Online citations, reference lists, and bibliographies.
← Back to Search

Flavin-containing Polyamine Oxidase Is A Hydrogen Peroxide Source In The Oxidative Response To The Protein Phosphatase Inhibitor Cantharidin In Zea Mays L.

A. Cona, G. Rea, M. Botta, F. Corelli, R. Federico, R. Angelini
Published 2006 · Medicine, Biology

Cite This
Download PDF
Analyze on Scholarcy
Share
In this study, the specific contribution of polyamine oxidase (PAO), a hydrogen peroxide (H2O2)-producing enzyme, to the oxidative burst induced in maize mesocotyl by the phosphatase inhibitor cantharidin was examined. For this purpose, a pharmacological approach was applied using, either in vitro or in vivo, two strong inhibitors of maize PAO (MPAO), N-prenylagmatine (G3) and its structural analogue Ro5, as well as diphenyleneiodonium (DPI), an inhibitor of the phagocyte NAD(P)H oxidase. DPI was shown to be a good MPAO inhibitor in vitro. G3, Ro5, and DPI were very effective in inhibiting in vivo the extracellular accumulation of H2O2 that is released by mesocotyl segments upon spermidine supply. G3 and Ro5 did not show any inhibition in vitro of either horseradish peroxidase or barley oxalate oxidase. Moreover, G3 and Ro5 did not inhibit the extracellular accumulation of superoxide radical that is released in vivo upon NADH supply. G3, Ro5, and DPI strongly affected H2O2 production induced in maize mesocotyl by cantharidin. Histochemical localization of H2O2 in cantharidin-treated mesocotyl cross-sections revealed an increase of H2O2-specific staining in the epidermal and subepidermal tissues. The effect was also inhibited by G3 and DPI. Moreover, an increase in MPAO activity was observed in the same tissues upon cantharidin treatment. All these data suggest that G3 and Ro5 behave as powerful and selective inhibitors of MPAO activity either in vitro or in vivo and that MPAO activity contributes to a major part of the cantharidin-induced H2O2 synthesis in the apoplastic milieu of maize mesocotyl.
This paper references
10.1046/J.1439-0434.2002.00816.X
Polyamine metabolism in an incompatible interaction between barley and the powdery mildew fungus, Blumeria graminis f. sp. hordei
T. Cowley (2002)
10.1104/pp.103.024737
Induction of Hypersensitive Cell Death by Hydrogen Peroxide Produced through Polyamine Degradation in Tobacco Plants1
Hiroshi Yoda (2003)
10.1016/0031-9422(89)85004-6
Properties of the polyamine oxidase from the cell wall of maize seedlings
R. Federico (1989)
10.1016/S1369-5266(02)00285-6
Complexity, cross talk and integration of plant MAP kinase signalling.
C. Jonak (2002)
Intraprotoplasmic and walllocalised formation of arabinoxylanbound diferulates and larger ferulate couplingproducts in maize cellsuspension cultures
SC Fry (2000)
10.1242/dev.00998
LRR-containing receptors regulating plant development and defense
Anne Diévart (2004)
10.1104/pp.104.044784
Production of Reactive Oxygen Intermediates (O2˙−, H2O2, and ˙OH) by Maize Roots and Their Role in Wall Loosening and Elongation Growth
A. Liszkay (2004)
10.1038/nature01485
Reactive oxygen species produced by NADPH oxidase regulate plant cell growth
J. Foreman (2003)
10.1016/0169-4758(94)90161-9
Superoxide dismutase.
E. James (1994)
10.1104/PP.127.1.159
Regulation of the Arabidopsis transcriptome by oxidative stress.
R. Desikan (2001)
10.1016/J.PBI.2004.03.005
Reactive oxygen signalling: the latest news.
C. Laloi (2004)
10.1016/S0176-1617(89)80179-8
Histochemical Evidence of Polyamine Oxidation and Generation of Hydrogen Peroxide in the Cell Wall
R. Angelini (1989)
10.1021/jm00072a016
Novel hypotensive agents from Verbesina caracasana. 2. Synthesis and pharmacology of caracasanamide.
G. Delle Monache (1993)
10.1016/S0076-6879(94)33021-2
[18] Ferrous ion oxidation in presence of ferric ion indicator xylenol orange for measurement of hydroperoxides
S. Wolff (1994)
10.2165/00128415-199606230-00027
Nitric oxide
I. Rovira (1995)
10.1016/0960-894X(96)00079-0
Synthesis and preliminary pharmacological evaluation of analogues of caracasanamide, a hypotensive natural product
F. Corelli (1996)
and defense
M Dixon (1953)
10.1016/0003-2697(76)90527-3
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.
