Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Interactions Of Antimicrobial Compounds With Cross-linking Agents Of Alginate Dressings.

C. H. Goh, P. Heng, E. P. Huang, Benny Li, L. Chan
Published 2008 · Chemistry, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
OBJECTIVES The aim of this study was to investigate the antimicrobial activities of calcium ions and other cross-linking agents of alginate dressings, as well as their compatibility with commonly used topical antimicrobials. METHODS The antimicrobial activities of cross-linking agents and antimicrobials (five antibiotics and four antiseptics) were evaluated by the broth dilution method. The interactions between individual cross-linking agents and antimicrobials were evaluated using the chequerboard test against common skin pathogens, Staphylococcus aureus and Pseudomonas aeruginosa. RESULTS From the MIC determined, antibiotics were the most active, followed by the antiseptics and cross-linking agents. Calcium ions, which are commonly used to cross-link alginate, exhibited very weak antimicrobial activity and higher fractional inhibitory concentration than the other cross-linking agents. The use of calcium and gentamicin resulted in antagonism against S. aureus. In contrast, aluminium, zinc and copper ions exhibited higher antimicrobial activities but insignificant interactions with the antimicrobials. CONCLUSIONS Commonly used topical antimicrobials that are active against the skin pathogens S. aureus and P. aeruginosa could be potentially incompatible with calcium alginate dressings. Copper, zinc and aluminium ions are more suitable cross-linking agents for alginate as they do not show antagonism with the antimicrobials and could impart antimicrobial property to the resultant dressing.
This paper references



This paper is referenced by
10.3389/fimmu.2018.02377
Coinfection With Influenza A Virus and Klebsiella oxytoca: An Underrecognized Impact on Host Resistance and Tolerance to Pulmonary Infections
Kayla M. Lee (2018)
10.1002/MASY.201600141
Crosslinker Effects on Properties of Hydroxyethylacryl Chitosan/Sodium Alginate Hydrogel Films
P. Treenate (2017)
10.1016/J.CARBPOL.2009.11.044
Modifications of alginate-based scaffolds and characterizations of their pentoxifylline release properties
H. Lin (2010)
10.1590/S0037-86822011000400008
Nosocomial infection and characterization of extended-spectrum β-lactamases-producing Enterobacteriaceae in Northeast Brazil.
Afonso G Abreu (2011)
10.1371/journal.pone.0212819
Graphene oxide in zinc alginate films: Antibacterial activity, cytotoxicity, zinc release, water sorption/diffusion, wettability and opacity
Belén Frígols (2019)
10.1039/C6RA20892D
Design of a novel wound dressing consisting of alginate hydrogel and simvastatin-incorporated mesoporous hydroxyapatite microspheres for cutaneous wound healing
W. Yu (2016)
10.1007/978-3-540-92679-5_7
Microbial Production of Alginates: Physiology and Process Aspects
W. Sabra (2009)
10.1016/S1696-2818(09)72580-6
El antibiograma (II): fenotipos de resistencia y lectura interpretada
E. Cercenado (2009)
Antimicrobial Study of Some Chemical Preparations for Vaginal Isolates
Alaa Zanzal (2015)
10.1016/J.CARBPOL.2011.11.012
Alginates as a useful natural polymer for microencapsulation and therapeutic applications
C. H. Goh (2012)
10.5772/INTECHOPEN.80875
Calcium Alginate Polysaccharide Dressing as an Accelerated Treatment for Burn Wound Healing
J. Cherng (2018)
10.2147/IJN.S79981
Exploration of alginate hydrogel/nano zinc oxide composite bandages for infected wounds
A. Mohandas (2015)
10.1016/J.CARBPOL.2011.09.097
Cross-linker and non-gelling Na+ effects on multi-functional alginate dressings
C. H. Goh (2012)
10.1016/S1696-2818(09)71927-4
El antibiograma. Interpretación del antibiograma: conceptos generales (I)
E. Cercenado (2009)
Antibacterial Activity of Aluminum Potassium Sulfate and Syzygium Aromaticum Extract Against Pathogenic Microorganisms
Ilham Bnyan (2014)
10.1080/10412905.2014.949882
Antibacterial activity of peppermint fragrance micro–nanocapsules prepared with a new electrospraying method
S. Ghayempour (2014)
10.1016/j.bbamem.2014.05.005
Additivity and synergy between an antimicrobial peptide and inhibitory ions.
W. Walkenhorst (2014)
10.3389/fmicb.2018.02050
Listeria monocytogenes Response to Sublethal Chlorine Induced Oxidative Stress on Homologous and Heterologous Stress Adaptation
Mohit Bansal (2018)
10.1016/j.ijbiomac.2016.10.054
Role of alginate in antibacterial finishing of textiles.
J. Li (2017)
10.1177/0885328217739199
Chitosan-based coatings in the prevention of intravascular catheter-associated infections
G. Mendoza (2018)
10.1517/14656560903357491
Newer developments in the treatment of Gram-positive infections
P. Koomanachai (2009)
10.1111/j.1469-0691.2011.03570.x
Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance.
A. Magiorakos (2012)
10.6084/M9.FIGSHARE.C.2184391.V1
Synthesis, characterization and antimicrobial activity of zinc(II) ibuprofen complexes with nitrogen-based ligands
H. A. Ali (2016)
Inhibition of swarming in Proteus mirabilis by Alum (Hydrated Aluminum Potassium Sulfate)
Karama Tahreer Ahmed (2011)
Study the inhibition activity of the different concentrations of Alum on some pathogenic bacteria isolation from different sites of human body
H. Sura (2013)
10.1185/03007990802694741
Levofloxacin for the treatment of pneumonia caused by Streptococcus pneumoniae including multidrug-resistant strains: pooled analysis
J. Peterson (2009)
10.1111/iwj.12813
Enhanced wound‐healing performance of a phyto‐polysaccharide‐enriched dressing – a preclinical small and large animal study
Chih-Hsin Wang (2017)
10.14479/JKOOS.2015.20.4.463
Physical Properties of the Hydrogel Using Alginate
Chul-Min Woo (2015)
10.1016/j.carbpol.2018.01.044
Microbicidal gentamicin-alginate hydrogels.
Stalin Kondaveeti (2018)
Cu-alginate and Ca-alginate aerogels production by supercritical gel drying for biomedical applications
Lucia Baldino (2018)
10.1016/J.ARCPED.2016.06.002
Posologie des antibiotiques chez le nouveau-né : variations des pratiques et comment y remédier ?
S. Leroux (2016)
10.1007/s10096-012-1806-4
Comparative evaluation of Vitek 2 identification and susceptibility testing of urinary tract pathogens directly and isolated from chromogenic media
M. J. Muñoz-Dávila (2012)
See more
Semantic Scholar Logo Some data provided by SemanticScholar