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The Arabidopsis BAP1 And BAP2 Genes Are General Inhibitors Of Programmed Cell Death1[OA]

H. Yang, Shuhua Yang, Y. Li, J. Hua
Published 2007 · Medicine, Biology

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Here we identify the BAP1 and BAP2 genes of Arabidopsis (Arabidopsis thaliana) as general inhibitors of programmed cell death (PCD) across the kingdoms. These two homologous genes encode small proteins containing a calcium-dependent phospholipid-binding C2 domain. BAP1 and its functional partner BON1 have been shown to negatively regulate defense responses and a disease resistance gene SNC1. Genetic studies here reveal an overlapping function of the BAP1 and BAP2 genes in cell death control. The loss of BAP2 function induces accelerated hypersensitive responses but does not compromise plant growth or confer enhanced resistance to virulent bacterial or oomycete pathogens. The loss of both BAP1 and BAP2 confers seedling lethality mediated by PAD4 and EDS1, two regulators of cell death and defense responses. Overexpression of BAP1 or BAP2 with their partner BON1 inhibits PCD induced by pathogens, the proapototic gene BAX, and superoxide-generating paraquat in Arabidopsis or Nicotiana benthamiana. Moreover, expressing BAP1 or BAP2 in yeast (Saccharomyces cerevisiae) alleviates cell death induced by hydrogen peroxide. Thus, the BAP genes function as general negative regulators of PCD induced by biotic and abiotic stimuli including reactive oxygen species. The dual roles of BAP and BON genes in repressing defense responses mediated by disease resistance genes and in inhibiting general PCD has implications in understanding the evolution of plant innate immunity.
This paper references
10.1038/nrm1358
Controlled cell death, plant survival and development
Eric Lam (2004)
10.1105/tpc.7.1.29
Coordinated Activation of Programmed Cell Death and Defense Mechanisms in Transgenic Tobacco Plants Expressing a Bacterial Proton Pump.
R. Mittler (1995)
Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast.
P. James (1996)
10.1016/S0092-8674(03)00040-0
Arabidopsis RIN4 Is a Target of the Type III Virulence Effector AvrRpt2 and Modulates RPS2-Mediated Resistance
David Mackey (2003)
10.1046/j.1365-313X.1996.09030341.x
Genetic characterization of five powdery mildew disease resistance loci in Arabidopsis thaliana.
L. Adam (1996)
10.1016/S0092-8674(03)00036-9
Initiation of RPS2-Specified Disease Resistance in Arabidopsis Is Coupled to the AvrRpt2-Directed Elimination of RIN4
M. Axtell (2003)
10.1105/tpc.3.8.783
Differential regulation of superoxide dismutases in plants exposed to environmental stress.
E. W. Tsang (1991)
10.1101/GAD.952102
Epigenetic variation in Arabidopsis disease resistance.
T. Stokes (2002)
10.1104/pp.106.090837
Oviposition by Pierid Butterflies Triggers Defense Responses in Arabidopsis1[W][OA]
D. Little (2006)
10.1038/340245a0
A novel genetic system to detect protein–protein interactions
S. Fields (1989)
Genome-wide analysis of NBS-LRR-encoding genes in Arabidopsis
B C Meyers (2003)
10.1111/J.1365-313X.2005.02585.X
The BON/CPN gene family represses cell death and promotes cell growth in Arabidopsis.
Shuhua Yang (2006)
10.1046/J.1365-313X.2001.2641041.X
Constitutive disease resistance requires EDS1 in the Arabidopsis mutants cpr1 and cpr6 and is partially EDS1-dependent in cpr5.
J. Clarke (2001)
10.1111/J.1365-313X.2006.02869.X
The C2 domain protein BAP1 negatively regulates defense responses in Arabidopsis.
H. Yang (2006)
10.1101/GAD.918101
Plant growth homeostasis is controlled by the Arabidopsis BON1 and BAP1 genes.
J. Hua (2001)
10.1105/tpc.014662
Rapid Induction of Distinct Stress Responses after the Release of Singlet Oxygen in Arabidopsis Online version contains Web-only data. Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.014662.
R. G. op den Camp (2003)
10.1104/pp.104.043646
LESION SIMULATING DISEASE 1 Is Required for Acclimation to Conditions That Promote Excess Excitation Energy12[w]
A. Mateo (2004)
10.1038/sj.emboj.7601084
Role of SGT1 in resistance protein accumulation in plant immunity
C. Azevedo (2006)
10.1111/J.1365-313X.2006.02654.X
Arabidopsis Bax inhibitor-1 functions as an attenuator of biotic and abiotic types of cell death.
