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Effects Of A Dietary Intervention And Weight Change On Vasomotor Symptoms In The Women’s Health Initiative

C. Kroenke, B. Caan, M. Stefanick, G. Anderson, R. Brzyski, Karen C Johnson, E. Leblanc, Cathy C Lee, A. Z. La Croix, H. Park, S. Sims, M. Vitolins, R. Wallace
Published 2012 · Medicine

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Objective The aim of this study was to determine whether a dietary intervention designed to reduce fat intake and increase intake of fruit, vegetables, and whole grains, and weight loss, reduces vasomotor symptoms (VMS; ie, hot flashes or night sweats) in postmenopausal women. Methods We included 17,473 postmenopausal US women, ages 50 to 79 years, at baseline who participated in the Women’s Health Initiative Dietary Modification trial and were not taking menopausal hormone therapy. Logistic regression was used to evaluate associations. Results In multivariate-adjusted analyses, with simultaneous adjustment for the intervention and weight change, assignment to the dietary intervention versus the control arm was significantly (odds ratio [OR], 1.14; 95% CI, 1.01-1.28) related to a higher likelihood of symptom elimination among women with VMS at baseline. In addition, women with symptoms at baseline who lost 10 lb or more (OR, 1.23; 95% CI, 1.05-1.46) or lost 10% or more of their baseline body weight (OR, 1.56; 95% CI, 1.21-2.02) between baseline and year 1 were significantly more likely to eliminate VMS compared with those who maintained weight. Upon examining the joint effect of the dietary modification and weight loss, compared with women in the control arm who maintained weight, women who lost substantial weight (≥10%) as a part of the intervention (OR, 1.89; 95% CI, 1.39-2.57) but not as part of the control arm (OR, 1.40; 95% CI, 0.92-2.13) were significantly more likely to end VMS, although these two groups did not differ significantly from each other. Large weight loss (>22 lb), but not dietary changes, was related to the elimination of moderate/severe VMS. Conclusions Weight loss as part of a healthy dietary modification may help eliminate VMS among postmenopausal women.
This paper references
Menopausal syndrome.
A. L. Rogers (1951)
10.1016/S0140-6736(81)91161-2
HOT FLUSHES
(1981)
10.1037/0278-6133.9.5.529
Impact of stress on objectively recorded menopausal hot flushes and on flush report bias.
L. Swartzman (1990)
of Agriculture
(1990)
of Agriculture
(1990)
US Dept of Health and Human Services
(1990)
10.1016/0378-5122(91)90196-W
Menopausal symptoms among Thai women in Bangkok.
P. Sukwatana (1991)
10.1037//0003-066X.52.2.101
Women's health initiative. Why now? What is it? What's new?
K. Matthews (1997)
10.1089/JWH.1998.7.1149
Predictors of menopausal hot flashes.
C. Staropoli (1998)
10.1016/S0197-2456(97)00078-0
Design of the Women's Health Initiative clinical trial and observational study. The Women's Health Initiative Study Group.
G. Anderson (1998)
10.1111/1468-0009.00100
Social and economic disparities in health: thoughts about intervention.
S. Syme (1998)
Design of the Women ’ s Health Initiative clinical trial and observational study . The Women ’ s Health Initiative Study Group
(1998)
10.1016/S0002-9378(99)70437-0
Reduced thermoregulatory null zone in postmenopausal women with hot flashes.
R. Freedman (1999)
10.1007/S004840050123
Human morphology and temperature regulation
G. Anderson (1999)
10.1093/AJE/152.5.463
Relation of demographic and lifestyle factors to symptoms in a multi-racial/ethnic population of women 40-55 years of age.
E. Gold (2000)
10.1089/152460901750067133
Hot flashes in the late reproductive years: risk factors for Africa American and Caucasian women.
E. Freeman (2001)
10.1016/S0378-5122(01)00299-7
The prevalence of menopausal symptoms in a community in Singapore.
Harvey Chim (2002)
10.1207/S15327558IJBM0901_04
Changes in physical symptoms during the menopause transition
W. Brown (2002)
10.1093/HUMREP/17.5.1379
Health profile of middle-aged women: The Women's Health in the Lund Area (WHILA) study.
Cairu Li (2002)
10.1016/S0029-7844(02)02369-4
Menopausal Symptoms in Older Women and the Effects of Treatment With Hormone Therapy
V. Barnabei (2002)
10.1016/S0029-7844(02)02593-0
Smoking, Body Mass, and Hot Flashes in Midlife Women
M. Whiteman (2003)
10.1089/154099903766651586
Risk factors for hot flashes in midlife women.
