Rapid Atrophy Of The Lumbar Multifidus Follows Experimental Disc Or Nerve Root Injury
Paul William Hodges, Allison Kaigle Holm, Tommy Hansson, Sten H. Holm
Published 2006 · Medicine
Download PDFAnalyze on Scholarcy
Study Design. Experimental study of muscle changes after lumbar spinal injury. Objectives. To investigate effects of intervertebral disc and nerve root lesions on cross-sectional area, histology and chemistry of porcine lumbar multifidus. Summary of Background Data. The multifidus cross-sectional area is reduced in acute and chronic low back pain. Although chronic changes are widespread, acute changes at 1 segment are identified within days of injury. It is uncertain whether changes precede or follow injury, or what is the mechanism. Methods. The multifidus cross-sectional area was measured in 21 pigs from L1 to S1 with ultrasound before and 3 or 6 days after lesions: incision into L3–L4 disc, medial branch transection of the L3 dorsal ramus, and a sham procedure. Samples from L3 to L5 were studied histologically and chemically. Results. The multifidus cross-sectional area was reduced at L4 ipsilateral to disc lesion but at L4–L6 after nerve lesion. There was no change after sham or on the opposite side. Water and lactate were reduced bilaterally after disc lesion and ipsilateral to nerve lesion. Histology revealed enlargement of adipocytes and clustering of myofibers at multiple levels after disc and nerve lesions. Conclusions. These data resolve the controversy that the multifidus cross-sectional area reduces rapidly after lumbar injury. Changes after disc lesion affect 1 level with a different distribution to denervation. Such changes may be due to disuse following reflex inhibitory mechanisms.
This paper references
Radiographic demonstration of paraspinal muscle wasting in patients with chronic low back pain.
Robert G. Cooper (1992)
Volvo Award winner in biomechanical studies. Kinematic behavior of the porcine lumbar spine: A chronic lesion model. Spine 1997;22:2796–806
AM Kaigle (1997)
Degradation of myofibrillar proteins by cathepsins B and D.
Wilhelm Schwartz (1977)
Physiology of a microgravity environment invited review: microgravity and skeletal muscle.
Robert H Fitts (2000)
High-resolution Magnetic Resonance Imaging Is a Noninvasive Method of Observing Injury and Recovery in the Peripheral Nervous System
Beverly D L Aagaard (2003)
Skeletal muscle fiber atrophy: altered thin filament density changes slow fiber force and shortening velocity.
Danny A Riley (2005)
Effect of tissue fat and water content on nuclear magnetic resonance relaxation times of cardiac and skeletal muscle.
Thomas D. Scholz (1990)
Magnetic resonance imaging of the discs and trunk muscles in patients with chronic low back pain and healthy control subjects.
Riitta Parkkola (1993)
Local sympathetic denervation of white adipose tissue in rats induces preadipocyte proliferation without noticeable changes in metabolism.
Beatrice Cousin (1993)
Rapid atrophy of mouse soleus muscles after tenotomy depends on an intact innervation
Elspeth M. Mclachlan (1981)
Focal atrophy of the multifidus muscle in lumbosacral radiculopathy.
William W. Campbell (1998)
The Anatomy of Lumbosacral Posterior Rami and Meningeal Branches of Spinal Nerves (Sinu-Vertebral Nerves)
Herbert E. Pedersen (1956)
Contents of myosin heavy chains in denervated slow and fast rat leg muscles.
Anna Jakubiec-Puka (1999)
Interrelations of myogenic response, progressive atrophy of muscle fibers, and cell death in denervated skeletal muscle.
