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Anemia And Iron Deficiency: Effects On Pregnancy Outcome.

Lindsay H Allen
Published 2000 · Medicine
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This article reviews current knowledge of the effects of maternal anemia and iron deficiency on pregnancy outcome. A considerable amount of information remains to be learned about the benefits of maternal iron supplementation on the health and iron status of the mother and her child during pregnancy and postpartum. Current knowledge indicates that iron deficiency anemia in pregnancy is a risk factor for preterm delivery and subsequent low birth weight, and possibly for inferior neonatal health. Data are inadequate to determine the extent to which maternal anemia might contribute to maternal mortality. Even for women who enter pregnancy with reasonable iron stores, iron supplements improve iron status during pregnancy and for a considerable length of time postpartum, thus providing some protection against iron deficiency in the subsequent pregnancy. Mounting evidence indicates that maternal iron deficiency in pregnancy reduces fetal iron stores, perhaps well into the first year of life. This deserves further exploration because of the tendency of infants to develop iron deficiency anemia and because of the documented adverse consequences of this condition on infant development. The weight of evidence supports the advisability of routine iron supplementation during pregnancy.
This paper references
Protection of maternal iron stores in pregnancy.
Dawson Eb (1987)
10.1046/j.1365-2257.1996.00170.x
Erythrocyte ferritin in human neonates: maternofetal iron kinetics revisited.
Gilbert Tchernia (1996)
10.1046/j.1365-3016.1997.d01-16.x
The influence of maternal nutritional factors on intrauterine growth retardation in Brazil.
Patricia Helen Rondó (1997)
10.1016/0020-7292(81)90072-2
Maternal mortality at twelve teaching hospitals in Indonesia-an epidemiologic analysis.
I C Chi (1981)
10.1111/j.1753-4887.1992.tb07719.x
New insights into placental iron transport.
Edward D. Harris (1992)
10.1093/ajcn/71.5.1285s
Maternal hemoglobin concentration and birth weight.
Phillip J. Steer (2000)
10.1159/000243421
Relationship between newborn and maternal iron status and haematological indices.
Terence T Lao (1991)
10.1111/j.1471-0528.1979.tb10611.x
Red cell mass during and after normal pregnancy.
David J. Taylor (1979)
Controversies in therapeutics . Iron and folate supplements in pregnancy : supplementation is valuable only in selected patients
BM Hibbard (1993)
10.1093/ajcn/6.4.376
The Influence of Maternal Iron Deficiency on the Newborn
Thomas R.C. Sisson (1958)
10.1016/0143-4004(95)90096-9
Ferritin in cultured human cytotrophoblasts: synthesis and subunit distribution.
J. S. Starreveld (1995)
10.1038/sj.ejcn.1600517
Anaemia in pregnancy—a cross-sectional study in Singapore
K. P. Singh (1998)
10.3109/00016349309058158
Relationship between iron status in pregnant women and their newborn babies. Investigation in a Spanish population.
María José González Gaspar (1993)
10.1111/j.1479-828X.1965.tb00320.x
Severe Anaemia in Pregnancy (as seen in Kuala Lumpur, Malaysia)
Derek John Llewellyn (1965)
10.1016/0002-9378(91)90626-3
Anemia and spontaneous preterm birth
Mark A Klebanoff (1991)
Maternal hematologic levels and pregnancy outcomes.
StanleyM. Garn (1981)
10.1016/S0140-6736(86)91269-9
RELATION OF HAEMOGLOBIN LEVELS IN FIRST AND SECOND TRIMESTERS TO OUTCOME OF PREGNANCY
Joseph F. Murphy (1986)
Iron stores in pregnant Nigerians and their infants at term.
O. A. Ajayi (1988)
Relationship between maternal and neonatal iron stores.
Gülsevin Tekinalp (1996)
10.1111/j.1442-200X.1996.tb03526.x
Serum transferrin receptor levels in the evaluation of iron deficiency in the neonate.
Usha Rusia (1996)
10.1136/adc.66.4_Spec_No.422
Iron supplementation, maternal packed cell volume, and fetal growth.
Elina Hemminki (1991)
10.3109/00016348009156379
Serum ferritin as a measure of iron stores during and after normal pregnancy with and without iron supplements.
Jukka Puolakka (1980)
Effect of maternal iron deficiency anaemia on foetal outcome.
Usha Rusia (1995)
10.1093/ajcn/58.5.622
Evaluation of a gastric delivery system for iron supplementation in pregnancy.
