Online citations, reference lists, and bibliographies.
← Back to Search

Mitochondria-mitochondria Interaction Networks Show Altered Topological Patterns In Parkinson’s Disease

Massimiliano Zanin, Bruno F. R. Santos, Paul M.A. Antony, Clara Berenguer-Escuder, Simone B. Larsen, Zoé Hanss, Peter Barbuti, Aidos S. Baumuratov, Dajana Grossmann, Christophe Capelle, Joseph Weber, Rudi Balling, Markus Ollert, Rejko Krüger, Nico J. Diederich, Feng Q. He

Save to my Library
Download PDF
Analyze on Scholarcy Visualize in Litmaps
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Get Citationsy
SUMMARYMitochondrial dysfunction is linked to pathogenesis of Parkinson’s disease (PD). However, individual-mitochondria-based analyses do not show a uniform feature in PD patients. Since mitochondria interact with each other, we hypothesize that PD-related features might exist in topological patterns of mitochondria-mitochondria interaction networks (MINs). Here we showed that MINs form non-classical scale-free supernetworks in colonic ganglia both from healthy controls and PD patients, however, altered topological patterns are observed in PD patients. These patterns highly correlate with PD clinical scores and a machine-learning approach based on the MIN features accurately distinguish between patients and controls with an area-under-curve value of 0.989. The MINs of midbrain dopaminergic neurons (mDANs) derived from several genetic PD patients also display specific changes. CRISPR/CAS9-based genome correction of alpha-synuclein point mutations reverses the changes in MINs of mDANs. Our MIN network analysis opens a new dimension for a deeper characterization of various complex diseases with mitochondrial dysregulation.