Andrei B. Borisov (2001)
MR imaging and ultrasonography of the lumbar multifidus muscle: Comparison of two different modalities
J A Hides (1995)
The Multifidus Muscle in Patients with Lumbar Disc Herniation: A Histochemical and Morphometric Analysis of Intraoperative Biopsies
Mikko Mattila (1986)
The Relation Among Spinal Geometry on MRI, Paraspinal Electromyographic Abnormalities, and Age in Persons Referred for Electrodiagnostic Testing of Low Back Symptoms
Andrew J. Haig (2002)
Electromyographic Response of the Porcine Multifidus Musculature After Nerve Stimulation
Aage Indahl (1995)
Muscular atrophy following immobilization. A review
H J Appell (1990)
High-resolution magnetic resonance imaging is a noninvasive method of observing injury and recovery in the peripheral nervous system. Neurosurgery 2003;53:199–203
BD Aagaard (2003)
Lysosomes and disuse atrophy of skeletal muscle.
Stephen R. Max (1971)
Magnetic resonance imaging of the discs and trunk muscles in patients with chronic low back pain and healthy control subjects. Spine 1993;18:830–6
R Parkkola (1993)
Muscular Atrophy Following Immobilisation
Hans Joachim Appell (1990)
1987 Volvo Award in Basic Science: The Morphology of the Lumbar Erector Spinae
J E Macintosh (1987)
Are Sheep Spines a Valid Biomechanical Model for Human Spines?
Hans Joachim Wilke (1997)
Correlation between the MRI changes in the lumbar multifidus muscles and leg pain.
Deiary F. Kader (2000)
Increase in muscle nociceptive substances and anaerobic metabolism in patients with trapezius myalgia: microdialysis in rest and during exercise
Lars Rosendal (2004)
Body composition, endurance, strength, cross-sectional area, and density of MM erector spinae in men with and without low back pain.
G Hultman (1993)
Fiber type area and metabolic potential of the thigh muscle in man after knee surgery and immobilization.
Tom Häggmark (1981)
A role for FGF-6 in skeletal muscle regeneration.
Thomas Floss (1997)
A Universal Model of the Lumbar Back Muscles in the Upright Position
Nikolai Bogduk (1992)
The nerve supply to the human lumbar intervertebral discs.
Nikolai Bogduk (1981)
Acetylcholinesterase forms in fast and slow rabbit muscle
Francis Bacou (1982)
Clinical Presentation and Anatomic Position of L3-L4 Disc Herniation: A Prospective and Comparative Study
Eran Tamir (2004)
Evidence of lumbar multifidus muscle wasting ipsilateral to symptoms in patients with acute/subacute low back pain.
Julie A. Hides (1994)
Expression of specific white adipose tissue genes in denervation-induced skeletal muscle fatty degeneration.
J P Dulor (1998)
On the reflex effects from the knee joint of the cat.
Jan Ekholm (1960)
CT imaging of trunk muscles in chronic low back pain patients and healthy control subjects
Lieven A Danneels (2000)
1997 Volvo Award Winner in Biomechanical Studies: Kinematic Behavior of the Porcine Lumbar Spine: A Chronic Lesion Model
Allison M. Kaigle (1997)
The contribution of reflex inhibition to arthrogenous muscle weakness.
Maria Stokes (1984)
Comparative value of electromyographic, myelographic and clinical-neurological examinations in diagnosis of lumbar root compression syndrome.
B. Anders Knutsson (1961)
Effect of tendon release and delayed repair on the structure of the muscles of the rotator cuff: an experimental study in sheep.
Christian Gerber (2004)
Asymmetric atrophy of the supraspinatus muscle following tendon tear.
Dominik Christoph Meyer (2005)
Muscle atrophy in rats following denervation, casting, inflammation, and tenotomy.
Gerald J. Herbison (1979)
Multifidus Muscle Recovery Is Not Automatic After Resolution of Acute, First‐Episode Low Back Pain
Julie A. Hides (1996)
The fibre type composition of thoracic and lumbar paravertebral muscles in man.
Andrej Sirca (1985)
Atrophy of sacrospinal muscle groups in patients with chronic, diffusely radiating lumbar back pain
Erkki Laasonen (2004)
Histochemical study on the atrophy of the quadriceps femoris muscle caused by knee joint injuries of rats.
