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Multi‐faceted Regulation Of Cell Differentiation By Extracellular Matrix

C. Lin, M. Bissell
Published 1993 · Biology, Medicine

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Extracellular matrix (ECM) is an intricate network composed of an array of macromolecules, the importance of which is becoming increasingly apparent. The ECM is an integral part of the machinery that regulates cell function; its role in cell differentiation and tissue‐specific gene expression, although essential, is not yet understood. It can act as a positive as well as a negative regulator of functional differentiation depending on the cell type and the genes studied. It also acts in a hierarchical fashion, exacting higher and higher degrees of stringency to achieve full functional differentiation. Regulation by ECM is closely interrelated with the action of other regulators of cellular function, such as growth factors and hormones. But ECM may exert its regulation of gene expression by mechanisms distinct from those known for soluble transcription factors. In this short review, we describe three systems in which ECM has been shown to play a crucial role in functional differentiation, but we emphasize mainly the work from our own laboratory to provide a more in‐depth analysis of one system. The three systems are: mouse mammary epithelial cells, rat hepatocytes, and human keratinocytes. The crucial role of ECM in normal cell differentiation implies that its alteration may have serious consequences in malignancies and other diseases. The current functional cell culture models could provide powerful tools not only for understanding regulation of normal cell function but also for the studies of tumorigenesis and possibly cancer therapy.—Lin, C. Q., Bissell, M.J. Multi‐faceted regulation of cell differentiation by extracellular matrix. FASEB J. 7: 737‐743; 1993.
This paper references
MoL Cell. Biol
10.1126/SCIENCE.948753
Cytochrome P-450 induction by phenobarbital and 3-methylcholanthrene in primary cultures of hepatocytes.
G. Michalopoulos (1976)
10.1128/MCB.3.9.1552
Changes in liver-specific compared to common gene transcription during primary culture of mouse hepatocytes.
D. Clayton (1983)
Expression of extracellular matrix components is regulated by substratum.j
C. H. Streuli (1990)
10.1128/MCB.10.3.1239
Induction of albumin gene transcription in hepatocytes by extracellular matrix proteins.
J. M. Caron (1990)
Terminal differentiation of cultured epidermis
J. C. Adams (1989)
10.1038/340307A0
Fibronectin inhibits the terminal differentiation of human keratinocytes
J. Adams (1989)
Epiderma! differentiation
E Fuchs (1990)
10.1073/PNAS.85.7.2161
Cell-cell and cell-matrix interactions differentially regulate the expression of hepatic and cytoskeletal genes in primary cultures of rat hepatocytes.
A. Ben-Ze'ev (1988)
10.1073/PNAS.74.10.4466
Hormonal effects on intracellular and secreted casein in cultures of mouse mammary epithelial cells on floating collagen membranes.
J. Emerman (1977)
10.1210/mend-4-11-1661
Transcriptional Analysis of the Mouse β-Casein Gene
H. S. Goodman (1990)
10.1016/0092-8674(92)90115-S
Integrins: Versatility, modulation, and signaling in cell adhesion
R. Hynes (1992)
10.1128/MCB.12.3.905
High-level expression of the rat whey acidic protein gene is mediated by elements in the promoter and 3' untranslated region.
T. Dale (1992)
Study of hepatocyte function in cell culture.
D. Bissell (1976)
10.1091/MBC.1.1.45
A novel regulatory mechanism for whey acidic protein gene expression.
L. Chen (1989)
Influence of a reconstituted basement membrane and its components on casein gene expression and ECM REGULATION OF CELL DIFFERENTIATION 743 secretion in mouse mammary epithelial cells
M. L. Li (1987)
adhesion
C. Streuli (1992)
10.1016/S1569-2558(08)60236-2
The Significance of the Extracellular Matrix in Mammary Epithelial Carcinogenesis
C. Roskelley (1993)
Glucocorticoid-dependent expression of the albumin gene in adult rat hepatocytes.
K. Nawa (1986)
10.1073/PNAS.89.7.3130
Developmental and environmental regulation of a mammary gland-specific nuclear factor essential for transcription of the gene encoding beta-casein.
M. Schmitt-Ney (1992)
10.1073/PNAS.87.23.9118
Extracellular matrix and hormones transcriptionally regulate bovine beta-casein 5' sequences in stably transfected mouse mammary cells.
C. Schmidhauser (1990)
10.1083/JCB.110.4.1405
Expression of extracellular matrix components is regulated by substratum
C. Streuli (1990)
10.1073/PNAS.88.19.8392
Signal transduction by integrins: increased protein tyrosine phosphorylation caused by clustering of beta 1 integrins.
