding.
S. Fried (1983)
Biochemical aspects of nonshivering thermogenesis
J. Himms-Hagen (1978)
Lipolytic enzymes and plasma lipoprotein metabolism.
P. Nilsson-ehle (1980)
Effect of nutritional status on rat adipose tissue, muscle and post-heparin plasma clearing factor lipase activities: their relationship to triglyceride fatty acid uptake by fat-cells and to plasma insulin concentrations.
A. Cryer (1976)
Lipoprotein lipase activities in tissues of normal and genetically obese (ob-ob) mice.
E. Rath (1974)
Palmitate Metabolism and Norepinephrine Sensitivity in Brown Adipose, Liver, and White Adipose Tissues of Zucker Rats 1
T. R. Kasser (1982)
The utilization of ketone bodies by the interscapular brown adipose tissue of the rat.
L. Agius (1981)
Importance of muscle lipoprotein lipase in rats during suckling.
E. Planche (1980)

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J. Huguet (1989)
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K. Mori (2000)
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L. A. Smolin (1986)
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S. Kersten (2014)
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P. S. Mir (2012)
Effects of fasting on lipoprotein lipase activity in different depots of white and brown adipose tissues in diet-induced overweight rats.
I. Lladó (1999)
Weight cycling-induced alteration in fatty acid metabolism.
M. M. Sea (2000)
Energy utilization in food-restricted female rats.
J. Hill (1986)
An improved procedure for the isolation of rat brown adipose tissue cells.
M. Vendrell (1988)
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