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Thyroid Transcription Factor-1: A Review

S. Lau, D. Luthringer, R. Eisen
Published 2002 · Medicine, Biology

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Thyroid transcription factor-1 (TTF-1) is a 38-kd homeodomain containing DNA-binding protein originally identified in follicular cells of the thyroid and subsequently in pneumocytes. This review focuses on the utility of antisera in TTF-1 immunohistochemical staining in the diagnosis of neoplastic conditions. Based on published studies to date, anti-TTF-1 is a very useful reagent in distinguishing pulmonary adenocarcinoma from other primary carcinomas, identifying differentiated thyroid neoplasms, distinguishing mesothelioma from pulmonary adenocarcinoma, and distinguishing small cell carcinoma of the lung from Merkel cell carcinoma. It may also be useful in distinguishing neuroendocrine (NE) tumors of the lung from well-differentiated NE tumors from other sites, such as the intestine.
This paper references
Thyroid transcription factor-1 (TTF-1) in bronchioloalveolar carcinomas, lack of expression by mucinous subtype
S K Lau (2001)
10.1097/00000478-200106000-00015
Thyroid Transcription Factor-1 Distinguishes Metastatic Pulmonary From Well-Differentiated Neuroendocrine Tumors of Other Sites
A. Oliveira (2001)
10.1097/00000478-199702000-00014
Cytokeratin 20 immunoreactivity distinguishes Merkel cell (primary cutaneous neuroendocrine) carcinomas and salivary gland small cell carcinomas from small cell carcinomas of various sites.
J. Chan (1997)
10.1016/S0046-8177(00)80199-9
Differential expression of thyroid transcription factor 1 in small cell lung carcinoma and Merkel cell tumor.
A. L. Byrd-Gloster (2000)
Immunopathology of malignant mesothelioma and pulmonary adenocarcinoma
H Yamada
TTF-1 and CerbB-2 expression and correlation with survival in non-small cell lung cancer [abstract
S Syed (2002)
10.1128/MCB.12.2.576
Cell-type-specific expression of the rat thyroperoxidase promoter indicates common mechanisms for thyroid-specific gene expression.
H. Francis-Lang (1992)
Prognostic value of thyroid transcription factor-1 in primary, resected, non-small cell lung carcinoma.
F. Puglisi (1999)
10.1097/00000478-200011000-00009
Pulmonary Sclerosing Hemangioma Consistently Expresses Thyroid Transcription Factor-1 (TTF-1): A New Clue to Its Histogenesis
A. C. Chan (2000)
Thyroid transcription factor-1 (TTF-1) in bronchioloalveolar carcinomas, lack of expression by mucinous subtype [abstract
SK Lau (2001)
10.1023/A:1006102607697
Determination of lung as the primary site of cerebral metastatic adenocarcinomas using monoclonal antibody to thyroid transcription factor-1
R. Bohinski (1998)
10.1128/MCB.14.9.5671
The lung-specific surfactant protein B gene promoter is a target for thyroid transcription factor 1 and hepatocyte nuclear factor 3, indicating common factors for organ-specific gene expression along the foregut axis.
R. Bohinski (1994)
10.1046/j.1365-2559.2000.00801.x
Thyroid transcription factor‐1 is the superior immunohistochemical marker for pulmonary adenocarcinomas and large cell carcinomas compared to surfactant proteins A and B
Kaufmann (2000)
Immunohistochemical detection of CK5/6 and TTF-1 in malignant epithelioid mesothelioma: experience of the french mesothelioma panel [abstract
F Galateau-Salle (2001)
10.1210/MEND.8.8.7997232
Thyroid-specific expression and cyclic adenosine 3',5'-monophosphate autoregulation of the thyrotropin receptor gene involves thyroid transcription factor-1.
