Online citations, reference lists, and bibliographies.
← Back to Search

Wnt Signaling And The Activation Of Myogenesis In Mammals

G. Cossu, U. Borello
Published 1999 · Biology, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
In the amniote embryos, specification of skeletal myoblasts occurs in the paraxial mesoderm in response to a number of signaling molecules produced by neighboring tissues such as neural tube, notochord and dorsal ectoderm. Candidate molecules for this complex signaling activity include Sonic hedgehog, Wnts and Noggin as positive activators and BMP4 as a possible inhibitor. Recently, the receptors and the post‐receptor pathways for Sonic hedgehog and Wnts have been characterized, and this has opened up the possibility of linking these signaling events to the activation of myogenic regulatory factor genes such as Myf5 and MyoD and functionally related genes such as Pax3. Here we focus on the role of Wnts, their putative receptors Frizzled and the soluble antagonist Frzb1 in regulating mammalian myogenesis. Although it is becoming evident that the signaling downstream of Frizzled receptors is much more complex than anticipated, it is conceivable that it may lead to transcriptional activation of Myf5 and MyoD and to initiation of myogenesis. However, the fact that both Wnts and Sonic hedgehog have a strong effect on cell proliferation and survival suggests that they may contribute to the overall process of myogenesis by a combination of these different biological activities.
This paper references
Casein kinase I transduces
J. M. Peters (1999)
Sonic hedgehog controls epaxial muscle determination through Myf5 activation.
A. Borycki (1999)
10.1006/EXCR.1999.4592
Uno, nessuno e centomila: searching for the identity of mesodermal progenitors.
P. Bianco (1999)
10.1016/S0960-9822(99)80018-9
Sonic hedgehog signaling by the Patched–Smoothened receptor complex
M. Murone (1999)
10.1146/ANNUREV.BIOCHEM.67.1.753
TGF-beta signal transduction.
J. Massagué (1998)
10.1128/MCB.19.4.2853
Activated Notch Inhibits Myogenic Activity of the MADS-Box Transcription Factor Myocyte Enhancer Factor 2C
J. Wilson-Rawls (1999)
10.1038/376768A0
Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud
F. Bladt (1995)
Wnt signaling from the dorsal neural tube is required for the formation of the medial dermomyotome.
M. Ikeya (1998)
Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds.
B. Parr (1993)
Differential activation of Myf 5 and MyoD by different Wnts in explants of mouse paraxial mesoderm and the later activation of myogenesis in the absence of Myf 5
S. Tajbakhsh (1998)
10.1038/22214
Signal transduction: Neither straight nor narrow
M. Peifer (1999)
10.1016/S0092-8674(00)81921-2
Frzb-1 Is a Secreted Antagonist of Wnt Signaling Expressed in the Spemann Organizer
L. Leyns (1997)
10.1038/374350A0
Dorsalizing signal Wnt-7a required for normal polarity of D–V and A–P axes of mouse limb
B. Parr (1995)
Differential response of embryonic and fetal myoblasts to TGFβ: a possible regulatory mechanism of skeletal muscle
M. G. Cusella-DeAngelis (1994)
Dorsalization by Wnt 7 a of DV and AP axes of mouse limb
B. A. Parr (1995)
10.1016/0092-8674(94)90009-4
Patterning of mammalian somites by surface ectoderm and notochord: Evidence for sclerotome induction by a hedgehog homolog
C. Fan (1994)
Pax-3 is required for the development of limb muscles: a possible role for the migration of dermomyotomal muscle progenitor cells.
E. Bober (1994)
10.1016/S0092-8674(00)81198-8
Myogenesis: A View from Drosophila
M. Baylies (1998)
Sonic hedgehog is required for survival of both myogenic and chondrogenic somitic lineages.
M. Teillet (1998)
Mouse limb muscle
S. Tajbakhsh (1994)
WNT3a regulates AER formation and utilizes an intracellular signaling pathway distinct from the dorsoventral signal WNT7a during chick limb morphogenesis
M. Kengaku (1998)
10.1016/S0070-2153(08)60381-6
Cellular mechanisms of wingless/Wnt signal transduction.
H. Dierick (1999)
Notch signaling imposes two distinct blocks in the differentiation of C2C12 myoblasts.
D. Nofziger (1999)
10.1073/PNAS.91.2.747
Mouse limb muscle is determined in the absence of the earliest myogenic factor myf-5.
S. Tajbakhsh (1994)
10.1101/GAD.9.23.2911
Combinatorial signaling by Sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite.
A. Münsterberg (1995)
10.1016/S0925-4773(99)00205-1
Differential expression of the Wnt putative receptors Frizzled during mouse somitogenesis
U. Borello (1999)
10.1016/S0959-437X(97)80011-1
Establishing myogenic identity during somitogenesis.
S. Tajbakhsh (1997)
10.1016/S0959-437X(98)80122-6
Somitogenesis: segmenting a vertebrate.
