← Back to Search
Gene-asbestos Interaction In Malignant Pleural Mesothelioma Susceptibility.
S. Tunesi, D. Ferrante, D. Mirabelli, S. Andorno, M. Betti, G. Fiorito, S. Guarrera, E. Casalone, M. Neri, D. Ugolini, S. Bonassi, G. Matullo, I. Dianzani, C. Magnani
Published 2015 · Medicine
Download PDFAnalyze on Scholarcy
Asbestos exposure is the main risk factor for malignant pleural mesothelioma (MPM), a rare aggressive tumor. Nevertheless, on average less than 10% of subjects highly exposed to asbestos develop MPM, suggesting the possible involvement of other risk factors. To identify the genetic factors that may modulate the risk of MPM, we conducted a gene-environment interaction analysis including asbestos exposure and 15 single nucleotide polymorphisms (SNPs) previously identified through a genome-wide association study on Italian subjects. In the present study, we assessed gene-asbestos interaction on MPM risk using relative excess risk due to interaction and synergy index for additive interaction and V index for multiplicative interaction. Generalized multifactor dimensionality reduction (GMDR) analyses were also performed. Positive deviation from additivity was found for six SNPs (rs1508805, rs2501618, rs4701085, rs4290865, rs10519201, rs763271), and four of them (rs1508805, rs2501618, rs4701085, rs10519201) deviated also from multiplicative models. However, after Bonferroni correction, deviation from multiplicative model was still significant for rs1508805 and rs4701085 only. GMDR analysis showed a strong MPM risk due to asbestos exposure and suggested a possible synergistic effect between asbestos exposure and rs1508805, rs2501618 and rs5756444. Our results suggested that gene-asbestos interaction may play an additional role on MPM susceptibility, given that asbestos exposure appears as the main risk factor.
This paper references
Global gene expression profiling of human pleural mesotheliomas: identification of matrix metalloproteinase 14 (MMP-14) as potential tumour
S Crispi (2009)
XRCC1 and ERCC1 variants modify malignant mesothelioma risk: a case-control study.
M. Betti (2011)
PLINK: a tool set for whole-genome association and population-based linkage analyses.
S. Purcell (2007)
A pooling-based genome-wide analysis identifies new potential candidate genes for atopy in the European Community Respiratory Health Survey (ECRHS)
F. Castro-Giner (2009)
The CREST Biorepository: A Tool for Molecular Epidemiology and Translational Studies on Malignant Mesothelioma, Lung Cancer, and Other Respiratory Tract Diseases
Ugolini Donatella (2008)
A complex of two centrosomal proteins, CAP350 and FOP, cooperates with EB1 in microtubule anchoring.
Xiumin Yan (2006)
The CREST biorepository: a tool for molecular epidemiology and translational studies on malignant mesothelioma, lung cancer, and other respiratory tract diseases.
D. Ugolini (2008)
Genetic Variants Associated with Increased Risk of Malignant Pleural Mesothelioma: A Genome-Wide Association Study
G. Matullo (2013)
A combinatorial approach to detecting gene-gene and gene-environment interactions in family studies.
Xiang-Yang Lou (2008)
Genetic susceptibility to malignant mesothelioma and exposure to asbestos: the influence of the familial factor.
D. Ugolini (2008)
Mesothelioma in blood related subjects: report of 11 clusters among 1954 Italy cases and review of the literature.
V. Ascoli (2007)
Second Italian consensus conference on malignant pleural mesothelioma: state of the art and recommendations.
C. Pinto (2013)
Identification of a commonly amplified 4.3 Mb region with overexpression of C8FW, but not MYC in MYC-containing double minutes in myeloid malignancies.
C. Storlazzi (2004)
The Third Italian Consensus Conference for Malignant Pleural Mesothelioma: State of the art and recommendations.
S. Novello (2016)
Relation between exposure to asbestos and smoking jointly and the risk of lung cancer
P. Lee (2001)
XRCC 1 and ERCC 1 variants modify malignant mesothelioma risk : a case - control study
G. Matullo (2011)
In Arrayed Ranks: Array Technology in the Study of Mesothelioma
S. Gray (2009)
Familial aggregation of malignant mesothelioma in former workers and residents of Wittenoom, Western Australia
N. de Klerk (2013)
Genome-Wide Association Analysis of Eating Disorder-Related Symptoms, Behaviors, and Personality Traits
V. Boraska (2012)
Genetic susceptibility to malignant pleural mesothelioma and other asbestos-associated diseases.
M. Neri (2008)
Polymorphisms in DNA repair genes as risk factors for asbestosrelated malignant mesothelioma in a general population study
I Dianzani (2006)
A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence.
