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Thyroid Transcription Factor-1: A Review

S. Lau, D. Luthringer, R. Eisen
Published 2002 · Medicine, Biology

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Thyroid transcription factor-1 (TTF-1) is a 38-kd homeodomain containing DNA-binding protein originally identified in follicular cells of the thyroid and subsequently in pneumocytes. This review focuses on the utility of antisera in TTF-1 immunohistochemical staining in the diagnosis of neoplastic conditions. Based on published studies to date, anti-TTF-1 is a very useful reagent in distinguishing pulmonary adenocarcinoma from other primary carcinomas, identifying differentiated thyroid neoplasms, distinguishing mesothelioma from pulmonary adenocarcinoma, and distinguishing small cell carcinoma of the lung from Merkel cell carcinoma. It may also be useful in distinguishing neuroendocrine (NE) tumors of the lung from well-differentiated NE tumors from other sites, such as the intestine.
This paper references
Thyroid transcription factor-1 (TTF-1) in bronchioloalveolar carcinomas, lack of expression by mucinous subtype
S K Lau (2001)
Thyroid Transcription Factor-1 Distinguishes Metastatic Pulmonary From Well-Differentiated Neuroendocrine Tumors of Other Sites
A. Oliveira (2001)
Cytokeratin 20 immunoreactivity distinguishes Merkel cell (primary cutaneous neuroendocrine) carcinomas and salivary gland small cell carcinomas from small cell carcinomas of various sites.
J. Chan (1997)
Differential expression of thyroid transcription factor 1 in small cell lung carcinoma and Merkel cell tumor.
A. L. Byrd-Gloster (2000)
Immunopathology of malignant mesothelioma and pulmonary adenocarcinoma
H Yamada
TTF-1 and CerbB-2 expression and correlation with survival in non-small cell lung cancer [abstract
S Syed (2002)
Cell-type-specific expression of the rat thyroperoxidase promoter indicates common mechanisms for thyroid-specific gene expression.
H. Francis-Lang (1992)
Prognostic value of thyroid transcription factor-1 in primary, resected, non-small cell lung carcinoma.
F. Puglisi (1999)
Pulmonary Sclerosing Hemangioma Consistently Expresses Thyroid Transcription Factor-1 (TTF-1): A New Clue to Its Histogenesis
A. C. Chan (2000)
Thyroid transcription factor-1 (TTF-1) in bronchioloalveolar carcinomas, lack of expression by mucinous subtype [abstract
SK Lau (2001)
Determination of lung as the primary site of cerebral metastatic adenocarcinomas using monoclonal antibody to thyroid transcription factor-1
R. Bohinski (1998)
The lung-specific surfactant protein B gene promoter is a target for thyroid transcription factor 1 and hepatocyte nuclear factor 3, indicating common factors for organ-specific gene expression along the foregut axis.
R. Bohinski (1994)
Thyroid transcription factor‐1 is the superior immunohistochemical marker for pulmonary adenocarcinomas and large cell carcinomas compared to surfactant proteins A and B
Kaufmann (2000)
Immunohistochemical detection of CK5/6 and TTF-1 in malignant epithelioid mesothelioma: experience of the french mesothelioma panel [abstract
F Galateau-Salle (2001)
Thyroid-specific expression and cyclic adenosine 3',5'-monophosphate autoregulation of the thyrotropin receptor gene involves thyroid transcription factor-1.
H. Shimura (1994)
Malignant mesothelioma: utility of the combination of calretinin and thyroid transcription factor-1 (TTF-1) antibodies [abstract
R Medina-Flores (2000)
Characterization of a thyroidspecific enhancer located 5.5 kilobase pairs upstream of the human thyroperoxidase gene
F Kikkawa (1990)
Upstream Enhancer Activity in the Human Surfactant Protein B Gene Is Mediated by Thyroid Transcription Factor 1 (*)
C. Yan (1995)
Thyroid Transcription Factor-1 Is Expressed in Extrapulmonary Small Cell Carcinomas but Not in Other Extrapulmonary Neuroendocrine Tumors
S. Agoff (2000)
Immunocytochemical expression of tissue specific transcription factor-1 in lung carcinoma.
