Online citations, reference lists, and bibliographies.

Endocrine And Metabolic Diseases Among Colorectal Cancer Survivors In A Population-Based Cohort.

Makenzie L. Hawkins, Brenna E Blackburn, Kerry G Rowe, John Snyder, Vikrant G. Deshmukh, Michael Newman, Alison Fraser, Ken Robert Smith, Kimberly A. Herget, Patricia A. Ganz, Niloy Jewel Samadder, Mia Hashibe
Published 2019 · Medicine, Biology
Cite This
Download PDF
Analyze on Scholarcy
BACKGROUND There are an estimated 1.4 million colorectal cancer (CRC) survivors in the United States. Research on endocrine and metabolic diseases over the long term in CRC survivors is limited. Obesity is a risk factor for CRC, thus it is of interest to investigate diseases that may share this risk factor such as diabetes for long-term health outcomes among CRC survivors. METHODS A total of 7,114 CRC patients were identified from Utah Population Database and matched to a general population cohort of 25,979 individuals on birth year, sex, and birth state. Disease diagnoses (assessed over three-time periods of 1-5 years, 5-10 years, and >10 years) were identified using electronic medical records and statewide ambulatory and inpatient discharge data. Cox proportional hazard models were used to estimate the risk of endocrine and metabolic disease. RESULTS Across all three-time periods, risks for endocrine and metabolic diseases was statistically significantly greater for CRC survivors compared to the general population cohort. At 1-5 years post diagnosis, CRC survivors' risk for diabetes mellitus with complications was statistically significantly elevated (HR = 1.36, 99% CI = 1.09-1.70). CRC survivors also experienced a 40% increased risk of obesity at 1-5 years post cancer diagnosis (HR = 1.40, 99%CI= 1.66-2.18) and a 50% increased risk at 5-10 years post diagnosis (HR = 1.50, 99%CI= 1.16-1.95). CONCLUSIONS Endocrine and metabolic diseases were statistically significantly higher in CRC survivors throughout the follow up periods of 1-5 years, 5-10 years and greater than 10 years post diagnosis. As the number of CRC survivors increases, understanding the long-term trajectory is critical for improved survivorship care.
This paper references
It's Not over When it's Over: Long-Term Symptoms in Cancer Survivors—A Systematic Review
Cherise Baldwin Harrington (2010)
Further Development of Flexible Parametric Models for Survival Analysis
Paul Lambert (2009)
Incidence of Diabetes in Colorectal Cancer Survivors.
Siddharth Singh (2016)
American Society of Clinical Oncology position statement on obesity and cancer.
Jennifer Ligibel (2014)
Do cancer survivors develop healthier lifestyle behaviors than the cancer-free population in the PLCO study?
Makenzie L. Hawkins (2016)
Annual Report to the Nation on the status of cancer, 1975-2010, featuring prevalence of comorbidity and impact on survival among persons with lung, colorectal, breast, or prostate cancer.
Brenda Kay Edwards (2014)
The relationship between diabetes and colorectal cancer prognosis: A meta-analysis based on the cohort studies
Bo Zhu (2017)
Confidence bands for a survival curve from censored data
William Jackson Hall (1980)
Metabolic Dysfunction, Obesity, and Survival Among Patients With Early-Stage Colorectal Cancer.
Elizabeth M. Cespedes Feliciano (2016)
Physical and psychological long-term and late effects of cancer.
Kevin D. Stein (2008)
Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association
Emelia J. Benjamin (2017)
Cancer treatment and survivorship statistics, 2016.
Kimberly D Miller (2016)
Trends in Obesity Prevalence in Adults With a History of Cancer: Results From the US National Health Interview Survey, 1997 to 2014.
Heather Greenlee (2016)
Diabetes mellitus and risk of colorectal cancer: a meta-analysis.
Susanna C. Larsson (2005)
NCCN Asia Consensus Statement prostate cancer.
Shiro Hinotsu (2018)
Assessing non-cancer-related health status of US cancer patients: other-cause survival and comorbidity prevalence.
Hyunsoon Cho (2013)
The Role of Obesity in Cancer Survival and Recurrence
Wendy Demark-Wahnefried (2012)
The Impact of Comorbidity on Survival of Danish Colorectal Cancer Patients from 1995 to 2006 - A Population-Based Cohort Study
Lene Hjerrild Iversen (2009)
The increasing incidence of young-onset colorectal cancer: a call to action.
Dennis J. Ahnen (2014)
Obesity and Risk of Colorectal Cancer: A Meta-analysis of 31 Studies with 70,000 Events
Alireza Ansary Moghaddam (2007)
American Cancer Society Colorectal Cancer Survivorship Care Guidelines.
Khaled el-Shami (2015)
Colorectal Cancer Outcomes, Recurrence, and Complications in Persons With and Without Diabetes Mellitus: A Systematic Review and Meta-Analysis
Kelly B. Stein (2009)
Provision and discussion of survivorship care plans among cancer survivors: results of a nationally representative survey of oncologists and primary care physicians.
Danielle Blanch-Hartigan (2014)
Lifestyle and quality of life in colorectal cancer survivors
Chloe Grimmett (2011)
The challenges of colorectal cancer survivorship.
Crystal Shereen Denlinger (2009)
The health and well-being of cancer survivors in the UK: findings from a population-based survey
J Elliott (2011)

Semantic Scholar Logo Some data provided by SemanticScholar