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Detection And Identification Of A Single DNA Base Molecule Using Surface-enhanced Raman Scattering (SERS)

K. Kneipp, H. Kneipp, V. B. Kartha, R. Manoharan, G. Deinum, I. Itzkan, R. Dasari, M. Feld
Published 1998 · Physics

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Nonresonant Raman cross sections of ~10 -16 cm 2 per molecule are shown to be related to surface-enhanced Raman scattering (SERS) on colloidal silver clusters at near-infrared (NIR) excitation. The enhancement is found to be independent of cluster sizes between 100 nm and 20 μm. These experimental findings demonstrate that NIR SERS on colloidal silver clusters is an excellent technique for single molecule detection that is applicable for a broad range of molecules including "colorless" biomolecules, for example nucleotides in DNA sequencing. As an example, we present the detection of a single adenine molecule without any labeling based on its intrinsic surface-enhanced Raman scattering.

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W. Zhang (2013)
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Kei Murakoshi (2014)
Metal particle-enhanced fluorescent immunoassays on metal mirrors.
E. Matveeva (2007)
A SERS probe of adenyl residues available for intermolecular interactions. Part I—adenyl ‘fingerprint’
L. Grajcar (2001)
Experimental parameters influencing surface-enhanced Raman scattering of bacteria.
M. Kahraman (2007)
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Ping Kao (2008)
Generation of Enhanced LSPR Field in Periodically Varying Height Metal Nano-pillars
N. Chamuah (2015)
Engineering photonic-plasmonic aperiodic surfaces for optical biosensing
L. Dal Negro (2010)
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