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Second-Look Surgery In Patients With Peritoneal Dissemination From Appendiceal Malignancy: Analysis Of Prognostic Factors In 98 Patients

José Esquivel, Paul H Sugarbaker
Published 2001 · Medicine
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ObjectiveTo establish selection criteria for reoperation in patients with peritoneal dissemination from appendiceal malignancy. Summary Background DataThe outcome of patients with mucinous appendiceal neoplasms with peritoneal surface dissemination has changed as a result of a better understanding of the clinical and pathologic features of this disease. This knowledge, combined with aggressive strategies for the use of perioperative intraperitoneal chemotherapy and peritonectomy procedures, has resulted in long-term disease-free survival in many of these patients. However, some of the patients develop progressive disease, and a question regarding additional surgery is appropriate. A critical analysis of the results of second-look surgery should assist in the management of patients with recurrent peritoneal surface dissemination of an appendiceal neoplasm. MethodsThree hundred twenty-one patients with epithelial peritoneal surface malignancy of appendiceal origin underwent surgery during a 12-year period. Ninety-eight of these patients (30.5%) underwent a second-look procedure. A database of selected clinical features regarding these 98 patients was gathered from the clinical records. A critical statistical analysis of these clinical features and their prognostic impact was performed using survival as an endpoint. All patients were managed by a treatment regimen that used cytoreductive surgery and intraperitoneal chemotherapy. ResultsThe overall 5-year survival rate of these 98 patients was 73.6%. This compared favorably with a 68% survival rate of 223 patients who did not undergo reoperation. Survival based on the number of cytoreductive surgeries and the free interval between them showed no significant difference. Patients who had second-look surgery with bowel obstruction as a symptom and those in whom the amount of tumor was increased or minimally decreased at the first and second cytoreductions had a significantly inferior 5-year survival rate. A complete second cytoreduction was associated with an improved 5-year survival rate. ConclusionsFollow-up of patients treated for peritoneal dissemination from neoplasms of appendiceal origin is indicated. Selected patients in whom recurrence develops are candidates for repeat cytoreductive surgery plus intraperitoneal chemotherapy with curative intent.
This paper references
Management of peritoneal surface malignancy using intraperitoneal chemotherapy and cytoreductive surgery. A manual for physicians and nurses, 3d ed
PH Sugarbaker (1998)
10.1007/s002689900560
Second-look Surgery after Cytoreduction and Intraperitoneal Chemotherapy for Peritoneal Carcinomatosis from Colorectal Cancer: Analysis of Prognostic Features
Alberto Gómez Portilla (1999)
10.1007/978-1-4613-1247-5_23
Clinical research methodologies in diagnosis and staging of patients with peritoneal carcinomatosis.
Pierre Jacquet (1996)
[Elective surgery in recurrent colon cancer with peritoneal seeding: when to and when not to proceed].
José Esquivel (1999)
Laser-mode electrosurgery. In: Sugarbaker PH, ed
PH Sugarbaker (1996)
10.1007/s10434-999-0727-7
Results of Treatment of 385 Patients With Peritoneal Surface Spread of Appendiceal Malignancy
Paul H Sugarbaker (1999)
10.1097/00000658-199501000-00004
Peritonectomy Procedures
Paul H Sugarbaker (2003)
10.1097/00000478-199512000-00006
Disseminated peritoneal adenomucinosis and peritoneal mucinous carcinomatosis. A clinicopathologic analysis of 109 cases with emphasis on distinguishing pathologic features, site of origin, prognosis, and relationship to "pseudomyxoma peritonei".
B M Ronnett (1995)
Management of peritoneal surface malignancy using intraperitoneal chemotherapy and cytoreductive surgery. A manual for physicians and nurses
P H Sugarbaker (1998)
Abdominal computed tomographic scan in the selection of patients with mucinous peritoneal carcinomatosis for cytoreductive surgery.
Pierre Jacquet (1995)
10.1007/978-1-4613-1247-5_6
Observations concerning cancer spread within the peritoneal cavity and concepts supporting an ordered pathophysiology.
Paul H Sugarbaker (1996)
Pseudomyxoma peritonei syndrome.
Paul H Sugarbaker (1996)
10.1007/978-1-4613-1247-5_17
Radiology of peritoneal carcinomatosis.
Ann G. Archer (1996)
10.1016/0002-9610(61)90749-8
CANCER OF THE COLON.
John P. L. Madden (1964)
10.1097/00000658-199402000-00002
Pseudomyxoma Peritonei Long‐Term Patient Survival with an Aggressive Regional Approach
David B. Gough (1994)
10.1016/S0959-8049(98)00375-X
Quantitative methodologies for selection of patients with recurrent abdominopelvic sarcoma for treatment.
B. Berthet (1999)
10.1007/978-1-4613-1247-5
Peritoneal Carcinomatosis: Principles of Management
Paul H Sugarbaker (1996)
10.1007/978-1-4613-1247-5_24
Laser-mode electrosurgery.
Paul H Sugarbaker (1996)



This paper is referenced by
10.1016/j.suronc.2010.09.002
Treatment of peritoneal carcinomatosis with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: state of the art and future developments.
Franco Roviello (2011)
10.1016/j.ejso.2014.08.476
Recurrence and outcome after complete tumour removal and hyperthermic intraperitoneal chemotherapy in 512 patients with pseudomyxoma peritonei from perforated appendiceal mucinous tumours.
A C Lord (2015)
10.1016/j.surge.2019.11.005
Re-do cytoreductive surgery for peritoneal surface malignancy: Is it worthwhile?