C. Di Loreto (1997)
A cell type specific factor recognizes the rat thyroglobulin promoter.
A. Musti (1987)
Concurrent Ki-67 and p53 Immunolabeling in Cutaneous Melanocytic Neoplasms: An Adjunct for Recognition of the Vertical Growth Phase in Malignant Melanomas?
Z. Kaleem (2000)
Cytokeratin subtypes and thyroid transcription factor –1 (ttf-1) immunostaining in large cell neuroendocrine carcinoma of the lung [abstract
DV Caccamo (2000)
A clinicopathologic study of 100 cases of pulmonary sclerosing hemangioma with immunohistochemical studies: TTF-1 is expressed in both round and surface cells, suggesting an origin from primitive respiratory epithelium.
M. Devouassoux-Shisheboran (2000)
Alveolar adenoma: a histochemical, immunohistochemical, and ultrastructural analysis of 17 cases.
L. M. Burke (1999)
R. Katoh (1998)
Value of thyroid transcription factor-1, E-cadherin, BG8, WT1, and CD44S immunostaining in distinguishing epithelial pleural mesothelioma from pulmonary and nonpulmonary adenocarcinoma.
N. Ordóñez (2000)
Identification of thyroid transcription factor-1 in C cells and parathyroid cells.
K. Suzuki (1998)
Utility of surfactant protein B precursor and thyroid transcription factor 1 in differentiating adenocarcinoma of the lung from malignant mesothelioma.
A. Khoór (1999)
The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary.
S. Kimura (1996)
Glucocorticoids Block Protein Kinase A Inhibition of Calcium-activated Potassium Channels (*)
M. Shipston (1996)
Thyroid Transcription Factor-1 in Normal, Hyperplastic, and Neoplastic Follicular Thyroid Cells Examined by Immunohistochemistry and Nonradioactive In Situ Hybridization
R. Katoh (2000)
Gene Structure and Expression of Human Thyroid Transcription Factor-1 in Respiratory Epithelial Cells (*)
K. Ikeda (1995)
TTF-1 gene expression in human lung tumours.
D. Fabbro (1996)
Immunohistochemical detection of CK5/6 and TTF-1 in malignant epithelioid mesothelioma: experience of the french mesothelioma panel
F Galateau-Salle
Diagnostic utility of thyroid transcription factor-1 TTF-1) in primary and common metastatic tumors of the lung [abstract
R Medina-Flores (2000)
Expression of thyroid transcription factor‐1 in pulmonary and extrapulmonary small cell carcinomas and other neuroendocrine carcinomas of various primary sites
Kaufmann (2000)
Immunostaining for thyroid transcription factor 1 and cytokeratin 20 aids the distinction of small cell carcinoma from Merkel cell carcinoma, but not pulmonary from extrapulmonary small cell carcinomas.
W. Cheuk (2001)
Surfactant proteins and thyroid transcription factor-1 in pulmonary and breast carcinomas.
P. Bejarano (1996)
The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain.
D. Lazzaro (1991)
Thyroid transcription factor-1 and cytokeratin 7 and 20 in pulmonary and breast carcinoma
HA Harlamert (1998)
Expression of thyroid transcription factor-1 (TTF-1) in human C cells and medullary thyroid carcinomas.
R. Katoh (2000)
Regulation of Clara cell secretory protein gene transcription by thyroid transcription factor-1.
L. Zhang (1997)
The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the fetal brain. Development 1991;113:1093–1104
D Lazzaro (1991)
Monoclonal antibody to thyroid transcription factor-1: production, characterization, and usefulness in tumor diagnosis.
A. Holzinger (1996)
Lung Cell-specific Expression of the Murine Surfactant Protein A (SP-A) Gene Is Mediated by Interactions between the SP-A Promoter and Thyroid Transcription Factor-1 (*)
M. Bruno (1995)
Mucinous bronchioloalveolar carcinomas display a specific pattern of mucin gene expression among primary lung adenocarcinomas.