L. Kornberg (1991)
10.1128/MCB.11.2.773
Extracellular signals that regulate liver transcription factors during hepatic differentiation in vitro.
J. Liu (1991)
Biol. Chem
10.1073/PNAS.86.1.104
Prolactin and glucocorticoid hormones synergistically induce expression of transfected rat beta-casein gene promoter constructs in a mammary epithelial cell line.
W. Doppler (1989)
10.1083/JCB.107.5.1927
An unusual strain of human keratinocytes which do not stratify or undergo terminal differentiation in culture
J. Adams (1988)
10.1172/JCI112887
Support of cultured hepatocytes by a laminin-rich gel. Evidence for a functionally significant subendothelial matrix in normal rat liver.
D. Bissell (1987)
10.1021/BI00267A025
Isolation and characterization of type IV procollagen, laminin, and heparan sulfate proteoglycan from the EHS sarcoma.
H. Kleinman (1982)
Expression of a whey acidic protein transgene during mammary development. Evidence for different mechanisms of regulation during pregnancy and lactation.
T. Burdon (1991)
10.1038/348699A0
A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas
P. Basset (1990)
Changes in the abundance and distribution of actin and associated proteins during terminal differentiation of human epidermal keratinocytes.
M. D. Kubler (1991)
Transcriptional analysis of the mouse beta - casein gene
C. Schmidhauser (1992)
Curr. Opin. Cell BioL
J. Cell BioL
10.1073/PNAS.85.23.9076
Conditional enhancement of liver-specific gene transcription.
K. Zaret (1988)
10.1083/JCB.98.1.16
Selective migration of terminally differentiating cells from the basal layer of cultured human epidermis
F. Watt (1984)
10.1016/0960-9822(92)90186-E
Signal transduction by integrin receptors for extracellular matrix: Cooperative processing of extracellular information
C. Damsky (1992)
10.1073/PNAS.81.12.3756
Epithelial mouse mammary cell line exhibiting normal morphogenesis in vivo and functional differentiation in vitro.
K. Danielson (1984)
10.1016/0092-8674(93)90586-F
Cell
AC Tose (1993)
10.1083/JCB.115.5.1383
Control of mammary epithelial differentiation: basement membrane induces tissue-specific gene expression in the absence of cell-cell interaction and morphological polarity
C. Streuli (1991)
Epiderma ! differentiation
J. G. Rheinwald (1975)
Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells.
J. Rheinwald (1975)
Transcriptional regulation of the albumin gene in cultured rat hepatocytes. Role of basement-membrane matrix.
D. Bissell (1990)
10.1016/0092-8674(90)90175-E
Changes in keratinocyte adhesion during terminal differentiation: Reduction in fibronectin binding precedes α5β1 integrin loss from the cell surface
J. Adams (1990)
Functional interplay between ECM and ECM - degrading proteinases in the mammary gland : a coordinate system for regulating mammary epithelium function
T. Fleming
Terminal differentiation of cultured epidermis cells
H Green (1977)
Dynamic reciprocity: how do extracellular matrix and hormones direct gene expression?
M. Bissell (1987)
10.1091/MBC.3.6.699
A novel transcriptional enhancer is involved in the prolactin- and extracellular matrix-dependent regulation of beta-casein gene expression.
C. Schmidhauser (1992)
10.1016/0022-5193(82)90388-5
How does the extracellular matrix direct gene expression?
M. Bissell (1982)
10.1093/NAR/18.10.2977
Tissue-specific, high level expression of the rat whey acidic protein gene in transgenic mice.
E. Bayna (1990)
10.1111/j.1749-6632.1980.tb29518.x
PHENOTYPIC STABILITY OF ADULT RAT HEPATOCYTES IN PRIMARY MONOLAYER CULTURE *
D. Bissell (1980)
10.1016/0955-0674(90)90085-S
Designer microenvironments for the analysis of cell and tissue function.
A. Stoker (1990)
Purified laminin can induce differentiation in mammary epithelial cells
C. Schmidhauser (1990)
10.1016/S0092-8674(75)80001-8
Seria cultivation of strains of human epidemal keratinocytes: the formation keratinizin colonies from single cell is
James G. Rheinwatd (1975)
Study of hepatocyte function in cell culture.
Bissell Dm (1976)
10.1073/PNAS.85.15.5576
Cell shape controls terminal differentiation of human epidermal keratinocytes.
F. Watt (1988)



This paper is referenced by
10.1080/10408369891234174
Growth factors and the kidney in diabetes mellitus.
G. Gambaro (1998)
The role of laminin-5 and its receptors in mammary epithelial cell branching morphogenesis.
