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Polyhydroxybutyrate-Coated Magnetic Nanoparticles For Doxorubicin Delivery: Cytotoxic Effect Against Doxorubicin-Resistant Breast Cancer Cell Line

Serap Yalçın, Gozde Unsoy, Pelin Mutlu, Rouhollah Khodadust, Ufuk Gunduz
Published 2014 · Medicine
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In this study, polyhydroxybutyrate (PHB)-coated magnetic nanoparticles (MNPs) were prepared by coprecipitation of iron salts (Fe2+ and Fe3+) by ammonium hydroxide. Characterizations of PHB-coated MNPs were performed by Fourier transform infrared spectroscopy, x-ray diffraction, dynamic light scattering, thermal gravimetric analysis, vibrating sample magnetometry, and transmission electron microscopy analyses. Doxorubicin was loaded onto PHB-MNPs, and the release efficiencies at different pHs were studied under in vitro conditions. The most efficient drug loading concentration was found about 87% at room temperature in phosphate-buffered saline (pH 7.2). The drug-loaded MNPs were stable up to 2 months in neutral pH for mimicking physiological conditions. The drug release studies were performed with acetate buffer (pH 4.5) that mimics endosomal pH. Doxorubicin (60%) released from PHB-MNPs within 65 hours. Doxorubicin-loaded PHB-MNPs were about 2.5-fold more cytotoxic as compared with free drug on resistant Michigan Cancer Foundation-7 (human breast adenocarcinoma, MCF-7) cell line (1 &mgr;M doxorubicin) in vitro. Therefore, doxorubicin-loaded PHB-MNPs lead to overcome the drug resistance.
This paper references
10.1002/jps.23524
Doxorubicin loading, release, and stability of polyamidoamine dendrimer-coated magnetic nanoparticles.
Khodadust Rouhollah (2013)
10.1016/0169-409X(95)00092-L
Biosynthetic polyhydroxyalkanoates and their potential in drug delivery
Colin W. Pouton (1996)
10.1021/js980065o
Novel degradable poly(ethylene glycol) hydrogels for controlled release of protein.
Xueyan Zhao (1998)
10.1016/S0142-9612(00)00151-4
Surface-immobilized dextran limits cell adhesion and spreading.
Stephen P. Massia (2000)
10.1128/mmbr.63.1.21-53.1999
Metabolic Engineering of Poly(3-Hydroxyalkanoates): From DNA to Plastic
Lara L Madison (1999)
Approaches that mitigate doxorubicin-induced delayed adverse effects on mitochondrial function in rat hearts; liposome-encapsulated doxorubicin or combination therapy with antioxidant.
Satoru Sugiyama (1995)
10.1038/nbt1340
Renal clearance of quantum dots
Hak Soo Choi (2007)
10.1155/2010/745120
Biosynthesis of Gold Nanoparticles (Green-gold) Using Leaf Extract of Terminalia Catappa
Balaprasad Ankamwar (2010)
10.1007/978-3-7091-6151-7_4
Recent Advances in the Description of the Structure of Water, the Hydrophobic Effect, and the Like-Dissolves-Like Rule
Roland Schmid (2001)
10.1002/jbm.820270904
Tissue response and in vivo degradation of selected polyhydroxyacids: polylactides (PLA), poly(3-hydroxybutyrate) (PHB), and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHB/VA).
Sylwester Gogolewski (1993)
10.1021/bc9002019
Antibody-drug conjugates: linking cytotoxic payloads to monoclonal antibodies.
Laurent Ducry (2010)
10.1021/js970084i
A novel biodegradable system based on gelatin nanoparticles and poly(lactic-co-glycolic acid) microspheres for protein and peptide drug delivery.
John K-J. Li (1997)
10.1177/106002808501900403
Doxorubicin: Alteration of Dose Scheduling as a Means of Reducing Cardiotoxicity
Bert L. Lum (1985)
Bacterial polyhydroxyalkanoates.
