Online citations, reference lists, and bibliographies.
← Back to Search

A Tale Of Two Toxicities: Malformed Selenoproteins And Oxidative Stress Both Contribute To Selenium Stress In Plants

D. Hoewyk
Published 2013 · Biology

Cite This
Download PDF
Analyze on Scholarcy
Share
BACKGROUND: Despite selenium's toxicity in plants at higher levels, crops supply most of the essential dietary selenium in humans. In plants, inorganic selenium can be assimilated into selenocysteine, which can replace cysteine in proteins. Selenium toxicity in plants has been attributed to the formation of non-specific selenoproteins. However, this paradigm can be challenged now that there is increasingly abundant evidence suggesting that selenium-induced oxidative stress also contributes to toxicity in plants. SCOPE: This Botanical Briefing summarizes the evidence indicating that selenium toxicity in plants is attributable to both the accumulation of non-specific selenoproteins and selenium-induced oxidative stress. Evidence is also presented to substantiate the claim that inadvertent selenocysteine replacement probably impairs or misfolds proteins, which supports the malformed selenoprotein hypothesis. The possible physiological ramifications of selenoproteins and selenium-induced oxidative stress are discussed. CONCLUSIONS: Malformed selenoproteins and oxidative stress are two distinct types of stress that drive selenium toxicity in plants and could impact cellular processes in plants that have yet to be thoroughly explored. Although challenging, deciphering whether the extent of selenium toxicity in plants is imparted by selenoproteins or oxidative stress could be helpful in the development of crops with fortified levels of selenium.
This paper references
10.1016/j.aquatox.2012.06.014
Accumulation of selenium in Ulva sp. and effects on morphology, ultrastructure and antioxidant enzymes and metabolites.
Michela Schiavon (2012)
10.1016/j.tplants.2010.12.006
Ancient and essential: the assembly of iron-sulfur clusters in plants.
J. Balk (2011)
10.1111/j.1365-3040.2011.02400.x
Glutathione in plants: an integrated overview.
G. Noctor (2012)
10.1007/s12011-011-9292-6
The Influence of Selenium on Root Growth and Oxidative Stress Induced by Lead in Vicia faba L. minor Plants
M. Mroczek-Zdyrska (2011)
10.1016/0891-5849(94)90007-8
On the nature of selenium toxicity and carcinostatic activity.
J. Spallholz (1994)
10.1093/jxb/ern243
Subcellular immunocytochemical analysis detects the highest concentrations of glutathione in mitochondria and not in plastids
B. Zechmann (2008)
10.1073/pnas.0810503106
Probing the role of the proximal heme ligand in cytochrome P450cam by recombinant incorporation of selenocysteine
Caroline Aldag (2009)
10.1007/978-3-642-10613-2_10
Selenium Metabolism in Plants
E. Pilon-Smits (2010)
10.1104/PP.67.5.1051
Exclusion of selenium from proteins of selenium-tolerant astragalus species.
T. A. Brown (1981)
10.1042/BJ20110025
Adenosine 5'-phosphosulfate reductase (APR2) mutation in Arabidopsis implicates glutathione deficiency in selenate toxicity.
Kevron Grant (2011)
10.1093/jxb/ers222
Selenite-induced hormonal and signalling mechanisms during root growth of Arabidopsis thaliana L.
Nóra Lehotai (2012)
10.1111/j.1744-7909.2007.00600.x
Selenium-induced changes in activities of antioxidant enzymes and content of photosynthetic pigments in Spirulina platensis.
T. Chen (2008)
10.1016/J.AQUATOX.2007.04.001
Effect of selenate on growth and photosynthesis of Chlamydomonas reinhardtii.
L. Geoffroy (2007)
10.1042/BJ20100368
Selenium compounds are substrates for glutaredoxins: a novel pathway for selenium metabolism and a potential mechanism for selenium-mediated cytotoxicity.
Marita Wallenberg (2010)
10.1104/PP.66.4.758
Identification of Selenocysteine in the Proteins of Selenate-grown Vigna radiata.
T. A. Brown (1980)
10.1089/ARS.2007.1528
From selenium to selenoproteins: synthesis, identity, and their role in human health.