H. Shimura (1994)
Malignant mesothelioma: utility of the combination of calretinin and thyroid transcription factor-1 (TTF-1) antibodies [abstract
R Medina-Flores (2000)
Characterization of a thyroidspecific enhancer located 5.5 kilobase pairs upstream of the human thyroperoxidase gene
F Kikkawa (1990)
10.1074/JBC.270.42.24852
Upstream Enhancer Activity in the Human Surfactant Protein B Gene Is Mediated by Thyroid Transcription Factor 1 (*)
C. Yan (1995)
10.1038/modpathol.3880044
Thyroid Transcription Factor-1 Is Expressed in Extrapulmonary Small Cell Carcinomas but Not in Other Extrapulmonary Neuroendocrine Tumors
S. Agoff (2000)
10.1136/jcp.50.1.30
Immunocytochemical expression of tissue specific transcription factor-1 in lung carcinoma.
C. Di Loreto (1997)
10.1093/NAR/15.20.8149
A cell type specific factor recognizes the rat thyroglobulin promoter.
A. Musti (1987)
10.1038/modpathol.3880040
Concurrent Ki-67 and p53 Immunolabeling in Cutaneous Melanocytic Neoplasms: An Adjunct for Recognition of the Vertical Growth Phase in Malignant Melanomas?
Z. Kaleem (2000)
Cytokeratin subtypes and thyroid transcription factor –1 (ttf-1) immunostaining in large cell neuroendocrine carcinoma of the lung [abstract
DV Caccamo (2000)
10.1097/00000478-200007000-00002
A clinicopathologic study of 100 cases of pulmonary sclerosing hemangioma with immunohistochemical studies: TTF-1 is expressed in both round and surface cells, suggesting an origin from primitive respiratory epithelium.
M. Devouassoux-Shisheboran (2000)
10.1016/S0046-8177(99)90270-8
Alveolar adenoma: a histochemical, immunohistochemical, and ultrastructural analysis of 17 cases.
L. M. Burke (1999)
10.1267/AHC.31.287
THYROID TRANSCRIPTION FACTOR-1 (TTF-1)
R. Katoh (1998)
10.1097/00000478-200004000-00016
Value of thyroid transcription factor-1, E-cadherin, BG8, WT1, and CD44S immunostaining in distinguishing epithelial pleural mesothelioma from pulmonary and nonpulmonary adenocarcinoma.
N. Ordóñez (2000)
10.1210/ENDO.139.6.6126
Identification of thyroid transcription factor-1 in C cells and parathyroid cells.
K. Suzuki (1998)
10.1016/S0046-8177(99)90096-5
Utility of surfactant protein B precursor and thyroid transcription factor 1 in differentiating adenocarcinoma of the lung from malignant mesothelioma.
A. Khoór (1999)
10.1101/GAD.10.1.60
The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary.
S. Kimura (1996)
10.1074/JBC.271.16.9197
Glucocorticoids Block Protein Kinase A Inhibition of Calcium-activated Potassium Channels (*)
M. Shipston (1996)
10.1038/modpathol.3880098
Thyroid Transcription Factor-1 in Normal, Hyperplastic, and Neoplastic Follicular Thyroid Cells Examined by Immunohistochemistry and Nonradioactive In Situ Hybridization
R. Katoh (2000)
10.1074/JBC.270.14.8108
Gene Structure and Expression of Human Thyroid Transcription Factor-1 in Respiratory Epithelial Cells (*)
K. Ikeda (1995)
10.1016/0959-8049(95)00560-9
TTF-1 gene expression in human lung tumours.
