Determining The Impact Of A Cancer Diagnosis On Diabetes Management
Laura C Pinheiro, Harveen Kaur, Daniela Nilo, Matthew Safford, Antonio P. DeRosa, Lisa M. Kern
Published 2019 · Medicine
Download PDFAnalyze on Scholarcy
Supplemental Digital Content is available in the text. Objectives: Cancer patients with comorbid diabetes have a 50% increased risk of all-cause mortality compared with cancer patients without diabetes. Less attention to diabetes management (glucose control, medication adherence, and diabetes self-management behaviors) during active cancer treatment is hypothesized as an explanation for worse outcomes among diabetic cancer patients. The objective of this systematic review is to determine and quantify how a cancer diagnosis impacts diabetes management. Methods: Quantitative and qualitative studies evaluating diabetes management among patients were identified by searching 4 databases: MEDLINE, EMBASE, The Cochrane Library, and Web of Science. Two independent reviewers extracted data and summarized results from eligible studies. Study quality was formally assessed. Results: Thirty-six studies met all inclusion criteria. We observed heterogeneity across studies in terms of study design, sample size, cancer site, type of diabetes management evaluated, and quality. Numerous articles discussed that overall, glucose control, medication adherence, and diabetes self-management behaviors declined following a cancer diagnosis. However, findings were inconsistent across studies. Conclusions: Although the effects of a cancer diagnosis on diabetes management are mixed, when results across studies were synthesized together, diabetes management appeared to generally decline after a cancer diagnosis. Declines in diabetes management seem to be primarily due to shifts in the priority of care from diabetes management to cancer. A next critical step in this line of work is to identify patient and provider level predictors of better or worse diabetes management to design and test interventions aimed at improving effective diabetes management for cancer patients.
This paper references
SEER Cancer Statistics Review, 1975-2003
Lynn A. G. Ries (2006)
CASP Checklists Critical Appraisal Skills Programme: making sense of evidence
Impact of Glycemic Control and Metformin Use on the Recurrence and Progression of Non-Muscle Invasive Bladder Cancer in Patients with Diabetes Mellitus
Ji Hoon Ahn (2016)
Changes in Medication Management After a Diagnosis of Cancer Among Medicare Beneficiaries With Diabetes.
Bruce C. Stuart (2015)
Cancer with diabetes: prevalence, metabolic control, and survival in an academic oncology practice.
Nina J. Karlin (2012)
Exploratory study of impact of cancer‐related posttraumatic stress symptoms on diabetes self‐ management among cancer
J James (2018)
Significance of preoperative HbA1c level in patients with diabetes mellitus and clinically localized prostate cancer.
Sung Kyu Hong (2009)
Impact of cancer on adherence to glucose-lowering drug treatment in individuals with diabetes
Marjolein M. J. Zanders (2015)
Adherence to oral diabetes medications and glycemic control during and following breast cancer treatment.
Gregory Sampang Calip (2015)
Does a prostate cancer diagnosis affect management of pre-existing diabetes? Results from PCBaSe Sweden: a nationwide cohort study
Danielle Crawley (2018)
Predictors of Diabetes Self-Management in Older Adults Receiving Chemotherapy
Denise Soltow Hershey (2014)
Postoperative Mortality in Cancer Patients With Preexisting Diabetes
Bethany B. Barone (2010)
Diabetes mellitus and breast cancer outcomes: a systematic review and meta-analysis.
Kimberly S. Peairs (2011)
Outcomes of preexisting diabetes mellitus in breast, colorectal, and prostate cancer
Robert I Griffiths (2017)
Perceived Impact of Cancer Treatment on Diabetes Self-Management
Denise Soltow Hershey (2012)
Gwyn McClelland (1891)
Under use of necessary care among cancer survivors.
Craig C. Earle (2004)
Patient outcomes from lung cancer and diabetes mellitus: a matched case–control study
Nina J. Karlin (2018)
Improving Coordination of Care Among Healthcare Professionals and Patients With Diabetes and Cancer.
Josilyn Goebel (2016)
A Framework To Facilitate the Use of Systematic Reviews and Meta-Analyses in the Design of Primary Research Studies
Matthew J. Thompson (2012)
Elevated Hemoglobin A1c Levels Are Associated with Worse Survival in Advanced Pancreatic Cancer Patients with Diabetes
Young Koog Cheon (2014)
Diabetes mellitus with poor glycemic control increases bladder cancer recurrence risk in patients with upper urinary tract urothelial carcinoma.
Yi-Sheng Tai (2015)
Changes in glucose-lowering drug use before and after cancer diagnosis in patients with diabetes.
Marjolein M. J. Zanders (2018)
Quality of Diabetes Care Among Cancer Survivors With Diabetes
Nancy L. Keating (2007)
Covidence Better systematic review management
Significance of preoperative HbA 1 c level in patients with
SS Kim (2014)
Hyperglycemia During Chemotherapy for Hematologic and Solid Tumors Is Correlated With Increased Toxicity
Antonella Brunello (2011)
Prostate Cancer Patients With Unmanaged Diabetes or Receiving Insulin Experience Inferior Outcomes and Toxicities After Treatment With Radiation Therapy
Nicholas G Zaorsky (2017)
Patterns of care related to age of men with prostate cancer.
