Online citations, reference lists, and bibliographies.

ENDOGENOUS ENDOPHTHALMITIS ASSOCIATED WITH INTRAVENOUS DRUG ABUSE: Seven-Year Experience At A Tertiary Referral Center

Paul P. Connell, Evelyn C. O'Neill, Fakir Mohammad Amirul Islam, Robert Buttery, Mark F. McCombe, Rohan Essex, Edward Roufail, Stephen Lash, B. P. Wolffe, Ben Clark, Daniel Chiu, William Campbell, Penelope L. Allen
Published 2010 · Medicine
Cite This
Download PDF
Analyze on Scholarcy
Share
Purpose: Intravenous drug use (IVDU) is a known risk factor for endogenous endophthalmitis. Endogenous fungal endophthalmitis (EFE) is emerging as a common problem among this community. We describe the management and visual outcomes of acute IVDU-associated EFE. Methods: A prospective consecutive case series of 19 patients presenting with presumed acute IVDU-associated EFE from 2001 to 2007 to the Royal Victorian Eye and Ear Hospital was included. All data were collected in a standardized manner. Outcome measures included visual acuity, microbial profiles, and vitrectomy rate. Results: Nineteen cases of IVDU-associated EFE were identified. Eight of these (42%) were men, and the mean age was 32.7 years (SD ± 8.0 years). Presenting visual acuity ranged from 6/6 to perception of light, with 58% having a visual acuity of 6/48 or less at presentation. Thirteen (68.4%) were culture positive with all cultures identifying Candida species, and 52.7% underwent vitrectomy. Fifty percent of subjects overall achieved a final visual acuity of 6/18 or better. Men demonstrated improved visual acuity when compared with women (P = 0.04). Age had no effect on final acuity. Conclusion: Intravenous drug use is a significant risk factor for developing EFE. Good visual outcomes can be achieved with early treatment, often with intravitreal therapy alone.
This paper references
Epidemiological and clinical approach to the study of candidiasis caused by Candida albicans in heroin addicts in the Paris region: analysis of 35 observations.
Michael J. Mellinger (1982)
Report of a ten-year retrospective study
A A Okada (1994)
10.1136/bjo.86.8.940
Presumed ocular candidiasis in drug misusers after intravenous use of oral high dose buprenorphine (Subutex)
Nathalie Cassoux (2002)
10.1016/S0163-4453(03)00078-1
Aspergillus endophthalmitis: an unusual complication of disseminated infection in renal transplant patients.
Silke Schelenz (2003)
10.1097/IAE.0b013e318185e943
FUNGAL ENDOPHTHALMITIS: Fourteen Years’ Experience From a Center in India
Arunaloke Chakrabarti (2008)
10.1016/s0161-6420(13)31255-x
Endogenous bacterial endophthalmitis. Report of a ten-year retrospective study.
Annabelle A Okada (1994)
10.3928/1542-8877-19970301-03
Treatment outcomes in a 10-year study of endogenous fungal endophthalmitis.
T F Essman (1997)
10.1097/00055735-199806000-00012
Treatment outcomes of endogenous fungal endophthalmitis.
William E Smiddy (1998)
[Endogenous Candida endophthalmitis in drug misusers injecting intravenous buprenorphine].
David Hirsbein (2008)
10.1080/09273940802689396
Vitrectomy for Endogenous Fungal Endophthalmitis
Xi Shen (2009)
10.1093/infdis/152.3.577
Cutaneous, ocular, and osteoarticular candidiasis in heroin addicts: new clinical and therapeutic aspects in 38 patients.
B. Dupont (1985)
10.1093/jac/28.suppl_A.83
Fungal infections in drug users.
C. L. Leen (1991)
10.1093/infdis/162.1.115
The clinical spectrum of endophthalmitis: incidence, predisposing factors, and features influencing outcome.
S K Shrader (1990)
10.5301/EJO.2009.881
Diagnostic utility of polymerase chain reaction on intraocular specimens to establish the etiology of infectious endophthalmitis.
Parameswaran Sowmya (2009)
Epidemiological and clinical approach to the study of candidiasis caused by Candida albicans in heroin addicts in the Paris region: analysis
M Mellinger (1982)
10.4103/0019-5359.27972
Evaluation of outcome of various treatment methods for endogenous endophthalmitis.
Tulsi Keswani (2006)
10.1007/s00417-005-0182-5
Relation between stage of endogenous fungal endophthalmitis and prognosis
Hiroshi Takebayashi (2005)
10.1016/S0181-5512(08)70351-6
Endophtalmie endogène à Candida secondaire à l’utilisation de la buprénorphine par voie intraveineuse
David Hirsbein (2008)
First contact management of postoperative endophthalmitis. A retrospective analysis.
Lalit Verma (2004)
10.1136/bjo.2008.146639
Rapid detection and quantification of Propionibacteriaceae
Pablo L. Goldschmidt (2008)
10.1136/bjo.2008.152181
New test for the diagnosis of bacterial endophthalmitis
Pablo L. Goldschmidt (2009)
10.1097/00000441-200503000-00010
Endogenous Endophthalmitis and Disseminated Intravascular Coagulation Complicating a Klebsiella pneumoniae Perirenal Abscess in a Patient with Type 2 Diabetes
Kohzo Takebayashi (2005)
10.1159/000052035
Substitution with Buprenorphine in Methadone- and Morphine Sulfate-Dependent Patients
Jacques Bouchez (1998)
Endophthalmitis in patients with disseminated fungal disease.
Stephen S. Feman (2002)
Fungal endophthalmitis: fourteen years
A Chakrabarti (2008)
10.5694/j.1326-5377.2005.tb06764.x
Fungal endophthalmitis in intravenous drug users injecting buprenorphine contaminated with oral Candida species.
Craig A. Aboltins (2005)
10.1086/514972
Candida albicans endophthalmitis in brown heroin addicts: response to early vitrectomy preceded and followed by antifungal therapy.
César Martínez-Vázquez (1998)
10.1159/000090580
Diagnosis and Treatment of Endogenous Fungal Endophthalmitis
Michael A Williams (2006)