M. Whiteman (2003)
10.1097/01.MLR.0000093479.39115.AF
Health-Related Quality of Life in a Multiethnic Sample of Middle-Aged Women: Study of Women’s Health Across the Nation (SWAN)
N. Avis (2003)
10.1016/S1047-2797(03)00042-5
The Women's Health Initiative recruitment methods and results.
J. Hays (2003)
10.1097/00042192-200301000-00005
Sleep difficulty in women at midlife: a community survey of sleep and the menopausal transition *
H. Kravitz (2003)
10.1001/JAMA.289.7.895
Is this woman perimenopausal?
L. Bastian (2003)
Is this woman perimenopausal? JAMA 2003;289:895-902
(2003)
10.1001/ARCHPSYC.61.1.62
Hormones and menopausal status as predictors of depression in women in transition to menopause.
E. Freeman (2004)
10.4065/79.6.777
Measuring hot flashes: summary of a National Institutes of Health workshop.
Heather G Miller (2004)
10.1093/AJE/KWH168
Lifestyle and demographic factors in relation to vasomotor symptoms: baseline results from the Study of Women's Health Across the Nation.
E. Gold (2004)
10.1055/S-2005-869479
Pathophysiology and treatment of menopausal hot flashes.
R. Freedman (2005)
10.1097/01.AOG.0000158120.47542.18
Menopausal Symptoms and Treatment-Related Effects of Estrogen and Progestin in the Women's Health Initiative
V. Barnabei (2005)
10.1016/J.MATURITAS.2005.05.005
Background factors influencing somatic and psychological symptoms in middle-age women with different hormonal status. A population-based study of Swedish women.
Cairu Li (2005)
10.1016/J.AMJMED.2005.09.049
Lifestyle factors: are they related to vasomotor symptoms and do they modify the effectiveness or side effects of hormone therapy?
G. Greendale (2005)
10.1097/01.gme.0000185754.85328.44
Dietary factors and vasomotor symptoms in breast cancer survivors: the WHEL Study
E. Gold (2006)
10.2105/AJPH.2005.066936
Longitudinal analysis of the association between vasomotor symptoms and race/ethnicity across the menopausal transition: study of women's health across the nation.
E. Gold (2006)
10.1001/ARCHINTE.166.12.1262
Severe hot flashes are associated with chronic insomnia.
M. Ohayon (2006)
10.1089/JWH.2006.0033
Ethnicity and vasomotor symptoms in postmenopausal women.
S. Appling (2007)
10.1007/s10552-008-9203-0
Pre-diagnosis body mass index, post-diagnosis weight change, and prognosis among women with early stage breast cancer
B. Caan (2008)
10.1080/13697130701744696
Frequency and severity of vasomotor symptoms among peri- and postmenopausal women in the United States
R. Williams (2008)
10.1093/AJE/KWM244
Adiposity and reporting of vasomotor symptoms among midlife women: the study of women's health across the nation.
R. Thurston (2007)
10.1007/s11606-008-0655-4
Revisiting the Duration of Vasomotor Symptoms of Menopause: A Meta-Analysis
M. Politi (2008)
10.1097/gme.0b013e31815879cf
Abdominal adiposity and hot flashes among midlife women
R. Thurston (2008)
Frequency and severity of vasomotor symptoms among peri- and postmenopausal women in the United States. Climacteric 2008;11:32-43
(2008)
10.1097/gme.0b013e31818d414e
Duration of vasomotor symptoms in middle-aged women: a longitudinal study
N. Col (2009)
10.1093/aje/kwp203
Gains in body fat and vasomotor symptom reporting over the menopausal transition: the study of women's health across the nation.
R. Thurston (2009)
10.1016/J.PAID.2008.09.014
Personality, Menopausal Symptoms, and Physical Activity Outcomes in Middle-Aged Women.
S. Elavsky (2009)
10.1353/pbm.0.0115
The Placebo Effect: Illness and Interpersonal Healing
F. Miller (2009)
10.1007/s10549-010-0802-6
Weight gain is associated with increased risk of hot flashes in breast cancer survivors on aromatase inhibitors
H. Su (2010)
10.1001/archinternmed.2010.162
An intensive behavioral weight loss intervention and hot flushes in women.
A. Huang (2010)
10.1016/j.fertnstert.2009.04.001
Serum leptin levels, hormone levels, and hot flashes in midlife women.
C. Alexander (2010)
10.1056/NEJMoa1103319
Active albuterol or placebo, sham acupuncture, or no intervention in asthma.
M. Wechsler (2011)
10.1001/archinternmed.2011.330
Soy isoflavones in the prevention of menopausal bone loss and menopausal symptoms: a randomized, double-blind trial.