M. McGrew (1998)
10.1007/s004290050276
Sonic hedgehog enhances somite cell viability and formation of primary slow muscle fibers in avian segmented mesoderm
G. Cann (1999)
10.1016/0092-8674(92)90507-9
Targeted inactivation of the muscle regulatory gene Myf-5 results in abnormal rib development and perinatal death
T. Braun (1992)
Control of somite patterning by Sonic hedgehog and its downstream signal response genes.
A. Borycki (1998)
10.1016/S0960-9822(99)80310-8
Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in aG-protein-dependent manner
L. C. Sheldahl (1999)
10.1016/S0092-8674(00)81922-4
Frzb, a Secreted Protein Expressed in the Spemann Organizer, Binds and Inhibits Wnt-8
S. Wang (1997)
10.1101/GAD.13.2.225
Sonic hedgehog promotes somitic chondrogenesis by altering the cellular response to BMP signaling.
L. Murtaugh (1999)
Uno, Nessuno E Centomila
L. Pirandello (1983)
Mouse Wnt genes exhibit discrete domains of expression in early embryonic CNS and limb
B. A. Parr (1993)
10.1038/382225A0
A new member of the frizzled family from Drosophila functions as a Wingless receptor
P. Bhanot (1996)
10.1006/DBIO.1995.1130
Myogenic specification of somites is mediated by diffusible factors.
N. Buffinger (1995)
Transplacental delivery of the Wnt antagonist Frzb1 inhibits development of caudal paraxial mesoderm and skeletal myogenesis in mouse embryos.
U. Borello (1999)
10.1007/s004410051281
Genetic and epigenetic control of muscle development in vertebrates
B. Brand-Saberi (1999)
Noggin acts downstream of Wnt and Sonic Hedgehog to antagonize BMP4 in avian somite patterning.
E. Hirsinger (1997)
10.1016/S0092-8674(00)81291-X
Lateral and Axial Signals Involved in Avian Somite Patterning: A Role for BMP4
O. Pourquié (1996)
10.1073/PNAS.90.11.5242
Control of dorsoventral patterning of somitic derivatives by notochord and floor plate.
O. Pourquié (1993)
10.1126/SCIENCE.280.5367.1274
Distinct WNT pathways regulating AER formation and dorsoventral polarity in the chick limb bud.
M. Kengaku (1998)
Sonic Hedgehog induces proliferation of committed skeletal muscle cells in the chick limb.
D. Duprez (1998)
Coordinate actions of BMPs, Wnts, Shh and noggin mediate patterning of the dorsal somite.
C. Marcelle (1997)
Differential activation of Myf5 and MyoD by different Wnts in explants of mouse paraxial mesoderm and the later activation of myogenesis in the absence of Myf5.
S. Tajbakhsh (1998)
10.1016/S0070-2153(08)60382-8
Seeking muscle stem cells.
J. Miller (1999)
Differential response of embryonic and fetal myoblasts to TGF beta: a possible regulatory mechanism of skeletal muscle histogenesis.
M. G. Cusella-De Angelis (1994)
Disruption of the mouse MRF 4 gene identifies multiple waves of myogenesis in the myotome Development
M. Peifer (1995)
Dorsalization by Wnt7a of DV and AP axes of mouse
B. A. Parr (1995)
10.1016/0168-9525(96)10025-1
How is myogenesis initiated in the embryo?
G. Cossu (1996)
Activation of different myogenic pathways: myf-5 is induced by the neural tube and MyoD by the dorsal ectoderm in mouse paraxial mesoderm.
G. Cossu (1996)
10.1038/43830
Casein kinase I transduces Wnt signals
John M. Peters (1999)
10.1016/S0955-0674(99)80031-3
Regulation of LEF-1/TCF transcription factors by Wnt and other signals.
Q. Eastman (1999)
Myogenesis in paraxial mesoderm: preferential induction by dorsal neural tube and by cells expressing Wnt-1.
H. Stern (1995)
MyoD and Myf-5 differentially regulate the development of limb versus trunk skeletal muscle.
B. Kablar (1997)
Disruption of the mouse MRF4 gene identifies multiple waves of myogenesis in the myotome.
A. Patapoutian (1995)
10.1146/ANNUREV.CELLBIO.14.1.59
Mechanisms of Wnt signaling in development.
A. Wodarz (1998)
Patterning of mammalian somites by dorsal ectoderm and notochord: evidence for sclerotome induction by a hedgehog
C. Fan (1994)
Frzb1 is a secreted antagonist of Wnt signaling expressed in the Spemann
L. Leyns (1997)
10.1016/S0092-8674(00)80189-0
Redefining the Genetic Hierarchies Controlling Skeletal Myogenesis: Pax-3 and Myf-5 Act Upstream of MyoD
S. Tajbakhsh (1997)
10.1006/DBIO.1995.0008
The in vivo expression of the FGF receptor FREK mRNA in avian myoblasts suggests a role in muscle growth and differentiation.
