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Successful Intravenous Thrombolysis In A 14-year-old Boy With Ischemic Stroke.

Isabel Sampaio, F. Abecasis, S. Quintas, T. Moreno, C. Camilo, Marisa Vieira, T. Pinho e Melo, M. Correia
Published 2011 · Medicine

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We report a healthy 14-year-old boy with an acute left middle cerebral artery stroke, treated 2 hours after the onset of symptoms with intravenous recombinant tissue plasminogen activator (r-TPA). Recanalization of the middle cerebral artery was documented with transcranial Doppler during the first 5 minutes of intravenous r-TPA perfusion, and progressive recovery of the neurological deficits occurred. Although lack of evidence regarding safety and efficacy in children precludes the recommendation of systematic use of r-TPA in pediatric stroke, we propose that this option should be considered and discussed with the parents, especially in older children presenting within 3 hours in centers with experience in adult thrombolysis.
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