D. Fabbro (1996)
Immunohistochemical detection of CK5/6 and TTF-1 in malignant epithelioid mesothelioma: experience of the french mesothelioma panel
F Galateau-Salle
Diagnostic utility of thyroid transcription factor-1 TTF-1) in primary and common metastatic tumors of the lung [abstract
R Medina-Flores (2000)
10.1046/j.1365-2559.2000.00890.x
Expression of thyroid transcription factor‐1 in pulmonary and extrapulmonary small cell carcinomas and other neuroendocrine carcinomas of various primary sites
Kaufmann (2000)
10.1043/0003-9985(2001)125<0228:IFTTFA>2.0.CO;2
Immunostaining for thyroid transcription factor 1 and cytokeratin 20 aids the distinction of small cell carcinoma from Merkel cell carcinoma, but not pulmonary from extrapulmonary small cell carcinomas.
W. Cheuk (2001)
Surfactant proteins and thyroid transcription factor-1 in pulmonary and breast carcinomas.
P. Bejarano (1996)
The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain.
D. Lazzaro (1991)
Thyroid transcription factor-1 and cytokeratin 7 and 20 in pulmonary and breast carcinoma
HA Harlamert (1998)
10.1016/S0046-8177(00)80255-5
Expression of thyroid transcription factor-1 (TTF-1) in human C cells and medullary thyroid carcinomas.
R. Katoh (2000)
10.1016/S0167-4781(96)00180-7
Regulation of Clara cell secretory protein gene transcription by thyroid transcription factor-1.
L. Zhang (1997)
The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the fetal brain. Development 1991;113:1093–1104
D Lazzaro (1991)
10.1089/HYB.1996.15.49
Monoclonal antibody to thyroid transcription factor-1: production, characterization, and usefulness in tumor diagnosis.
A. Holzinger (1996)
10.1074/JBC.270.12.6531
Lung Cell-specific Expression of the Murine Surfactant Protein A (SP-A) Gene Is Mediated by Interactions between the SP-A Promoter and Thyroid Transcription Factor-1 (*)
M. Bruno (1995)
10.1053/HUPA.2001.22752
Mucinous bronchioloalveolar carcinomas display a specific pattern of mucin gene expression among primary lung adenocarcinomas.
M. Copin (2001)
Thyroid transcription factor-1 (TTF-1) is a more sensitive lung carcinoma marker than surfactant APOA1
SS Anderson (1998)
Immunopathology of malignant mesothelioma and pulmonary adenocarcinoma [abstract
H Yamada (2001)
10.1053/HUPA.2000.16667
Variable expression of keratins and nearly uniform lack of thyroid transcription factor 1 in thyroid anaplastic carcinoma.
M. Miettinen (2000)
TTF-1 and C-erbB-2 expression and correlation with survival in non-small cell lung cancer
S Syed
10.1210/MEND.7.12.8145764
Thyroid transcription factor 1 activates the promoter of the thyrotropin receptor gene.
D. Civitareale (1993)
10.1002/j.1460-2075.1990.tb07574.x
Thyroid nuclear factor 1 (TTF‐1) contains a homeodomain and displays a novel DNA binding specificity.
S. Guazzi (1990)
10.1097/00000478-200103000-00011
Immunoreactivity for Thyroid Transcription Factor-1 in Stage I Non–Small Cell Carcinomas of the Lung
G. Pelosi (2001)
10.1128/MCB.10.12.6216
Characterization of a thyroid-specific enhancer located 5.5 kilobase pairs upstream of the human thyroid peroxidase gene.
F. Kikkawa (1990)
10.1074/JBC.271.12.6881
Transcription of the Lung-specific Surfactant Protein C Gene Is Mediated by Thyroid Transcription Factor 1 (*)
S. E. Kelly (1996)
10.1177/030089168907500614
Large Cell Neuroendocrine Carcinoma of the Lung
M. Barbareschi (1989)
10.1097/00000478-200009000-00004
Value of Thyroid Transcription Factor-1 Immunostaining in Distinguishing Small Cell Lung Carcinomas From Other Small Cell Carcinomas
N. Ordóñez (2000)
10.1159/000332172
Thyroid Transcription Factor-1 and Cytokeratins 7 and 20 in Pulmonary and Breast Carcinoma
H. A. Harlamert (1998)
10.1128/MCB.18.12.7410
Thyroid Transcription Factor 1 Is Calcium Modulated and Coordinately Regulates Genes Involved in Calcium Homeostasis in C Cells
K. Suzuki (1998)
10.1177/44.7.8675988
Expression of thyroid transcription factor-1(TTF-1) in fetal and neonatal human lung.
