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Dietary Oxidized Linoleic Acid Modifies Lipid Composition Of Rat Liver Microsomes And Increases Their Fluidity.

E. Hochgraf, S. Mokady, U. Cogan
Published 1997 · Biology, Medicine

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The effect of dietary oxidized oil on the lipid composition, fluidity and function of rat liver microsomes was studied. Male growing rats were fed diets containing 10 g/100 g of a fresh (control) or oxidized (experimental) linoleic acid-rich preparation for 4 wk. High levels of fluorescent compounds and of thiobarbituric acid reactive substances indicated the occurrence of substantial lipid peroxidation in the microsomes of the experimental rats. The fluidity of the liver microsomes derived from rats fed the experimental diet was significantly higher than that of the membranes of the controls. This was due to profound differences in lipid composition of the liver microsomes, namely, a lower cholesterol to phospholipid molar ratio and a greater arachidonic acid content in the phospholipids of the rats fed the experimental diet. The fluidity differences were accompanied by greater activity of the microsomal enzymes, aldehyde dehydrogenase and NADPH cytochrome C reductase. The study demonstrated that ingestion of oxidized lipids caused profound alterations in membrane composition, fluidity and function. These alterations are likely to be associated with an enhanced cholesterol turnover, as indicated by the greater cholesterol excretion observed for the experimental rats.
This paper references
Effects of a fraction of thermally oxidized soy bean oil on growing rats
P. Benedetti (1987)
10.1002/IJCH.197400078
Fluidity and Order in the Hydrocarbon‐Water Interface of Synthetic and Biological Micelles as Determined by Fluorescence Polarization
M. Shinitzky (1974)
10.1111/J.1432-1033.1973.TB02956.X
Lipid peroxidation of rat-liver microsomes. Its effect on the microsomal membrane and some membrane-bound microsomal enzymes.
J. Högberg (1973)
Official Methods of Analysis
W. Horwitz (1980)
Role of acyl-CoA: cholesterol acyltransferase in cellular cholesterol metabolism.
K. Suckling (1985)
10.1093/JN/103.10.1502
Mode of action of selenium and vitamin E in prevention of exudative diathesis in chicks.
T. Noguchi (1973)
10.1146/ANNUREV.NU.06.070186.001333
Regulation of cholesterol biosynthesis.
H. Rudney (1986)
10.1093/ajcn/53.4.1050S
Protective role of vitamin E in biological systems.
L. Packer (1991)
10.1159/000177791
Liver microsomal mixed-function oxidases in response to polyunsaturated/saturated and n-6/n-3 fatty acid ratios of dietary lipids in rats.
M. Saito (1994)
10.3177/JNSV.35.25
Succinate dehydrogenase and synthetic pathways of glucose 6-phosphate are also the markers of the toxicity of orally administered secondary autoxidation products of linoleic acid in rat liver.
Kazuki Kanazawa (1989)
10.1093/JN/124.3.331
Dietary fat saturation and chain length modulate guinea pig hepatic cholesterol metabolism.
M. Fernández (1994)
10.3177/JNSV.39.411
Response of liver microsomal mixed-function oxidases to dietary linoleic acid levels in rats.
M. Saito (1993)
10.1016/0005-2760(88)90338-4
The alpha-tocopherol and phospholipid fatty acid content of rat liver subcellular membranes in vitamin E and selenium deficiency.
J. Buttriss (1988)
10.1016/0271-5317(95)00065-Q
Dietary oxidized oil and the activity of antioxidant enzymes and lipoprotein peroxidation in rats
I. Hayam (1995)
10.1007/BF02668129
Quantitative analysis of phospholipids by thin-layer chromatography and phosphorus analysis of spots
G. Rouser (2007)
10.1111/j.1365-2141.1986.tb02906.x
Changes in fluidity and composition of erythrocyte membranes and in composition of plasma lipids in Type I diabetes
M. Bryszewska (1986)
Stimulation of HMG-CoA reductase as a consequence of phenobarbital-induced primary stimulation of cholesterol 7 alpha-hydroxylase in rat liver.