M. M. Bradford (1976)
10.1016/S0014-5793(98)00311-1
Maize polyamine oxidase: primary structure from protein and cDNA sequencing
P. Tavladoraki (1998)
10.1016/0092-8674(92)90530-P
Elicitor- and wound-induced oxidative cross-linking of a proline-rich plant cell wall protein: A novel, rapid defense response
D. Bradley (1992)
10.1111/J.1399-3054.1995.TB00959.X
The cryptic-growth response of maize coleoptiles and its relationship to H2O2-dependent cell wall stiffening
M. Hohl (1995)
10.1007/BF00196879
Hydrogen peroxide-mediated cell-wall stiffening in vitro in maize coleoptiles
P. Schopfer (2004)
10.1093/JEXBOT/53.372.1367
The apoplastic oxidative burst in response to biotic stress in plants: a three-component system.
G. Bolwell (2002)
Abscisic acid activation of plasma membrane Ca channels in guard cells
Y Murata (2001)
10.1038/35021067
Calcium channels activated by hydrogen peroxide mediate abscisic acid signalling in guard cells
Zhen-Ming Pei (2000)
10.1046/J.1365-313X.2002.01342.X
The plasma membrane oxidase NtrbohD is responsible for AOS production in elicited tobacco cells.
F. Simon-Plas (2002)
10.1007/s004250050544
De-etiolation causes a phytochrome-mediated increase of polyamine oxidase expression in outer tissues of the maize mesocotyl: a role in the photomodulation of growth and cell wall differentiation
M. Laurenzi (1999)
10.1016/0014-5793(90)80974-N
Hydrogen peroxide production during experimental protein glycation
Z. Y. Jiang (1990)
rbohA, a rice
KE Kosack (1996)
10.1093/emboj/cdg277
NADPH oxidase AtrbohD and AtrbohF genes function in ROS‐dependent ABA signaling in Arabidopsis
J. Kwak (2003)
10.1007/s00425-003-1028-1
Evidence for the involvement of cell wall peroxidase in the generation of hydroxyl radicals mediating extension growth
A. Liszkay (2003)
10.1104/PP.126.3.1055
Role of auxin-induced reactive oxygen species in root gravitropism.
J. H. Joo (2001)
NADH - stimulated , cyanideresistant superoxide production in maize coleoptiles analyzed with a tetrazoliumbased assay
G Frahry (2001)
10.1016/S0005-2728(99)00049-3
The plasma membrane NADH oxidase of HeLa cells has hydroquinone oxidase activity.
T. Kishi (1999)
10.1105/tpc.13.1.179
Hydrogen Peroxide Acts as a Second Messenger for the Induction of Defense Genes in Tomato Plants in Response to Wounding, Systemin, and Methyl Jasmonate
M. Orozco-Cárdenas (2001)
10.1080/14756360109162364
Inhibition of Pig Liver and Zea mays L. Polyamine Oxidase: A Comparative Study
R. Federico (2001)
10.1042/BJ3550795
Involvement of mitogen-activated protein kinase activation in the signal-transduction pathways of the soya bean oxidative burst.
A. T. Taylor (2001)
10.1104/pp.104.055483
Spatial and Temporal Distribution of Polyamine Levels and Polyamine Anabolism in Different Organs/Tissues of the Tobacco Plant. Correlations with Age, Cell Division/Expansion, and Differentiation1
K. Paschalidis (2005)
10.1038/415977a
MAP kinase signalling cascade in Arabidopsis innate immunity
T. Asai (2002)
10.1021/BI036152Z
Molecular basis for the binding of competitive inhibitors of maize polyamine oxidase.
A. Cona (2004)
at Pennsylvania State University on February 20 Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B
Cona (2003)
10.1006/JMBI.1999.3310
Sequence and structure-based prediction of eukaryotic protein phosphorylation sites.
N. Blom (1999)
10.1016/S0168-9452(00)00380-0
FAD-containing polyamine oxidases: a timely challenge for researchers in biochemistry and physiology of plants.
M. Šebela (2001)
Arabidopsis gp 91 phox homologues AtrbohD and AtrbohF are required for accumulation of reactive oxygen intermediates in the plant defence response
MA Torres (2002)
maize coleoptiles and its relationship to H2O2-dependent cellwall stiffening
R Huckelhoven (1999)
10.1038/29087
Nitric oxide functions as a signal in plant disease resistance
M. Delledonne (1998)
10.1080/15216540211474
Oxalate, Germins, and Higher‐Plant Pathogens
B. Lane (2002)
10.1046/J.1365-313X.1998.00136.X
Six Arabidopsis thaliana homologues of the human respiratory burst oxidase (gp91phox).