N. Watanabe (2006)
10.1016/S1360-1385(03)00108-0
Lesion mimic mutants: keys for deciphering cell death and defense pathways in plants?
Séverine Lorrain (2003)
10.1093/emboj/cdg006
Pseudomonas type III effector AvrPtoB induces plant disease susceptibility by inhibition of host programmed cell death
R. B. Abramovitch (2003)
10.1016/S0092-8674(00)81912-1
The Barley Mlo Gene: A Novel Control Element of Plant Pathogen Resistance
R. Büschges (1997)
10.1016/S1369-5266(00)00177-1
Genes controlling expression of defense responses in Arabidopsis--2001 status.
J. Glazebrook (2001)
10.1042/BST0330389
Serpentine plant MLO proteins as entry portals for powdery mildew fungi.
R. Panstruga (2005)
10.1046/J.1365-313X.2000.00654.X
Agrobacterium transient expression system as a tool for the isolation of disease resistance genes: application to the Rx2 locus in potato.
A. Bendahmane (2000)
Reactive oxygen species in plant cell death
F Van Breusegem (2006)
10.1104/pp.105.063586
Functional Analysis of Arabidopsis Ethylene-Responsive Element Binding Protein Conferring Resistance to Bax and Abiotic Stress-Induced Plant Cell Death1
Taro Ogawa (2005)
10.1111/J.1365-313X.2006.02793.X
The role of EDS1 (enhanced disease susceptibility) during singlet oxygen-mediated stress responses of Arabidopsis.
Christian Ochsenbein (2006)
10.1105/TPC.010085
The Disease Resistance Signaling Components EDS1 and PAD4 Are Essential Regulators of the Cell Death Pathway Controlled by LSD1 in Arabidopsis
C. Rustérucci (2001)
10.1126/SCIENCE.1109977
Antagonistic Control of Disease Resistance Protein Stability in the Plant Immune System
B. F. Holt (2005)
10.1111/j.1364-3703.2006.00359.x
Transient over-expression of barley BAX Inhibitor-1 weakens oxidative defence and MLA12-mediated resistance to Blumeria graminis f.sp. hordei.
R. Eichmann (2006)
10.1105/tpc.9.9.1573
The cpr5 mutant of Arabidopsis expresses both NPR1-dependent and NPR1-independent resistance.
S. Bowling (1997)
10.1146/annurev.arplant.48.1.251
THE OXIDATIVE BURST IN PLANT DISEASE RESISTANCE.
C. Lamb (1997)
10.1016/S0092-8674(00)81873-5
Programmed Cell Death in Animal Development
M. D. Jacobson (1997)
10.1073/pnas.211423998
Mammalian Bax-induced plant cell death can be down-regulated by overexpression of Arabidopsis Bax Inhibitor-1 (AtBI-1)
M. Kawai-yamada (2001)
10.1105/tpc.020479
A Haplotype-Specific Resistance Gene Regulated by BONZAI1 Mediates Temperature-Dependent Growth Control in Arabidopsis
Shuhua Yang (2004)
10.1105/tpc.106.042747
Distinct Domains in the ARC Region of the Potato Resistance Protein Rx Mediate LRR Binding and Inhibition of Activation[W]
G. Rairdan (2006)
10.1016/S0960-9822(99)80341-8
Animal cell-death suppressors Bcl-xL and Ced-9 inhibit cell death in tobacco plants
I. Mitsuhara (1999)
10.1046/J.1365-313X.1999.00420.X
Inhibition of protoporphyrinogen oxidase expression in Arabidopsis causes a lesion-mimic phenotype that induces systemic acquired resistance.
A. Molina (1999)
10.1046/J.1365-313X.2001.01136.X
A high-throughput method for quantifying growth of phytopathogenic bacteria in Arabidopsis thaliana.
P. Tornero (2001)
10.1105/TPC.010226
A Humidity-Sensitive Arabidopsis Copine Mutant Exhibits Precocious Cell Death and Increased Disease Resistance
N. Jambunathan (2001)
A gain-of-function mutation in a plant disease resistance gene leads to constitutive activation of downstream signal transduction pathways in suppressor of npr1-1, constitutive 1
Y Zhang (2003)
10.1038/nature05286
The plant immune system
J. Jones (2006)
10.1016/J.PBI.2005.05.010
Plant immunity: the EDS1 regulatory node.
M. Wiermer (2005)
10.1146/ANNUREV.ARPLANT.54.031902.135035
Understanding the functions of plant disease resistance proteins.