Charles L Bennett (1991)
The impact of diabetes process and outcome quality measures on overall survival in patients with co-morbid colorectal cancer
Elizabeth Y Chiao (2010)
The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies.
Erik von Elm (2007)
Effects of cancer comorbidity on disease management: making the case for diabetes education (a report from the SOAR program).
Lauren Irizarry (2013)
Racial/Ethnic differences in receipt of timely adjuvant therapy for older women with breast cancer: are delays influenced by the hospitals where patients obtain surgical care?
Rachel A Freedman (2013)
Racial Disparities in Diabetes Care Processes, Outcomes, and Treatment Intensity
Michele Heisler (2003)
Results of General Internal Medicine Consultations for Diabetes Mellitus in 283 Cancer Patients
Wenli Liu (2007)
mellitus and clinically localized prostate cancer
Y Huang (2009)
The impact of having both cancer and diabetes on patient-reported outcomes: a systematic review and directions for future research
Pauline Aj Vissers (2015)
Comparison of Diabetes Management Status between Cancer Survivors and the General Population: Results from a Korean Population-Based Survey
Ji-Yeon Shin (2014)
Prevalence, awareness, control, and treatment of hypertension and diabetes in korean cancer survivors: a cross-sectional analysis of the fourth and fifth Korea national health and nutrition examination surveys.
Kyung-Hyun Choi (2013)
Hyperglycemia among hospitalized cancer patients with co-existing diabetes mellitus.
Nina J. Karlin (2015)
Chemotherapy and Glycemic Control in Patients with Type 2 Diabetes and Cancer: A Comparative Case Analysis
Denise Soltow Hershey (2017)
A retrospective analysis to identify the factors affecting infection in patients undergoing chemotherapy.
Ji Hyun Park (2015)
Intensive Versus Conventional Insulin Therapy in Type 2 Diabetes Patients Undergoing D2 Gastrectomy for Gastric Cancer: A Randomized Controlled Trial
Shou-gen Cao (2010)
Age-related patterns of care: evidence against ageism in the treatment of early-stage breast cancer.
Edward Guadagnoli (1997)
Serum glucose and hemoglobin A1C levels at cancer diagnosis and disease outcome.
Ben Boursi (2016)
Characteristics associated with nonadherence to medications for hypertension, diabetes, and dyslipidemia among breast cancer survivors
Gregory Sampang Calip (2016)
Cancer Facts & Figures
Prognostic factors for resected non‐small cell lung cancer in patients with type 2 diabetes mellitus
Woo Sik Yu (2018)
Effect of Uncontrolled Diabetes on Outcomes After Cystectomy in Patients With Bladder Cancer: A Population-Based Study.
Izak Faiena (2016)
Elevated HbA1c Is an Independent Predictor of Aggressive Clinical Behavior in Patients with Colorectal Cancer: A Case-Control Study
Ali A Siddiqui (2008)
An Elevated HbA1c Level Is Associated With Short-Term Adverse Outcomes in Patients With Gastrointestinal Cancer and Type 2 Diabetes Mellitus
Yingchun Huang (2017)
Optimal glycemic target level for colon cancer patients with diabetes.
Shin Jun Lee (2017)
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.
David Moher (2009)
Diabetes and cancer: a consensus report.
Edward L. Giovannucci (2010)
Treatment and outcomes in diabetic breast cancer patients
Heather Taffet Gold (2014)
Diabetes management before and after cancer diagnosis: missed opportunity.
Nengliang Yao (2015)
Glycosylated hemoglobin A1c and lack of association with symptom severity in American Journal of Clinical Oncology Volume
MJ Hammer (2019)
Importance of Glycemic Control in Cancer Patients with Diabetes: Treatment through End of Life
Denise Soltow Hershey (2017)
Androgen-deprivation therapy and diabetes control among diabetic men with prostate cancer.
Nancy L. Keating (2014)
How much time do patients with diabetes spend on self-care?
Monika M. Safford (2005)
Differences Between Primary Care Physicians’ and Oncologists’ Knowledge, Attitudes and Practices Regarding the Care of Cancer Survivors
Arnold L. Potosky (2011)
Glycosylated patients undergoing chemotherapy for solid tumors
M J Hammer (2015)
Patterns of care related to age of breast cancer patients.
Sheldon Greenfield (1987)
Annual Report to the Nation on the status of cancer, 1975-2010, featuring prevalence of comorbidity and impact on survival among persons with lung, colorectal, breast, or prostate cancer.
Brenda Kay Edwards (2014)
Colorectal Cancer Outcomes, Recurrence, and Complications in Persons With and Without Diabetes Mellitus: A Systematic Review and Meta-Analysis
Kelly B. Stein (2009)
Exploratory study of impact of cancer‐related posttraumatic stress symptoms on diabetes self‐management among cancer survivors
Janey James (2018)
The Effect of Incident Cancer, Depression and Pulmonary Disease Exacerbations on Type 2 Diabetes Control
Elizabeth A Bayliss (2010)
Glycemic control and prostate cancer progression: results from the SEARCH database.
Howard S Kim (2010)