M. A. Torres (1998)
10.1038/nature01681
Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B
R. V. Montfort (2003)
Nicotiana benthamiana gp91(phox) homologs NbrbohA and NbrbohB participate in H 2 O 2 accumulation and resistance to Phytophthora infestans
H Yoshioka (2003)
Solution and solid - phase synthesis of amino - alkylguanidines inhibiting polyamine oxidase and nitric oxide synthase
T Cowley (2002)
10.1016/S1360-1385(03)00135-3
Reactive oxygen species and hormonal control of cell death.
Kirk Overmyer (2003)
Oxidation state of the activesite cysteine in protein tyrosine phosphatase 1 B
RL vanMontfort (2003)
10.1016/0092-8674(94)90544-4
H2O2 from the oxidative burst orchestrates the plant hypersensitive disease resistance response
Alex Levine (1994)
10.1146/ANNUREV.PP.37.060186.001121
Cross-Linking of Matrix Polymers in the Growing Cell Walls of Angiosperms
S. Fry (1986)
10.1104/pp.010646
Copper Amine Oxidase Expression in Defense Responses to Wounding and Ascochyta rabiei Invasion1
G. Rea (2002)
10.1105/tpc.008680
Nicotiana benthamiana gp91phox Homologs NbrbohA and NbrbohB Participate in H2O2 Accumulation and Resistance to Phytophthora infestans Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.008680.
H. Yoshioka (2003)
10.1046/J.1432-1327.2001.02296.X
A barley polyamine oxidase isoform with distinct structural features and subcellular localization.
M. Cervelli (2001)
of polyamine oxidase
N Blom (1999)
10.1111/J.1365-313X.2004.02234.X
A subset of hypersensitive response marker genes, including HSR203J, is the downstream target of a spermine signal transduction pathway in tobacco.
Yoshihiro Takahashi (2004)
10.1007/s004250000376
NADH-stimulated, cyanide-resistant superoxide production in maize coleoptiles analyzed with a tetrazolium-based assay
G. Frahry (2001)
age, cell division/expansion, and differentiation
ZM Pei (2000)
10.1021/JM991004L
Novel hypotensive agents from Verbesina caracasana. 6. Synthesis and pharmacology of caracasandiamide.
M. Carmignani (1999)
10.1016/S0176-1617(11)81346-5
Sub-cellular localization and tissue distribution of polyamine oxidase in maize (Zea mays L.) seedlings.
Maria Ida Augeri (1990)
10.1073/pnas.231178298
Signal interactions between nitric oxide and reactive oxygen intermediates in the plant hypersensitive disease resistance response
M. Delledonne (2001)
10.1104/pp.105.063941
Sites and Regulation of Polyamine Catabolism in the Tobacco Plant. Correlations with Cell Division/Expansion, Cell Cycle Progression, and Vascular Development1
K. Paschalidis (2005)
Histochemical evidence of of polyamine oxidation and hydrogen peroxide generation in the cell wall
R. Angelini (1989)
10.1104/pp.103.036764
Ectopic Expression of Maize Polyamine Oxidase and Pea Copper Amine Oxidase in the Cell Wall of Tobacco Plants1
G. Rea (2004)
Arabidopsis OST1 protein kinase mediates the regulation of stomatal aperture by abscisic acid and acts upstream of reactive oxygen production
Ac Mustilli (2002)
10.1016/0009-8981(81)90049-8
The application of a sensitive uricase-peroxidase couple reaction to a centrifugal fast analyser for the determination of uric acid.
J. D. Artiss (1981)
10.1104/pp.011379
Polyamine Oxidase, a Hydrogen Peroxide-Producing Enzyme, Is Up-Regulated by Light and Down-Regulated by Auxin in the Outer Tissues of the Maize Mesocotyl1
A. Cona (2003)
10.1104/pp.103.020792
Redox Control of Protein Tyrosine Phosphatases and Mitogen-Activated Protein Kinases in Plants
R. Gupta (2003)
10.1104/PP.119.4.1251
Hypersensitive cell death and papilla formation in barley attacked by the powdery mildew fungus are associated with hydrogen peroxide but not with salicylic acid accumulation
Huckelhoven (1999)
Ascochyta rabiei invasion
L Requena (1999)
Solution and solid-phase synthesis of aminoalkylguanidines inhibiting polyamine oxidase and nitric oxide synthase
F. Corelli (2002)
10.1046/J.1365-313X.1996.10030515.X
rbohA, a rice homologue of the mammalian gp91phox respiratory burst oxidase gene.