Vignesh Narasimhan (2019)
10.1007/978-1-4614-9022-7_5
Carcinomatosis: Cytoreduction and Heated Intraperitoneal Chemotherapy (HIPEC) Versus Palliation
Björn L.D.M. Brücher (2014)
10.3978/j.issn.2078-6891.2015.131
Repeat cytoreductive surgery with hyperthermic intraperitoneal chemotherapy: review of indications and outcomes.
Harveshp Mogal (2016)
10.1097/01.sla.0000133183.15705.71
Incomplete Cytoreduction in 174 Patients With Peritoneal Carcinomatosis From Appendiceal Malignancy
Olivier Glehen (2004)
10.1046/j.1365-2168.2002.01967.x
Cytoreduction including total gastrectomy for pseudomyxoma peritonei.
Paul H Sugarbaker (2002)
10.1007/s10350-005-0196-4
Malignancies of the Appendix: Beyond Case Series Reports
Marcia L. McGory (2005)
10.1016/j.ejso.2013.12.021
Pre-operative tumour marker status predicts recurrence and survival after complete cytoreduction and hyperthermic intraperitoneal chemotherapy for appendiceal Pseudomyxoma Peritonei: Analysis of 519 patients.
Panagiotis Taflampas (2014)
10.1007/s00595-010-4495-6
Cytoreductive surgery with intraperitoneal chemotherapy to treat pseudomyxoma peritonei at nonspecialized hospitals
Toshiyuki Kitai (2010)
10.1245/s10434-014-3869-1
Predictive and Prognostic Survival Factors in Peritoneal Carcinomatosis from Appendiceal Cancer After Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy
William Jimenez (2014)
10.1245/s10434-012-2788-2
Surveillance MR Imaging is Superior to Serum Tumor Markers for Detecting Early Tumor Recurrence in Patients with Appendiceal Cancer Treated with Surgical Cytoreduction and HIPEC
Russell N. Low (2012)
10.7150/jca.5831
Patients at Risk for Peritoneal Surface Malignancy of Colorectal Cancer Origin: The Role of Second Look Laparotomy
Björn L.D.M. Brücher (2013)
10.1007/s12094-015-1413-9
Recommendations in the management of epithelial appendiceal neoplasms and peritoneal dissemination from mucinous tumours (pseudomyxoma peritonei)
P. Barrios (2015)
10.1002/bjs5.50262
Repeat cytoreductive surgery with or without intraperitoneal chemotherapy for recurrent epithelial appendiceal neoplasms
J B Karpes (2020)
10.3748/wjg.v22.i46.10249
“En bloc” caudate lobe and inferior vena cava resection following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal and liver metastasis of colorectal cancer
Patricia Sánchez-Velázquez (2016)
[Pseudomyxoma peritonei treated with complete resection and immediate intraperitoneal chemotherapy].
Dominique M Elias (2003)
10.1016/j.ejso.2013.08.017
Repeated cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in peritoneal carcinomatosis from appendiceal cancer: analysis of survival outcomes.
Armando Sardi (2013)
10.1245/s10434-012-2236-3
Combined Diffusion-Weighted and Gadolinium-Enhanced MRI Can Accurately Predict the Peritoneal Cancer Index Preoperatively in Patients Being Considered for Cytoreductive Surgical Procedures
Russell N. Low (2012)
Implantación en Mallorca de un programa de Tratamiento multimodal de la Carcinomatosis Peritoneal mediante Quimioterapia Sistémica, Cirugía Citorreductora y Quimioterapia Intraperitoneal Hipertérmica (HIPEC)
Rafael Soriano (2012)
10.1245/s10434-008-0073-1
Hyperthermic Intraperitoneal Chemotherapy with Oxaliplatin for Peritoneal Carcinomatosis Arising from Appendix: Preliminary Results of a Survival Analysis
Eric Marcotte (2008)
Chimiohyperthermie intrapéritonéale à l’oxaliplatinedans le traitement de la carcinose péritonéaled’origine appendiculaire
Éric Marcotte (2010)
Outcomes of cytoreductive surgery and HIPEC for pseudomyxoma peritonei of appendiceal origin from two Indian centers: A preliminary five-year experience.
Aditi Bhatt (2017)
10.1007/s10434-004-1161-5
Lymph Node Metastasis in Epithelial Malignancies of the Appendix With Peritoneal Dissemination Does Not Reduce Survival in Patients Treated by Cytoreductive Surgery and Perioperative Intraperitoneal Chemotherapy
PhD S. González-Moreno MD (2004)
10.1016/j.ejso.2009.06.008
Critical assessment of preoperative and operative risk factors for complications after iterative peritonectomy procedures.
Akshat Saxena (2010)
10.1007/s10147-017-1217-8
Repeat cytoreduction and hyperthermic intraperitoneal chemotherapy for recurrent peritoneal carcinomatosis of appendiceal origin
Toshiyuki Kitai (2017)
10.1016/S0021-7697(09)72398-1
[Digestive oncology: surgical practices].
Khlif Slim (2009)
Management of pseudomyxoma peritonei.
Simon A. Fallis (2015)
10.1186/s12957-016-0804-x
Repeated cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with recurrent peritoneal carcinomatosis
Nikolaos Vassos (2016)
10.1245/ASO.2003.08.004
Cytoreductive Surgery Combined With Hyperthermic Intraperitoneal Intraoperative Chemotherapy for Peritoneal Carcinomatosis Arising From Colon Adenocarcinoma
Pierluigi Pilati (2003)
10.1245/s10434-019-07374-z
Selection and Characteristics of Patients with Peritoneal Dissemination from Appendiceal Cancer with Exceptional/Poor Survival After CRS/HIPEC
Carlos Munoz-Zuluaga (2019)
10.1016/S1155-1968(10)53974-9
Traitement des pathologies tumorales du péritoine
Dominique Elias (2010)
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