Online citations, reference lists, and bibliographies.

Characterization Of A Novel Mouse CDNA, ES18, Involved In Apoptotic Cell Death Of T-cells.

E. Park, J. Kim, R. H. Seong, C. Kim, S. D. Park, S. Hong
Published 1999 · Medicine, Biology
Cite This
Download PDF
Analyze on Scholarcy
Share
Using the modified screening approach in combination with expressed sequence tags, we have identified several novel cDNAs from mouse embryonic stem (ES) cells, whose expression is tissue-restricted and/or developmentally regulated. One of the cDNAs, ES18, is preferentially expressed in lymph node and thymus, and contains noteworthy features of transcriptional regulator. The expression of ES18 transcript was selectively regulated during the apoptosis of T-cell thymoma S49.1 induced by several stimuli. Interestingly, the ES18 transcript was differently regulated in the mutually antagonistic process, between dexamethasone- and A23187-induced cell death of T-cells. Moreover, the message level of ES18 was selectively enhanced by staurosporine, a broad protein kinase inhibitor, but not by other protein kinase inhibitors such as GF109203X and H89. In addition, ES18 transcript was induced by C2-ceramide, which is a mediator of both dexamethasone- and staurosporine-induced apoptotic signaling. We further showed that transient overexpression of ES18 in mouse T-cell lymphoma increased the apoptotic cell death. These data suggest that ES18 may be selectively involved in specific apoptotic processes in mouse T-cells.
This paper references



This paper is referenced by
10.1002/ijc.31638
miR-134 targets PDCD7 to reduce E-cadherin expression and enhance oral cancer progression.
Shih-Yuan Peng (2018)
10.1016/j.cancergen.2018.12.001
The clinical and prognostic significance of FIS1, SPI1, PDCD7 and Ang2 expression levels in acute myeloid leukemia.
Reham Abdel Haleem Abo El-Wafa (2019)
Minor Spliceosome through Alterna ve Splicing and Nuclear Reten on of the U 11 / U 12 65 K mRNA
Jens Verbeeren (2015)
10.1038/sj.gene.6364306
Deregulated stress system in non-obese diabetic lymphocyte
Zhanguo Liu (2006)
10.1074/mcp.O111.010389
Proteome-wide Detection of Abl1 SH3-binding Peptides by Integrating Computational Prediction and Peptide Microarray*
Zheng Xu (2011)
found in the U 2-dependent spliceosome The human 18 S U 11 / U 12 snRNP contains a set of novel proteins not
Claudia Schneider (2004)
The U 11 / U 12 snRNP 65 K protein acts as a molecular bridge , binding the U 12 snRNA and U 1159 K protein
Heike Benecke (2005)
10.1080/13550280701258399
Brain-derived human immunodeficiency virus-1 Tat exerts differential effects on LTR transactivation and neuroimmune activation
L. Boven (2011)
U12-type Spliceosome : Localization and Effects of Splicing Efficiency on Gene Expression
Heli K. J. Pessa (2010)
10.3389/fonc.2019.01397
Array Comparative Genomic Hybridization Analysis Reveals Significantly Enriched Pathways in Canine Oral Melanoma
Ginevra Brocca (2019)
10.1101/2020.05.18.101246
The minor and major spliceosome interact to regulate alternative splicing around minor introns
Anouk M. Olthof (2020)
10.1371/journal.pone.0084150
Identification of Novel Molecular Markers for Prognosis Estimation of Acute Myeloid Leukemia: Over-Expression of PDCD7, FIS1 and Ang2 May Indicate Poor Prognosis in Pretreatment Patients with Acute Myeloid Leukemia
Yiming Tian (2014)
Semantic Scholar Logo Some data provided by SemanticScholar