Q. Groom (1996)
10.1007/s40278-019-57243-4
Hydrogen peroxide
M. Schmeißer (1999)
10.1016/S0031-9422(98)00004-1
Inhibition of O2-reducing activity of horseradish peroxidase by diphenyleneiodonium.
G. Frahry (1998)
10.1042/BJ3320507
Oxidative scission of plant cell wall polysaccharides by ascorbate-induced hydroxyl radicals.
S. Fry (1998)
10.1104/PP.122.4.1379
Extracellular H(2)O(2) induced by oligogalacturonides is not involved in the inhibition of the auxin-regulated rolB gene expression in tobacco leaf explants.
D. Bellincampi (2000)
10.1073/PNAS.97.6.2940
Functional analysis of oxidative stress-activated mitogen-activated protein kinase cascade in plants.
Y. Kovtun (2000)
10.1042/BJ2900041
Studies on the inhibitory mechanism of iodonium compounds with special reference to neutrophil NADPH oxidase.
B. O’Donnell (1993)
10.1089/15230860260196272
Redox control of protein tyrosine phosphorylation.
H. Yamamura (2002)
10.1074/JBC.M406314200
Diphenyleneiodonium Inhibits the Cell Redox Metabolism and Induces Oxidative Stress*
C. Riganti (2004)
10.1007/978-1-4684-5637-0_54
Purification of polyamine oxidase from maize seedlings by immunoadsorbent column.
R. Federico (1988)
10.1007/s00425-004-1435-y
Cellular re-distribution of flavin-containing polyamine oxidase in differentiating root and mesocotyl of Zea mays L. seedlings
A. Cona (2004)
10.1073/pnas.012452499
Arabidopsis gp91phox homologues AtrbohD and AtrbohF are required for accumulation of reactive oxygen intermediates in the plant defense response
M. A. Torres (2001)
10.1016/0022-1759(85)90337-0
Detection of monoclonal antibodies specific for carbohydrate epitopes using periodate oxidation.
M. Woodward (1985)
10.1073/PNAS.92.10.4120
Role of phosphorylation in elicitation of the oxidative burst in cultured soybean cells.
S. Chandra (1995)
10.1042/BJ3430185
Barley (Hordeum vulgare) oxalate oxidase is a manganese-containing enzyme.
L. Requena (1999)
10.1016/S0969-2126(99)80037-9
A 30 Å long U-shaped catalytic tunnel in the crystal structure of polyamine oxidase
C. Binda (1999)
10.3109/10715769709065766
The tetrazolium dyes MTS and XTT provide new quantitative assays for superoxide and superoxide dismutase.
M. Sutherland (1997)
10.1007/s004250000330
Intraprotoplasmic and wall-localised formation of arabinoxylan-bound diferulates and larger ferulate coupling-products in maize cell-suspension cultures
S. Fry (2000)
10.1105/tpc.007906
Arabidopsis OST1 Protein Kinase Mediates the Regulation of Stomatal Aperture by Abscisic Acid and Acts Upstream of Reactive Oxygen Species Production Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.007906.
A. Mustilli (2002)
10.1042/BJ0550170
The determination of enzyme inhibitor constants.
M. Dixon (1953)



This paper is referenced by
10.1007/s00425-014-2027-0
Constitutive S-adenosylmethionine decarboxylase gene expression increases drought tolerance through inhibition of reactive oxygen species accumulation in Arabidopsis
Soo Jin Wi (2014)
10.1104/pp.108.122614
Apoplastic Polyamine Oxidation Plays Different Roles in Local Responses of Tobacco to Infection by the Necrotrophic Fungus Sclerotinia sclerotiorum and the Biotrophic Bacterium Pseudomonas viridiflava1[W]
M. Marina (2008)
10.1016/j.phytochem.2014.06.003
A proposed interplay between peroxidase, amine oxidase and lipoxygenase in the wounding-induced oxidative burst in Pisum sativum seedlings.
T. Roach (2015)
Enhancement of research interests in physiology and biochemistry of blister beetles (Coleoptera: Meloidae):A review
Karem S. Ghoneim (2013)
10.3389/fpls.2017.01445
Hydrogen Peroxide Is Involved in β-Cyclodextrin-hemin Complex-Induced Lateral Root Formation in Tomato Seedlings
W. Cui (2017)
10.1093/jxb/erp256
Polyamine oxidase activity contributes to sustain maize leaf elongation under saline stress.