M. Stahlman (1996)
Expression of thyroid-specific transcription factors TTF-1 and PAX-8 in human thyroid neoplasms.
D. Fabbro (1994)
10.1002/j.1460-2075.1989.tb08391.x
A thyroid‐specific nuclear protein essential for tissue‐specific expression of the thyroglobulin promoter.
D. Civitareale (1989)
Diagnostic utility of thyroid transcription factor-1 TTF-1) in primary and common metastatic tumors of the lung
R Medina-Flores
10.1038/modpathol.3880289
Anaplastic Large Cell Lymphoma: The Shifting Sands of Diagnostic Hematopathology
E. Jaffe (2001)
10.1128/MCB.11.10.4927
Thyroid-specific enhancer-binding protein (T/EBP): cDNA cloning, functional characterization, and structural identity with thyroid transcription factor TTF-1.
K. Mizuno (1991)
Thyroid transcription factor-1: immunohistochemical evaluation in pulmonary neuroendocrine tumors.
A. Folpe (1999)
10.1016/S0304-3835(97)00466-7
TTF-1 protein expression in pleural malignant mesotheliomas and adenocarcinomas of the lung.
C. Di Loreto (1998)



This paper is referenced by
10.1016/j.lungcan.2012.05.091
Cyto-histologic agreement in pathologic subtyping of non small cell lung carcinoma: review of 602 fine needle aspirates with follow-up surgical specimens over a nine year period and analysis of factors underlying failure to subtype.
G. da Cunha Santos (2012)
10.1055/s-0031-1272866
Pathological diagnosis and classification of lung cancer in small biopsies and cytology: strategic management of tissue for molecular testing.
W. Travis (2011)
10.1055/s-0034-1365157
[Pleural effusion cytology of asbestos-associated malignant mesothelioma and lung carcinoma in the diagnosis of occupational diseases by the statutory accident insurance funds].
S. Biesterfeld (2014)
10.3892/ol.2014.2036
Anaplastic thyroid carcinoma with diffuse thoracic skin metastasis: A case report
S. Altınay (2014)
Follicular thyroid carcinoma presenting as axial skeletal metastases.
S. Sreedharan (2007)
10.1038/srep08649
Diagnostic and Prognostic Significances of MUC5B and TTF-1 Expressions in Resected Non-Small Cell Lung Cancer
Ryo Nagashio (2015)
10.1097/PAS.0000000000000876
Immunohistochemical Characterization of the Origins of Metastatic Well-differentiated Neuroendocrine Tumors to the Liver
Z. Yang (2017)
10.1097/01.XEJ.0000415808.32127.71
Immunohistochemical study of Napsin A and thyroid transcription factor-1 in non-small-cell lung carcinoma
Heba Mohamed Tawfik (2012)
10.1043/1543-2165(2008)132[384:AOITTD]2.0.CO;2
Application of immunohistochemistry to the diagnosis of primary and metastatic carcinoma to the lung.
J. Jagirdar (2008)
10.3346/JKMS.2003.18.4.494
Thyroid transcription factor-1 (TTF-1) expression in human lung carcinomas: its prognostic implication and relationship with wxpressions of p53 and Ki-67 proteins.