E. Sudjana-Sugiaman (1994)
10.1007/978-1-4684-4667-8_20
Membrane Fluidity and Receptor Function
M. Shinitzky (1984)
10.1152/AJPGI.1993.264.3.G561
Effect of dietary lipid peroxides on metabolism of serum chylomicrons in rats.
I. Staprans (1993)
A simple method for the isolation and purification of total lipides from animal tissues.
J. Folch (1957)
10.1021/JF00037A009
Influence of diet on lipid oxidation and membrane structure in porcine muscle microsomes
F. Monahan (1994)
10.1007/BF02545589
The use of thiobarbituric acid as a measure of fat oxidation
C. G. Sidwell (1954)
The analysis of fats and oils
V. C. Mehlenbacher (1960)
10.1007/BF02612488
Estimating carbonyl compounds in rancid fats and foods
A. S. Henick (1954)
10.1016/0891-5849(91)90021-T
Vitamin E, diethylmaleate and bromotrichloromethane interactions in oxidative damage in vivo.
C. Dillard (1991)
10.1016/0955-2863(93)90024-Q
Dietary oxidized oil enhances the activity of (Na+K+) ATPase and acetylcholinesterase and lowers the fluidity of rat erythrocyte membrane
I. Hayam (1993)
10.1093/JN/120.8.857
Riboflavin deficiency and the function and fluidity of rat erythrocyte membranes.
G. Levin (1990)
10.1016/0955-2863(95)00152-2
Dietary influences on membrane function : importance in protection against oxidative damage and disease
H. Wiseman (1996)
10.1093/JN/126.6.1635
Dietary protein modifies oxidized cholesterol-induced alterations of linoleic acid and cholesterol metabolism in rats.
K. Osada (1996)
10.1159/000177532
Effect of dietary vitamin E on the toxicity of autoxidized oil to rats.
H. Yoshida (1989)
10.1016/0003-9861(89)90081-7
Oxidation of aldehydic products of lipid peroxidation by rat liver microsomal aldehyde dehydrogenase.
D. Y. Mitchell (1989)



This paper is referenced by
10.1023/A:1007046931427
Membrane changes in rat erythrocyte ghosts on ghee feeding
T. Niranjan (2004)
Biological assessment and methods to evaluate lipid peroxidation when feeding thermally-oxidized lipids to young pigs.
Pai Liu (2012)
10.1007/s11745-998-0206-x
The effect of dietary vitamin E supply and a moderately oxidized oil on activities of hepatic lipogenic enzymes in rats
K. Eder (1998)
10.1111/ANU.12057
Dietary high level of vitamin premix can eliminate oxidized fish oil–induced oxidative damage and loss of reducing capacity in juvenile largemouth bass (Micropterus salmoides)
Y. Yuan (2014)
10.1007/S003940070027
Chronic vitamin E inadequacy and thermally treated oils affect the synthesis of hepatic metallothionein isoforms
G. Stangl (2000)
10.1093/JN/133.9.2830
Thermally oxidized dietary fats increase the susceptibility of rat LDL to lipid peroxidation but not their uptake by macrophages.
K. Eder (2003)
10.1016/J.JNUTBIO.2005.08.011
Differential action of 13-HPODE on PPARalpha downstream genes in rat Fao and human HepG2 hepatoma cell lines.
B. König (2006)
10.3389/fphys.2020.00712
Interplay Between Plasma Membrane Lipid Alteration, Oxidative Stress and Calcium-Based Mechanism for Extracellular Vesicle Biogenesis From Erythrocytes During Blood Storage
Anne-Sophie Cloos (2020)
10.1007/s11745-999-0418-0
The effects of a dietary oxidized oil on lipid metabolism in rats
K. Eder (1999)
10.1023/A:1021172620295
Amyloid Beta Peptide Membrane Perturbation Is the Basis for its Biological Effects
J. Kanfer (2004)
10.1007/s11745-998-0267-x
Dietary oxidized cholesterol modulates cholesterol metabolism and linoleic acid desaturation in rats fed high-cholesterol diets
K. Osada (1998)
10.1016/j.brainres.2007.12.006
Contribution of calpain activation to early stages of hippocampal damage during oxygen–glucose deprivation
M. Grammer (2008)
10.1024/0300-9831.76.6.398
Research paper effects of 13-HPODE on expression of genes involved in thyroid hormone synthesis, iodide uptake and formation of hydrogen peroxide in porcine thyrocytes.
