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Liver And Bone Metastases From Small Bowel Neuroendocrine Tumor Respond To 177Lu-DOTATATE Induction And Maintenance Therapies.

William Makis, Karey McCann, Francois A Buteau, A. J. Mcewan
Published 2015 · Medicine
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A 73-year-old man diagnosed with small bowel neuroendocrine tumor (NET) with liver and bone metastases was treated with 4 induction cycles and 2 maintenance cycles of Lu-DOTATATE peptide receptor radionuclide therapy (PRRT). His symptoms and mobility improved significantly following induction as well as maintenance treatments, and posttherapy imaging studies showed significant improvement in metastatic liver and bone disease. Current protocols consisting of 4 induction cycles of Lu-DOTATATE only may not be sufficient to optimally treat neuroendocrine liver and bone metastases, and further research into maintenance Lu-DOTATATE therapy is warranted.
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