Williams K Simmons (1993)
10.1016/0029-7844(95)00437-8
Serum Ferritin: A Predictor of Early Spontaneous Preterm Delivery
Tsunenobu Tamura (1996)
Effect of intramuscular iron therapy in anaemic pregnant women.
K. Prema (1982)
10.3109/00016347509156332
Absorption of supplemental iron during pregnancy - a longitudinal study with repeated bone-marrow studies and absorption measurements.
Bernhard Svanberg (1975)
10.1111/j.1365-3016.1994.tb00497.x
The epidemiology of perinatal death in Jamaica.
Rosemary Greenwood (1994)
10.1016/S0002-9378(94)70305-1
Maternal erythropoietin in singleton pregnancies: a randomized trial on the effect of oral hematinic supplementation.
Desmond P. J. Barton (1994)
10.2307/1966951
Maternal mortality in rural Bangladesh: the Tangail District.
M. Alauddin (1986)
Cellular immunity status in anaemia in pregnancy.
A Kandoi (1991)
10.1159/000176693
Iron supplements versus placebo during pregnancy: its effects on iron and folate status on mothers and newborns.
Jacqueline Zittoun (1983)
10.3109/00016349409023439
Iron status markers and serum erythropoietin in 120 mothers and newborn infants. Effect of iron supplementation in normal pregnancy.
Nils Thorm Milman (1994)
10.1093/tropej/43.2.89
Fetal growth in maternal anaemia.
P N Singla (1997)
10.1097/00006250-199102000-00005
The Relationship Between Maternal Hematocrit and Pregnancy Outcome
Zong MENG LU (1991)
Iron supplementation during pregnancy. Effect on iron status markers, serum erythropoietin and human placental lactogen. A placebo controlled study in 207 Danish women.
Nils Thorm Milman (1991)
10.1111/j.1471-0528.1978.tb14905.x
Routine administration of iron and vitamins during pregnancy: review of controlled clinical trials.
Elina Hemminki (1978)
10.1111/j.1651-2227.1983.tb09768.x
Cord blood haemoglobin, iron and ferritin status in maternal anaemia.
Radheshyam M. Agrawal (1983)
10.1093/ajcn/55.5.985
Anemia vs iron deficiency: increased risk of preterm delivery in a prospective study.
Theresa O. Scholl (1992)
10.1093/tropej/42.2.75
Iron status of newborns born to iron deficient anaemic mothers.
Tomiko Hokama (1996)
Impact of anaemia prophylaxis in pregnancy on maternal haemoglobin, serum ferritin & birth weight.
Kailash Nath Agarwal (1991)
10.1016/0020-7292(95)02322-4
Beyond maternal mortality--magnitude, interrelationship, and consequences of women's health, pregnancy-related complications and nutritional status on pregnancy outcomes.
Marjorie A. Koblinsky (1995)
10.1016/S0002-9378(96)70054-6
Plasma ferritin and pregnancy outcome.
Robert L Goldenberg (1996)
The prevention of anemia in pregnancy in primigravidae in the guinea savanna of Nigeria
AF Fleming (1986)
10.1093/ajcn/66.5.1178
Effect of iron supplementation on the iron status of pregnant women: consequences for newborns.
Paul Preziosi (1997)



This paper is referenced by
Consequences of maternal iron deficiency during pregnancy for the offspring Short term Long term Reduced fetal weight Increased blood pressure Asymmetric organ growth Increased glucose tolerance Fe deficiency Impaired cognitive and behavioural Lower survival rate function
Lorraine Gambling (2005)
10.1079/PNS2004385
Iron, copper and fetal development.
Lorraine Gambling (2004)
10.25911/5d7786f5a8369
Epidemiology of soil-transmitted helminth infections in Timor-Leste
Suzanne Campbell (2016)
10.17776/CSJ.522226
Assessment of Gluten-Free Food Sourced Heavy Metal Accumulation for Celiac People
Mustafa Soylak (2019)
10.3233/HAB-190388
Anaemia and thrombocytopenia among pregnant women attending Aminu Kano Teaching Hospital, Kano State, North Western Nigeria.
Osaro Erhabor (2019)
10.4269/ajtmh.2009.80.36
Geophagy (Soil-eating) in relation to Anemia and Helminth infection among HIV-infected pregnant women in Tanzania.