L. Papp (2007)
10.1016/0167-4838(86)90205-0
High-yield chemical assembly of [2Fe-2X] (X = S, Se) clusters into spinach apoferredoxin: product characterization by resonance Raman spectroscopy
J. Meyer (1986)
10.1104/pp.109.144808
Arabidopsis Putative Selenium-Binding Protein1 Expression Is Tightly Linked to Cellular Sulfur Demand and Can Reduce Sensitivity to Stresses Requiring Glutathione for Tolerance1[W]
V. Hugouvieux (2009)
10.1104/pp.102.010280
Characterization of a NifS-Like Chloroplast Protein from Arabidopsis. Implications for Its Role in Sulfur and Selenium Metabolism1
E. Pilon-Smits (2002)
10.1007/s00299-010-0902-0
Arabidopsis root growth dependence on glutathione is linked to auxin transport
Anna Koprivova (2010)
10.1016/S0031-9422(00)89282-1
Synthesis of selenocysteine by cysteine synthases from selenium accumulator and non-accumulator plants
B.Hock Ng (1978)
10.1111/j.1399-3054.2007.01002.x
Transcriptome analyses give insights into selenium-stress responses and selenium tolerance mechanisms in Arabidopsis.
Doug van Hoewyk (2008)
10.1046/J.1365-313X.2002.01474.X
The impact of oxidative stress on Arabidopsis mitochondria.
L. Sweetlove (2002)
10.1104/pp.107.110742
Cooperative Ethylene and Jasmonic Acid Signaling Regulates Selenite Resistance in Arabidopsis1[W][OA]
M. Tamaoki (2008)
10.1104/pp.110.156570
Molecular Mechanisms of Selenium Tolerance and Hyperaccumulation in Stanleya pinnata1[W][OA]
J. L. Freeman (2010)
10.1016/j.jplph.2011.10.012
The effects of short-term selenium stress on Polish and Finnish wheat seedlings-EPR, enzymatic and fluorescence studies.
M. Łabanowska (2012)
10.1016/J.TPLANTS.2004.03.006
Role of plant heat-shock proteins and molecular chaperones in the abiotic stress response.
W. Wang (2004)
10.1111/j.1365-3040.2011.02387.x
Redox regulation in plant programmed cell death.
M. D. de Pinto (2012)
10.1371/JOURNAL.PBIO.0030375
Different Catalytic Mechanisms in Mammalian Selenocysteine- and Cysteine-Containing Methionine-R-Sulfoxide Reductases
H. Kim (2005)
10.1016/j.tplants.2009.06.006
Selenium in higher plants: understanding mechanisms for biofortification and phytoremediation.
Y. Zhu (2009)
10.1146/ANNUREV.ARPLANT.51.1.401
SELENIUM IN HIGHER PLANTS.
N. Terry (2000)
10.1016/j.plaphy.2009.11.001
The effects of Se phytotoxicity on the antioxidant systems of leaf tissues in barley (Hordeum vulgare L.) seedlings.
Mikail Akbulut (2010)
10.1016/S0308-8146(01)00115-7
Effects of selenate supplemented fertilisation on the selenium level of cereals — identification and quantification of selenium compounds by HPLC–ICP–MS
M. Stadlober (2001)
10.1071/FP07010
Selenium-induced oxidative stress in coffee cell suspension cultures.
R. A. Gomes-Junior (2007)
10.1007/s00775-009-0480-1
Characterization of a modified nitrogenase Fe protein from Klebsiella pneumoniae in which the 4Fe4S cluster has been replaced by a 4Fe4Se cluster
P. Hallenbeck (2009)
10.1080/10715760290021225
Mitochondrial Superoxide Radical Formation is Controlled by Electron Bifurcation to the High and Low Potential Pathways
K. Staniek (2002)
10.1111/j.1438-8677.2011.00535.x
Ecological aspects of plant selenium hyperaccumulation.
A. F. El Mehdawi (2012)
10.1104/pp.105.068684
Overexpression of AtCpNifS Enhances Selenium Tolerance and Accumulation in Arabidopsis1
Douglas Van Hoewyk (2005)
10.1104/pp.106.081158
Spatial Imaging, Speciation, and Quantification of Selenium in the Hyperaccumulator Plants Astragalus bisulcatus and Stanleya pinnata1
J. L. Freeman (2006)
10.1016/J.ENVEXPBOT.2012.09.002
The roles of selenium in protecting plants against abiotic stresses
R. Feng (2013)
10.1016/j.jprot.2011.12.030
Proteomics analysis reveals multiple regulatory mechanisms in response to selenium in rice.
Yu-Dong Wang (2012)
10.1111/J.1365-313X.2005.02413.X
Analysis of sulfur and selenium assimilation in Astragalus plants with varying capacities to accumulate selenium.