Na-Hye Myong (2003)
10.1016/B978-1-4160-5766-6.00018-2
Chapter 14 – Immunohistology of the Gastrointestinal Tract
A. Krasinskas (2011)
10.1002/cncy.20005
A technique to improve diagnostic information from fine‐needle aspirations
B. Skov (2009)
10.1007/978-0-387-32122-6
Color Atlas of Immunocytochemistry in Diagnostic Cytology
P. Ganjei-Azar (2006)
10.1038/modpathol.3800629
TTF-1 and p63 for distinguishing pulmonary small-cell carcinoma from poorly differentiated squamous cell carcinoma in previously pap-stained cytologic material
N. Kalhor (2006)
10.1016/S0755-4982(05)84140-5
Carcinome vsiculaire de la thyrode avec mtastases cutanes de localisations inhabituelles
I. Ghfir (2005)
10.21276/APALM.1839
Role of Immunohistochemistry in The Subtyping of Non Small Cell Lung Carcinoma on True Cut Lung Biopsies
M. Alekhya (2018)
Akciğer Dişindaki Tümörlerde İmmunhistokimyasal TTF-1 Ekspresyonu
Zeynep Tosuner (2014)
10.1097/PAI.0b013e3181c29407
Expression of Thyroid Transcription Factor-1 in Colorectal Carcinoma
B. Xu (2010)
10.1016/B978-1-4160-5766-6.00017-0
Chapter 13 – Immunohistology of Skin Tumors
M. R. Wick (2010)
10.1378/chest.10-3149
Clinical significance of thyroid transcription factor-1 in advanced lung adenocarcinoma under epidermal growth factor receptor tyrosine kinase inhibitor treatment.
Kuei-Pin Chung (2012)
10.1097/PAI.0b013e3182612643
Applications and Limitations of Immunohistochemical Expression of “Napsin-A” in Distinguishing Lung Adenocarcinoma From Adenocarcinomas of Other Organs
M. Kadivar (2013)
10.1007/s13353-010-0022-0
The −112G > A polymorphism of the secretoglobin 3A2 (SCGB3A2) gene encoding uteroglobin-related protein 1 (UGRP1) increases risk for the development of Graves’ disease in subsets of patients with elevated levels of immunoglobulin E
D. Chistiakov (2010)
10.1159/000326434
Thyroid Transcription Factor–1 Immunocytochemical Staining of Pleural Fluid Cytocentrifuge Preparations for Detection of Small Cell Lung Carcinoma
J. Liu (2004)
10.1016/S0761-8425(08)74980-5
Pleurésies malignes révélatrices d’un cancer : comparaison des étiologies avec les pleurésies métastatiques d’un cancer connu
L. Cellerin (2008)
10.1038/bjc.2011.281
Generation and evaluation of a monoclonal antibody, designated MAdL, as a new specific marker for adenocarcinomas of the lung
H. Schultz (2011)
A Comparative Study of International Classification forLung Cancer and WHO Classification in Histological Diagnosis of Lung Cancer in Small Biopsies
I. Nithya (2015)
10.5578/tt.24112
Duodenal and pancreas metastasis from lung cancer.
T. Tamura (2017)
10.1007/s11626-007-9062-0
Mutational analysis of thyroid transcription factor-1 gene (TTF-1) in lung carcinomas
X. Y. Bai (2007)
10.4103/1742-6413.94570
Dual color multiplex TTF-1 + Napsin A and p63 + CK5 immunostaining for subcategorizing of poorly differentiated pulmonary non-small carcinomas into adenocarcinoma and squamous cell carcinoma in fine needle aspiration specimens
S. Sethi (2012)
10.1200/JCO.2010.28.8126
The evolving role of histology in the management of advanced non-small-cell lung cancer.
C. Langer (2010)
10.1097/01.pas.0000126780.10029.f0
Current Practical Applications of Diagnostic Immunohistochemistry in Breast Pathology
M. Lerwill (2004)
10.1097/PAI.0b013e318245c730
Desmoglein-3 and Napsin A Double Stain, a Useful Immunohistochemical Marker for Differentiation of Lung Squamous Cell Carcinoma and Adenocarcinoma From Other Subtypes
Y. Ağaçkıran (2012)
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