Online citations, reference lists, and bibliographies.
← Back to Search

Feasibility Of A Screening Programme For Lung Cancer In Former Asbestos Workers.

G. Mastrangelo, M. N. Ballarin, Ernesto Bellini, R. Bizzotto, F. Zannol, F. Gioffrè, M. Gobbi, Gianna Tessadri, L. Marchiori, Gianluca Marangi, Saverio Bozzolan, J. Lange, F. Valentini, P. Spolaore
Published 2008 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
BACKGROUND Low-dose computed tomography (CT) has been found to detect more Stage IA lung cancer than chest x-ray. AIMS To investigate whether lung cancer screening with CT was effective and acceptable in former asbestos workers. METHODS CT scanning was carried out following the protocol previously described in the literature. A questionnaire was used to assess cumulative asbestos exposure. An economic analysis was also performed. Informed consent was obtained from all patients. RESULTS A total of 1119 male asbestos workers (58% of invited) were examined, of whom 65% were smokers or ex-smokers. Mean age was 57.1 years with mean cumulative exposure to asbestos of 123 fibres/ml x years. Pleural plaques were found in 375 workers (32%), while 338 workers (29%) were included in the radiological follow-up, which led to 25 biopsies (13 of lung, 9 of pleura, 3 of both) and five screen-detected lung cancers (0.4%), one in Stage I. Incidence rate was 149 per 10(5), equal to that in the male general population of similar age. The expenses for diagnosis were 1014 and 244962 Euro per screened subject and screen-detected lung cancer case, respectively. CONCLUSIONS Screening adherence and frequency of detection were low, while costs and radiation dose were high. In spite of a high cumulative asbestos exposure, lung cancer risk was not increased relative to the general population. The screening programme was not felt to be cost-effective from the perspective of the government as a third-party funding agency.
This paper references
Screening for lung cancer: a review of the current literature.
P. Bach (2003)
Lung cancer screening using low-dose spiral CT: results of baseline and 1-year follow-up studies.
T. Nawa (2002)
Computed tomography screening for lung cancer in asbestos-exposed workers.
M. Tiitola (2002)
Results of three-year mass screening programme for lung cancer using mobile low-dose spiral computed tomography scanner
S. Sone (2001)
Lung cancer screening with CT: Mayo Clinic experience.
S. Swensen (2003)
A systematic review and lessons learned from early lung cancer detection trials using low-dose computed tomography of the chest.
G. Bepler (2003)
Screening in chronic disease
G. Friedman (1993)
Screening for lung cancer.
E. Patz (2000)
The exposuretimeresponse relationship between occupational asbestos exposure and lung cancer in two German case - control studies
M Hauptmann (2002)
in asbestos - exposed workers
S Diederich (2002)
Multicentric study on malignant pleural mesothelioma and non-occupational exposure to asbestos
C. Magnani (2000)
Lung cancer screening using low dose spiral CT
T. Nawa (2000)
Computed Tomography Screening
D. Brenner (2006)
Early lung cancer action project
C. Henschke (2000)
Radiation risks potentially associated with low-dose CT screening of adult smokers for lung cancer.
D. Brenner (2004)
Screening for asymptomatic early bronchogenic carcinoma with low dose CT of the chest
S. Diederich (2000)
Screening for lung cancer with low-dose helical computed tomography: anti-lung cancer association project.
T. Sobue (2002)
Screening in Chronic Disease
J. Mandel (1985)
Pleural plaques as risk indicators for malignant pleural mesothelioma: a necropsy-based study.
C. Bianchi (1997)
Screening for lung cancer: the guidelines.
P. Bach (2003)
Lung cancer screening with low-dose CT.
S. Diederich (2003)
The exposure-time-response relationship between occupational asbestos exposure and lung cancer in two German case-control studies.
M. Hauptmann (2002)
International expert meeting on new advances in the radiology and screening of asbestos-related diseases.
A. Tossavainen (2000)

This paper is referenced by
In this issue of Occupational Medicine.
J. Hobson (2008)
Évaluation du suivi post-exposition amiante de techniciens en télécommunications
Jean-François Ruiz (2018)
CT scan procedure for lung cancer screening in asbestos-exposed workers.
M. Ollier (2014)
Pleural plaques and the risk of pleural mesothelioma.
J. Pairon (2013)
Unanswered Questions Regarding Asbestos Exposure: Concerns for the Next Generation
D. Banks (2012)
Chest CT scan screening for lung cancer in asbestos occupational exposure: a systematic review and meta-analysis.
M. Ollier (2014)
Asbest und seine Spätfolgen – Zeit für ein Screening?
T. Kraus (2014)
Diagnostic value of microRNAs in asbestos exposure and malignant mesothelioma: systematic review and qualitative meta-analysis
Luigina Micolucci (2016)
Suivi après exposition professionnelle à l’amiante : modalités et dispositifs étrangers ☆ ☆☆
A. Massardier-Pilonchéry (2011)
Facts, rumours and speculations about the mesothelioma epidemic
J. Van Meerbeeck (2011)
Osteopontin, asbestos exposure and pleural plaques: a cross-sectional study
G. Mastrangelo (2011)
Low-dose computed tomography screening for lung cancer in people with workplace exposure to asbestos.
P. Maisonneuve (2019)
Role of a serum‐based biomarker panel in the early diagnosis of lung cancer for a cohort of high‐risk patients
Dawei Yang (2015)
Non-asbestos Risks of Asbestos Abatement Workers
J. Lange (2009)
Detection of lung cancer in silicosis patients using a tumor-marker panel.
J. Schneider (2010)
Imaging of malignant pleural mesothelioma: it is possible a screening or early diagnosis program?-a systematic review about the use of screening programs in a population of asbestos exposed workers.
F. Falaschi (2018)
Früherkennung von Lungenkrebs bei asbestexponierten Arbeitnehmern
K. Hofmann-Preiss (2016)
Asbestos exposure, pleural plaques, and the risk of death from lung cancer.
J. Pairon (2014)
Low-dose chest computed tomography screening of subjects exposed to asbestos.
Katsuya Kato (2018)
Asbestos exposure and benign asbestos diseases in 772 formerly exposed workers: dose-response relationships.
G. Mastrangelo (2009)
Clinical Aspects of Asbestos-Related Diseases—What Are the Unresolved Topics?
D. Banks (2014)
Baseline Characteristics of Participants in the Randomized National Lung Screening Trial
D. Aberle (2010)
Early stages of mesothelioma, screening and biomarkers.
S. Klebe (2011)
Post-occupational health surveillance of asbestos workers.
G. Mastrangelo (2013)
Urinary asbestos fibers and inorganic particles in past asbestos workers
Sara Zaina (2016)
Computed tomography screening for lung diseases among asbestos-exposed workers
T. Vierikko (2010)
Occupational toxicology of asbestos-related malignancies
M. Lotti (2010)
Asbest und seine Spätfolgen - Zeit für ein Screening?
Uta Ochmann (2015)
Early detection of lung cancers - Comparison of computed tomography, cytology and fuzzy-based tumor markers panels.
J. Schneider (2010)
Semantic Scholar Logo Some data provided by SemanticScholar