M. Copin (2001)
Thyroid transcription factor-1 (TTF-1) is a more sensitive lung carcinoma marker than surfactant APOA1
SS Anderson (1998)
Immunopathology of malignant mesothelioma and pulmonary adenocarcinoma [abstract
H Yamada (2001)
Variable expression of keratins and nearly uniform lack of thyroid transcription factor 1 in thyroid anaplastic carcinoma.
M. Miettinen (2000)
TTF-1 and C-erbB-2 expression and correlation with survival in non-small cell lung cancer
S Syed
Thyroid transcription factor 1 activates the promoter of the thyrotropin receptor gene.
D. Civitareale (1993)
Thyroid nuclear factor 1 (TTF‐1) contains a homeodomain and displays a novel DNA binding specificity.
S. Guazzi (1990)
Immunoreactivity for Thyroid Transcription Factor-1 in Stage I Non–Small Cell Carcinomas of the Lung
G. Pelosi (2001)
Characterization of a thyroid-specific enhancer located 5.5 kilobase pairs upstream of the human thyroid peroxidase gene.
F. Kikkawa (1990)
Transcription of the Lung-specific Surfactant Protein C Gene Is Mediated by Thyroid Transcription Factor 1 (*)
S. E. Kelly (1996)
Large Cell Neuroendocrine Carcinoma of the Lung
M. Barbareschi (1989)
Value of Thyroid Transcription Factor-1 Immunostaining in Distinguishing Small Cell Lung Carcinomas From Other Small Cell Carcinomas
N. Ordóñez (2000)
Thyroid Transcription Factor-1 and Cytokeratins 7 and 20 in Pulmonary and Breast Carcinoma
H. A. Harlamert (1998)
Thyroid Transcription Factor 1 Is Calcium Modulated and Coordinately Regulates Genes Involved in Calcium Homeostasis in C Cells
K. Suzuki (1998)
Expression of thyroid transcription factor-1(TTF-1) in fetal and neonatal human lung.
M. Stahlman (1996)
Expression of thyroid-specific transcription factors TTF-1 and PAX-8 in human thyroid neoplasms.
D. Fabbro (1994)
A thyroid‐specific nuclear protein essential for tissue‐specific expression of the thyroglobulin promoter.
D. Civitareale (1989)
Diagnostic utility of thyroid transcription factor-1 TTF-1) in primary and common metastatic tumors of the lung
R Medina-Flores
Anaplastic Large Cell Lymphoma: The Shifting Sands of Diagnostic Hematopathology
E. Jaffe (2001)
Thyroid-specific enhancer-binding protein (T/EBP): cDNA cloning, functional characterization, and structural identity with thyroid transcription factor TTF-1.
K. Mizuno (1991)
Thyroid transcription factor-1: immunohistochemical evaluation in pulmonary neuroendocrine tumors.
A. Folpe (1999)
TTF-1 protein expression in pleural malignant mesotheliomas and adenocarcinomas of the lung.
C. Di Loreto (1998)

This paper is referenced by
Cyto-histologic agreement in pathologic subtyping of non small cell lung carcinoma: review of 602 fine needle aspirates with follow-up surgical specimens over a nine year period and analysis of factors underlying failure to subtype.
G. da Cunha Santos (2012)
Pathological diagnosis and classification of lung cancer in small biopsies and cytology: strategic management of tissue for molecular testing.
W. Travis (2011)
[Pleural effusion cytology of asbestos-associated malignant mesothelioma and lung carcinoma in the diagnosis of occupational diseases by the statutory accident insurance funds].
S. Biesterfeld (2014)
Anaplastic thyroid carcinoma with diffuse thoracic skin metastasis: A case report
S. Altınay (2014)
Follicular thyroid carcinoma presenting as axial skeletal metastases.