G. Martin (2003)
10.1038/ng1639
Pathogen-induced, NADPH oxidase–derived reactive oxygen intermediates suppress spread of cell death in Arabidopsis thaliana
M. A. Torres (2005)
10.1023/A:1026552827716
Regulators of cell death in disease resistance
K. Shirasu (2004)
10.1073/PNAS.0407094101
Expression of antiapoptotic genes bcl-xL and ced-9 in tomato enhances tolerance to viral-induced necrosis and abiotic stress.
P. Xu (2004)
10.1073/pnas.091108998
Abrogation of disease development in plants expressing animal antiapoptotic genes
M. Dickman (2001)
10.1073/PNAS.96.14.7956
Bax-induced cell death in tobacco is similar to the hypersensitive response.
C. Lacomme (1999)
10.1074/JBC.M107375200
Vesicle-associated Membrane Protein ofArabidopsis Suppresses Bax-induced Apoptosis in Yeast Downstream of Oxidative Burst*
A. Levine (2001)
Transient overexpression of barley BAX Inhibitor-1 weakens oxidative defence and MLA12-mediated resistance to Blumeria graminus f.sp. hordei
R Eichmann (2006)
10.1038/sj.emboj.7600910
Adi3 is a Pdk1‐interacting AGC kinase that negatively regulates plant cell death
T. Devarenne (2006)
10.1146/ANNUREV.PHYTO.36.1.393
Programmed cell death in plant disease: the purpose and promise of cellular suicide.
D. Gilchrist (1998)
10.1038/35081161
Plant pathogens and integrated defence responses to infection
J. Dangl (2001)
10.1016/S1369-5266(00)00216-8
Regulation and execution of programmed cell death in response to pathogens, stress and developmental cues.
E. Beers (2001)
10.1016/1369-5266(88)80051-7
Resistance response physiology and signal transduction.
D. Scheel (1998)
10.4161/psb.1.4.3221
Systemic Acquired Resistance
U. Conrath (2006)
10.1016/j.cub.2003.12.017
Plant Immunity: The Origami of Receptor Activation
P. Schulze-Lefert (2004)
10.1016/S0014-5793(01)03098-8
The Arabidopsis thaliana ethylene‐responsive element binding protein (AtEBP) can function as a dominant suppressor of Bax‐induced cell death of yeast
L. Pan (2001)
10.1126/SCIENCE.1067554
The RAR1 Interactor SGT1, an Essential Component of R Gene-Triggered Disease Resistance
C. Azevedo (2002)
10.1146/annurev.py.09.090171.001423
Current status of the gene-for-gene concept
H. H. Flor (1971)
10.1104/pp.106.090878
Cell Death Suppressor Arabidopsis Bax Inhibitor-1 Is Associated with Calmodulin Binding and Ion Homeostasis1[OA]
Yuri Ihara-Ohori (2006)
10.1073/pnas.93.22.12094
Programmed cell death: a way of life for plants.
J. Greenberg (1996)
10.1016/j.cell.2006.02.008
Host-Microbe Interactions: Shaping the Evolution of the Plant Immune Response
S. Chisholm (2006)
10.1111/j.1462-5822.2004.00361.x
The role and regulation of programmed cell death in plant–pathogen interactions
J. Greenberg (2004)



This paper is referenced by
10.1186/s12870-015-0506-5
Substantial reprogramming of the Eutrema salsugineum (Thellungiella salsuginea) transcriptome in response to UV and silver nitrate challenge
Stefanie Mucha (2015)
10.1094/MPMI-06-12-0164-R
The AvrB_AvrC domain of AvrXccC of Xanthomonas campestris pv. campestris is required to elicit plant defense responses and manipulate ABA homeostasis.
Y. P. Ho (2013)
10.3390/ijms160613937
Transcriptome-Wide Identification of miRNA Targets under Nitrogen Deficiency in Populus tomentosa Using Degradome Sequencing
Min Chen (2015)
10.3389/fpls.2018.00726
VvBAP1 Is Involved in Cold Tolerance in Vitis vinifera L.