Kosuke Kawai (2009)
10.3390/nu8020098
Anemia and Micronutrient Status of Women of Childbearing Age and Children 6–59 Months in the Democratic Republic of the Congo
Sarah Harvey-Leeson (2016)
10.1111/jog.13569
Maternal anemia during pregnancy and slightly higher risk of asthma in male offspring
Maijakaisa Harju (2018)
10.1079/BJN2001444
Vitamin A and iron supplementation of Indonesian pregnant women benefits vitamin A status of their infants.
Marjanka K. Schmidt (2001)
10.1080/01443615.2017.1325454
Maternal haemoglobin concentration and risk of preterm birth in a Chinese population
Yiting Zhang (2018)
10.1172/jci127341
Effects of maternal iron status on placental and fetal iron homeostasis.
Veena Sangkhae (2019)
10.7897/2321-6328.01403
UMBILICAL CORD BLOOD NUTRIENTS AMONG LOW BIRTH WEIGHT AND NORMAL BIRTH WEIGHT BABIES IN PRIMARY HEALTH CARE SETUP IN LUCKNOW , INDIA
Krishna Kumar Sahu (2013)
10.1371/journal.pone.0088496
Effects of Multimicronutrient Supplementation during Pregnancy on Postnatal Growth of Children under 5 Years of Age: A Meta-Analysis of Randomized Controlled Trials
Wei-ping Lu (2014)
10.6133/apjcn.2008.17.s2.04
Recommended dietary allowances harmonization in Southeast Asia.
Corazon V. C. Barba (2008)
Technologies for Health Consultative Meeting: MNCH Pathways
Presented February (2012)
10.3109/14767051003678226
Micronutrients and women of reproductive potential: required dietary intake and consequences of dietary deficienty or excess. Part II - Vitamin D, Vitamin A, Iron, Zinc, Iodine, Essential Fatty Acids
Joe Leigh Simpson (2011)
10.1203/PDR.0b013e3181be79c2
Iron Deficiency and Renal Development in the Newborn Rat
Keri A Drake (2009)
Determination of Hemoglobin and Serum Ferritin in anemic pregnant women and their newborns in Khartoum state
El Rashid Ali Abdelgader Mulla (2016)
10.1079/BJN20031043
Mental and psychomotor development in Indonesian infants of mothers supplemented with vitamin A in addition to iron during pregnancy.
Marjanka K. Schmidt (2004)
10.1177/156482650702800405
Iron-Deficiency Anemia among Children in Southwest Iran
Bijan Keikhaei (2007)
PREVALENCE AND DETERMINANTS OF ANAEMIA IN THIRD TRIMESTER PREGNANCY IN FAYOUM GOVERNORATE-EGYPT
El Ashiry (2014)
Iron-de ciency anaemia during the rst two years of life
Magnus Domellöf (2002)
10.1177/156482650903000204
Impact of a Positive Deviance Approach to Improve the Effectiveness of an Iron-Supplementation Program to Control Nutritional Anemia among Rural Senegalese Pregnant Women
Mamadou Ndiaye (2009)
10.1093/heapol/czaa012
‘If he sees it with his own eyes, he will understand’: how gender informed the content and delivery of a maternal nutrition intervention in Burkina Faso
Jasmin Isler (2020)
10.1016/j.vhri.2019.09.008
Association of Socioeconomic Status With Childhood Anemia Among Infant, Toddler, and Preschool Children in Bangladesh.
G M Rabiul Islam (2019)
10.3390/nu12061644
Foods to Avoid While Breastfeeding? Experiences and Opinions of Polish Mothers and Healthcare Providers
Karolina Karcz (2020)
10.1093/ajcn/nqy366
Serum ferritin, soluble transferrin receptor, and total body iron for the detection of iron deficiency in early pregnancy: a multiethnic population-based study with low use of iron supplements.
Marthe-Lise Næss-Andresen (2019)
INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES
Publisher Chandrasekhara Rao Baru (2014)
Anemia, FGI, Gestational age, Hemoglobin levels, IUGR, Pregnancy outcome.
Maneesha Shrivastava (2014)
10.1002/14651858.CD011400
Food fortification with multiple micronutrients: impact on health outcomes
Jai K. Das (2014)
10.3390/nu6093747
Dietary Determinants of and Possible Solutions to Iron Deficiency for Young Women Living in Industrialized Countries: A Review
Kathryn L. Beck (2014)
10.1007/s40620-015-0191-3
Best practices on pregnancy on dialysis: the Italian Study Group on Kidney and Pregnancy
Gianfranca Cabiddu (2015)
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