T. Sors (2005)
10.1074/JBC.M004985200
Substituting Selenocysteine for Catalytic Cysteine 41 Enhances Enzymatic Activity of Plant Phospholipid Hydroperoxide Glutathione Peroxidase Expressed in Escherichia coli *
S. Hazebrouck (2000)
10.1007/s13668-011-0003-x
Selenium Supplementation and Cancer Prevention
C. Davis (2012)
10.1104/pp.103.026989
Overexpression of Selenocysteine Methyltransferase in Arabidopsis and Indian Mustard Increases Selenium Tolerance and Accumulation1
D. Leduc (2004)
10.1073/pnas.1220589110
Evidence for participation of the methionine sulfoxide reductase repair system in plant seed longevity
Emilie Châtelain (2013)
10.1042/BJ1630521
Activation of selenate by adenosine 5'-triphosphate sulphurylase from Saccharomyces cerevisiae.
G. L. Dilworth (1977)
10.1177/1040638711435407
Toxicokinetics and pathology of plant-associated acute selenium toxicosis in steers
T. Z. Davis (2012)
10.1104/PP.67.5.1054
Selenium toxicity: aminoacylation and Peptide bond formation with selenomethionine.
D. Eustice (1981)
10.1089/ars.2012.5013
Selenocysteine in thiol/disulfide-like exchange reactions.
R. Hondal (2013)
10.1021/BI00177A034
The formation of diselenide bridges in proteins by incorporation of selenocysteine residues: biosynthesis and characterization of (Se)2-thioredoxin.
S. Mueller (1994)
10.1093/pcp/pcs015
Malformed selenoproteins are removed by the ubiquitin--proteasome pathway in Stanleya pinnata.
Melissa Sabbagh (2012)
10.4161/psb.3.10.6050
New insights into the roles of ethylene and jasmonic acid in the acquisition of selenium resistance in plants
M. Tamaoki (2008)
10.1016/S0883-2927(99)00035-9
Soil, grain and water chemistry in relation to human selenium-responsive diseases in Enshi District, China
F. Fordyce (2000)
10.1104/pp.106.091462
Characterization of a Selenate-Resistant Arabidopsis Mutant. Root Growth as a Potential Target for Selenate Toxicity1[OA]
Elie G El Kassis (2007)
10.1007/s00425-010-1323-6
Selenium accumulation in lettuce germplasm
S. J. Ramos (2010)
10.1007/s00425-003-1070-z
Overexpression of cystathionine-γ-synthase enhances selenium volatilization in Brassica juncea
T. Huysen (2003)
10.1371/journal.pone.0036343
Sodium Selenide Toxicity Is Mediated by O2-Dependent DNA Breaks
G. Peyroche (2012)
10.1104/pp.109.142521
Involvement of a Broccoli COQ5 Methyltransferase in the Production of Volatile Selenium Compounds[C][OA]
Xin Zhou (2009)
10.1111/J.1432-1033.1996.0235U.X
On the mechanism of selenium tolerance in selenium-accumulating plants. Purification and characterization of a specific selenocysteine methyltransferase from cultured cells of Astragalus bisculatus.
B. Neuhierl (1996)



This paper is referenced by
10.1016/j.phytochem.2020.112499
Effect of selenium-sulfur interaction on the anabolism of sulforaphane in broccoli.
Shuxiang Mao (2020)
10.3390/plants8100427
Selenium Application During Radish (Raphanus sativus) Plant Development Alters Glucosinolate Metabolic Gene Expression and Results in the Production of 4-(methylseleno)but-3-enyl glucosinolate
M. McKenzie (2019)
10.1016/j.bbagen.2018.05.006
Selenium metabolism in plants.
P. White (2018)
10.1016/j.jplph.2015.04.003
Stuck between a ROS and a hard place: Analysis of the ubiquitin proteasome pathway in selenocysteine treated Brassica napus reveals different toxicities during selenium assimilation.
Aleksandar Dimkovikj (2015)
10.1007/s10653-016-9857-6
Selenium speciation in wheat grain varies in the presence of nitrogen and sulphur fertilisers
Elliott G. Duncan (2016)
10.1002/JPLN.201800295
Selenium uptake and fruit quality of pear (Pyrus communis L.) treated with foliar Se application
X. Deng (2019)
10.1016/J.SCIENTA.2014.09.049
Mycorrhizal inoculation affected growth, mineral composition, proteins and sugars in lettuces biofortified with organic or inorganic selenocompounds
C. Sanmartín (2014)
Biochemical indicators of selenium toxicity tolerance in wheat (Triticum aestivum L.)
