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Role Of Granulocyte Colony‐stimulating Factor And Granulocyte‐macrophage Colony‐stimulating Factor In The Treatment Of Patients With HIV Infection

L. Frumkin
Published 1997 · Medicine

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The recombinant hurman colony‐stimulating factors, granulocyte colony‐stimulati ng factor (G‐CSF) and granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) are hematopoietic cytok ines that increase neutrophil number and enhance their function. In patients with HIV infection, G‐CSF and GM‐CSF have reversed or prevented neutropenia even during periods of full‐dose myelotoxic therapy. Both colony‐stimulating factors (CSFs) also have improved defects in neutrophil function in the setting of HIV infection. In non‐neutropenic animal models of opportunistic bacterial or fungal infections, use of CSFs has increased survival. Future clinical applications of CSF s may include the adjunctive treatment of specific HIV‐related opportunistic infections in addition to an expanding role in the treatment of HIV‐associated neutropenia and defects in neutrophil function.



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