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New Horizons In The Pathogenesis, Diagnosis And Management Of Sarcopenia
A. Sayer, S. Robinson, H. Patel, Tea Shavlakadze, C. Cooper, M. Grounds
Published 2013 · Medicine
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Sarcopenia is the age-related loss of skeletal muscle mass and function. It is now recognised as a major clinical problem for older people and research in the area is expanding exponentially. One of the most important recent developments has been convergence in the operational definition of sarcopenia combining measures of muscle mass and strength or physical performance. This has been accompanied by considerable progress in understanding of pathogenesis from animal models of sarcopenia. Well-described risk factors include age, gender and levels of physical activity and this knowledge is now being translated into effective management strategies including resistance exercise with recent interest in the additional role of nutritional intervention. Sarcopenia is currently a major focus for drug discovery and development although there remains debate about the best primary outcome measure for trials, and various promising avenues to date have proved unsatisfactory. The concept of ‘new tricks for old drugs’ is, however, promising, for example, there is some evidence that the angiotensin-converting enzyme inhibitors may improve physical performance. Future directions will include a deeper understanding of the molecular and cellular mechanisms of sarcopenia and the application of a lifecourse approach to understanding aetiology as well as to informing the optimal timing of interventions.
This paper references
Dietary protein recommendations and the prevention of sarcopenia
D. Paddon-Jones (2009)
Developmental influences, muscle morphology, and sarcopenia in community-dwelling older men.
H. Patel (2012)
Hormone replacement therapy and physical function in healthy older men. Time to talk hormones?
M. Giannoulis (2012)
Muscle strength in older community-dwelling men is related to type of milk feeding in infancy.
S. Robinson (2012)
Dietary protein and exercise training in ageing.
R. Koopman (2011)
Advantages of dietary, exercise-related, and therapeutic interventions to prevent and treat sarcopenia in adult patients: an update
D. Waters (2010)
Strategies for reducing oxidative damage in ageing skeletal muscle.
M. Jackson (2009)
Mammalian target of rapamycin complex 1 activation is required for the stimulation of human skeletal muscle protein synthesis by essential amino acids.
J. Dickinson (2011)
Systematic literature review of randomized control trials assessing the effectiveness of nutrition interventions in community-dwelling older adults.
Kristofer Bandayrel (2011)
Protein and energy supplementation in elderly people at risk from malnutrition.
A. C. Milne (2009)
Vitamin D-related changes in physical performance: A systematic review
C. Annweiler (2009)
Nutrition and Sarcopenia: A Review of the Evidence and Implications for Preventive Strategies
S. Robinson (2012)
Distribution of different fiber types in human skeletal muscles: Effects of aging studied in whole muscle cross sections
J. Lexell (1983)
Figure 3. A lifecourse approach to sarcopenia
Quantification of Ceroid and Lipofuscin in Skeletal Muscle
Hatice Tohma (2011)
Progressive resistance strength training for improving physical function in older adults.
Chiung-Ju Liu (2009)
Synthesis, modification and turnover of proteins during aging.
S. Rattan (2010)
The developmental origins of sarcopenia
A. Sayer (2008)
Dietary implications on mechanisms of sarcopenia: roles of protein, amino acids and antioxidants.
J. Kim (2010)
Delayed but excellent myogenic stem cell response of regenerating geriatric skeletal muscles in mice
T. Shavlakadze (2009)
Of bears, frogs, meat, mice and men: complexity of factors affecting skeletal muscle mass and fat
T. Shavlakadze (2006)
Figure 3. A lifecourse approach to sarcopenia [47
The Healthcare Costs of Sarcopenia in the United States
I. Janssen (2004)
Role of the nervous system in sarcopenia and muscle atrophy with aging: strength training as a countermeasure
P. Aagaard (2010)
Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia.
R. Fielding (2011)
Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials
H. Bischoff-Ferrari (2009)
Frailty and sarcopenia: definitions and outcome parameters
C. Cooper (2012)
Vitamin D and Human Skeletal Muscle
B. Hamilton (2010)
Vitamin D deficiency and frailty in older Americans
E. Wilhelm-Leen (2010)
Factors contributing to neuromuscular impairment and sarcopenia during aging
E. Edström (2007)
Activation of mTOR signalling in young and old human skeletal muscle in response to combined resistance exercise and whey protein ingestion.
M. Farnfield (2012)
Considerations in the Development of Drugs to Treat Sarcopenia
E. Brass (2011)
Current patterns of diet in community-dwelling older men and women: results from the Hertfordshire Cohort Study.
S. Robinson (2009)
Yufei Li (2011)
The anabolic response to resistance exercise and a protein-rich meal is not diminished by age
T. B. Symonsi (2011)
Muscle atrophy in immobilization and senescence in humans
A. Murton (2009)
Aa Sayer (2010)
International working group on Sarcopenia
W. C. Chumlea (2011)
Objectively measured physical capability levels and mortality: systematic review and meta-analysis
R. Cooper (2010)
Oxidative stress as a therapeutic target during muscle wasting: considering the complex interactions
P. Arthur (2008)
Frailty and the role of nutrition in older people. A review of the current literature.
M. Kaiser (2010)
Striking Denervation of Neuromuscular Junctions without Lumbar Motoneuron Loss in Geriatric Mouse Muscle
R. Chai (2011)
Adverse events associated with testosterone administration.
S. Basaria (2010)
Interventions for preventing falls in older people living in the community.
L. Gillespie (2009)
Sarcopenia: characteristics, mechanisms and functional significance.
M. Narici (2010)
Does sarcopenia originate in early life? Findings from the Hertfordshire cohort study.