Stephen YongGu Lee (1996)
10.1016/0168-3659(91)90041-B
In vivo peptide release from poly(dl-lactic acid-co-glycolic acid) copolymer 5050 microspheres
J. M. Ruiz (1991)
10.1007/s002530051427
A rapid method for detecting bacterial polyhydroxyalkanoates in intact cells by Fourier transform infrared spectroscopy
Ki-Heon Hong (1999)
10.3174/ajnr.A1590
Uses of Nanoparticles for Central Nervous System Imaging and Therapy
James M. Provenzale (2009)
10.1163/156856209X410283
Application of Polyhydroxyalkanoates Nanoparticles as Intracellular Sustained Drug-Release Vectors
Yu-Cui Xiong (2010)
10.1002/med.21280
Doxorubicin-induced cardiotoxicity: from bioenergetic failure and cell death to cardiomyopathy.
Filipa S. Carvalho (2014)
10.2147/IJN.S596
Drug delivery and nanoparticles: Applications and hazards
Wim H de Jong (2008)
10.1016/S0167-577X(99)00181-0
DNA-magnetite nanocomposite materials
Stéphane Mornet (2000)
10.1016/S0009-2541(96)00055-1
Controlled biomineralization of magnetic minerals by magnetotactic bacteria
Dennis A. Bazylinski (1996)
10.1103/PhysRevB.9.3891
Superparamagnetism and relaxation effects in granular Ni-Si O 2 and Ni- Al 2 O 3 films
Jonathan I. Gittleman (1974)
10.1002/jps.20833
Poly(N-vinyl-pyrrolidone)-block-poly(D,L-lactide) as polymeric emulsifier for the preparation of biodegradable nanoparticles.
Geneviève Gaucher (2007)
10.1007/s11095-012-0679-7
Magnetic Nanoparticles for Cancer Diagnosis and Therapy
Mehmet Veysel Yigit (2012)
10.1016/0142-9612(90)90026-M
Degradation of poly(ester) microspheres.
Heying Wang (1990)
10.1159/000384833
Immunochemistry and immunology of collagen and gelatin.
Hans Gerhard Schwick (1969)
In vivo peptide release from poly (lactic-coglycolic acid) copolymer 50/50 microspheres
JM Ruiz (1991)
10.1016/j.jmmm.2005.01.064
Superparamagnetic nanoparticles for biomedical applications: possibilities and limitations of a new drug delivery system
Tobias Neuberger (2005)
Development of rational in vitro models for drug resistance in breast cancer and modulation of MDR by selected compounds.
Meltem Demirel Kars (2006)
10.1166/JBN.2012.1360
Electrospun fibers and tissue engineering.
Lin Jin (2012)
10.2174/1568009033482047
Energy dependent transport of xenobiotics and its relevance to multidrug resistance.
Rajendra P Sharma (2003)
10.1163/156856297X00119
Rifampicin carrying polyhydroxybutyrate microspheres as a potential chemoembolization agent.
A. Kassab (1997)
10.1007/s11051-012-0964-8
Synthesis optimization and characterization of chitosan-coated iron oxide nanoparticles produced for biomedical applications
Gozde Unsoy (2012)
10.1023/A:1005637827426
Preparation and characterization of native poly(3-hydroxybutyrate) microspheres from Ralstonia eutropha
Guk Jin Kim (2004)
10.1164/rccm.200504-613PP
The potential advantages of nanoparticle drug delivery systems in chemotherapy of tuberculosis.
Svetlana E. Gelperina (2005)
10.1016/0968-5677(96)00031-4
Supramolecular assembly of hydrophobized polysaccharides
Kazunari Akiyoshi (1996)
10.1016/S1043-6618(05)80122-7
Effect of flunarizine on the delayed cardiotoxicity of doxorubicin in rats.
Fabrizio Villani (1991)
10.1016/S1470-2045(05)01737-7
Theragnostic imaging for radiation oncology: dose-painting by numbers.