Lixia Hou (2018)
10.1111/j.1742-4658.2009.07193.x
Plant oxylipins: role of jasmonic acid during programmed cell death, defence and leaf senescence
C. Reinbothe (2009)
10.1186/s12864-016-3039-x
Allyl-isothiocyanate treatment induces a complex transcriptional reprogramming including heat stress, oxidative stress and plant defence responses in Arabidopsis thaliana
R. Kissen (2016)
10.1080/07352680802467744
Programmed Cell Death in Plants: Orchestrating an Intrinsic Suicide Program Within Walls
E. Lam (2008)
10.1105/tpc.107.057067
Conserved C-Terminal Motifs Required for Avirulence and Suppression of Cell Death by Phytophthora sojae effector Avr1b[W]
D. Dou (2008)
Implications of OEP16 protein in the photoprotection of Arabidopsis thaliana during light stress
Iga Samol (2009)
10.1104/pp.17.00273
Cooperative Regulatory Functions of miR858 and MYB83 during Cyst Nematode Parasitism1[OPEN]
Sarbottam Piya (2017)
10.1016/S1673-8527(09)60085-0
A nuclear-encoded mitochondrial gene AtCIB22 is essential for plant development in Arabidopsis.
Lihua Han (2010)
10.1007/s00299-010-0941-6
Arabidopsis DAL1 and DAL2, two RING finger proteins homologous to Drosophila DIAP1, are involved in regulation of programmed cell death
B. M. S. S. Basnayake (2010)
10.1186/1471-2229-13-7
Expression-based and co-localization detection of arabinogalactan protein 6 and arabinogalactan protein 11 interactors in Arabidopsis pollen and pollen tubes
M. Costa (2012)
10.1093/jxb/erv161
SRC2-1 is required in PcINF1-induced pepper immunity by acting as an interacting partner of PcINF1.
Zhi-qin Liu (2015)
10.1093/jxb/erp104
Characterization of a canola C2 domain gene that interacts with PG, an effector of the necrotrophic fungus Sclerotinia sclerotiorum
X. Wang (2009)
10.1016/j.febslet.2009.07.020
A protein containing an XYPPX repeat and a C2 domain is associated with virally induced hypersensitive cell death in plants
M. Sakamoto (2009)
10.1186/gb-2014-15-6-r87
Functional analysis of Arabidopsis immune-related MAPKs uncovers a role for MPK3 as negative regulator of inducible defences
Nicolas Frei dit Frey (2013)
Détoxication des mycotoxines par les plantes : analyse de l'interaction entre Brachypodium distachyon et Fusarium graminearum
Jean-Claude Pasquet (2014)
10.17169/REFUBIUM-17875
Arabidopsis thaliana thermomemory of prolonged cold stress and its ecophysiological consequences with respect to the plastidic antioxidant system
J. Cvetkovic (2016)
10.1016/j.crvi.2010.03.007
Compatible plant-aphid interactions: how aphids manipulate plant responses.
P. Giordanengo (2010)
10.1007/978-1-4614-0634-1_13
Abiotic Stress and Role of Salicylic Acid in Plants
M. Hara (2012)
10.1371/journal.pone.0187114
Comparison of the transcriptomic analysis between two Chinese white pear (Pyrus bretschneideri Rehd.) genotypes of different stone cells contents
Jinyun Zhang (2017)
10.1093/jxb/erx136
VpPUB24, a novel gene from Chinese grapevine, Vitis pseudoreticulata, targets VpICE1 to enhance cold tolerance
Wenkong Yao (2017)
10.1146/annurev-phyto-102313-045854
Susceptibility genes 101: how to be a good host.
Chris C N van Schie (2014)
10.1007/s00425-007-0680-2
Molecular characterization of a pepper C2 domain-containing SRC2 protein implicated in resistance against host and non-host pathogens and abiotic stresses
Young-Cheol Kim (2007)
10.3390/ijms20061476
Molecular Players of EF-hand Containing Calcium Signaling Event in Plants
Tapan Kumar Mohanta (2019)
Identification and characterization of ERFIb transcription factor binding motifs and their target genes
J. T. Bulcha (2013)
10.1186/s12864-015-1249-2
Genome-wide analysis of bHLH transcription factor and involvement in the infection by yellow leaf curl virus in tomato (Solanum lycopersicum)
Jinyan Wang (2015)
10.1111/ppl.12434
NORE1/SAUL1 integrates temperature-dependent defense programs involving SGT1b and PAD4 pathways and leaf senescence in Arabidopsis.
Il Hwan Lee (2016)
10.1016/J.ENVEXPBOT.2019.103867
Interplay between phosphoinositides and actin cytoskeleton in the regulation of immunity related responses in Arabidopsis thaliana seedlings
Tetiana Kalachova (2019)
10.1007/s10535-013-0330-4
Characterization of a wheat C2 domain protein encoding gene regulated by stripe rust and abiotic stresses
G. Zhang (2013)
Genetic and Molecular Characterization of Leaf Rust Resistance from Uncharacterized Sources of Durum Wheat (Triticum turgidum L. ssp. durum)
Dhouha Kthiri (2017)
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