A. A. Rodríguez (2009)
Thermotolerance and Antioxidant Response Induced by Putrescine and Heat Acclimation in Wheat Seedlings
Bavita Asthir (2011)
10.1104/pp.110.171413
Perturbation of spermine synthase Gene Expression and Transcript Profiling Provide New Insights on the Role of the Tetraamine Spermine in Arabidopsis Defense against Pseudomonas viridiflava1[C][W]
M. González (2011)
10.1111/j.1365-3040.2011.02387.x
Redox regulation in plant programmed cell death.
M. D. de Pinto (2012)
10.1071/FP19264
Biochemical and molecular approach of oxidative damage triggered by water stress and rewatering in sunflower seedlings of two inbred lines with different ability to tolerate water stress.
Federico Arcos Ramírez (2020)
10.1007/s00709-017-1139-3
Polyamines increase nitric oxide and reactive oxygen species in guard cells of Arabidopsis thaliana during stomatal closure
Srinivas Agurla (2017)
10.1016/j.freeradbiomed.2011.03.036
Involvement of calcium-mediated effects on ROS metabolism in the regulation of growth improvement under salinity.
M. Shoresh (2011)
10.1002/9781119468677.ch37
H2O2, NO, and H2S
C. J. da-Silva (2019)
10.1016/j.jplph.2011.01.007
Polyamine catabolism is involved in response to salt stress in soybean hypocotyls.
María Paula Campestre (2011)
10.1007/s00726-011-1012-1
Polyamine catabolism: target for antiproliferative therapies in animals and stress tolerance strategies in plants
P. Tavladoraki (2011)
10.3389/fpls.2016.00824
Copper-Containing Amine Oxidases and FAD-Dependent Polyamine Oxidases Are Key Players in Plant Tissue Differentiation and Organ Development
P. Tavladoraki (2016)
10.3390/plants4030489
Cell Wall Amine Oxidases: New Players in Root Xylem Differentiation under Stress Conditions
Sandip Annasaheb Ghuge (2015)
10.1186/s12864-019-6109-z
2-DE-based proteomic analysis of protein changes associated with etiolated mesocotyl growth in Zea mays
Liangjie Niu (2019)
10.1007/s11427-020-1773-7
Formyl tetrahydrofolate deformylase affects hydrogen peroxide accumulation and leaf senescence by regulating the folate status and redox homeostasis in rice.
Erhui Xiong (2020)
10.7717/peerj.3050
Real-time monitoring of superoxide anion radical generation in response to wounding: electrochemical study
Ankush Prasad (2017)
10.1371/journal.pone.0120708
Spermine Alleviates Drought Stress in White Clover with Different Resistance by Influencing Carbohydrate Metabolism and Dehydrins Synthesis
Z. Li (2015)
The influence of UV-B type radiation of different wavelengths on the activity of the antioxidant enzymes throughout the development of the Zea mays L. plants under low temperature conditions.
M. Orodan (2013)
10.1016/j.plaphy.2014.05.004
Wound healing response and xylem differentiation in tobacco plants over-expressing a fungal endopolygalacturonase is mediated by copper amine oxidase activity.
Alessandra Cona (2014)
10.3389/fpls.2016.00230
Hydrogen Peroxide Signaling in Plant Development and Abiotic Responses: Crosstalk with Nitric Oxide and Calcium
Lijuan Niu (2016)
Extracellular production of reactive oxygen species in response to abiotic stress in seeds
T. Roach (2009)
10.1080/03235400802425754
Infection induced defence responses in sorghum, with special emphasis on accumulation of reactive oxygen species and cell wall modifications
Puttalingaiah Basavaraju (2010)
10.3389/fpls.2014.00095
Physiological and molecular implications of plant polyamine metabolism during biotic interactions
J. F. Jiménez-Bremont (2014)
10.1007/978-3-030-11129-8
Nitric Oxide and Hydrogen Peroxide Signaling in Higher Plants
D. Gupta (2019)
10.1104/pp.16.01118
An NADPH-Oxidase/Polyamine Oxidase Feedback Loop Controls Oxidative Burst Under Salinity1
K. Gémes (2016)
10.1007/978-981-13-1244-1_12
Mechanism of Stomatal Closure in Plants Exposed to Drought and Cold Stress.
Srinivas Agurla (2018)
PRELIMINARY STUDIES REGARDING THE INFLUENCE OF UV RADIATIONS WITH DIFFERENT WAVELENGHTS ON TISSUE SAMPLES FROM ZEA MAYS
M. Orodan (2013)
10.1104/pp.107.108902
Involvement of Polyamine Oxidase in Wound Healing12[W]
R. Angelini (2007)
See more
Semantic Scholar Logo Some data provided by SemanticScholar