Y Okada (1989)
Volvo award in basic science. The morphology of the lumbar erector spinae. Spine 1987;12:658–68
JE Macintosh (1987)
Fat content of lumbar extensor muscles and low back disability: a radiographic and clinical comparison.
Hannu Alaranta (1993)
Interaction Between the Porcine Lumbar Intervertebral Disc, Zygapophysial Joints, and Paraspinal Muscles
Aage Indahl (1997)
Effect of a 17 day spaceflight on contractile properties of human soleus muscle fibres.
Jeffrey J Widrick (1999)
Rat supraspinatus muscle atrophy after tendon detachment.
Elisabeth R. Barton (2005)
Adaptation of fibers in fast-twitch muscles of rats to spaceflight and hindlimb suspension.
Bolan Jiang (1992)
Histochemical Changes in the Multifidus Muscle in Patients With Lumbar Intervertebral Disc Herniation
Kiyoshi Yoshihara (2001)
The use of a quadruped as an in vivo model for the study of the spine – biomechanical considerations
Theodoor H Smit (2002)
The inflammatory response to muscle injury and its clinical implications
DL Macintyre (1995)
Stability increase of the lumbar spine with different muscle groups: a biomechanical in vitro study.
Ian A. F. Stokes (1995)
Long-Term Effects of Specific Stabilizing Exercises for First-Episode Low Back Pain
Julie A. Hides (2001)
Effect of peripheral nerve injury on nuclear magnetic resonance relaxation times of rat skeletal muscle.
Yuki Hayashi (1997)
The Attachments of the Lumbar Erector Spinae
J E Macintosh (1991)
Angiogenic and inflammatory responses following skeletal muscle injury are altered by immune neutralization of endogenous basic fibroblast growth factor, insulin-like growth factor-1 and transforming growth factor-β1
Jean-Pascal Lefaucheur (1996)
Limb blood flow, cardiac output and quadriceps muscle bulk following spinal cord injury and the effect of training for the Odstock functional electrical stimulation standing system
P Taylor (1993)
Histochemistry and Morphology of Erector Spinae Muscle in Lumbar Disc Herniation
Xiao Zhong Zhu (1989)
MR imaging and ultrasonography of the lumbar multifidus muscle: Comparison of two different modalities. Spine 1995;20:54–5
JA Hides (1995)
Analysis of vertebral muscle obtained during surgery for correction of a lumbar disc disorder.
David Malcolm Ford (1983)
Knee joint effusion and quadriceps reflex inhibition in man.
John D. Spencer (1984)
Posterior Surgical Approach to the Lumbar Spine and Its Effect on the Multifidus Muscle
Ben R. Weber (1997)
Histochemistry and Morphology of the Multifidus Muscle in Lumbar Disc Herniation: Comparative Study Between Diseased and Normal Sides
Wei-guo Zhao (2000)
Functional and structural adaptations of skeletal muscle to microgravity.
Robert H Fitts (2001)
This paper is referenced by
Association between radiculopathy and lumbar multifidus atrophy in magnetic resonance imaging.
Ji Hye Min (2013)
Functional scores and subjective responses of injured workers with back or neck pain treated with chiropractic care in an integrative program: a retrospective analysis of 100 cases.
Donald Aspegren (2009)
The role of the lumbar multifidus in chronic low back pain: a review.
Michael D Freeman (2010)
Evaluation and Treatment Strategies for Care of the Injured Lumbar Spine After a Motor Vehicle Accident
Terry A. Pratt (2015)
Symmetry of paraspinal muscle denervation in clinical lumbar spinal stenosis: support for a hypothesis of posterior primary ramus stretching?