This paper is referenced by
10.1007/978-3-319-23416-8_19
Emerging Infectious Uveitis: Candida
J Gueudry (2017)
10.1186/s40942-016-0043-x
Intralesional antibiotic injection using 41G needle for the management of subretinal abscess in endogenous endophthalmitis
Pradeep Venkatesh (2016)
10.1016/j.jemermed.2016.09.011
A Rare Central Nervous System Fungal Infection Resulting from Brown Heroin Use.
Eric Melnychuk (2017)
10.1016/j.jcjo.2015.11.004
Chronic mucocutaneous candidiasis presenting as Candida endophthalmitis.
Qianqian Wang (2016)
10.1177/2474126418788498
Endogenous Endophthalmitis: Has the Opioid Crisis Impacted the Rates and Severity of Intravenous Drug-Related Cases?
Jonathan Foster Russell (2018)
10.1111/1469-0691.12118
Endophthalmitis
Marlene L. Durand (2013)
10.1016/j.annemergmed.2011.07.033
Man with blurred vision. Endogenous candida endophthalmitis caused by urinary tract infection.
Kuan-Jen Chen (2012)
10.1001/jamaophthalmol.2017.0650
An Outbreak of Endogenous Fungal Endophthalmitis Among Intravenous Drug Abusers in New England
Aubrey R Tirpack (2017)
10.1016/B978-1-4557-0737-9.00087-4
Chapter 87 – Endogenous Endophthalmitis: Bacterial and Fungal
Stephen G. Schwartz (2012)
10.11131/2018/101283
Anterior Chamber Culture at the Conclusion of Cataract Surgery and Its Relation to Post-Cataract Surgery Endophthalmitis
Olivia Fox (2018)
10.1186/1869-5760-3-60
Endogenous fungal endophthalmitis: risk factors, clinical features, and treatment outcomes in mold and yeast infections
Jayanth Sridhar (2013)
10.1016/j.ophtha.2014.03.037
Retinal neovascularization and endogenous fungal endophthalmitis in intravenous drug users.
Thuy Doan (2014)
10.3341/JKOS.2018.59.3.282
A case of fungal endophthalmitis after having received extraction of wisdom tooth in healthy woman
Min Woo Lee (2018)
10.1016/j.sjopt.2012.02.011
Endophthalmitis: A review of recent trends.
Janice R. Safneck (2012)
10.4172/2476-2075.1000108
Endophthalmitis Prevention, Diagnostic Procedures and Treatment
Xhevat Lumi (2016)
10.1080/09273948.2019.1705497
Does Endogenous Endophthalmitis Need a More Aggressive Treatment?
Sara Spelta (2020)
10.1016/J.ORET.2019.06.004
Bacterial Endogenous Endophthalmitis in Bacteremic Inpatients.
Greg Budoff (2019)
10.1097/IAE.0000000000000084
ENDOGENOUS ENDOPHTHALMITIS ASSOCIATED WITH INTRAVENOUS DRUG ABUSE
S. Patel (2014)
10.1007/s10792-018-0997-9
Ocular culture-proven endogenous endophthalmitis: a 5-year retrospective study of the microorganism spectrum at a tertiary referral center in Turkey
Hande Celiker (2018)
10.1016/J.ORET.2016.10.013
Intravenous Drug Use-Associated Endophthalmitis.
Bobeck S. Modjtahedi (2017)
10.1136/bjophthalmol-2014-305030
Microbiological isolates and antibiotic sensitivities in culture-proven endophthalmitis: a 15-year review
Thomas P Moloney (2014)
10.1080/09273948.2018.1465100
Endogenous Fungal Endophthalmitis Associated with Genitourinary Procedures
Boya Lei (2018)
10.5772/26929
Ocular Complications of Endocarditis
Ozlem Ozturk Sahin (2012)
10.1080/08820538.2016.1228396
The Role of Vitrectomy in the Management of Fungal Endophthalmitis
Yewlin E. Chee (2017)
Endoftalmitis endógena por Candida albicans; presentación de un caso
Marilú Anahí Guido-Jiménez (2011)
10.1080/09273948.2016.1195000
Endogenous Endophthalmitis in the American and Korean Population: An 8-year Retrospective Study
Heeyoon Cho (2018)
10.1007/s00417-017-3760-4
59 eyes with endogenous endophthalmitis– causes, outcomes and mortality in a Danish population between 2000 and 2016
S. Bjerrum (2017)
Semantic Scholar Logo Some data provided by SemanticScholar