Manpreet Kaur (2016)
10.1111/pbi.12897
Transcriptome‐wide comparison of selenium hyperaccumulator and nonaccumulator Stanleya species provides new insight into key processes mediating the hyperaccumulation syndrome
J. Wang (2018)
10.1016/j.jplph.2015.05.009
Molybdenum accumulation, tolerance and molybdenum-selenium-sulfur interactions in Astragalus selenium hyperaccumulator and nonaccumulator species.
Rachael Ann DeTar (2015)
10.1007/978-3-319-56249-0_4
Mechanisms of Plant Selenium Hyperaccumulation
Elizabeth A H Pilon-Smits (2017)
10.1080/15592324.2016.1171451
Defects in endoplasmic reticulum-associated degradation (ERAD) increase selenate sensitivity in Arabidopsis
D. Hoewyk (2018)
10.3389/fpls.2015.00002
Exploring the importance of sulfate transporters and ATP sulphurylases for selenium hyperaccumulation—a comparison of Stanleya pinnata and Brassica juncea (Brassicaceae)
Michela Schiavon (2015)
10.1111/nph.14378
The fascinating facets of plant selenium accumulation - biochemistry, physiology, evolution and ecology.
Michela Schiavon (2017)
10.1080/10643389.2019.1598240
Understanding selenium metabolism in plants and its role as a beneficial element
R. Chauhan (2019)
10.1111/pce.12762
Loss-of-function mutations in the APX1 gene result in enhanced selenium tolerance in Arabidopsis thaliana.
L. Jiang (2016)
10.3389/fpls.2016.01371
Selenium Biofortification in Radish Enhances Nutritional Quality via Accumulation of Methyl-Selenocysteine and Promotion of Transcripts and Metabolites Related to Glucosinolates, Phenolics, and Amino Acids
Michela Schiavon (2016)
10.1016/j.ecoenv.2020.111045
Effects of different exogenous selenium on Se accumulation, nutrition quality, elements uptake, and antioxidant response in the hyperaccumulation plant Cardamine violifolia.
M. Wu (2020)
10.1016/j.chemosphere.2017.03.046
Phenotypical, physiological and biochemical analyses provide insight into selenium-induced phytotoxicity in rice plants.
M. Mostofa (2017)
10.1016/J.ENVEXPBOT.2018.03.023
Comparative effects on nutritional quality and selenium metabolism in two ecotypes of Brassica rapa exposed to selenite stress
Nannan Li (2018)
10.1016/j.ecoenv.2018.06.014
Comparative orchestrating response of four oilseed rape (Brassica napus) cultivars against the selenium stress as revealed by physio-chemical, ultrastructural and molecular profiling.
Z. Ulhassan (2018)
10.5772/intechopen.90295
Uptake, Metabolism and Toxicity of Selenium in Tropical Plants
Abiodun Humphrey Adebayo (2020)
10.1016/j.plaphy.2020.02.024
Overexpression of ethylene response factor ERF96 gene enhances selenium tolerance in Arabidopsis.
L. Jiang (2020)
10.1515/bmc-2017-0007
Recent advances in the mechanism of selenoamino acids toxicity in eukaryotic cells
M. Lazard (2017)
10.1186/s12870-014-0259-6
Selenite activates the alternative oxidase pathway and alters primary metabolism in Brassica napus roots: evidence of a mitochondrial stress response
Aleksandar Dimkovikj (2014)
10.2478/s11756-018-0017-6
Effect of sodium selenate on photosynthetic efficiency, antioxidative defence system and micronutrients in maize (Zea mays)
S. Sharma (2018)
10.1016/j.ecoenv.2019.109942
Selenomethionine induces oxidative stress and modifies growth in rice (Oryza sativa L.) seedlings through effects on hormone biosynthesis and primary metabolism.
R. P. Malheiros (2019)
ELUCIDATION OF SELENIUM TOLERANCE MECHANISMS IN Puccinellia distans ( Jacq . ) Parl . USING A TRANSCRIPTOMIC
(2018)
10.1016/j.scitotenv.2019.134541
Exposure to a high selenium environment in Punjab, India: Biomarkers and health conditions.
R. Chawla (2019)
10.1007/978-3-030-34694-2_7
Biofortification of Brassicas for Quality Improvement
M. S. Sujith Kumar (2020)
10.1016/j.jplph.2018.11.003
Plant selenium toxicity: Proteome in the crosshairs.
Z. Kolbert (2019)
10.1080/15592324.2016.1171451
Defects in endoplasmic reticulum-associated degradation (ERAD) increase selenate sensitivity in Arabidopsis
D. Van Hoewyk (2018)
See more
Semantic Scholar Logo Some data provided by SemanticScholar