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The Structure Of Signal Peptides From Bacterial Lipoproteins.

G. Heijne
Published 1989 · Biology

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Statistical analysis of lipoprotein and non-lipoprotein signal peptides reveals that the two classes differ significantly only in the region close to the signal peptidase cleavage site. This region is apolar and has the consensus sequence LA(G,A) decreases C in the lipoproteins, but is polar and has small, uncharged residues in positions -3 and -1 in the non-lipoproteins. A simple search for matches to the lipoprotein consensus cleavage site suffices to discriminate between the two groups with close to 100% reliability.
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This paper is referenced by
10.1128/JB.180.14.3570-3577.1998
The D-xylose-binding protein, XylF, from Thermoanaerobacter ethanolicus 39E: cloning, molecular analysis, and expression of the structural gene.
M. Erbeznik (1998)
10.1111/j.1365-2958.1990.tb02065.x
Cysteine‐rich outer membrane proteins of Chlamydia trachomatis display compensatory sequence changes between biovariants
J. E. Allen (1990)
Computational prediction and comparative analysis of protein subcellular localization in bacteria
J. Gardy (2006)
CHARACTERISATION, RECOMBINANT EXPRESSION AND IMMUNOGENICITY OF BHLP29.7, AN OUTER MEMBRANE LIPOPROTEIN OF BRACHYSPIRA HYODYSENTERIAE
T. La (2006)
10.1074/jbc.274.40.28191
The Potential Active Site of the Lipoprotein-specific (Type II) Signal Peptidase of Bacillus subtilis *
H. Tjalsma (1999)
10.1007/s002030000201
Molecular analysis of the ggtBCD gene cluster of Synechocystis sp. strain PCC6803 encoding subunits of an ABC transporter for osmoprotective compounds
S. Mikkat (2000)
Archaeal signal peptides — A comparative survey at the genome data
S. L. Bardy (2003)
10.1111/J.1432-1033.1993.TB18143.X
Characterization of the nisin gene cluster nisABTCIPR of Lactococcus lactis. Requirement of expression of the nisA and nisI genes for development of immunity.
O. Kuipers (1993)
10.1101/GR.3257305
Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
S. Lewenza (2005)
10.1128/JB.05813-11
The extended signal peptide of the trimeric autotransporter EmaA of Aggregatibacter actinomycetemcomitans modulates secretion.
X. Jiang (2011)
10.1046/J.1432-1327.2001.02193.X
Biochemical characterization and identification of catalytic residues in alpha-glucuronidase from Bacillus stearothermophilus T-6.
G. Zaide (2001)
10.1128/AEM.68.8.3932-3942.2002
The Peptidyl-Prolyl Isomerase Motif Is Lacking in PmpA, the PrsA-Like Protein Involved in the Secretion Machinery of Lactococcus lactis
S. Drouault (2002)
10.1016/J.VIROL.2006.03.001
The ltp gene of temperate Streptococcus thermophilus phage TP-J34 confers superinfection exclusion to Streptococcus thermophilus and Lactococcus lactis.
Xingmin Sun (2006)
10.1101/GR.9.12.1189
Regulation of the alpha-galactosidase activity in Streptococcus pneumoniae: characterization of the raffinose utilization system.
C. Rosenow (1999)
Fluorescent Biomarkers for Membrane Separation
Anja Ruud Winther (2015)
10.1016/bs.ampbs.2016.07.003
The Journey of Lipoproteins Through the Cell: One Birthplace, Multiple Destinations.
J. Szewczyk (2016)
Receptors in the Regulation of Suicidal Erythrocyte
Eberhard Karls (2009)
10.1016/bs.apcsb.2015.03.003
Recombinant Lipoproteins as Novel Vaccines with Intrinsic Adjuvant.
P. Chong (2015)
10.1099/13500872-145-6-1369
A novel protein of Erysipelothrix rhusiopathiae that confers haemolytic activity on Escherichia coli.
S. Makino (1999)
10.1093/FEMSPD/FTW110
Excavating the surface-associated and secretory proteome of Mycobacterium leprae for identifying vaccines and diagnostic markers relevant immunodominant epitopes.
A. Rana (2016)
10.1128/9781555815530.CH12
What Genomics Has Taught Us about Gram-Positive Protein Secretion and Targeting
O. Schneewind (2007)
10.1016/j.bbamcr.2013.11.009
Sec-secretion and sortase-mediated anchoring of proteins in Gram-positive bacteria.
O. Schneewind (2014)
10.1046/j.1365-2958.1997.6542024.x
KapB is a lipoprotein required for KinB signal transduction and activation of the phosphorelay to sporulation in Bacillus subtilis
V. Dartois (1997)
10.1007/s00203-001-0364-4
Biochemical and antigenic characterisation of Mycoplasma gallisepticum membrane proteins P52 and P67 (pMGA)
G. Jan (2001)
10.1016/j.bbamcr.2014.04.022
Secretion of bacterial lipoproteins: through the cytoplasmic membrane, the periplasm and beyond.
W. Zückert (2014)
10.1099/13500872-141-3-611
Resistance of Neisseria gonorrhoeae to antimicrobial hydrophobic agents is modulated by the mtrRCDE efflux system.
Kayla E. Hagman (1995)
10.1128/MMBR.64.3.515-547.2000
Signal Peptide-Dependent Protein Transport inBacillus subtilis: a Genome-Based Survey of the Secretome
H. Tjalsma (2000)
10.1073/pnas.1707813114
Structural insights into lipoprotein N-acylation by Escherichia coli apolipoprotein N-acyltransferase
C. Noland (2017)
From Sequence to Sorting : Prediction of Signal Peptides
H. Nielsen (1999)
10.1074/JBC.M411232200
The Neisseria meningitidis Outer Membrane Lipoprotein FrpD Binds the RTX Protein FrpC*
Kateřina Procházková (2005)
10.1016/S0378-1097(03)00843-7
Cloning and molecular characterization of a unique hemolysin gene of Vibrio pommerensis sp. nov.: development of a DNA probe for the detection of the hemolysin gene and its use in identification of related Vibrio spp. from the Baltic Sea.
J. Jores (2003)
stearothermophilus Geobacillus Xylo-Oligosaccharides in Expression of an ABC Transporter for A Two-Component System Regulates the
Shoham Langut (2006)
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