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Toxicity Of Non-steroidal Anti-inflammatory Drugs To Gyps Vultures: A New Threat From Ketoprofen

V. Naidoo, K. Wolter, D. Cromarty, M. Diekmann, N. Duncan, A. Meharg, M. Taggart, L. Venter, R. Cuthbert
Published 2009 · Biology, Medicine

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Three Gyps vulture species are on the brink of extinction in South Asia owing to the veterinary non-steroidal anti-inflammatory drug (NSAID) diclofenac. Carcasses of domesticated ungulates are the main food source for Asia's vultures and birds die from kidney failure after consuming diclofenac-contaminated tissues. Here, we report on the safety testing of the NSAID ketoprofen, which was not reported to cause mortality in clinical treatment of scavenging birds and is rapidly eliminated from livestock tissues. Safety testing was undertaken using captive non-releasable Cape griffon vultures (Gyps coprotheres) and wild-caught African white-backed vultures (G. africanus), both previously identified as susceptible to diclofenac and suitable surrogates. Ketoprofen doses ranged from 0.5 to 5 mg kg−1 vulture body weight, based upon recommended veterinary guidelines and maximum levels of exposure for wild vultures (estimated as 1.54 mg kg−1). Doses were administered by oral gavage or through feeding tissues from cattle dosed with ketoprofen at 6 mg kg−1 cattle body weight, before slaughter. Mortalities occurred at dose levels of 1.5 and 5 mg kg−1 vulture body weight (within the range recommended for clinical treatment) with the same clinical signs as observed for diclofenac. Surveys of livestock carcasses in India indicate that toxic levels of residual ketoprofen are already present in vulture food supplies. Consequently, we strongly recommend that ketoprofen is not used for veterinary treatment of livestock in Asia and in other regions of the world where vultures access livestock carcasses. The only alternative to diclofenac that should be promoted as safe for vultures is the NSAID meloxicam.
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This paper is referenced by
The non-steroidal anti-inflammatory drug nimesulide kills Gyps vultures at concentrations found in the muscle of treated cattle
T. Galligan (2021)
Organic contaminants in Ganga basin: from the Green Revolution to the emerging concerns of modern India
Aurora Ghirardelli (2021)
Non-Steroidal Anti-Inflammatory Drugs (NSAIDS) and their Effect on Old World Vultures: A Scoping Review
Omar Jiménez-López (2021)
Nimesulide poisoning in white-rumped vulture Gyps bengalensis in Gujarat, India
K. Nambirajan (2021)
Contrasting Trends in Abundance of Indian Vultures (Gyps indicus) Between Two Study Sites in Neighboring Indian States
C. Mcclure (2021)
Trends in the availability of the vulture-toxic drug, diclofenac, and other NSAIDs in South Asia, as revealed by covert pharmacy surveys
T. Galligan (2020)
NSAIDs detected in Iberian avian scavengers and carrion after diclofenac registration for veterinary use in Spain.
Marta Herrero-Villar (2020)
Pharmacokinetics of a Single Dose of Oral Meloxicam in Rehabilitated Wild Brown Pelicans (Pelecanus occidentalis)
Molly D. Horgan (2020)
Serum Chemistry Values in Wild Black Vultures in Mississippi, USA
F. Cunningham (2020)
Identifying suitable reintroduction sites for the White-rumped Vulture (Gyps bengalensis) in India's Western Ghats using niche models and habitat requirements
N. R. Anoop (2020)
Validation of Multi-Residue Method for Quantification of Antibiotics and NSAIDs in Avian Scavengers by Using Small Amounts of Plasma in HPLC-MS-TOF
P. Gómez-Ramírez (2020)
Simultaneous non-steroidal anti-inflammatory drug electrodetection on nitrogen doped carbon nanodots and nanosized cobalt phthallocyanine conjugate modified glassy carbon electrode
Nyaradzai Dondo (2020)
Population Status and Nesting Activity of White-Rumped Vulture Gyps bengalensis in Kotli District, Azad Jammu and Kashmir, Pakistan
Shakeel Ahmad (2020)
Partial recovery of Critically Endangered Gyps vulture populations in Nepal
T. Galligan (2019)
Mass mortality of birds on railway track genetically identified as critically endangered Red-headed Vulture (Sarcogyps calvus) in Ranipur Wildlife Sanctuary, Uttar Pradesh, India
H. Khatri (2019)
Supplementary material from "A restatement of the natural science evidence base on the effects of endocrine disrupting chemicals on wildlife"
H. Godfray (2019)
Building a Vulture-Safe Zone
T. Galligan (2019)
Potential exposure to diclofenac in Spain of European vultures
Á. Camiña (2019)
Vulture conservation: the case for urgent action
R. Safford (2019)
Monitoring the release of anti-inflammatory and analgesic pharmaceuticals in the receiving environment
S. Aydın (2019)
Analytical and mathematical assessment of emerging pollutants fate in a river system.
C. Noutsopoulos (2019)
Biodegradation of NSAIDs and their effect on the activity of ligninolytic enzymes from Pleurotus djamor
Rosbi Cruz-Ornelas (2019)
Population-level impacts of chemical contaminants on apex avian species
R. F. Shore (2019)
Multidrug resistance protein 4 (MRP4) is expressed as transcript variants in both Gallus domesticus and Gyps himalyanesis.
S. Barik (2019)
Chapter 5 – Birds
M. Hawkins (2018)
The use of toxicokinetics and exposure studies to show that carprofen in cattle tissue could lead to secondary toxicity and death in wild vultures.
V. Naidoo (2018)
Pharmaceuticals in water, fish and osprey nestlings in Delaware River and Bay.
Thomas G. Bean (2018)
Development of a QuEChERS method for simultaneous analysis of antibiotics in carcasses for supplementary feeding of endangered vultures.
P. Gómez-Ramírez (2018)
Ruthenium(II)-Catalyzed C-H Difluoromethylation of Ketoximes: Tuning the Regioselectivity from the meta to the para Position.
Chunchen Yuan (2018)
Toxicology of Birds of Prey
J. Smits (2018)
The use of liver slices from the Cape vulture (Gyps coprotheres) to better understand the role of liver toxicity of non-steroidal anti-inflammatory drugs (NSAIDs) in vultures.
E. O. Adawaren (2018)
Techniques for Monitoring Drug Efficacy.
M. Visser (2018)
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