S. Sreedharan (2007)
Diagnostic and Prognostic Significances of MUC5B and TTF-1 Expressions in Resected Non-Small Cell Lung Cancer
Ryo Nagashio (2015)
Immunohistochemical Characterization of the Origins of Metastatic Well-differentiated Neuroendocrine Tumors to the Liver
Z. Yang (2017)
Immunohistochemical study of Napsin A and thyroid transcription factor-1 in non-small-cell lung carcinoma
Heba Mohamed Tawfik (2012)
Application of immunohistochemistry to the diagnosis of primary and metastatic carcinoma to the lung.
J. Jagirdar (2008)
Thyroid transcription factor-1 (TTF-1) expression in human lung carcinomas: its prognostic implication and relationship with wxpressions of p53 and Ki-67 proteins.
Na-Hye Myong (2003)
Chapter 14 – Immunohistology of the Gastrointestinal Tract
A. Krasinskas (2011)
A technique to improve diagnostic information from fine‐needle aspirations
B. Skov (2009)
Color Atlas of Immunocytochemistry in Diagnostic Cytology
P. Ganjei-Azar (2006)
TTF-1 and p63 for distinguishing pulmonary small-cell carcinoma from poorly differentiated squamous cell carcinoma in previously pap-stained cytologic material
N. Kalhor (2006)
Carcinome vsiculaire de la thyrode avec mtastases cutanes de localisations inhabituelles
I. Ghfir (2005)
Role of Immunohistochemistry in The Subtyping of Non Small Cell Lung Carcinoma on True Cut Lung Biopsies
M. Alekhya (2018)
Akciğer Dişindaki Tümörlerde İmmunhistokimyasal TTF-1 Ekspresyonu
Zeynep Tosuner (2014)
Expression of Thyroid Transcription Factor-1 in Colorectal Carcinoma
B. Xu (2010)
Chapter 13 – Immunohistology of Skin Tumors
M. R. Wick (2010)
Clinical significance of thyroid transcription factor-1 in advanced lung adenocarcinoma under epidermal growth factor receptor tyrosine kinase inhibitor treatment.
Kuei-Pin Chung (2012)
Applications and Limitations of Immunohistochemical Expression of “Napsin-A” in Distinguishing Lung Adenocarcinoma From Adenocarcinomas of Other Organs
M. Kadivar (2013)
The −112G > A polymorphism of the secretoglobin 3A2 (SCGB3A2) gene encoding uteroglobin-related protein 1 (UGRP1) increases risk for the development of Graves’ disease in subsets of patients with elevated levels of immunoglobulin E
D. Chistiakov (2010)
Thyroid Transcription Factor–1 Immunocytochemical Staining of Pleural Fluid Cytocentrifuge Preparations for Detection of Small Cell Lung Carcinoma
J. Liu (2004)
Pleurésies malignes révélatrices d’un cancer : comparaison des étiologies avec les pleurésies métastatiques d’un cancer connu
L. Cellerin (2008)
Generation and evaluation of a monoclonal antibody, designated MAdL, as a new specific marker for adenocarcinomas of the lung
H. Schultz (2011)
A Comparative Study of International Classification forLung Cancer and WHO Classification in Histological Diagnosis of Lung Cancer in Small Biopsies
I. Nithya (2015)
Duodenal and pancreas metastasis from lung cancer.
T. Tamura (2017)
Mutational analysis of thyroid transcription factor-1 gene (TTF-1) in lung carcinomas
X. Y. Bai (2007)
Dual color multiplex TTF-1 + Napsin A and p63 + CK5 immunostaining for subcategorizing of poorly differentiated pulmonary non-small carcinomas into adenocarcinoma and squamous cell carcinoma in fine needle aspiration specimens
S. Sethi (2012)
The evolving role of histology in the management of advanced non-small-cell lung cancer.
C. Langer (2010)
Current Practical Applications of Diagnostic Immunohistochemistry in Breast Pathology
M. Lerwill (2004)
Desmoglein-3 and Napsin A Double Stain, a Useful Immunohistochemical Marker for Differentiation of Lung Squamous Cell Carcinoma and Adenocarcinoma From Other Subtypes
Y. Ağaçkıran (2012)
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