Xiang-Yang Lou (2007)
Melanoma: targeting signaling pathways and RaLP.
Luigi Pasini (2009)
Applied Logistic Regression.
A. Scott (1991)
Global Gene Expression Profiling Of Human Pleural Mesotheliomas: Identification of Matrix Metalloproteinase 14 (MMP-14) as Potential Tumour Target
S. Crispi (2009)
What's wrong with Bonferroni adjustments
T. Perneger (1998)
Polymorphisms in DNA repair genes as risk factors for asbestos-related malignant mesothelioma in a general population study.
I. Dianzani (2006)
Melanoma: targeting signaling pathways and RaLP
Luigi Pasini (2009)
Confidence Intervals for Measures of Interaction
S. Assmann (1996)
Breakpoints of burkitt's lymphoma t(8;22) translocations map within a distance of 300 kb downstream of MYC
R. Zeidler (1994)
A genome-wide association study for malignant mesothelioma risk.
G. Cadby (2013)
Confidence interval estimation of interaction.
D. Hosmer (1992)
Increased risk of malignant mesothelioma of the pleura after residential or domestic exposure to asbestos: a case-control study in Casale Monferrato, Italy.
C. Magnani (2001)
A review of transcriptome studies combined with data mining reveals novel potential markers of malignant pleural mesothelioma.
O. Melaiu (2012)
This paper is referenced by
Risk of second primary cancers after malignant mesothelioma and vice versa.
Tianhui Chen (2016)
Oncogenetics of Lung Cancer Induced by Environmental Carcinogens
Victor D Martinez (2018)
Asbestos-Related Pleural Diseases: The Role of Gene-Environment Interactions
V. Dolžan (2019)
Malignant Mesothelioma and Delivery of Polyphenols
K. Bishop (2016)
Inherited Genetic Mutations and Polymorphisms in Malignant Mesothelioma: A Comprehensive Review
V. Panou (2020)
Genomics and Epigenetics of Malignant Mesothelioma
Adam P Sage (2018)
The Potential Protective Effects of Polyphenols in Asbestos-Mediated Inflammation and Carcinogenesis of Mesothelium
M. Benvenuto (2016)
Interactions between polymorphisms in the 3′untranslated region of the cyclin dependent kinase 6 gene and the human papillomavirus infection, and risk of cervical precancerous lesions
X. Ye (2017)
The Prognostic Role of TNM Staging Compared With Tumor Volume and Number of Pleural Sites in Malignant Pleural Mesothelioma.
C. Proto (2019)
ERS/ESTS/EACTS/ESTRO guidelines for the management of malignant pleural mesothelioma
A. Scherpereel (2020)
Prostate Carcinoma and Pleural Mesothelioma: An Extremely Rare Co-occurrence
Tej Prakash Soni (2019)
Gene-Environment Interactions: The Case of Asbestosis
V. Dolžan (2017)
The role of gene–environment interplay in occupational and environmental diseases: current concepts and knowledge gaps
Elizabeth Kwo (2017)
Pathway Analyses Identify Novel Variants in the WNT Signaling Pathway Associated with Tuberculosis in Chinese Population
X. Hu (2016)
Malignant pleural mesothelioma in a 17-year old boy: A case report and literature review
C. Pérez-Guzmán (2016)
Interaction between susceptibility loci in cGAS-STING pathway, MHC gene and HPV infection on the risk of cervical precancerous lesions in Chinese population
Di Xiao (2016)
Incidence and familial risk of pleural mesothelioma in Sweden: a national cohort study
J. Ji (2016)
The role of Mean Platelet Volume/platelet count Ratio and Neutrophil to Lymphocyte Ratio on the risk of Febrile Seizure
Zhi-gang Liu (2018)
Matrix Metalloproteinases Polymorphisms as Baseline Risk Predictors in Malignant Pleural Mesothelioma
Danijela Štrbac (2018)
ERS/ESTS/EACTS/ESTRO guidelines for the management of malignant pleural mesothelioma.
I. Opitz (2020)
Malignant pleural mesothelioma: Presentation of a case report
Munir Ahmad (2018)
Interaction Between Susceptibility Loci in MAVS and TRAF3 Genes, and High-risk HPV Infection on the Risk of Cervical Precancerous Lesions in Chinese Population
Di Xiao (2018)
Pleural mesothelioma and lung cancer: the role of asbestos exposure and genetic variants in selected iron metabolism and inflammation genes
F. Celsi (2019)
Sensitivity to asbestos is increased in patients with mesothelioma and pathogenic germline variants in BAP1 or other DNA repair genes
M. Betti (2018)
Genetic predisposition for malignant mesothelioma: A concise review.
M. Betti (2019)