A. Sayer (2004)
Exercise for improving balance in older people.
T. Howe (2007)
ACE inhibitors for sarcopenia--as good as exercise training?
M. Witham (2008)
Orally administered leucine enhances protein synthesis in skeletal muscle of diabetic rats in the absence of increases in 4E-BP1 or S6K1 phosphorylation.
J. Anthony (2002)
Dietary protein intake is associated with lean mass change in older, community-dwelling adults: the Health, Aging, and Body Composition (Health ABC) Study.
D. Houston (2008)
Grip strength and cardiovascular drug use in older people: findings from the Hertfordshire Cohort Study.
T. A. Ashfield (2010)
Type 2 diabetes, muscle strength, and impaired physical function: the tip of the iceberg?
A. Sayer (2005)
Absence of insulin signalling in skeletal muscle is associated with reduced muscle mass and function: evidence for decreased protein synthesis and not increased degradation
E. O'neill (2009)
European working group on sarcopenia in older people. Sarcopenia: European consensus on definition and diagnosis: report of the European working group on sarcopenia in older people
A. Cruz-Jentoft (2010)
This paper is referenced by
Modeling human cancer cachexia in colon 26 tumor-bearing adult mice
E. Talbert (2014)
Normative data for handgrip strength in children and adolescents in the Maule Region, Chile: Evaluation based on chronological and biological age
R. Gomez-Campos (2018)
Effects of Blood Flow Restriction Training with Protein Supplementation on Muscle Mass And Strength in Older Men.
C. Centner (2019)
The impact of diet and physical activity on skeletal muscle mass and strength in Caucasian women: implications for sarcopenia prevention
K. Shilland (2015)
Macrophage Depletion in Elderly Mice Improves Response to Tumor Immunotherapy, Increases Anti-tumor T Cell Activity and Reduces Treatment-Induced Cachexia
Lelinh Duong (2018)
Improving nutritional status assessment in patients with chronic pancreatitis.
A. D. Hintaran (2018)
Associação entre sarcopenia com variáveis de qualidade de vida em idosos quilombolas
S. Néto (2016)
78IS GRIP STRENGTH ASSOCIATED WITH LUNG FUNCTION IN OLDER HOSPITALISED PATIENTS
S. J. Holmes (2014)
МОЛЕКУЛЯРНЫЕ АСПЕКТЫ ПАТОГЕНЕЗА САРКОПЕНИИ ПРИ ХРОНИЧЕСКОЙ БОЛЕЗНИ ПОЧЕК: ИНТЕГРАТИВНАЯ РОЛЬ mTOR
M. G. Gasanov (2018)
The Pilates method improves the relationship agonist-antagonist flexor and extensor knee in elderly: a randomized controlled trial.
Deise A. A. Pires-Oliveira (2015)
Age-related change in muscle mass, strength and function in healthy adult Irish women
P. Francis (2014)
Evaluation of Sarcopenia in Renal Transplant Recipients
N. Ozkayar (2014)
Life Expectancy, Health, and Functioning Among the 85-Plus Population in Europe and the United States
E. Crimmins (2013)
Mortality in the Hertfordshire Ageing Study: association with level and loss of hand grip strength in later life
H. Syddall (2017)
A NEW PROPOSAL FOR THE CLINICAL-FUNCTIONAL CATEGORIZATION OF THE ELDERLY: VISUAL SCALE OF FRAILTY (VS-FRAILTY)
E. Moraes (2016)
Efectividad de una intervención multifactorial para la modificación de parámetros de fragilidad en población anciana
L. Liebana (2019)
Association between APOE Genotype and Change in Physical Function in a Population-Based Swedish Cohort of Older Individuals Followed Over Four Years
I. Skoog (2016)
The association between blood concentration of 25- hydroxyvitamin D and sarcopenia: a meta-analysis.
J. Luo (2018)
Skeletal muscle degeneration and regeneration in mice and flies.
Mamta Rai (2014)
Validation of the Thai version of SARC-F, MSRA-7, and MSRA-5 questionnaires compared to AWGS 2019 and sarcopenia risks in older patients at a medical outpatient clinic
Phuriwat Akarapornkrailert (2020)
Advanced quantitative methods in correlating sarcopenic muscle degeneration with lower extremity function biometrics and comorbidities
K. Edmunds (2018)
The short-term effects of a sports stacking intervention on the cognitive and perceptual motor functioning in geriatrics.
R. Naidoo (2018)
Sarcopenia, malnutrition and nutrient density in older people
A. Smith (2014)
Transforming the future of ageing
Jean-Pierre Michel (2019)
L'impact de la consommation de protéines post exercice en résistance sur la faim, l'appétit et l'apport énergétique subséquent des hommes âgés sarcopéniques
Morgane Du Bois-dit-Bonclaude (2015)
Malnutrition in hospitalised patients and clinical outcomes : a missed opportunity?
Su Lin Lim (2014)
Go-sha-jinki-Gan (GJG), a traditional Japanese herbal medicine, protects against sarcopenia in senescence-accelerated mice.
Y. Kishida (2015)
Therapies for sarcopenia and regeneration of old skeletal muscles
M. Grounds (2014)
Bridging the gap between the laboratory and the clinic for patients with sarcopenia
M. Witham (2018)
Clinical Outcomes of Impaired Muscle and Bone Interactions
O. Demontiero (2014)
Self-reported walking speed: a useful marker of physical performance among community-dwelling older people?
H. Syddall (2015)
The Combination of Physical Exercise with Muscle-Directed Antioxidants to Counteract Sarcopenia: A Biomedical Rationale for Pleiotropic Treatment with Creatine and Coenzyme Q10
M. Guescini (2017)See more