S. Levis (2011)
10.1016/j.maturitas.2010.11.012
The effect of synthetic genistein on menopause symptom management in healthy postmenopausal women: a multi-center, randomized, placebo-controlled study.
M. Evans (2011)



This paper is referenced by
10.1016/J.WJAM.2021.07.003
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Kun-Ling Xu (2021)
10.1016/j.maturitas.2021.05.006
Carbohydrate quality index: Its relationship to menopausal symptoms in postmenopausal women.
Saman Mohsenian (2021)
10.1007/978-3-030-85484-3_12
Nutrition and Weight Management in Midlife
Maya Feller (2021)
10.1007/978-3-030-85484-3_8
Vasomotor Symptoms
P. Geraghty (2021)
10.1016/B978-0-12-821573-9.00019-9
Lifestyle factors and women's health
A. Kermack (2021)
10.22454/FAMMED.2021.204951
The Handbook of Wellness Medicine
J. Snellings (2021)
10.1108/nfs-06-2021-0195
High plant-based diet and physical activity in women during menopausal transition
M. Lombardo (2021)
10.3390/cancers13112710
Is Breast Cancer Risk Associated with Menopausal Hormone Therapy Modified by Current or Early Adulthood BMI or Age of First Pregnancy?
Eleni Leventea (2021)
10.1016/j.maturitas.2021.10.015
Life Habits Of Postmenopausal Women: Association Of Menopause Symptom Intensity And Food Consumption By Degree Of Food Processing
Priscilla Rayanne e Silva Noll (2021)
10.21518/2079-701X-2020-21-192-198
ВАЗОМОТОРНЫЕ СИМПТОМЫ КЛИМАКТЕРИЯ: ТОЛЬКО ЛИ ПРИЛИВЫ ЖАРА? АЛЬТЕРНАТИВНЫЕ (НЕГОРМОНАЛЬНЫЕ) МЕТОДЫ КОРРЕКЦИИ С ДОКАЗАННОЙ ЭФФЕКТИВНОСТЬЮ (ОБЗОР ЛИТЕРАТУРЫ)
В. Н. Касян (2021)
10.1017/9781108650182.024
Pharmaceuticals and Alternatives for Wellness
T. Parisi (2020)
10.1080/09637486.2020.1851658
A practical nutritional guide for the management of sleep disturbances in menopause
Daniela Laudisio (2020)
10.1017/9781108650182.041
Developing Purpose, Meaning, and Achievements
J. Vilhauer (2020)
10.1017/9781108650182.014
Wellness Interventions in Patients Living with Chronic Medical Conditions
A. J. Steiner (2020)
10.1017/9781108650182.001
Defining Wellness
W. Ishak (2020)
10.1017/9781108650182.027
Sex, Intimacy, and Well-Being
Kailee Marin (2020)
10.1017/9781108869102.026
Non-hormonal Treatments for Menopausal Symptoms
J. Sassarini (2020)
10.1017/9781108650182.020
Wellness Interventions in the Workplace
R. Chernoff (2020)
10.1017/9781108650182.043
Connection, Compassion, and Community
R. Hedrick (2020)
10.1017/9781108650182.050
The Personalized Wellness Life Plan
W. Ishak (2020)
10.1017/9781108650182.023
Nutraceuticals and Wellness
Dax Volle (2020)
10.1097/GME.0000000000001599
A selective serotonin receptor agonist for weight loss and management of menopausal vasomotor symptoms in overweight midlife women: a pilot study.
E. Kapoor (2020)
10.1017/9781108650182.022
Nutrition
James L. Lundy (2020)
10.1017/9781108650182.004
Wellness Measurement
T. Melchert (2020)
10.1017/9781108650182.026
Sleep, Rest, and Relaxation in Improving Wellness
Ashley Ngor (2020)
10.1016/j.idairyj.2020.104688
Association between dairy consumption and menopausal symptoms: A cross-sectional study among Iranian postmenopausal women
M. Abshirini (2020)
10.1017/9781108650182
The Handbook of Wellness Medicine
(2020)
10.1017/9781108650182.002
Screening and Assessment Methods for Wellness
J. Greenberg (2020)
10.1017/9781108650182.013
Wellness in Endocrine and Metabolic Disorders
Steven Clevenger (2020)
10.1017/9781108650182.035
Circadian Rhythm in the Digital Age
Mona Ezzat-Velinov (2020)
10.1016/j.maturitas.2020.07.001
The Mediterranean diet and menopausal health: An EMAS position statement.
A. Cano (2020)
10.1017/9781108650182.015
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A. Mays (2020)
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