S. Stahl (1997)
Apoptosis and remodeling of mammary gland tissue during involution proceeds through p53-independent pathways.
M. Li (1996)
Dissection moléculaire de l’interaction de la DNA topoisomérase I avec la matrice extracellulaire et les fibroblastes
Karine Beauchemin (2009)
10.11606/D.9.2006.TDE-05092006-095948
Associação entre alta expressão e atividade de metaloproteinases e presença de HPV em linhagens de carcinomas cervicais humanos
L. Cardeal (2006)
Maintenance of primary human hepatocyte function in vitro by extracellular matrix scaffolds
T. Sellaro (2008)
10.1007/978-3-642-59766-4_5
Regulation of gene expression by changes in cell adhesion.
T. Kuzumaki (2000)
10.1210/JC.2002-021213
Decreased type I collagen expression in human uterine cervix during pregnancy.
M. Iwahashi (2003)
10.1016/j.exer.2020.108138
Integrin: Basement membrane adhesion by corneal epithelial and endothelial cells.
T. McKay (2020)
10.1111/j.1749-6632.1994.tb21741.x
Negative Regulation of Placental Fibronectin Expression by Glucocorticoids and Cyclic Adenosine 3′,5′‐Monophosphate a b
S. Guller (1994)
10.1016/0167-4889(94)90045-0
Forskolin induces the reorganization of extracellular matrix fibronectin and cytoarchitecture in 3T3-F442A adipocytes: its effect on fibronectin gene expression.
J. Antras-Ferry (1994)
10.1038/s41598-019-56632-3
Matrisome-Associated Gene Expression Patterns Correlating with TIMP2 in Cancer
David Peeney (2019)
10.1016/S0022-5347(05)65620-0
Reactive stroma in prostate cancer progression.
J. A. Tuxhorn (2001)
10.1007/0-387-28274-2_11
Extracellular Matrix and Mesothelioma: Some Clues to the Invasive Behavior of Mesothelioma
J. Klominek (2005)
10.1002/3527600906.MCB.200400091
Matrix, Extracellular and Interstitial
A. Akalu (2006)
10.1002/3527600906.MCB.200400044
Mammalian Cell Culture Methods
D. Hülser (2006)
10.1007/s11626-999-0048-y
Culture of primary bovine mammary epithelial cells
E. Matitashvili (1999)
10.1016/j.critrevonc.2012.06.007
Issues to be considered when studying cancer in vitro.
B. Čunderlíková (2013)
10.3109/03008209909029109
The effect of caloric restriction on the aortic tissue of aging rats.
C. Fornieri (1999)
10.1002/(SICI)1097-0029(19970901)38:5<473::AID-JEMT3>3.0.CO;2-J
Epithelial‐mesenchymal interactions in the alteration of gene expression and morphology following lung injury
M. O’Reilly (1997)
Mammary epithelial cells undergo secretory differentiation in cycling virgins but require pregnancy for the establishment of terminal differentiation.
G. Robinson (1995)
Elastin receptor and cell-matrix interactions in heart transplant-associated arteriosclerosis.
A. Hinek (1997)
10.1016/S0092-8674(00)81392-6
The Adaptor Protein Shc Couples a Class of Integrins to the Control of Cell Cycle Progression
K. Wary (1996)
10.1111/j.1699-0463.1995.tb01119.x
The glomerular mesangium: studies of its developmental origin and markers in vivo and in vitro
Harry HÖLthofer (1995)
10.1016/S1569-2582(98)80020-2
Chapter 5 The role of extracellular matrix during development
E. J. Sanders (1998)
10.1046/J.1432-0436.1994.5730187.X
Application of cantharidin or 12-O-tetradecanoylphorbol-13-acetate on mouse epidermis induces a cell population shift that causes altered keratin distribution.
A. Heyden (1994)
10.1007/978-0-387-87429-6_3
Pulmonary Vascular Development
R. Jones (2011)
10.1007/978-3-319-42023-3
Systems Biology of Tumor Microenvironment
K. Rejniak (2016)
10.1007/BF02723051
Cardiogel: A biosynthetic extracellular matrix for cardiomyocyte culture
W. H. VanWinkle (2007)
Type XIII collagen: regulation of cardiovascular development and malignant transformation in transgenic mice
M. Sund (2001)
10.1016/S0070-2153(04)64009-9
Integrins and angiogenesis.
D. Stupack (2004)
10.1095/biolreprod.108.067637
Integrin Activation in Bovine Placentomes and in Caruncular Epithelial Cells Isolated from Pregnant Cows
P. S. Bridger (2008)
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