Andrew J. Haig (2013)
Comparison of MRI cross-sectional area and functions of core muscles among asymptomatic individuals with and without lumbar intervertebral disc degeneration
Gyeong-tae Gwak (2019)
Evaluation of epaxial muscle structure in dogs with spinal disease
Anna Fredrika Boström (2018)
Evaluation der Neuen Rückenschule
C. Borys (2013)
Cervical Paraspinal Muscle Atrophy Rates Following Laminoplasty and Laminectomy with Fusion for Cervical Spondylotic Myelopathy.
Adedayo O. Ashana (2017)
Cross-sectional area of the paraspinal muscles and its association with muscle strength among fighter pilots: a 5-year follow-up
Tuomas Honkanen (2019)
Comparison of the Cross-Sectional Area of Longus Colli Muscle Between Patients With Cervical Radicular Pain and Healthy Controls.
Pardis Noormohammadpour (2017)
Epaxial musculature, motor control, and its relationship with back pain in the horse: objective clinical physical therapy, pathological, and imaging studies.
Narelle Stubbs (2011)
Evaluation of lumbar multifidus muscle in patients with lumbar disc herniation: are complex quantitative MRI measurements needed?
Bulent Colakoglu (2019)
Evaluation der Neuen Rückenschule
Ziele der Neuen Rückenschule (2014)
Behavior of the lumbar multifidus during lower extremity movements in people with recurrent low back pain during symptom remission.
David A. Macdonald (2011)
Electromyographic analysis of training to selectively strengthen the lumbar multifidus muscle: effects of different lifting directions and weight loading of the extremities during quadruped upper and lower extremity lifts.
Mitsuhiro Masaki (2015)
Intervertebral disc herniation effects on multifidus muscle composition and resident stem cell populations
Obiajulu Agha (2020)
Mesenchymal Stem Cell Treatment of Intervertebral Disc Lesion Prevents Fatty Infiltration and Fibrosis of the Multifidus Muscle, but not Cytokine and Muscle Fiber Changes
G. James (2016)
Cross‐sectional area of lumbar spinal muscles and vertebral endplates: a secondary analysis of 91 computed tomography images of children aged 2–20
Ella Been (2018)
Single-motor-unit discharge characteristics in lumbar multifidus muscle of acute low back pain patients.
Lise Raven Lothe (2019)
Increased intramuscular fatty infiltration without differences in lumbar muscle cross-sectional area during remission of unilateral recurrent low back pain.
Roseline D'hooge (2012)
2014 ISSLS Presidential Address.
Jeremy C. T. Fairbank (2015)
Fear-avoidance beliefs are associated with a high fat content in the erector spinae: a 1.5 tesla magnetic resonance imaging study
Eddo Wesselink (2019)
The new "Tehran Back Belt": Design then testing during a simulated sitting task improved biomechanical spine muscle activity
Hamidreza Mokhtarinia (2019)
Predictors of clinical success with stabilization exercise are associated with lower levels of lumbar multifidus intramuscular adipose tissue in patients with low back pain
Jeffrey J. Hebert (2018)
Physiology and pathophysiology of low back pain in ballet dancers
Jan E. Gildea (2015)
Development and Validation of a Method to Measure Lumbosacral Motion Using Ultrasound Imaging.
Wolbert van den Hoorn (2016)
Different ways to balance the spine in sitting: Muscle activity in specific postures differs between individuals with and without a history of back pain in sitting
Andrew P Claus (2018)
Reorganization of the motor cortex is associated with postural control deficits in recurrent low back pain.
H. -W. Tsao (2008)
Utilization of structural and biochemical cues to enhance peripheral nerve regeneration
Balendu Shekhar Jha (2011)
Efficacy of administered mesenchymal stem cells in the initiation and co‐ordination of repair processes by resident disc cells in an ovine (Ovis aries) large destabilizing lesion model of experimental disc degeneration
Cindy C Shu (2018)
Asymmetric Degeneration of Paravertebral Muscles in Patients With Degenerative Lumbar Scoliosis
Najibullah Shafaq (2012)See more