Søren M Bentzen (2005)
10.1016/S1381-1169(98)00043-0
Entrapment of lipases in hydrophobic magnetite-containing sol-gel materials: magnetic separation of heterogeneous biocatalysts
Manfred Theodor Reetz (1998)
Effect of trimetazidine on early and delayed doxorubicin myocardial toxicity.
Gian Paolo Perletti (1989)
10.1016/S0021-9673(00)00107-2
Application of magnetite and silica-magnetite composites to the isolation of genomic DNA.
John I. Taylor (2000)
10.1016/S0376-7388(00)81375-7
Morphological changes of ethylene/vinyl acetate-based controlled delivery systems during release of water-soluble solutes
Eva S. Miller (1983)
10.1016/j.jconrel.2008.01.013
Hydrophobically modified glycol chitosan nanoparticles-encapsulated camptothecin enhance the drug stability and tumor targeting in cancer therapy.
Kyung Hyun Min (2008)
10.1166/JBN.2012.1431
Preparation and characterization of magnetically responsive bacterial polyester based nanospheres for cancer therapy.
Ebru Erdal (2012)
10.1007/s11095-008-9763-4
Design of Biodegradable Nanoparticles for Oral Delivery of Doxorubicin: In vivo Pharmacokinetics and Toxicity Studies in Rats
Dhaval R. Kalaria (2008)
10.1016/S0304-8853(98)00575-7
Chemiluminescence enzyme immunoassay using ProteinA-bacterial magnetite complex
Tadashi Matsunaga (1999)
10.1590/S0104-66322004000100002
THE EFFECT OF SOME PROCESSING CONDITIONS ON THE CHARACTERISTICS OF BIODEGRADABLE MICROSPHERES OBTAINED BY AN EMULSION SOLVENT EVAPORATION PROCESS
Juliana Lemos Maia (2004)
10.1081/DDC-100102252
Self-assembling nanospheres of hydrophobized pullulans in water.
Youngseok Jeong (1999)



This paper is referenced by
10.1016/j.ijbiomac.2019.12.181
Polyhydroxyalkanoates (PHA): From production to nanoarchitecture.
Roshanak Tarrahi (2019)
10.1517/17425247.2016.1156671
Biodegradable polymers for targeted delivery of anti-cancer drugs
Sindhu Doppalapudi (2016)
10.1016/j.ijbiomac.2018.03.050
Poly(3-hydroxybutyrate)/polyethylene glycol-NiO nanocomposite for NOR delivery: Antibacterial activity and cytotoxic effect against cancer cell lines.
Mohamed Abdelwahab (2018)
10.3390/pharmaceutics11030120
Functional Magnetic Core-Shell System-Based Iron Oxide Nanoparticle Coated with Biocompatible Copolymer for Anticancer Drug Delivery
Thai Thanh Hoang Thi (2019)
10.1016/j.msec.2020.110799
Microbiologically extracted poly(hydroxyalkanoates) and its amalgams as therapeutic nano-carriers in anti-tumor therapies.
Jay M. Korde (2020)
10.1016/B978-0-323-46143-6.00026-9
Targeted drug delivery via chitosan-coated magnetic nanoparticles
Gozde Unsoy (2017)
10.1088/2043-6254/AA5E33
New developments in breast cancer therapy: role of iron oxide nanoparticles
Shivani Thoidingjam (2017)
10.1007/s10876-018-1454-7
Utilization of Chemically Synthesized Super Paramagnetic Iron Oxide Nanoparticles in Drug Delivery, Imaging and Heavy Metal Removal
P Usha Sruthi (2018)
10.1007/978-3-030-10614-0_38-1
Iron Oxide-Based Polymeric Magnetic Nanoparticles for Drug and Gene Delivery: In Vitro and In Vivo Applications in Cancer
Serap Yalçın (2019)
10.1002/biot.201900283
Recent Progress in Polyhydroxyalkanoates-Based Copolymers for Biomedical Applications.
Z. Luo (2019)
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