S. Luci (2006)
10.1016/B978-1-893997-92-9.50015-3
Nutritional and Physiological Effects of Used Frying Oils and Fats
G. Márquez-Ruiz (2007)
10.21608/eajbsc.2020.100600
The Protective Effect of Cinnamon against Thermally Oxidized Palm Oil in Broiler Chickens
S. A. Ali (2020)
10.1201/9781420006902.ch36
Biological effects of oxidized fatty acids.
C. Chow (2000)
10.1016/J.BCP.2006.10.027
Activation of PPARalpha lowers synthesis and concentration of cholesterol by reduction of nuclear SREBP-2.
B. König (2007)
Phospholipid and Free Fatty Acid Content of Rat Brain Mitochondria Following Linseed Dietary Supplementation
E. Petrova (2017)
10.1515/jbcpp-2016-0138
Aged coconut oil with a high peroxide value induces oxidative stress and tissue damage in mercury-treated rats
S. Abarikwu (2018)
10.1093/JN/130.7.1800
Depletion of α-Tocopherol and Astaxanthin in Atlantic Salmon (Salmo salar) Affects Autoxidative Defense and Fatty Acid Metabolism
J. G. Bell (2000)
10.1093/JN/137.9.2018
Thermally oxidized oil increases the expression of insulin-induced genes and inhibits activation of sterol regulatory element-binding protein-2 in rat liver.
Alexander M. Koch (2007)
10.1371/journal.pone.0134733
In Vivo Effects of Free Form Astaxanthin Powder on Anti-Oxidation and Lipid Metabolism with High-Cholesterol Diet
Y. Chen (2015)
10.1016/S0304-4165(99)00039-2
Dietary soybean protein moderates the deleterious disturbance of lipid metabolism caused by exogenous oxidized cholesterol in rats.
K. Osada (1999)
10.1016/S1388-1981(00)00119-0
Phospholipase A(2)s and lipid peroxidation.
S. Nigam (2000)
10.1021/jp503381r
Lipid-modified polyethylenimine-mediated DNA attraction evaluated by molecular dynamics simulations.
S. Bagai (2014)
10.22358/JAFS/68037/2000
The response of rats to long-term feeding with diets containing oxidized fat. 2. Biochemical indicators in the serum, liver, and bone mineralization.
J. Juśkiewcz (2000)
10.4137/LPI.S904
Changes and Effects of Dietary Oxidized Lipids in the Gastrointestinal Tract
Gloria Márquez-Ruiz (2008)
10.1111/J.1439-0396.1998.TB00631.X
VITAMIN E STATUS AND TISSUE FATTY ACID COMPOSITION IN RATS FED A MODERATELY OXIDIZED SOYBEAN OIL AT LOW OR HIGH VITAMIN E SUPPLY
K. Eder (1998)
Anti-cancer effects of Momordica charantia in-vitro
G. Manoharan (2011)
10.1007/S11746-009-1368-5
Carob Fruit Polyphenols Reduce Tocopherol Loss, Triacylglycerol Polymerization and Oxidation in Heated Sunflower Oil
Daniele C Zulim Botega (2009)
10.4141/CJAS09095
Dietary lipid oxidation and vitamin E supplementation influence in vivo erythrocyte traits and postmortem leg muscle lipid oxidation in broiler chickens.
A. Schiavone (2010)
10.1016/J.ANIFEEDSCI.2010.07.011
The use of recycled oils from the food industry in growing rabbit feeds in substitution of fresh oil does not affect performance
E. Blas (2010)
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