C. Marcelle (1995)



This paper is referenced by
Uterine Lipoleiomyoma: Review of literature and Two Case Reports
N. Kandemir (2011)
10.1242/dev.02517
The Wnt/β-catenin pathway regulates Gli-mediated Myf5 expression during somitogenesis
U. Borello (2006)
10.1111/J.1432-0436.2006.00129.X
Wnt/β-catenin pathway activation and myogenic differentiation are induced by cholesterol depletion
C. Mermelstein (2007)
10.1093/NAR/29.14.3041
Genomic cloning of the Hsc71 gene in the hermaphroditic teleost Rivulus marmoratus and analysis of its expression in skeletal muscle: identification of a novel muscle-preferred regulatory element.
J. H. Park (2001)
Carboxypeptidase Z ( CPZ ) modulates Wnt signaling and regulates the development of skeletal elements in the chicken
Rhv ()
10.1002/jcsm.12011
The delayed recovery of the remobilized rat tibialis anterior muscle reflects a defect in proliferative and terminal differentiation that impairs early regenerative processes
Lamia Slimani (2015)
10.1016/j.molmet.2020.101078
Wnt/β-catenin signaling regulates adipose tissue lipogenesis and adipocyte-specific loss is rigorously defended by neighboring stromal-vascular cells
Devika P Bagchi (2020)
10.1007/s00018-019-03373-1
Vertebrate cranial mesoderm: developmental trajectory and evolutionary origin
Bhakti Vyas (2019)
10.1002/GENE.20107
Temporally controlled targeted somatic mutagenesis in skeletal muscles of the mouse
M. Schuler (2005)
10.1038/labinvest.3700509
Wnt signaling and human diseases: what are the therapeutic implications?
Jinyong Luo (2007)
10.1089/SCD.2007.0058
Skeletal muscle development and regeneration.
S. Grefte (2007)
10.1371/journal.pone.0053171
Deep RNA Sequencing of the Skeletal Muscle Transcriptome in Swimming Fish
A. Palstra (2013)
10.1002/stem.57
SOX15 and SOX7 Differentially Regulate the Myogenic Program in P19 Cells
J. Savage (2009)
10.1053/j.gastro.2013.09.044
Activated wnt signaling in stroma contributes to development of pancreatic mucinous cystic neoplasms.
M. Sano (2014)
10.1111/febs.12383
Epigenetic control of skeletal muscle regeneration
L. Giordani (2013)
10.1242/dev.00686
Carboxypeptidase Z (CPZ) modulates Wnt signaling and regulates the development of skeletal elements in the chicken
C. Moeller (2003)
10.1016/S1471-4906(01)01941-X
Decoy receptors: a strategy to regulate inflammatory cytokines and chemokines.
A. Mantovani (2001)
10.1007/978-94-015-9662-6_9
MUSCLE ENHANCED TRAITS IN CATTLE AND SHEEP
N. Cockett (2001)
10.1016/S0925-4773(00)00540-2
Dorsal dermis development depends on a signal from the dorsal neural tube, which can be substituted by Wnt-1
Isabel Olivera-Martínez (2001)
10.1201/B15797-5
Fetal Programming of Skeletal Muscle Development
M. Zhu (2009)
10.1074/jbc.M202668200
Slug Is a Novel Downstream Target of MyoD
P. Zhao (2002)
10.1128/MCB.01180-14
WNT/β-Catenin Signaling Regulates Multiple Steps of Myogenesis by Regulating Step-Specific Targets
A. Suzuki (2015)
10.1016/S2095-3119(13)60419-0
Dynamic Expression of MicroRNA-127 During Porcine Prenatal and Postnatal Skeletal Muscle Development
Y. Yang (2014)
10.1128/MCB.01285-13
Regulation of the Follistatin Gene by RSPO-LGR4 Signaling via Activation of the WNT/β-Catenin Pathway in Skeletal Myogenesis
X. Han (2013)
10.1007/0-306-48158-8_7
Wnt signaling in human cancer.
P. Morin (2003)
10.1159/000091714
The Neural Tube Is Required to Maintain Primary Segmentation in the Sclerotome
Karen Colbjørn Larsen (2006)
10.1242/jcs.004739
FHL3 binds MyoD and negatively regulates myotube formation
D. L. Cottle (2007)
10.2527/jas.2009-2311
Fetal programming of skeletal muscle development in ruminant animals.
M. Du (2010)
10.1074/jbc.M110.169391
A WNT/β-Catenin Signaling Activator, R-spondin, Plays Positive Regulatory Roles during Skeletal Myogenesis*
X. Han (2011)
10.1387/IJDB.062141AS
Developmental expression of Shisa-2 in Xenopus laevis.
A. Silva (2006)
Development and characterisation of a novel myotube-motoneuron 3D co-culture system
A. Smith (2012)
10.1016/bs.pmbts.2017.11.026
Wnt Signaling in Skeletal Muscle Development and Regeneration.
F. Girardi (2018)
See more
Semantic Scholar Logo Some data provided by SemanticScholar